Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Thursday, 24 August 2017

Herbal Therapy: Andrographis, The Natural Herbal Medicine for Protection of Cigarette Smoke Induced Lung Disease

Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......

Cigarette contains harmful chemicals including acetone, acetic acid, ammonia, arsenic, benzene butane, etc......which have been proven to induced varies respiratory diseases, including lung disease.

According to the The First Affiliated Hospital of Zhengzhou University, in CS-exposed mice, andrographolide, a chemical constituent found in Andrographis, significantly attenuated lung inflammation through reduced numbers of total cells of neutrophils, a common type of white blood cells, and macrophages, a cell found in stationary form in the tissues of infection in bronchial alveolar lavage fluid (BALF) of intestinal lung disease, together with decreased production of cytokine/chemokine(small cytokine), pro-inflammatory meediators into BALF.

Dr. Yang D., the lead author in the study said, " Andrographolide, a bioactive molecule isolated from Andrographispaniculata, could protect against cigarette smoke (CS)-induced lung injury through activation of heme oxygenase-1 (HO-1), (an enzyme with function in response stress)".

The study also insisted that the effects of andrographis in ameliorated cigarette smoke-induced lung disease, probably involved the activation of protein in mediated cellular responses STAT3, together with enzyme HO-1.

In female BALB/c mice exposed to 2 weeks of cigarette smoke(CS0 followed by a single intratracheal instillation of NTHi, a respiratory tract pathogen common in local infection study, andrographolide promoted gene expression of antioxidant enzymes such as heme oxygenase-1 (HO-1), glutathione reductase (GR), glutathione peroxidase-2 (GPx-2), glutamate-cysteine ligase modifier (GCLM), and NAD(P)H quinone oxidoreductase 1 (NQO1), against lung inflammation caused by NTHi in cigarette smoke.

Furthermore, in cigarette smoke-induced oxidative lung injury, andrographolide activated nuclear factor erythroid-2-related factor 2 (Nrf2), a protein in regulated expression of antioxidant proteins against oxidative damage.

The study also suggested, the phytochemical also suppressed cigarette smoke-induced increases in lavage fluid cell counts, pro inflammatory cutokines and oxidative stress, through enhancing production of antioxidant properties against biomarkers in inducing lung diseases.

The information collected through studies strongly support a therapeutic potential for andrographolide in preventing lung diseases caused by harmful chemicals and pathogens in cigarette smoke.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1 by Yang D1, Zhang W, Song L, Guo F.(PubMed)
(2) Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide by Tan WS1, Peh HY1, Liao W1, Pang CH1, Chan TK1,2, Lau SH3, Chow VT2,3, Wong WS1,4.(PubMed)
(3) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity by Guan SP1, Tee W, Ng DS, Chan TK, Peh HY, Ho WE, Cheng C, Mak JC, Wong WS.(PubMed)

Food Therapy: Cinnamon, The Whole Herbal Medicine for Osteopenic Disease

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient.
Herbal medicine can only ease symptoms gradually, depending to stage of the treatment which directly address to the cause of disease.

Recent study suggested that cinnamon may be effective in prevented and treatment of osteopenic disease by inhibiting protein in transferred information of cytokine production involved cell survival.

Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Osteopenic disease is the early stage of osteoporosis involved the deletion of bone density in comparison to the healthy person.

According to the Keio University, cinnamon suppressed the osteoclastogenesis, protected bone density against erosion, interleukin-4 (IL-4), an anti-inflammatory cytokine, involved production of white blood cell in inhibition of osteoclast differentiation through expression of T cell of immune system.

Dr. Tsuji-Naito K. in the study of Interleukin-4 suggested that Cinnamomum zeylanicum (C. zeylanicum) exhibited the strong inhibitory effects on osteoclastogenesis,......involved the regulation of white blood cells in osteoclastogenesis.

In a comprehensive systematic review of vitro and in-vivo, using databases from PubMed, Web of Science, SciVerse Scopus published before 31st December 2012, cinnamon has shown to express inhibitory effects on osteoclastogenesis with minimal toxic and adverse effects.

The effectiveness of cinnamon in reduced risk of Osteopenic diseasesin inducing bone loss, including osteoporosis, bone metastasis, and rheumatoid arthritis may be resulted of inhibition of inflammatory cytokins expression in immune system. Use of cinnamon should be taken with care, as the herbal medicine has induced toxicity if overdoses.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1 by Takatsuna H1, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K.(PubMed)
(2) Aldehydic components of cinnamon bark extract suppresses RANKL-induced osteoclastogenesis through NFATc1 downregulation by Tsuji-Naito K1.(PubMed)
(3) Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review by Ranasinghe P1, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P.(PubMed)

Wednesday, 23 August 2017

Food Therapy: Green Tea, the Best Anti Asthma Functional Whole Food

Green tea may be a potential therapeutic functional food for prevention and treatment of asthma, a chronic inflammatory disease, touching people of all ages, particular in children, a renowned institute suggested

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will solve the problem.

According to the joint study lead by the Ben Gurion University of the Negev, Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), a flavonoid found in green tea exhibited anti-oxidant/anti-inflammatory effects against various diseases, including asthma.

The study also demonstrated the function of Kaempferol in reduced oxidative stress through scavenging free radicals and superoxide radicals effects as well as preserving the activity of various anti-oxidant enzymes in attenuated production of pro inflammatory cytokins.

In fact, evidence from in vitro and in vivo assays, postulated that aqueous fraction of green tea also exerted anti-asthmatic signaling activity in ovalbumin-induced asthmatic model.

Further more, in the study of mice induced asthma by an ovalbumin, aqueous extract of green tea displayed a potent anti-asthmatic activity by increasing the expression level of tumor necrosis factor-beta, (a protein involved production of one of the inflammatory cytokin in the acute phase) and interferon-gamma in displacement of immune function against microbial infection and decreased expression of anti-asthmatic cytokines in the lung.

More importantly, green tea alleviated asthmatic symptoms by increasing the expression of Th1 cell-in regulated the production of interferon-gamma and interleukin (IL)-2, proinflammatory cytokins and tumour necrosis factor.

Promissingly, another green tea constituent, namely Chafuroside A (CFA), water-soluble flavone C-glycoside, in an experimental asthma/chronic obstructive pulmonary disease (COPD)-rat model, treatment with Chafuroside A at 0.5mg/kg, 1.0mg/kg could attenuate inflammatory symptoms and ameliorate antigen-induced airway inflammation, respectively.

Dr, Onoue S, the lead author in above study said, " A self-assembled micellar (SAM) formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases".

Unfortunately, there are few reports suggested that green tea-induced asthma in tea-sensitive patients, as epigallociatechin gallate induced histamine release through IgE-mediated response.

Taking together, there is no doubt that green tea may be considered as a functional food for prevention and treatment of asthma, but people with tea sensitive syndrome should avoid drinking green tea unless with approval of related field specialist.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Kaempferol, a potential cytostatic and cure for inflammatory disorders by Rajendran P1, Rengarajan T1, Nandakumar N2, Palaniswami R3, Nishigaki Y1, Nishigaki I4.(PubMed)
(2) An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers by Heo JC1, Rho JR, Kim TH, Kim SY, Lee SH.(PubMed)
(3) Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats by Onoue S1, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, Yamada S.(PubMed)

Herbal Therapy: Topical Aloe Vera, The best Whole Food Medicine for Treatment of Burn

Good news for people working in kitchen, topical Aloe vera may be the next generation of herbal medicine for treatment of burn and promoted burn healing.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to enormous health benefits, used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, anhe d elevated of cholesterol, etc.

According to review of the data base of studies in MEDLINE, CINAHL, Cochrane Library, HealthSTAR, DARE, South-East Asia Database, Chinese Databases, and several Thai local Databases (1918-June 2004), Aloe vera has found to process a significant effect for burn wound healing with 8.79 days shorter in compared to control group.

Dr. Maenthaisong R, the lead researcher said, " cumulative evidence tends to support that aloe vera might be an effective interventions used in burn wound healing for first to second degree burns".

In fact, the efficacy of topical Aloe vera gel in the treatment of thermal burns is the result of its chemical constituents in exhibition of different pharmacological actions.

Other study support the efficacy of Aloe Vera for treatment of thermo burn, conducted by the Chulalongkorn University Hospital, in a total of 48 male Wistar rats equally divided into 4 groups as follows: sham controls, untreated burn-wound rats, those treated with once-daily application of normal saline (NSS) and those treated with once-daily application of lyophilized Aloe vera gel, topical administration of aloe vera gel after 14 days, showed a arteriolar diameter increased up to normal condition and the healing area of the Aloe vera-treated wound was far better than other experiment groups.

There is no doubt that topical loe vera may be used as potential herbal medicine for treatment of both anti-inflammation and wound healing applied on a second degree burn wound.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The efficacy of aloe vera used for burn wound healing: a systematic review by Maenthaisong R1, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(2) The therapeutic efficacy and properties of topical Aloe vera in thermal burns by Somboonwong J1, Duansak N.(PubMed)
(3) Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rat by Somboonwong J1, Thanamittramanee S, Jariyapongskul A, Patumraj S.(PubMed)

Tuesday, 22 August 2017

Alternative Therapy: Yoga Reduced Symptom and Improved Quality of Life of Endometrial Women

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Yoga therapy is associated to reduced chronic pelvic pain, menstrual patterns, and improved quality of life (QoL), a renowned study suggested.

Endometriosis is a condition of endometrial tissue formed outside the uterus and reacted to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Yoga, the accident technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled trial conducted at the University of Campinas Medical School, Campinas, SP, Brazil with 40 women randomly divided into two groups: an intervention group of women who practiced yoga (n = 28) with 90-min scheduled yoga sessions twice a week for 8 weeks.and a control group of women who did not practice yoga (n = 12), Yoga participants showed a significant reduction of pelvic pain and improved quality of life.

Furthermore, Yoga group in the endometriosis Health Profile (EHP)-30 questionnaire also expressed the domains of pain, well-being, and image are improved over time in compared non yoga group.

More importantly, in the understanding of women perception of pain management involved with pain-associated endometriosis attribute to yoga practice, 15 Fifteen women with pain-associated endometriosis practiced yoga for 8 weeks, showed significant improved in control pelvic pain attributed to the integration of body and psyche yoga practice.

Yoga attendees also insisted that breathing techniques (pranayama) learned in yoga may also increase the ability in relieved pain.

There is no doubt that certain yoga postures can provide relief from the symptoms and increased quality of life for endometrial sufferers. It is recommended that lessons can only be taken with proper supervision from an experienced yoga instructor or yoga therapist.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) The Practice of Hatha Yoga for the Treatment of Pain Associated with Endometriosis by Gonçalves AV1, Barros NF2, Bahamondes L1.(PubMed)
(2) A Qualitative Study on the Practice of Yoga for Women with Pain-Associated Endometriosis by Gonçalves AV1, Makuch MY1, Setubal MS1, Barros NF2, Bahamondes L1.(PubMed)

Herbal Therapy: Green tea, the Best Anti Obesity Functional Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Green tea is found to consist an anti obesity function, a recent study by popular institute suggested.

Green tea, considered as a functional food, linking numbers of health benefit has been reported by several renowned research and studies. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice ginger will do the trick.

Obesity is a medical condition of excess body fat accumulated overtime. A person is considered an obese if excess body weight relatively to the height is over 30 in BMI index.

According to the University of the Punjab, Epigallocatechin gallate, a polyphenol found in tea plants exhibited anti obesity effect through modulation of thePPAR[gamma] pathway in metabolism involved fat cells/adipose tissues.

In animal study, the chemical constituent stopped the adipogenic cell differentiation through different proteins and transcription factors in expression of adipocyte formation which is considered as fat cell development in contribution to obesity.

Dr. Javaid MS, the lead author in the study said, "Docking analysis of PPAR gamma and epigallocatechin gallate demonstrated that epigallocatechin gallate binds with PPAR gamma at its active site and blocks its activity".

Also, in animal induced by high fat diet, green tea Epigallocatechin 3-gallate (EGCG),exerted anti obesity effects through reduced plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation involved proteins or lipids expression.

Dietary EGCG tested in C57BL/6 mice induced by high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on low-fat diet for the same period, also showed a significanty reduced weight gain, plasma glucose, insulin level, liver and kidney weight, which can be seen in obesity in compared control mice.

Importantly, green tea Epigallocatechin 3-gallate (EGCG fed mice novally decreased the levels of AGEs(advanced glycation end product) in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of activating Nrf2, antioxidant response and enhanced anti oxidative stress ratio of GSH/GSSG.

Other searchers opinionated the effect of green tea in reduced fat/adipose tissues accumulation in obese subject is a result of the pro-oxidant action of EGCG, in de activated cellular production of reactive oxygen species, through indication of adenosine monophosphate-activated protein kinase in suppressed gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis(fat and adiposed metabolism).

Taking together, green tea with all the phytochemicals may be used as anti obesity functional food to help control hyperglycemia, reduce weight, and alleviate diabetes complications.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Sources
(1) Epigallocatechin Gallate as an anti-obesity therapeutic compound: an in silico approach for structure-based drug designing by Javaid MS1, Latief N1, Ijaz B1, Ashfaq UA2(PubMed).
(2) Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3(PubMed)
(3) Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity by Suzuki T1, Pervin M2, Goto S3, Isemura M4, Nakamura Y5.(PubMed)

Monday, 21 August 2017

Herbal Therapy: Chaste Tree Berry, the Best MALE Osteoprotective Natural Medicine

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of times.

In a total of 60, 3-month-old male rats orchidectomized and divided into five groups with each group either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks, rats treated with Vitex agnus castus at highest dose displayed a recover of 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with other administrations.

The study also found out that Vitex agnus castus is more protective in treating osteoprorsis in male population in compared female counter part.

Dr. Sehmisch S, the lead author said, " Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT".

Further more, In the study to compare group of animals (n = 8) treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks and control animals (n = 8) received sterile olive oil s.c. by the same schedule, Vitex agnus-castus L. (Vac) essential oil treated group also exerted a significant bone metabolism in 16-month-old male Wistar rats.

The osteoporosis protection can be observed through the lower of Serum osteocalcin (OC) and calcium (Ca2+) in Vitex agnus-castus L. (Vac) essential oil and decreased of bone turnover treated group in compared control in middle-aged male rats..

Taking together, Chaste tree berry showed a strong support in reduced early onset of osteoporosis of male gander through improved bone metabolism and calcium status, but further large size and multi centers studies are necessary to validate this potency.

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation by Sehmisch S1, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK.(PubMed)
(2) Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats (Researchgate)