Food Therapy: Coffee and Coffee caffeine A Potent Depressive Beverage?

By Kyle J. Norton


In compared to herbal medicine, food therapy is one the best medicines to ease symptoms slowly, depending to stages of the treatment which directly address to the cause of disease, without inducing adverse effects

Epidemiological studies do not agreed that coffee and coffee caffeine have a positive effect in reduced depression, a review literature study suggested.

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Depression is a normally neuro response as part of our daily lives such as the loss of s job, the death of a love one, and illness.
Over 30 million Americans suffer from depression and the amounts are increasing in an alarming rate.

According to the University of Naples Federico II, over 2 decades, many studies addressed the concerns of coffee intake may have a implication of incidence of depression, but several phytochemical studies indicated a different outcome as caffeine and certain major phyto constituents exhibited antidepressant effects through multiple molecular mechanisms.

Dr. Tenore GC, the lead researcher said, "coffee can be considered a drink which has different positive effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However, heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased blood pressure, nausea, and restlessness".

Contrastively, caffeine in coffee showed a strongly inverse association in cases of postpartum depression and comorbid panic disorder.

Other researchers in the searching of the efficacy of coffee and risk of depression through data base from PubMed and PsychINFO insisted that although literature data are conflicting, caffeine found in coffee indicated a significant reduced effect on symptoms of clinical depression.

Additionally, in a cross-sectional study in 10,177 Korean individuals aged 20-97 years with prevalence of self-reported depression of 14.0% and that of self-reported clinical depression of 3.7%. participated in the fifth Korean National Health and Nutrition Examination Survey. to determine the effect of consumption of coffee and risk of depression, after adjusting to other factors, returned survey from patients, can be cataloged into the followings

For general depression
1. The relative odd ratio of patients drinking less than one cup/week was 0.84
2. The relative odd ratio of patients drinking one to six cups/week was 0.63
3. The relative odd ratio of patients drinking for one cup/day was 0.69
4. The relative odd ratio of patients drinking for two cups/day was 0.54
5. The relative odd ratio of patients drinking for three or more cups/day was .58

For clinical depression, similar observations also have been recorded
1. The relative odd ratio of patients drinking less than one cup/week was 1.00
2. The relative odd ratio of patients drinking one to six cups/week was 0.51
3. The relative odd ratio of patients drinking for one cup/day was 0.57
4. The relative odd ratio of patients drinking for two cups/day was 0.57
5. The relative odd ratio of patients drinking for three or more cups/day was 0.41

The findings although is not linearly, coffee and coffee caffeine intake expressed a protective effect in ameliorated risk of depression.

Taking together, there is no doubt that coffee and coffee caffeine intake daily and regularly have a profound effect in depression but further cohost large sample sized studies are necessary to find out other factors may contribute to either outcomes.

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Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and Depression: A Short Review of Literature by Tenore GC1, Daglia M, Orlando V, D'Urso E, Saadat SH, Novellino E, Nabavi SF, Nabavi SM.(PubMed)
(2) [Coffee consumption in depressive disorders: it's not one size fits all].[Article in Italian] by Rusconi AC, Valeriani G, Carluccio GM, Majorana M, Carlone C, Raimondo P, Ripà S, Marino P, Coccanari de Fornari MA, Biondi M.(PubMed)

Food Therapy: Coffee and Coffee Caffeine in Reduced Risk of Breast Cancer Selectively

By Kyle J. Norton

In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Recent studies suggested that coffee and coffee caffeine may have a potentially effect in reduced risk and treatment of breast cancer, selectively.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of literature from database of PubMed with selection of 37 published articles, involving 59,018 breast cancer cases and 966,263 participants, suggested that
1. There are no significant association of coffee and coffee caffeine intake and breast cancer risk
2. Post menopause women drinking coffee daily and regularly have a reduced risk of breast cancer developing.
3. Women who are BRCA1 mutation carriers showed a positive risk of breast cancer from coffee intake

The study also indicated that for additional cup of coffee consumed risk of breast caner decrease by 2% and 1% for every 200mg/day increment in caffeine intake.

Contrastively, in a case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries.to determine coffee and coffee caffeine intake against the risk of breast cancer, returned self-administered questionnaire. showed a significant correlation of coffee intake in the elevated breast caner risk.

Women with breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee showed a relative risk odd ratio of 1.00, 0.90, 0.75 and 0.31, respectively.

The finding evidences of relative odd ratio of suggested that risk of breast cancer was reduced in this group of women linearly to numbers of coffee and coffee caffeine consumed daily.

Dr, Jiang W, lead author said, " (According to the findings) women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk"

Interesting, in the investigated the common A to C polymorphism in the CYP1A2 gene associated with decreased enzyme inducibility and impaired caffeine metabolism of caffeine to examine the risk of breast caner in BRCA1 mutation carriers of 411 BRCA1 mutation carriers (170 cases and 241 controls) researchers at the University of Toronto found that risk of breast cancer decrease significantly by 64% in BRCA1 mutation carriers with at least one C polymorphism in the CYP1A2 gene but not in CYP1A2 AA group in compared to women who never consumed coffee.

Collectively, coffee and coffee caffeine may only benefit to certain ages and genes expression but harmful to the others. Further cohost studies are necessary to clarify these controversies..

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FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies by Jiang W1, Wu Y, Jiang X.(PubMed)
(2) Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers by Nkondjock A1, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA.(PubMed)
(3) The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers by Kotsopoulos J1, Ghadirian P, El-Sohemy A, Lynch HT, Snyder C, Daly M, Domchek S, Randall S, Karlan B, Zhang P, Zhang S, Sun P, Narod SA.(PubMed)

Herbal Therapy: Chaste Tree Berry The Best Anticonvulsant Herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants has formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

A study conducted by a respectable institution suggested that Chaste Tree Berry exhibited anticonvulsant activity in patients with seizures.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In a study using animal model of maximal electroshock seizures (MES) and induced seizures (MES) by administrated pentylenetetarazole (PTZ), intake of ethanolic leaf extract of Vitex-negundo, at doses of 250, 500 and 1000 mg/kg p.o, exerted a significant of postictal depression, an altered state of consciousness after an epileptic seizure in the dose of 1000 mg/kg body weight in comparison to control but no effects in other applications.

At doses of (1000 mg/kg, po), the ethanolic leaf extract exhibited a 50% half life protection in chronic seizures after 24-hour injection against PTZ induced seizures. Researchers also found that the efficacy of the extract at that doses is the result of valporic acid, a major ingredient found in Chaste tree berry.

Dr. Tandon VR and co author Dr. Gupta RK. of the study said, " The anticonvulsant activity of Vitex-negundo has not been found equi-effective with standard drugs".

Further more, because of the potentiation of diphenylhydantoin and valporic acid isolated Vitex-negundo displayed a significant effect in treating animal model, the extract may be used as an adjuvant therapy along with standard anticonvulsants.

Additionally, according to the Baqiyatallah University of Medical Sciences, hydrophilic extract of Vitex agnus castus fruit (Vitex) administered doses (60, 120 or 180 mg/kg) showed a strong anti convulsant activity even at low dose (60 mg/kg) of Vitex by increasing the after discharge(AD) threshold and decrease the after discharge duration ( ADD) and and stage 5 duration (S5D).

Promisingly, at the highest does, the extract inhibited significantly seizure stage (P<0.01) and reduced or prevented epileptic activity as demonstrated by reduction of ADD and S5D (length of convulsion) in a dose dependent manner.

More importantly, methanolic extract (ME) of the leaves of V. negundo salso showed to process the  analgesic properties and potentiated analgesia demonstrated by morphine and pethidine in protection against strychnine and leptazole induced convulsions.

Taking together, Chaste Tree Berry may be one of next generation therapeutic herbal medicine consisted a strong effect for prevention and treatment of seizure as a result of abundant phytochemicals, but intake of large amount should taken with care to reduce risk of toxicity.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) An experimental evaluation of anticonvulsant activity of Vitex-negundo by Tandon VR1, Gupta RK.(PubMed)
(2) The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats by Saberi M1, Rezvanizadeh A, Bakhtiarian A.(PubMed)
(2) CNS activity of Vitex negundo Linn. in mice by Gupta M1, Mazumder UK, Bhawal SR.(PubMed)

Food therapy: Coffee Reduced Risk of Melanoma, Particular in People with Altered GSTM1 and GSTT1 Gene

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease the symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of coffee regularly may have positive effect in reduced risk of Melanoma, particular in healthy people with alternated genes GSTM1 and GSTT1 expression, a renowned institute study suggested.

Melanoma is a type of malignant skin cancer caused by DNA damage, most often caused by ultraviolet radiation from sunshine or tanning beds inducing irregular growth of skin cells.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Istituto Dermopatico dell'Immacolata, in compared to low coffee intake, high frequency of coffee drinking (>once daily) with ≤7 times weekly , showed a significant lower risk of melanoma.

Interestingly, in the group people with GSTM1 and GSTT1 null polymorphisms(altered gene expression) subjects, coffees showed an extreme high protective effect against forming of Melanoma.

Also in the searching of PubMed and EMBASE databases from the earliest available online indexing year to March 2017 for a dose-response meta-analysis on prospective cohort studies, researchers at the Jagiellonian University Medical College, insisted that linear dose dependent are associated to the development of melanoma risk and total coffee consumption.

Risk of melanoma is reduced by 3% for every cup of coffee intake per day.

Dr. Micek A, the lead author in the joint study said, "(According to) a total of seven studies eligible for meta-analysis were identified that comprised 1,418,779 participants and 9211 melanoma cases,......coffee intake may be inversely associated with incidence of melanoma".

Further in the demonstration of 2 case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases), in compared the lower and higher caffeine intake daily, caffeinated coffee showed a the pooled relative risk (RR) of 0.81.

Risk of additional cup of coffee caffeine consumption, relative odd ratio of risk of melanoma deceased by 0.955
Importantly, the study found no correlated and linear dose dependent of decaffeinate coffee and risk melanoma regardless to volume of daily intake in teasing subjects.

Taking altogether, there is no doubt that caffeine coffee have a significant effect in reduced risk of malanoma in healthy and altered GSTM1 and GSTT1 expression subjects in linearly dose-dependent 

manner.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms by Fortes C1, Mastroeni S, Boffetta P, Antonelli G, Pilla MA, Bottà G, Anzidei P, Venanzetti F.(PubMed)
(2) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1(PubMed).

Food Therapy: Coffee and Coffee caffeine, In Attenuated Risk of Ulcerative Colitis?

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease the symptoms, depending to stages of the treatment which directly address to the cause of disease.

Epidemiological studies do not agreed that intake of coffee and coffee caffeine regularly may have a profound effect in attenuated risk of ulcerative colitis.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Ulcerative colitis is an inflammatory bowel disease characterized by long-lasting inflammation and ulcers (sores) in the digestive tract.

In the reviewed study of a total of 442 patients 73% regularly consume coffee. 96% of patients attributing a positive and 91% of patients attributing no impact of coffee intake on IBD regularly drink coffee and surprisingly even 49% of those patients that assign a negative impact on disease symptoms, researchers at the University Hospital Zurich found that most patient with IBD showed a coffee drinking habit and addressed that coffee has helped modifying symptoms of the disease.

Other in the total of 81 UC patients recruited at all stages of the disease process, after completion of a 7 d diet diary, Caffeine and decaffeinated coffee showed a clinical significance in reduced risk of UC and may be considered a functional food included in potentially therapeutic diet.

Dr. Magee EA, the lead author said, " ......decaffeinated coffee was associated with a better clinical state than the caffeine containing version".

Contrastively, the investigation of a population-based, case-control study of the risk of ulcerative colitis associated with coffee and alcohol use among the 304,000 members of a prepaid health plan, coffee expressed no association with either amount of coffee consumed daily, or cumulative coffee consumption before disease onset and altered the risk of developing ulcerative colitis.

Taking altogether, the findings showed an inclusive result of the efficacy of coffee and coffee caffeine consumption in reduced risk of ulcerative colitis. Therefore more cohost with large sample size studies are necessary before coffee can be confirmed as a functional food for use in reduced onset and treatment of ulcerative colitis.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Patients' perceptions on the impact of coffee consumption in inflammatory bowel disease: friend or foe?--a patient survey by Barthel C1,2, Wiegand S3,4, Scharl S5, Scharl M6,7, Frei P8, Vavricka SR9, Fried M10, Sulz MC11,12, Wiegand N13,14, Rogler G15,16, Biedermann L17.(PubMed)
(2) Associations between diet and disease activity in ulcerative colitis patients using a novel method of data analysis by Magee EA1, Edmond LM, Tasker SM, Kong SC, Curno R, Cummings JH.(PubMed)
(3) Coffee and alcohol use and the risk of ulcerative colitis by Boyko EJ1, Perera DR, Koepsell TD, Keane EM, Inui TS.(PubMed)

Food Therapy: Coffee and Coffee Caffeine in Improved Complexity of Cognitive Performance?

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease the symptoms, depending to stages of treatment which directly address to the cause of disease.

Epidemiological studies do not agreed that regular coffee consumption may associate to improve cognitive function, a joint study lead by the Universidade Federal de Minas Gerais suggested.

Cognitive function is a cerebral activities in acquired knowledge, including all means and mechanisms of acquiring information.
Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In a cohort of 14,563  public service workers (35-74 years old) to examine the coffee consumption habits and cognitive function using standardized neuropsychological test, researchers at the above institutes filed the following results
1. Elderly drinking 2-3 cups/day, showed a significant improvement in the mean words remembered on learning, recall, and word recognition in compared to never/almost never groups.

2. And those drinking more than 3 cups a day exhibited an increased mean words pronounced, according to the semantic verbal fluency test in compared to the same groups.

Dr. Araújo LF, the lead author said, "coffee consumption might be slightly beneficial to memory in elderly but lacks a dose response relationship".

Further more, in 2,914 participants from the population-based Rotterdam Study (mean age: 59.3±7.2 years, 55% females) to assess coffee consumption, performed brain MRI, and cognition at baseline, researchers found that
1. Higher coffee consumption showed a lower prevalence of lacunar infarcts [odds ratio per cup increase: 0.88 (95% CI:0.79;0.98)]involved development of stroke, and smaller hippocampal volume in expression of memory ability.
2. Coffee consumption promoted better performance on the Letter Digit Substitution Task
3. But do not improved on the 15-Word Learning test delayed recall.

Dr. Araújo LF, again said, "...(there is a) complex associations between coffee consumption, brain structure, and cognition. Higher coffee consumption was cross-sectionally associated with a lower occurrence of lacunar infarcts and better executive function.

Interestingly, according to the study of coffee consumption and other baseline variables of 2606 middle-aged Finnish twins assessed in 1975 and 1981 by postal questionnaires, with after the median follow-up of 28 y, coffee consumption was not an independent predictor of cognitive performance in old age, according to the linear regression analysis.

The study also insisted that coffee drinking did not affect the risk of mild cognitive impairment or dementia, but expressed an inconsistent cognitive score.

Taking altogether, coffee and coffee caffeine can only improve performance of some cognitive function but not at a whole, particular in older population.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Inconsistency of Association between Coffee Consumption and Cognitive Function in Adults and Elderly in a Cross-Sectional Study (ELSA-Brasil) by Araújo LF1, Giatti L2, Reis RC3, Goulart AC4, Schmidt MI5, Duncan BB6, Ikram MA7, Barreto SM8.(PubMed)
(2) Association of Coffee Consumption with MRI Markers and Cognitive Function: A Population-Based Study by Araújo LF1,2, Mirza SS2, Bos D2,3, Niessen WJ3,4, Barreto SM1, van der Lugt A3, Vernooij MW2,3, Hofman A2, Tiemeier H2,5,6, Ikram MA2,3,(PubMed)
(3) Coffee drinking in middle age is not associated with cognitive performance in old age by Laitala VS1, Kaprio J, Koskenvuo M, Räihä I, Rinne JO, Silventoinen K.(PubMed)

Food Therapy: Coffee and Coffee Caffeine In Reduced Risk and Treatment of Localized and Advanced Prostate Cancer

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Good news for men coffee lovers, coffee and coffee caffeine consumption daily and regularly are associated to attenuated risk and treatment of prostate cancer, epidemiological study suggested.

Coffee, has become a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Prostate Cancer is a medical condition characterized by cell growth disorderable and uncontrollable in the prostate.

In the study of the efficacy of coffee intake and risk of prostate cancer (PC-3 and DU145) on 6,989 men of the Moli-sani cohort aged ≥50 years showed that
1. Risk of prostate cancer reduced by 53% in people drinking over>3 cups/day in compared to participants at the lowest consumption (0-2 cups/day)
2. Injection of caffeine in both cancer cell lines PC-3 and DU145 showed a substantial activity in reduction of proliferative and metastatic behaviors.

Caffeine demonstration exerted significantly anti proliferative and anti metastatic activity on two prostate cancer cell lines, may be attributed to its bioactive compounds in expression of anti cancer in various mechanisms.
Other, in the selection of twenty-eight studies (14 case-control and 14 cohort studies) on coffee caffeine (CC) with 42399 PC patients for the final meta-analysis searched from data bases of Pubmed and Embase, researchers, filed the following results

1. There was no significant association of prostate cancer in regard to high versus non/lowestCC intake.

2. Coffee and coffee caffeine intake showed a localized effect in subtype of prostate cancer but not advanced prostate cancer. 

These result showed a significant effect of coffee in reduced risk of early stage of prostate cancer and coffee do not associate to risk of prostate cancer.

More profoundly in the report of a prospective analysis of 47,911 men with intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study
1. Men, drinking six or more cups per day had a lowest relative risk for overall prostate cancer in compared to nondrinkers.

2. Over all, Coffee consumption was not associated with the risk of nonadvanced or low-grade prostate cancers and was only weakly inversely associated with high-grade prostate cancer

3. There was no different effect of regular and decaffeinated coffee in ameliorated risk of prostate cancer.

Taking altogether, there is no doubt that coffee and coffee caffeine intake were associated linearly to
reduced risk of localized and advanced and lethal prostate cancer, Risk of cancer is also reduced proportionally with additional cup of coffee consumed.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) An Up-to-date Meta-analysis of Coffee Consumption and Risk of Prostate Cancer by Xia J1, Chen J2, Xue JX3, Yang J3, Wang ZJ3.(PubMed)
(2) Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models by Pounis G1, Tabolacci C2, Costanzo S1, Cordella M2, Bonaccio M1, Rago L3, D'Arcangelo D4, Filippo Di Castelnuovo A1, de Gaetano G1, Donati MB1, Iacoviello L1,5, Facchiano F2; Moli-sani study investigators6.(PubMed)
(3) Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study by Wilson KM1, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, Giovannucci E, Mucci LA.(PubMed)