Saturday, 30 September 2017

Food Therapy: Kidney bean, the Whole Food in Reduced Risk and Treatment of Leukemia

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international jourenal Pharma and Bio science, ISSN 0975-6299.

If you expect that food and herbal medicine will ease the symptoms of your illness immediately after few day of treatment, you will be disappointed. Symptoms of the diseases can only be eased gradually, depending to stages of the treatment which directly address to the cause of the disease.

Intake of cooked Dried red kidney beans regularly may reduce risk and delay progression risk of Leukemia, a renowned institute study proposed.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Leukemia is condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chemical compound purified from dried kidney beans, namely, 7.3-kDa antifungal peptide, used mainly for treatment of fungal overgrowth, showed to suppress the spread of leukemia L1210 cells with an half concentration of 5.2±0.4 µM and 7.6±0.6 µM, according to the China Agricultural University.

Dr. Ma DZ, the lead researcher said, "(the antifungal peptide isolated from dried Nepalese large red beans) exerted an antiproliferative action on L1210 leukemia cells with an an half concentration of high doses at 15 and 60 microM, respectively".

Other chemical compound, L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds also enhanced anti-proliferative effect on ALL cells according to the WST-8 cell viability assay kit.

Furthermore, treatment of L-asparaginaseenzyme also involved significant in induced early apoptosis in acute Lymphoblastic leukemia in test subjects jn vivo.

According to the joint study lead by the King Abdulaziz University, the efficacy of novel L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds (P-Asp) in mice study showed that  mice treated with P-Asp had less distinct allergenic responses by immune system in expression of higher risk of carcinogens and reduced treatment effects.

There is no doubt that kidney beans may be a potential health benefit in targeting the risk of  Leukemia in early stage and prevent the progression of the cancer through anti-proliferative and induced tumors cell death.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) An antifungal peptide with antiproliferative activity toward tumor cells from red kidney beans by Li M1, Wang H, Ng TB.(PubMed)
(2) A peptide with potent antifungal and antiproliferative activities from Nepalese large red beans by Ma DZ1, Wang HX, Ng TB.(PubMed)
(3) Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean" by Sun J1, Wang H, Ng TB.(PubMed)
(4) Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells by Li M1,2, Liu Q3, Cui Y4, Li D5, Wang H6, Ng TB7.(PubMed)

Thursday, 28 September 2017

Food Therapy: Black bean, the Functional Food In Reduced Risk and Treatment of Osteocarcinoma

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black bean regular may reduce risk and delay progression and treatment of osteocarcinoma, an invasive form of bone cancer.

Osteocarcinoma is a condition of bone cancer caused by irregular cell growth in bone, affecting mostly adolescents and young adults..

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the The Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti proliferative activity against tumor cell lines MG-63 and HepG2 but not the normal cell line.

Malignant osteocarcinoma cell treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death through interfering the first stage of tumor cell division in expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization in controlling plasma membrane of a muscle or nerve cell


Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro inflammatory expressions.

Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteocarcinoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values".

The findings suggested that black bean may be considered as functional food in improved bone health as well as reducing risk and treatment of  osteocarcinoma, but further studies are necessary to confirm it's potency.


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

Food Therapy: Black Bean the Best on Ameliorated Oxidative Stress in Chronic Diseases

By Kyle J. Norton


People who turn to alternative medicine for treatment of diseases in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean may be used as function food to counter the over expression of free radicals through improved antioxidant activity, a university study postulated.

Oxidative Stress is the imbalance between free radical and antioxidant expression.
Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Illinois at Urbana-Champaign, the use of common bean peptides may contribute to reduced risk of complications associated to chronic diseases, including oxidative stress.

Proteins and synthesized pure peptides from Mexican black and Brazilian Carioca bean, all showed a significantly rate in reduced oxidative stress through over expression of antioxidant activity.

In a randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions, then blood of participants is collection before (fasting) and five hours postprandially, Oxidized LDL (oxLDL) showed a trend of declining observed after the Back Bean and antioxidant capacity matched meals at five hours compared to the FM group.

Dr. Reverri EJ, the lead author said" black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity".

In the compared black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE), on streptozotocin-induced diabetic mice study conducted by the Xuzhou Medical College, after 4 weeks of injection, researchers found that PPE, BBPE or PPE + BBPE, DM mice showed in some different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity.

The result indicated that mice treated with black bean or combination of black bean showed a significant in reduced levels of oxidative stress through enhanced antioxidant activities.

Taking together,  black bean may have a potential used as therapeutic whole food therapy for treatment in reduced oxidative stress in chronic illness.



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,(PubMed)
(3) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)

Food Therapy: Black Bean, The Best Functional Food in Reduced Risk of CVD and Heart Complications in Diabetics

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black or common bean may be considered as function foods in attenuated risk of Cardivascular disease, a renowned institute postulated.

Cardiovascular disease is a condition of heart attack caused by block of blood in vessel as a result of narrowing and hardening of blood vessels.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, individuals who eat more bean in promoted less glycaemic stress (hyperglycaemia and hyperinsulinaemia) may have a reduced risk of CVD,

The study also addressed the importance of bean efficacy on glycaemic response and the impact of that relationship may have on the risk of developing diabetes and CVD.
In Sprague-Dawley rats model and C57Bl/6 mice induced obesity by a diet, both bean diet,groups showed a significant in reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG in short-term. And bean-fed obese mice not only induced weight loss but also improved plasma lipid profile within a 12 d time frame in compared to other groups.

The weight loss and reduced levels of blood cholesterol in tested subjects provided a significant information of dried bean function in ameliorated risk of cardiovascular disease.

Other in the study of risk of development of cardiovascular complications in patients with diabetes, suggested that the imbalance between reactive oxygen species and antioxidant systems in patients with types 2 diabetes may be leading causes of heart complications involving high cardiac collagen content.

Therefor, increased intake of bean diet may play a prevalent role in reduced risk of CVD by increased total antioxidant activity and reduced the expression of hyperglycaemic state, catalase and superoxide dismutase activity and tissue damage caused by lipid peroxidation.

Dr. Oliveira RJ, the lead author said, "The phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications".

Collectively, adding a bean portion in your diet daily may have a substantially reduced risk of heart disease and  heart complications in diabetics, in comparison to people with typical American diet.


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats by Oliveira RJ1, de Oliveira VN, Deconte SR, Calábria LK, da Silva Moraes A, Espindola FS.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Elevated and Ameliorated Menopause Symptoms Differently

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Menopause is a natural and biological progression of women at certain age. The reduced hormone levels of inaction of ovaries induced menstruation stop and a set of symptoms

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

A study conducted by a renowned institute suggested that coffee nd coffee caffeine may have potential effect in reduced severity of some menopause symptoms and elevation of others.

In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011, caffeine intake in participants showed a greater positive effect in expression of vasomotor symptom of menopause women in compared to non drinkers group.

Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to non drinkers.

And caffeine intake also is found as one of predictor in  exhibited both hot flashes (HF) and night sweats (NS)  in the same study group.

But in animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.

Administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.

Taking altogether, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.


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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT.(PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)

Food Therapy: Kidney bean, the Best Anti-cancer Healthy Whole Food

By Kyle J. Norton

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Kidney bean may have potential effects against irregular cell growth in the body, causing various types of cancer, a recent study proposed.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Cancer, a group of diseases characterized by cells growing and multiplying disordered and uncontrollable in our body. At the late stage, cancer cells may travel a distance away from the original site to invase other tissues and organs.

According to the joint study lead by the Shenzhen University, chemical compound 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), showed an efficacy in inhibited HepG2 activity in compared to MCF7 cells through induced anti proliferative and anti apoptotic activities.

The study also found that epithelial tumor cell lines ( HONE-1) also are inhibited by chemical compound lectin in activation of various extrinsic apoptosis pathway involved cell death.

Dr. Chan YS, the lead author said, " The (anti proliferative) activity could be reduced by addition of glucosamine, which occupies the binding sites of WKBL, indicating that carbohydrate binding is crucial for the activity".

Beside chemical compound 60-kDa glucosamine binding lectin, 64-kDa glucosamine-specific lectin isolated from brown kidney bean also exhibited antiproliferative activity against nubers of cell lines including human breast cancer (MCF7) cells, hepatoma (HepG2) cells and nasopharyngeal carcinoma (CNE1 and CNE2) cells with concentration of an inhibitor of 5.12 µM, 32.85 µM, 3.12 µM and 40.12 µM respectively after treatment for 24 hours.

Particularly in breast cancer cell line MCF7, formation of apoptotic bodies of the tumors are associated to apoptosis involved estrogen receptor(ER) stress and directed protein response.

Taking together, Kidney bean processed an anti cancer effects by exhibited anti proliferative and anti apoptotic activities against the early stage of development and progression of the cancer in various pathway. Please note that raw kidney beans are toxic.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) White kidney bean lectin exerts anti-proliferative and apoptotic effects on cancercells by Chan YS1, Xia L2, Ng TB3.(PubMed)
(2) Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells by Chan YS1, Wong JH, Fang EF, Pan W, Ng TB.(PubMed)

Wednesday, 27 September 2017

Food Therapy: Kidney bean, The Natural Whole Food with Anti-Microbial Activities

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over laast 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Recently study conducted by renowned institute suggested that oral administrated kidney bean may have a potential health benefits in reduced risk and treatment of microbial infection.

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol and good sources of protein and mineral.

According to the research article posted at the Journal of Microbial & Biochemical Technology, lectins isolated from kidney bean seed displayed a significant antifungal and anti bacteria activity on many straits of Staphylococcus aureus ATCC 6538, and Streptococcus mutants ATCC 25175, Pseudomonas aeruginosa ATCC 10145 and Klebsiella pneumonia and Candida albican.

The chemical compound lectins also manifested inhibitory effects on human immunodeficiency virus-1 reverse transcriptase of enzymes in catalyzed the formation of RNA from a DNA and alpha-glucosidase in lower the rate of glucose absorption.

Dr. Ye XY, the lead author in the study said, " It(Lectins) exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani".

Other researchers suggested that the potency of kidney bean in exhibited anti microbial effect may be a result of its source of nondigestible fermentable components and phenolic compounds. 

In  healthy mice exposed to dextran sodium sulphate (DSS) (via drinking water, 2% DSS w/v, 7 days) induced colitis and fed with one of three isocaloric diets: basal diet control (BD), or BD supplemented with 20% cooked white (WK) or dark red kidney (DK) bean flour for 3 weeks, mice fed with both bean diets reduced, significantly disease severity, colonic damage and exerted increased mRNA expression of antimicrobial effects involved innate immunity and protected mucosa from insults through stabilizing the mucus layer and promoted healing of the epithelium and reduced proinflammatory cytokins demonstration.

Furthermore, cooked white (WK) or dark red kidney (DK) bean fed mice also enhanced microbial-derived SCFA metabolite production in regulated fermentation products, gut barrier integrity and the microbial defensive response .....
Taking together, Kidney beans ( Phaseolus) showed to process a strong anti-microbial effect in reduced infection and inflammation caused by straits of bacteria and fungi, especially in protected the digestive system against inflammation cause of  colitis.




Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antimicrobial Activities of Lectins Extracted from Some Cultivars of Phaseolus vulgaris by SeedsEinas Hamed El-S1, Magda Mahmoud Ibrahim El-A2and Mervat Mounir S1(Journal of Microbial & Biochemical Technology)
(2) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA6.(PubMed)
(3) Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds by Ye XY1, Ng TB, Tsang PW, Wang J.(PubMed)