Food Therapy: Coffee and Coffee Caffeine In Reduced Risk and Treatment of Localized and Advanced Prostate Cancer

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Good news for men coffee lovers, coffee and coffee caffeine consumption daily and regularly are associated to attenuated risk and treatment of prostate cancer, epidemiological study suggested.

Coffee, has become a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Prostate Cancer is a medical condition characterized by cell growth disorderable and uncontrollable in the prostate.

In the study of the efficacy of coffee intake and risk of prostate cancer (PC-3 and DU145) on 6,989 men of the Moli-sani cohort aged ≥50 years showed that
1. Risk of prostate cancer reduced by 53% in people drinking over>3 cups/day in compared to participants at the lowest consumption (0-2 cups/day)
2. Injection of caffeine in both cancer cell lines PC-3 and DU145 showed a substantial activity in reduction of proliferative and metastatic behaviors.

Caffeine demonstration exerted significantly anti proliferative and anti metastatic activity on two prostate cancer cell lines, may be attributed to its bioactive compounds in expression of anti cancer in various mechanisms.
Other, in the selection of twenty-eight studies (14 case-control and 14 cohort studies) on coffee caffeine (CC) with 42399 PC patients for the final meta-analysis searched from data bases of Pubmed and Embase, researchers, filed the following results

1. There was no significant association of prostate cancer in regard to high versus non/lowestCC intake.

2. Coffee and coffee caffeine intake showed a localized effect in subtype of prostate cancer but not advanced prostate cancer. 

These result showed a significant effect of coffee in reduced risk of early stage of prostate cancer and coffee do not associate to risk of prostate cancer.

More profoundly in the report of a prospective analysis of 47,911 men with intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study
1. Men, drinking six or more cups per day had a lowest relative risk for overall prostate cancer in compared to nondrinkers.

2. Over all, Coffee consumption was not associated with the risk of nonadvanced or low-grade prostate cancers and was only weakly inversely associated with high-grade prostate cancer

3. There was no different effect of regular and decaffeinated coffee in ameliorated risk of prostate cancer.

Taking altogether, there is no doubt that coffee and coffee caffeine intake were associated linearly to
reduced risk of localized and advanced and lethal prostate cancer, Risk of cancer is also reduced proportionally with additional cup of coffee consumed.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) An Up-to-date Meta-analysis of Coffee Consumption and Risk of Prostate Cancer by Xia J1, Chen J2, Xue JX3, Yang J3, Wang ZJ3.(PubMed)
(2) Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models by Pounis G1, Tabolacci C2, Costanzo S1, Cordella M2, Bonaccio M1, Rago L3, D'Arcangelo D4, Filippo Di Castelnuovo A1, de Gaetano G1, Donati MB1, Iacoviello L1,5, Facchiano F2; Moli-sani study investigators6.(PubMed)
(3) Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study by Wilson KM1, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, Giovannucci E, Mucci LA.(PubMed)

Food Therapy: Coffee Caffeine Does Not Associate to Poor Child Cognition and Behavior

By Kyle J. Norton


Food therapy is a slowly recover but effective method used in transnational medicine to ease symptoms of disease, depending to stage of the treatment which directly address to the roots of the cause without inducing adverse effects.

Epidemiological studies do not agree that maternal Caffeine Intake during pregnancy may have a negative impact in child cognition and behavior, a new study suggested.

Coffee, second to green tea is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Cognition and Behavior is a group of neuro function involving sensation and perception, learning and memory, attention, mental imagery, conceptual presentation, language expression, emotion response, motor control,.....

In the study of examine maternal serum paraxanthine at <20 and ≥26 weeks' gestation with the child's intelligence quotient (IQ) and problem behaviors at ages 4 and 7 years among 2,197 mother-child pairs, researchers showed that paraxanthine, a structurally related to caffeine.and caffeine's primary metabolite concentration has a significantly inverted effect at ≥26 weeks' gestation with child's IQ at age 7 years.

And at <20 weeks, paraxanthine also expressed a linearly associated with internalizing behavior at age 4 years.

Interestingly, after taking into account of over a range of values applicable to most pregnant women, researchers indicated that coffee caffeine in contribution to serum paraxanthine concentration showed no significant effect in association with childhood IQ or problem behaviors.

Contrast to the healthy mothers, Women's reported coffee intake per day during pregnancy was associated with lower child's Behavior Rating Scale (BRS), a complete overview of child and adolescent concerns and disorders, ratings in anemic children. Even with inclusion of other contributing factors and after anemic children given appropriated treatment, coffee consumption continuously showed a Poor Child Cognition and Behavior.

Dr.Engle PL, the lead author said, " The effects of postnatal coffee ingestion in Guatemala were seen for sleep duration, but not for cognitive development. Prenatal coffee ingestion was negatively associated with Behavior Rating Scales".

Taking altogether, coffee caffeine intake during pregnancy may not have any meaningful effect in association to children cognitive development and measurement of Behavior Rating Scales, excluding anemic children,

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age by Klebanoff MA, Keim SA.(PubMed)
(2) Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep by Engle PL1, VasDias T, Howard I, Romero-Abal ME, Quan de Serrano J, Bulux J, Solomons NW, Dewey KG.(PubMed)

Food Therapy: High Coffee Intake During Pregnancy, A Potential Risk Of Infant's Acute Lymphoblastic Leukemia (ALL)

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly addresses to the cause of disease.

Women, drinking moderated coffee during pregnancy may have a profound effect in increased risk of infants' acute lymphoblastic leukemia (ALL), a renowned institute suggested.

Coffee, the popular and social beverage all over the world, after green tea, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Acute leukemia is condition of rapid increase in the numbers of extreme immature white blood cells in the blood stream,  tissues and organs.

According to the 12 case-control studies, comprising a total of 3649 cases and 5705 controls, coffee and coffee caffeine consumption were associated linearly to higher risk of childhood leukemia, by the dose-response analyses.

Dr. Thomopoulos TP, the lead researchers said, " detrimental association between maternal coffee consumption and childhood leukemia risk and provide indications for a similar role of maternal cola intake".

Instantly, in the review of literature data base of up to May 5, 2013, and the lists of references of retrieved articles in screened to identify additional relevant studies, researchers filed the following results
1. In low to moderate-level drinkers during pregnancy, risk of children Acute Lymphoblastic Leukemia (ALL)  was 1.22
2. A maternal coffee highest consumption was statistically significantly associated with childhood ALL of 1.65 in compared to non drinker.

Dr. Cheng J, the lead author said, "maternal coffee consumption during pregnancy may increase the risk of childhood AL" and " linear dose-response relationship of coffee consumption and childhood AL (P for nonlinearity = .68), including childhood ALL and childhood AML; with increased coffee consumption, the risk of childhood AL increased".

Furthermore, in the reviewed French ESCALE study, included 764 AL cases and 1,681 controls in 2003-2004 in women with Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867), regular coffee drinking expected mother was associated with childhood AL and the incidence increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week).

There was no association between gene alternation and risk of children ALL found among these women.

The findings suggested that maternal coffee consumption during pregnancy may increase risk of childhood AL. Women who have a previous history of this type of incidence should reduce intake of coffee in preventive measure.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta-analysis by Thomopoulos TP1, Ntouvelis E1, Diamantaras AA2, Tzanoudaki M3, Baka M4, Hatzipantelis E5, Kourti M6, Polychronopoulou S7, Sidi V6, Stiakaki E8, Moschovi M9, Kantzanou M1, Petridou ET10.(PubMed)
(2) Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a metaanalysis by Cheng J1, Su H2, Zhu R3, Wang X1, Peng M1, Song J1, Fan D1.(PubMed)

Food Therapy: High Coffee Consumption Increased Risk of Neural Tube Defects for Women with Alternated Gene CYP1A2

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


In compared to herbal medicine, food therapy even takes longerto ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of high amount of coffee and coffee caffeine during pregnancy may increased risk of infant
Neural Tube Defects, a renowned institute study suggested

Neural tube defects are prenatal defects of infants in related to the neuro system including the brain, spine, or spinal cord.

Coffee,  a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the study of total average daily caffeine from coffee, tea, soda, and chocolate consumption during the year before pregnancy for 768 mothers of infants with NTDs and 4143 mothers of infants without birth defects who gave birth during 1997 through 2002, returned questionnaire by participants showed a strong correlated between coffee and caffeine intake and risk of neural tube defect of spina bifida, But modestly increased risk of general NTDs and encephalocele.

More profoundly, in the reviewed literature in data base of PubMed, Springer Link and Elsevier databases up to August, 2014, out of a total of of six case-control studies and one cohort study,
The risk of neural tubal defects showed a relative odd ratio of 0.86 for total NTDs in pooled effect estimate of maternal coffee consumption during pregnancy, particular in the spina bifida subtype of NTD.

According the University of California women who carried alternated gene CYP1A2 (involved liver function in the metabolism of foreign substance entering to the body) with high amount of coffee and caffeine intake during pregnancy may also be associated to increased risk of neural tube defects (NTDs) due to increased oxidizer status.

In the self-reported coffee, tea, soda, and chocolate intake for mothers of 768 NTD cases, and 4143 controls delivered from 1997 to 2002. A subset of 306 NTD and 669 control infants and their parents with gene mutation, Mothers who consumed caffeine, bearing a mutation genes in oxidization, CYP1A2*1F quickly and acetylized NAT2 slowly had a non significantly elevated estimated risk for an NTD-affected pregnancy.

The risk of  neural tube defects was multiplied many times in women who carry the lone mutated gene CYP1A2*1F.

Taking altogether, pregnant women with high amount of coffee and coffee caffeine consumption may have a non significant risk to Neural Tube Defects and Sub types. But for women with genetic alternative gene CYP1A2*1F  should reduced intake of coffee with doctor recommendation during pregnancy.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Maternal caffeine consumption and risk of neural tube defects by Schmidt RJ1, Romitti PA, Burns TL, Browne ML, Druschel CM, Olney RS; National Birth Defects Prevention Study.(PubMed)
(2) Caffeine, selected metabolic gene variants, and risk for neural tube defects.
Schmidt RJ1, Romitti PA, Burns TL, Murray JC, Browne ML, Druschel CM, Olney RS; Nationa by Birth Defects Prevention Study(PubMed)

Food Therapy: Coffee and Coffee Caffeine, The Potent Ingredients in Reduced Risk of Basal Cell Skin Cancer

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Coffee caffeine consumption regularly is associated to ameliorated risk of basal cell carcinoma of the skin, the Queensland Institute of Medical Research study suggested.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Basal cell cancer is the most common type of skin cancer characterized by abnormal growth of the cells in the lowest layer of the epidermis. The cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area and accounted for more than 90% of all skin cancer in the U.S.

In the study among 1,325 randomly selected adult residents of a subtropical Australian community collected in 1992, 1994, and 1996, returned food frequency questionnaires from participants showed a  significantly lower relative risk in people with with prior skin cancers by 25% with daily consumption of four cups of regular coffee.

For people without previous history of skin disease, consumption of neither caffeinated nor decaffeinated coffee regardless of amount intake expressed no risk of basal cell carcinoma of the skin.

Dr. Miura K, the lead author said, " Among people with prior skin cancers, a relatively high caffeine intake may help prevent subsequent BCC development. However, caffeine intake appears not to influence the risk of SCC."

Also, in the evaluation of the effects of tea, coffee, and caffeine related to early-onset BCC from data of 767 non-Hispanic Whites under age 40 in Connecticut. BCC cases (n=377) identified through Yale's Dermatopathology database and controls (n=390) of individuals in the same database, participants interview revealed combined regular consumption of caffeinated coffee plus hot tea expressed a strong inverse association of early-onset BCC.

According to the analysis, risk of BCC was reduced by as much as 43% in this group in compared to non drinking group.

Researchers at the study also indicated that the efficacy in reduced risk of basal cell carcinoma of the skin from these 2 beverages may be attributed to chemical component of caffeine.

Promisingly. in the support of caffeine administration in prevented squamous cells skin cancer development, the Nurses' Health Study and the Health Professionals Follow-up Study, postulated the following results.
1. Caffeine intake from all dietary sources was inversely associated with BCC risk even people who only consumed less than 1 cup of caffeinated coffee per month.
2. Women who consumed more than 3 cups/d had the relative odd risk ratio of 0.79, in compared to 0.90 in men with the same cups intake.
3. Decaffeinated coffee consumption showed no association in decreased BCC risk.

The finding evidences expressed that coffee and coffee caffeine consumption have a significant effect in reduced risk of basal cell carcinoma of the skin, particular in people with previous skin cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Caffeine intake and risk of basal cell and squamous cell carcinomas of the skin in an 11-year prospective study by Miura K1, Hughes MC, Green AC, van der Pols JC.(PubMed)
(2) Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study by Ferrucci LM1, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST.(PubMed)
(3) Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin by Song F1, Qureshi AA, Han J.(PubMed)

Food Therapy: Coffee, the Best Function Food for Reduced Serum Uric Acid Level

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy, sometimes even takes longer than 3 months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Good News for coffee lovers, intake of coffee is associated to ameliorated level of uric acid, a marker of gout incidence, a renowned institute study suggested.

But intake foods with high amount of purines may cause an excess of uric acid in your blood.

According to the observation of data from 14,758 participants ages >/=20 years in the Third National Health and Nutrition Examination Survey (1988-1994), decreased serum uric acid level is associated to increased coffee intake.
Serum uric acid level was significant lower with coffee intake of 4 to 5 and >/=6 cups daily in compared to non drinkers.

The study also indicated that serum uric acid was not effected by total caffeine from coffee and other beverages.

Additionally, researchers in the review of data base of MEDLINE, EMBASE, the Cochrane library, and KoreaMed for all articles published before January 2015, 9 studies published between 1999 and 2014, containing a total of 175,310 subjects, demonstrated that coffee has a significantly lowering effect on serum UA.

And Amount of coffee required to lower serum UA is different in gender. Women are required to consumse more cups of coffee (4-6 cups/day) in compared to their male counterpart (1-3 cups/day) to exhibited same effects

Significantly, incidence of gout was even reduced linearly in participants with intake of 1 cup/day or more with no different in both genders.

Promisingly, in a total of 11.662 men and women aged 49-76 years, excluding those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease, daily consumption of coffee has a significantly inverse associations with serum UA concentrations in men.

But in compared to women participants, male participants expressed a statistically significant elevation of inverse association between coffee and serum UA levels.

Taking together, intake of coffee is associated to reduced level of serum uric acid in the blood depending to numbers of cup intake per day.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey by Choi HK1, Curhan G.(PubMed)
(2) Effects of coffee consumption on serum uric acid: systematic review and meta-analysis by Park KY1, Kim HJ2, Ahn HS2, Kim SH1, Park EJ1, Yim SY3, Jun JB4.(PubMed)
(3) The relation of coffee consumption to serum uric Acid in Japanese men and women aged 49-76 years by Pham NM1, Yoshida D, Morita M, Yin G, Toyomura K, Ohnaka K, Takayanagi R, Kono S.(PubMed)

Food Therapy, High Coffee Intake and Calcium Fortified Foods in Risk of Osteoporosis (OP)

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to the stages of the treatment which directly address to the cause of disease.

Epidemiological studies do not agree that coffee and coffee caffeine may have an increased risk of bone loss, inducing osteoporosis in healthy adults and menopause women.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In a longitudinal population-based Swedish Mammography Cohort, included 61,433 women born in 1914-1948, with followed up from 1987 through 2008. returned questionnaires by participants showed insignificant effects of coffee consumption in correlated to bone loss inducing fracture of any type to 14,738 women , and 3,871 had a hip fracture.

According to the reported, high coffee intake (≥4 cups daily) was associated with a 2%-4% lower bone density, the risk of osteoporosis had a relative risk ratio of 1.28 in compared to a low intake (<1 cup daily) group.
Dr. Hallström H, the lead author said, "high coffeeconsumption was associated with a small reduction in bone density that did not translate into an increased risk of fracture".

Further more, the a cohort of 31,527 Swedish women aged 40-76 years at baseline in 1988, at the follow-up of 10.3 years, osteoporotic fractures is found in 3,279 cases proposed that risk of high coffee in take((>330 mg/day) showed a moderated relative risk ratio of increased risk of fracture of 1.20 in compared to low coffee consumption(<200 mg/day).

More impotantly, low calcium intake (<700 mg/day) also is found to associate to increased risk of fracture with both a high caffeine intake and coffee consumption.

According to the found evidences, National Food Administration, the institute conducted the study opinionated that people drinking more than 4 cups of coffee equivalence to 330 mg may be at risk of fracture and osteoporosis, moderately.

Interestingly, in a 980 postmenopausal women aged 50 to 98 years (mean age, 72.7 years) participated between 1988 and 1991 in determinated the risk association to lifetime intake of caffeinated coffee, in cup-years, to bone mineral density (BMD) of the hip and spine in postmenopausal women, long term coffee intake expressed a profound effect with statistically significant graded association with caffeinated coffee and decreasing BMD at both the hip and spine.

But this result was revered for those women, drinking at least one glass of milk per day during most of their adult lives.

The found evidence, suggested that high amount intake of coffee and caffeine may have a negative impact in increased moderated risk of osteoporosis but intake of calcium supplement or calcium fortified milk or products may ease the concerns.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Long-term coffee consumption in relation to fracture risk and bone mineral density in women by Hallström H, Byberg L, Glynn A, Lemming EW, Wolk A, Michaëlsson K.(PubMed)
(2) Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women by Hallström H1, Wolk A, Glynn A, Michaëlsson K.(PubMed)
(3) Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study by Barrett-Connor E1, Chang JC, Edelstein SL.(PubMed)