Food Therapy: Black bean, the Functional Food In Reduced Risk and Treatment of Osteocarcinoma

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black bean regular may reduce risk and delay progression and treatment of osteocarcinoma, an invasive form of bone cancer.

Osteocarcinoma is a condition of bone cancer caused by irregular cell growth in bone, affecting mostly adolescents and young adults..

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the The Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti proliferative activity against tumor cell lines MG-63 and HepG2 but not the normal cell line.

Malignant osteocarcinoma cell treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death through interfering the first stage of tumor cell division in expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization in controlling plasma membrane of a muscle or nerve cell

Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro inflammatory expressions.

Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteocarcinoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values".

The findings suggested that black bean may be considered as functional food in improved bone health as well as reducing risk and treatment of  osteocarcinoma, but further studies are necessary to confirm it's potency.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

Food Therapy: Black Bean the Best on Ameliorated Oxidative Stress in Chronic Diseases

By Kyle J. Norton


People who turn to alternative medicine for treatment of diseases in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean may be used as function food to counter the over expression of free radicals through improved antioxidant activity, a university study postulated.

Oxidative Stress is the imbalance between free radical and antioxidant expression.
Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Illinois at Urbana-Champaign, the use of common bean peptides may contribute to reduced risk of complications associated to chronic diseases, including oxidative stress.

Proteins and synthesized pure peptides from Mexican black and Brazilian Carioca bean, all showed a significantly rate in reduced oxidative stress through over expression of antioxidant activity.

In a randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions, then blood of participants is collection before (fasting) and five hours postprandially, Oxidized LDL (oxLDL) showed a trend of declining observed after the Back Bean and antioxidant capacity matched meals at five hours compared to the FM group.

Dr. Reverri EJ, the lead author said" black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity".

In the compared black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE), on streptozotocin-induced diabetic mice study conducted by the Xuzhou Medical College, after 4 weeks of injection, researchers found that PPE, BBPE or PPE + BBPE, DM mice showed in some different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity.

The result indicated that mice treated with black bean or combination of black bean showed a significant in reduced levels of oxidative stress through enhanced antioxidant activities.

Taking together,  black bean may have a potential used as therapeutic whole food therapy for treatment in reduced oxidative stress in chronic illness.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,(PubMed)
(3) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)

Food Therapy: Black Bean, The Best Functional Food in Reduced Risk of CVD and Heart Complications in Diabetics

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black or common bean may be considered as function foods in attenuated risk of Cardivascular disease, a renowned institute postulated.

Cardiovascular disease is a condition of heart attack caused by block of blood in vessel as a result of narrowing and hardening of blood vessels.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, individuals who eat more bean in promoted less glycaemic stress (hyperglycaemia and hyperinsulinaemia) may have a reduced risk of CVD,

The study also addressed the importance of bean efficacy on glycaemic response and the impact of that relationship may have on the risk of developing diabetes and CVD.
In Sprague-Dawley rats model and C57Bl/6 mice induced obesity by a diet, both bean diet,groups showed a significant in reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG in short-term. And bean-fed obese mice not only induced weight loss but also improved plasma lipid profile within a 12 d time frame in compared to other groups.

The weight loss and reduced levels of blood cholesterol in tested subjects provided a significant information of dried bean function in ameliorated risk of cardiovascular disease.

Other in the study of risk of development of cardiovascular complications in patients with diabetes, suggested that the imbalance between reactive oxygen species and antioxidant systems in patients with types 2 diabetes may be leading causes of heart complications involving high cardiac collagen content.

Therefor, increased intake of bean diet may play a prevalent role in reduced risk of CVD by increased total antioxidant activity and reduced the expression of hyperglycaemic state, catalase and superoxide dismutase activity and tissue damage caused by lipid peroxidation.

Dr. Oliveira RJ, the lead author said, "The phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications".

Collectively, adding a bean portion in your diet daily may have a substantially reduced risk of heart disease and  heart complications in diabetics, in comparison to people with typical American diet.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats by Oliveira RJ1, de Oliveira VN, Deconte SR, Calábria LK, da Silva Moraes A, Espindola FS.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Elevated and Ameliorated Menopause Symptoms Differently

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Menopause is a natural and biological progression of women at certain age. The reduced hormone levels of inaction of ovaries induced menstruation stop and a set of symptoms

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

A study conducted by a renowned institute suggested that coffee nd coffee caffeine may have potential effect in reduced severity of some menopause symptoms and elevation of others.

In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011, caffeine intake in participants showed a greater positive effect in expression of vasomotor symptom of menopause women in compared to non drinkers group.

Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to non drinkers.

And caffeine intake also is found as one of predictor in  exhibited both hot flashes (HF) and night sweats (NS)  in the same study group.

But in animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.

Administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.

Taking altogether, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT.(PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)

Food Therapy: Kidney bean, the Best Anti-cancer Healthy Whole Food

By Kyle J. Norton

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Kidney bean may have potential effects against irregular cell growth in the body, causing various types of cancer, a recent study proposed.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Cancer, a group of diseases characterized by cells growing and multiplying disordered and uncontrollable in our body. At the late stage, cancer cells may travel a distance away from the original site to invase other tissues and organs.

According to the joint study lead by the Shenzhen University, chemical compound 60-kDa glucosamine binding lectin, white kidney bean lectin (WKBL), showed an efficacy in inhibited HepG2 activity in compared to MCF7 cells through induced anti proliferative and anti apoptotic activities.

The study also found that epithelial tumor cell lines ( HONE-1) also are inhibited by chemical compound lectin in activation of various extrinsic apoptosis pathway involved cell death.

Dr. Chan YS, the lead author said, " The (anti proliferative) activity could be reduced by addition of glucosamine, which occupies the binding sites of WKBL, indicating that carbohydrate binding is crucial for the activity".

Beside chemical compound 60-kDa glucosamine binding lectin, 64-kDa glucosamine-specific lectin isolated from brown kidney bean also exhibited antiproliferative activity against nubers of cell lines including human breast cancer (MCF7) cells, hepatoma (HepG2) cells and nasopharyngeal carcinoma (CNE1 and CNE2) cells with concentration of an inhibitor of 5.12 µM, 32.85 µM, 3.12 µM and 40.12 µM respectively after treatment for 24 hours.

Particularly in breast cancer cell line MCF7, formation of apoptotic bodies of the tumors are associated to apoptosis involved estrogen receptor(ER) stress and directed protein response.

Taking together, Kidney bean processed an anti cancer effects by exhibited anti proliferative and anti apoptotic activities against the early stage of development and progression of the cancer in various pathway. Please note that raw kidney beans are toxic.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) White kidney bean lectin exerts anti-proliferative and apoptotic effects on cancercells by Chan YS1, Xia L2, Ng TB3.(PubMed)
(2) Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells by Chan YS1, Wong JH, Fang EF, Pan W, Ng TB.(PubMed)

Food Therapy: Kidney bean, The Natural Whole Food with Anti-Microbial Activities

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over laast 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Expectation of easing symptoms after a few days of herbal treatment, in most cases are ended with disappointment. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly addresses to the cause of the disease.

Recently study conducted by renowned institute suggested that oral administrated kidney bean may have a potential health benefits in reduced risk and treatment of microbial infection.

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol and good sources of protein and mineral.

According to the research article posted at the Journal of Microbial & Biochemical Technology, lectins isolated from kidney bean seed displayed a significant antifungal and anti bacteria activity on many straits of Staphylococcus aureus ATCC 6538, and Streptococcus mutants ATCC 25175, Pseudomonas aeruginosa ATCC 10145 and Klebsiella pneumonia and Candida albican.

The chemical compound lectins also manifested inhibitory effects on human immunodeficiency virus-1 reverse transcriptase of enzymes in catalyzed the formation of RNA from a DNA and alpha-glucosidase in lower the rate of glucose absorption.

Dr. Ye XY, the lead author in the study said, " It(Lectins) exerted a suppressive effect on growth of the fungal species Fusarium oxysporum, Coprinus comatus, and Rhizoctonia solani".

Other researchers suggested that the potency of kidney bean in exhibited anti microbial effect may be a result of its source of nondigestible fermentable components and phenolic compounds. 

In  healthy mice exposed to dextran sodium sulphate (DSS) (via drinking water, 2% DSS w/v, 7 days) induced colitis and fed with one of three isocaloric diets: basal diet control (BD), or BD supplemented with 20% cooked white (WK) or dark red kidney (DK) bean flour for 3 weeks, mice fed with both bean diets reduced, significantly disease severity, colonic damage and exerted increased mRNA expression of antimicrobial effects involved innate immunity and protected mucosa from insults through stabilizing the mucus layer and promoted healing of the epithelium and reduced proinflammatory cytokins demonstration.

Furthermore, cooked white (WK) or dark red kidney (DK) bean fed mice also enhanced microbial-derived SCFA metabolite production in regulated fermentation products, gut barrier integrity and the microbial defensive response .....

Taking together, Kidney beans ( Phaseolus) showed to process a strong anti-microbial effect in reduced infection and inflammation caused by straits of bacteria and fungi, especially in protected the digestive system against inflammation cause of  colitis.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Antimicrobial Activities of Lectins Extracted from Some Cultivars of Phaseolus vulgaris by SeedsEinas Hamed El-S1, Magda Mahmoud Ibrahim El-A2and Mervat Mounir S1(Journal of Microbial & Biochemical Technology)
(2) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA6.(PubMed)
(3) Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds by Ye XY1, Ng TB, Tsang PW, Wang J.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Intake and Risk of Gallstone and Gallstone Diseases

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Epidemiological studies, linking coffee consumption in reduced risk of gallstone, but not gallstone disease have been contradictory.

Gallstone is a stone formed within the gallbladder out of bile components as a result of building up of undissolved cholesterol over a prolonged period of time.

Coffee, a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of 174 cases of gallstones determined by ultrasonography, 104 cases of postcholecystectomy, and 6889 controls of normal gallbladder in the total of 7637 men received a health examination at four hospitals of the Self-Defense Forces (SDF) with 174 cases of prevalent gallstones, 50 had been aware of having gallstones, researchers found that coffee and coffee caffeine drinkers express a high risk of gallstone incidence in compared to non drinkers.

In these group of middle-aged Japanese men, the relative odds ratios of gallstone disease 1.7 for coffee consumption of five cups or more per day vs. no consumption and 2.2 for caffeine intake of 300 mg/day or more vs. less than 100 mg/day.

Obviously, these findings contradicted to other studies in support of risk of gallstone reduced by coffee and caffeine intake, including the study conducted by Harvard School of Public Health.

Other, in the review literature of database from PubMed and EMBASE of all published studies before June 2015 researchers at The First Affiliated Hospital of Zhengzhou University files the following results
1. Coffee intake regularly and daily had a significantly reduced risk of gallstone disease, in related females, but not in males. based on prospective studies.

2. For patients drinking one cup of coffee per day, the risk of of gallstone disease was 0.95
3. For patients drinking 2, 4 and 6 cups of coffee per day, the estimated RRs of gallstone disease reduced to 0.89 (95% CI, 0.79 to 0.99), 0.81 and .75 respectively.
4, Coffee intake showed a linear association to ameliorated risk of gallstone diseases.

Interestingly, in a cohort of 80,898 women age 34-59 years in 1980 who had no history of gallstone disease, during 20 years of follow-up, researchers filed the below results
1. Compared to non caffeine coffee drinkers women, the multivariate relative risks of gallstone disease with cholecystectomy in compared to consistent intake of caffeinated coffee (0, 1, 2-3, and > or =4 cups/day) were 1.0, 0.91, 0.78, and 0.72 respectively.
2. Coffee caffeine intake was inversely associated to risk of cholecystectomy.
3. Caffeine intake (< or =25, 26-100, 101-200, 201-400, 401-800, and >800 mg/day) is linearly associated to reduced risk of gallstone disease with multivariate relative ratio of 1.0, 1.03, 1.01, 0.94, 0.85, and 0.85 4. Decaffienated coffee was not associated with risk.

There is no doubt that the study addresses a significantly inverse association in reduced risk of gallstone disease among coffee drinkers linearly.

Taking altogether, the contradictory result may warrant a further study, before one can make a decision of the effect of coffee and coffee caffeine in concern of risk of gallstone, but not in the attnuated risk of symptomatic gallstone disease.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Lossu

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men by Ishizuk H1, Eguchi H, Oda T, Ogawa S, Nakagawa K, Honjo S, Kono S.(PubMed)
(2) Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease by Zhang YP1, Li WQ1, Sun YL1, Zhu RT1, Wang WJ1.(PubMed)
(3) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men by Leitzmann MF1, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E.(PubMed)