Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Yuan Zhi, sweet and slightly cool herb is also known as Thinleaf Milkwort Root, used in TCM as antibiotic property, anti-viral property(732), anti cancer(734) and anti depression(733) agents in treating hepatitis B, tumors in the digestive, respiratory systems and in the uterus, etc., as it calms the heart, transforms phlegm, resolves furuncle and oedema, expel toxin, etc. by enhancing the functions of spleen, lung and liver channels.
Phytochemicals
1. Protein-bound polysaccharide (PSK)
2. Polysaccharopeptides (PSP)
3. Tenuifolin
4. Onjisaponin B
5. Etc.
Yuan Zhi used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to its effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(735). In aging related dementia, based on the history of use, and pharmacological investigation, Yuan Zhi showed a strong evidence in memory improving, including cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing Yuan zhi, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(737).
1. In Alzheimer's disease (AD)
In free radical involved neuro-degeneration in Alzheimer's disease (AD), pretreament with Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH) prescription significantly exhibited cytoprotective effects, through elevating cell survival, antioxidant enzyme activities and resulted ecreased production of malondialdehyde (MDA) associated to Alzheimer's disease (AD)(738). Smart Soup (SS), composed of Rhizoma Acori Tatarinowii (AT), Poria cum RadixPini (PRP) and Radix Polygalae (RP), in oral administration of SS ameliorated the cognitive impairment of AD in animal model, effectively reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss(739).
2. In Parkinson's disease
Mutant Huntingtin gene caused by a poly-glutamine expansion in huntingtin( 740)and A53T α-synuclein, a protein found abundantly in the human brain, at the tips of nerve cells (neurons)(741) have shown to be associated with the development of Huntington disease and Parkinson disease. Yuan Zhi phytochemical, onjisaponin B and ethanol extracts showed to induce autophagy(743) through signalling pathway in participation of regulation of vascular function(742) in protection of cells against pro-neuro apoptosis via the mitochondrial pathway(744). According to college ofPharmacy and Kyung Hee East-West Pharmaceutical Research Institute, in mouse models of Parkinson's disease, Yuan Zhi also exhibited it protective effects on dopaminergic neurons induced by toxicity(745).
3. In Huntington diseases
Mutant Hungtintin caused of degradation of long-lived cytoplasmic proteins, protein complexes (the gel-like substance enclosed within the cell membrane)(747), or damaged organelles(tiny structures that perform very specific functions within cells)(748) attenuated autophagy in association of the development of Huntington diseases(746), Onjisaponin B, found in Yuan Zhi, effectively induced autophagy through its acceleration of both the removal of mutant huntingtin and and α-synuclein in PC-12 cells(749), which contain mixture of neuroblastic cells and eosinophilic cells(750).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(732) First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga by Frasson AP1, dos Santos O, Duarte M, da Silva Trentin D, Giordani RB, da Silva AG, da Silva MV, Tasca T, Macedo AJ.(PubMed)
(733) Potential antidepressant properties of Radix Polygalae (Yuan Zhi) by Liu P1, Hu Y, Guo DH, Wang DX, Tu HH, Ma L, Xie TT, Kong LY.(PubMed)
(734) High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. by Mazzio E1, Badisa R, Mack N, Deiab S, Soliman KF.(PubMed)
(735) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(737) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(738) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK. (PubMed)
(739) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(740) Allele-specific silencing of mutant Huntington’s disease gene by Yu Zhang, Joshua Engelman, and Robert M. Friedlander*(PubMed)
(741) Alpha-synuclein(Wikipedia)
(742) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats by Liqun Ma1,2, Shuangtao Ma1,2, Hongbo He1, Dachun Yang1, Xiaoping Chen1, Zhidan Luo1, Daoyan Liu1 and Zhiming Zhu1(Hypertension research)
(743) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(744) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein by Sarkar S1, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC.(PubMed)
(745) Polygalae radix inhibits toxin-induced neuronal death in the Parkinson's disease models. by Choi JG1, Kim HG, Kim MC, Yang WM, Huh Y, Kim SY, Oh MS.(PubMed)
(746) Huntington's disease: degradation of mutant huntingtin by autophagy by Sarkar S1, Rubinsztein DC.(PubMed)
(747) Cytoplasm(Wikipedia)
(748) What are Organelles?(Wisegreek)
(749) Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells by Wu AG1, Wong VK, Xu SW, Chan WK, Ng CI, Liu L, Law BY.(PubMed)
(750) PC12 cell line(Wikipedia)
Wednesday, 8 February 2017
Tuesday, 7 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix rehmanniae(Di Huang)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Radix rehmanniae, a sweet and bitter herb, is also known as Di huang(sheng di huang is Cold in nature and shu di huang is Warm in nature), used in tradition Chinese medicine over thousand of years for treatment of the weakness caused by tuberculosis, vomiting blood, nose bleeding, coughing blood, bleeding in the uterus as its function of blood tonification, by enhancing function of heart, kidney, and liver channels(796).
Phytochemicals(797)
1. Sterol
2. Catalpol
3. Rehmanniosides A-D
4. Leonuride
5. Aucubin
6. Melittoside
7. Jioglutoside A-B, 6-O-E-feruloyl ajugol
8. Rehmaglutins A-D
9. Glutinoside, purpureaside C
10. Etc.
Di huang used in the treatment and prevention of dementia(798) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(799). In senile dementia, Di huang exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. Neuroprotective effects
Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), congaing Di huang and 17 other herbs, exhibited anti lipid peroxidation and antioxidant enzyme activities in decreased production of malondialdehyde (MDA) involved in neurodegeneration in Alzheimer's disease (AD)(801), through cholinesterase inhibited effects(802). Other prescriptive formula, palmul-chongmyeong-tang, in ischemia-induced rats, exhibited a protective effect against ischemia-induced neuronal and cognitive impairments of learning and memory(803).
2. Psychological symptoms
Polysaccharides extracted from shudihuang (radix rehmanniae preparata) in infant male rats study, significantly inhibited MSG-induced anxiety, through its phytochemicals in down regulation of beta-synuclein, protein DJ-1, linking toneurodegeneration in patient with dementia. etc.(804).
3. Improved earning and memory
In rats damaged thalamic arcuate nucleus, shu di-huang showed to up regulate the expression of hippocampal NGF, c-fos in improving the function of learning and memory(805). In dementia model, the herb decreased the times of mistakes and prolong the incubation period in step down task, through increased expression of hippocampal receptors, involved brain memory forming, organizing, and storing(806). Other formula, such as Ba-Wei-Di-Huang decoction, also enhanced capacity for learning and memory, through expression of autocrine motility factor receptor (AMFR), a multifunctional protein involved in cellular adhesion, proliferation, motility and apoptosis on animal model of Alzheimer's disease (AD)(807)(808)(809).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(796) Di Huang(Complementary and Alternative Healing University)
(797) HuangQin(Sen nong)
(798) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(799) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(800) Traditional chinese medicine for senile dementia. by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(801) Attenuating effect of a traditional korean formulation, Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), on hydrogen peroxide-induced injury in PC12 cells BY Koo BS1, Kim YK, Park KS, Chung KH, Kim CH.(PubMed)
(802) Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. by Zhang HY1, Tang XC.(PubMed)
(803) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(804) Mechanism-based anti-anxiety effects of polysaccharides extracted from shudihuang (radix rehmanniae preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins. by Cui Y1, Rong C, Wang J, Cui C, Wang L, Feng Z, Feng J, Niu B.(PubMed)
(805) [Effect of shu di-huang on the expression of c-fos and NGF in hippocampi and learning and memory of rats damaged thalamic arcuate nucleus].[Article in Chinese] by Cui Y1, Hou SL, Yan ZH, Chang ZF.(PubMed)
(806) [Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model].[Article in Chinese] by Cui Y1, Yan ZH, Hou SL, Chang ZF.(PubMed)
(807) Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. by Yang Y1, Cheng XR, Zhang GR, Zhou WX, Zhang YX.(PubMed)
(808) Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. by Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer's Disease Neuroimaging Initiative.(PubMed)
(809) Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. by Köhler S1, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, Foster JK, Moscovitch M, Winocour G, Szalai JP, Bronskill MJ.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix rehmanniae(Di Huang)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Radix rehmanniae, a sweet and bitter herb, is also known as Di huang(sheng di huang is Cold in nature and shu di huang is Warm in nature), used in tradition Chinese medicine over thousand of years for treatment of the weakness caused by tuberculosis, vomiting blood, nose bleeding, coughing blood, bleeding in the uterus as its function of blood tonification, by enhancing function of heart, kidney, and liver channels(796).
Phytochemicals(797)
1. Sterol
2. Catalpol
3. Rehmanniosides A-D
4. Leonuride
5. Aucubin
6. Melittoside
7. Jioglutoside A-B, 6-O-E-feruloyl ajugol
8. Rehmaglutins A-D
9. Glutinoside, purpureaside C
10. Etc.
Di huang used in the treatment and prevention of dementia(798) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(799). In senile dementia, Di huang exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. Neuroprotective effects
Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), congaing Di huang and 17 other herbs, exhibited anti lipid peroxidation and antioxidant enzyme activities in decreased production of malondialdehyde (MDA) involved in neurodegeneration in Alzheimer's disease (AD)(801), through cholinesterase inhibited effects(802). Other prescriptive formula, palmul-chongmyeong-tang, in ischemia-induced rats, exhibited a protective effect against ischemia-induced neuronal and cognitive impairments of learning and memory(803).
2. Psychological symptoms
Polysaccharides extracted from shudihuang (radix rehmanniae preparata) in infant male rats study, significantly inhibited MSG-induced anxiety, through its phytochemicals in down regulation of beta-synuclein, protein DJ-1, linking toneurodegeneration in patient with dementia. etc.(804).
3. Improved earning and memory
In rats damaged thalamic arcuate nucleus, shu di-huang showed to up regulate the expression of hippocampal NGF, c-fos in improving the function of learning and memory(805). In dementia model, the herb decreased the times of mistakes and prolong the incubation period in step down task, through increased expression of hippocampal receptors, involved brain memory forming, organizing, and storing(806). Other formula, such as Ba-Wei-Di-Huang decoction, also enhanced capacity for learning and memory, through expression of autocrine motility factor receptor (AMFR), a multifunctional protein involved in cellular adhesion, proliferation, motility and apoptosis on animal model of Alzheimer's disease (AD)(807)(808)(809).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(796) Di Huang(Complementary and Alternative Healing University)
(797) HuangQin(Sen nong)
(798) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(799) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(800) Traditional chinese medicine for senile dementia. by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(801) Attenuating effect of a traditional korean formulation, Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), on hydrogen peroxide-induced injury in PC12 cells BY Koo BS1, Kim YK, Park KS, Chung KH, Kim CH.(PubMed)
(802) Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. by Zhang HY1, Tang XC.(PubMed)
(803) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(804) Mechanism-based anti-anxiety effects of polysaccharides extracted from shudihuang (radix rehmanniae preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins. by Cui Y1, Rong C, Wang J, Cui C, Wang L, Feng Z, Feng J, Niu B.(PubMed)
(805) [Effect of shu di-huang on the expression of c-fos and NGF in hippocampi and learning and memory of rats damaged thalamic arcuate nucleus].[Article in Chinese] by Cui Y1, Hou SL, Yan ZH, Chang ZF.(PubMed)
(806) [Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model].[Article in Chinese] by Cui Y1, Yan ZH, Hou SL, Chang ZF.(PubMed)
(807) Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. by Yang Y1, Cheng XR, Zhang GR, Zhou WX, Zhang YX.(PubMed)
(808) Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. by Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer's Disease Neuroimaging Initiative.(PubMed)
(809) Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. by Köhler S1, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, Foster JK, Moscovitch M, Winocour G, Szalai JP, Bronskill MJ.(PubMed)
Monday, 6 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix angelica sinensis(Dang Qui)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix angelica sinensis(Dang Qui)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Dang Qui (Angelica sinensis), a sweet, acrid, bitter, warm herb is a GenusAngelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as antispasmodic(771), analgesic(772) and vasodilatory(772) agents, and to balance the hormones(773) in women for a normal menstrual cycle and menstruation with condition of blood stasis(774)(775) and clots(775) by strengthening heart, spleen, and liver channels. The herb is also used to treat constipation(775), reduced swelling(776), expels pus(775), etc.
Phytochemicals
1. Beta-sitosterol
2. Coumarins
3. Butylidine
4. Phthalide
5. Ligustilide
6. Sesquiterpenes
7. Carvacrol
8. B-pinene
9. Camphene,
10. P-cymene,
11. B-phellandrene
12. Myrcene
13. 6-n-butyl-cycloheptadiene-1,4, 2-methyl-dodecane-5-one,
14. Acetophenone,
15. B-bisabolene,
16. Isoacroraene,
17. Acoradiene
18. Etc.
Dang qui used in the treatment and prevention of dementia(777) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(778). In aging related dementia, based on the history of use, and pharmacological investigation, dang Qui showed a strong evidence in memory improving, through iestrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing dang qui, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(780).
Phthalide, a phytochemical found abundantly in dang qui, also an important bio-active constituent in Si-Wu-Tang and Fo-Shou-San, showed effectively in protect neurons against ROS-induced apoptosis by modulating apoptosis-related genes(781). Z-Ligustilide (LIG), a characterized phthalide, in rat study, exhibited anti vascular dementia and cerebrovascular insufficient activities through its antioxidant effect and improved cholinergic activity(782).
1. In cognitive impairments
In patients with cognitive impairment associated with chronic cerebral hypoperfusion, dang qui prevented neurotoxic effects of β-amyloid (Aβ), through its anti oxidative stress, inflammation and apoptosis functions(783). Its phytochemical Ligustilide (LIG), a main lipophilic component of Danggui also exhibited neuroprotective effect through anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex and in hippocampus in rat study(784).
2. Oxidative stress
Oxidative stress has been known to induced neurotoxicity and the underlying mechanisms causes of
Alzheimer's disease (AD). Decursin (D) and decursinol angelate (DA) found in dang qui, significantly suppressed Aβ aggregation and increased cellular resistance to Aβ-induced oxidative injury in the rat study(785). Coumarins, another chemical found in from Angelica, also effectively induced neuroprotective activity against glutamate-induced oxidative stress causes of cognitive deficits and brain damage(786), According to Seoul National University, 4 other new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol, 4"-hydroxydecursin, (2"S,3"S)-epoxyangeloyldecursinol, and (2"R,3"R)-epoxyangeloyldecursinol, also exhibited significant protective activity against glutamate-induced neurotoxicity(787). In transgenic mice model, traditional Chinese herbal formula Jangwonhwan (LMK03-Jangwonhwan), containing dang qui, improved cognitive impairment through detection and inhibition of AD-like pathology, such as cytotoxicity and Abeta(1-42)and Abeta(1-40) levels and beta-amyloid plaque deposition(788)
3. Behavioral and psychological symptoms
In behavioral and psychological symptoms of dementia patients, combination of ferulic acid and Angelica archangelica extract oral administration, significantly attenuated neuropsychiatric symptoms in 19 of 20 patients, including delusions, hallucinations, agitation/aggression, anxiety, apathy/indifference, irritability/lability and aberrant behavior, according toNational Hospital Organization Kikuchi Hospital(789). Yokukansan, also known as TJ-54, composed of seven herbs, including dang qui, showed to inhibit a variety of effects on various neurological symptoms, such as memory disturbance and behavioral and psychological symptoms of dementia(791) without adverse effects(790), probably through its neuroprotective effect against glutamate-induced excitotoxicity(792). In ischemic brain tissue, Z-Ligustilide (LIG), a phytochemical found in dang qui, oral administration of 10 or 40 mg/kg/day, significantly reduced malondialdehyde levels and increased superoxide dismutase activity, probably through its antioxidant effect in improved cholinergic activity(793), anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex, hippocampus(794) and ameliorated cognitive dysfunction(795) in 2VO rats study.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(777) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(778) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(779) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(780) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(781) Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong by Tang Y1, Zhu M, Yu S, Hua Y, Duan JA, Su S, Zhang X, Lu Y, Ding A.(PubMed)
(782) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(783) Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. by Xin J1, Zhang J, Yang Y, Deng M, Xie X.(PubMed)
(784) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(785) Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes by Li L1, Li W, Jung SW, Lee YW, Kim YH.(PubMed)
(786) Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. by Kang SY1, Kim YC.(PubMed)
(787) Four new neuroprotective dihydropyranocoumarins from Angelica gigas by Kang SY1, Lee KY, Sung SH, Kim YC.(PubMed)
(788) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(789) Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies. by Kimura T1, Hayashida H, Murata M, Takamatsu J.(PubMed)
(790) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(791) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(792) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells by Kawakami Z1, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y.(PubMed)
(793) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(794) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(795) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix angelica sinensis(Dang Qui)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Dang Qui (Angelica sinensis), a sweet, acrid, bitter, warm herb is a GenusAngelica from the family Apiaceae, indigenous to China, used as a Queen herb in traditional Chinese medicine as antispasmodic(771), analgesic(772) and vasodilatory(772) agents, and to balance the hormones(773) in women for a normal menstrual cycle and menstruation with condition of blood stasis(774)(775) and clots(775) by strengthening heart, spleen, and liver channels. The herb is also used to treat constipation(775), reduced swelling(776), expels pus(775), etc.
Phytochemicals
1. Beta-sitosterol
2. Coumarins
3. Butylidine
4. Phthalide
5. Ligustilide
6. Sesquiterpenes
7. Carvacrol
8. B-pinene
9. Camphene,
10. P-cymene,
11. B-phellandrene
12. Myrcene
13. 6-n-butyl-cycloheptadiene-1,4, 2-methyl-dodecane-5-one,
14. Acetophenone,
15. B-bisabolene,
16. Isoacroraene,
17. Acoradiene
18. Etc.
Dang qui used in the treatment and prevention of dementia(777) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(778). In aging related dementia, based on the history of use, and pharmacological investigation, dang Qui showed a strong evidence in memory improving, through iestrogen-like, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing dang qui, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(780).
Phthalide, a phytochemical found abundantly in dang qui, also an important bio-active constituent in Si-Wu-Tang and Fo-Shou-San, showed effectively in protect neurons against ROS-induced apoptosis by modulating apoptosis-related genes(781). Z-Ligustilide (LIG), a characterized phthalide, in rat study, exhibited anti vascular dementia and cerebrovascular insufficient activities through its antioxidant effect and improved cholinergic activity(782).
1. In cognitive impairments
In patients with cognitive impairment associated with chronic cerebral hypoperfusion, dang qui prevented neurotoxic effects of β-amyloid (Aβ), through its anti oxidative stress, inflammation and apoptosis functions(783). Its phytochemical Ligustilide (LIG), a main lipophilic component of Danggui also exhibited neuroprotective effect through anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex and in hippocampus in rat study(784).
2. Oxidative stress
Oxidative stress has been known to induced neurotoxicity and the underlying mechanisms causes of
Alzheimer's disease (AD). Decursin (D) and decursinol angelate (DA) found in dang qui, significantly suppressed Aβ aggregation and increased cellular resistance to Aβ-induced oxidative injury in the rat study(785). Coumarins, another chemical found in from Angelica, also effectively induced neuroprotective activity against glutamate-induced oxidative stress causes of cognitive deficits and brain damage(786), According to Seoul National University, 4 other new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol, 4"-hydroxydecursin, (2"S,3"S)-epoxyangeloyldecursinol, and (2"R,3"R)-epoxyangeloyldecursinol, also exhibited significant protective activity against glutamate-induced neurotoxicity(787). In transgenic mice model, traditional Chinese herbal formula Jangwonhwan (LMK03-Jangwonhwan), containing dang qui, improved cognitive impairment through detection and inhibition of AD-like pathology, such as cytotoxicity and Abeta(1-42)and Abeta(1-40) levels and beta-amyloid plaque deposition(788)
3. Behavioral and psychological symptoms
In behavioral and psychological symptoms of dementia patients, combination of ferulic acid and Angelica archangelica extract oral administration, significantly attenuated neuropsychiatric symptoms in 19 of 20 patients, including delusions, hallucinations, agitation/aggression, anxiety, apathy/indifference, irritability/lability and aberrant behavior, according toNational Hospital Organization Kikuchi Hospital(789). Yokukansan, also known as TJ-54, composed of seven herbs, including dang qui, showed to inhibit a variety of effects on various neurological symptoms, such as memory disturbance and behavioral and psychological symptoms of dementia(791) without adverse effects(790), probably through its neuroprotective effect against glutamate-induced excitotoxicity(792). In ischemic brain tissue, Z-Ligustilide (LIG), a phytochemical found in dang qui, oral administration of 10 or 40 mg/kg/day, significantly reduced malondialdehyde levels and increased superoxide dismutase activity, probably through its antioxidant effect in improved cholinergic activity(793), anti-apoptosis of neuron and anti-proliferation of astrocyte both in cortex, hippocampus(794) and ameliorated cognitive dysfunction(795) in 2VO rats study.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(736) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(777) Chinese herbs for dementia diseases. by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(778) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(779) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(780) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
(781) Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong by Tang Y1, Zhu M, Yu S, Hua Y, Duan JA, Su S, Zhang X, Lu Y, Ding A.(PubMed)
(782) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(783) Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment. by Xin J1, Zhang J, Yang Y, Deng M, Xie X.(PubMed)
(784) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion. by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(785) Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes by Li L1, Li W, Jung SW, Lee YW, Kim YH.(PubMed)
(786) Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity. by Kang SY1, Kim YC.(PubMed)
(787) Four new neuroprotective dihydropyranocoumarins from Angelica gigas by Kang SY1, Lee KY, Sung SH, Kim YC.(PubMed)
(788) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(789) Effect of ferulic acid and Angelica archangelica extract on behavioral and psychological symptoms of dementia in frontotemporal lobar degeneration and dementia with Lewy bodies. by Kimura T1, Hayashida H, Murata M, Takamatsu J.(PubMed)
(790) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(791) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(792) Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells by Kawakami Z1, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y, Kase Y.(PubMed)
(793) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
(794) Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion by Feng Z1, Lu Y, Wu X, Zhao P, Li J, Peng B, Qian Z, Zhu L.(PubMed)
(795) Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. by Kuang X1, Du JR, Liu YX, Zhang GY, Peng HY.(PubMed)
Sunday, 5 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Radix glycyrrhizae(Gan Cao)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix glycyrrhizae(Gan Cao)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Gan Cao, a sweet and neutral herb, also known as Licorice root, has been used in TCM as anti allergy(752), anti inflammation(751), anti ulcer(753), anti convulsion(754) agents and to treat stomach weakness(755), tired and lack of strength(756), enhance cardiac performance(757) and short of breath(758), cough with abundance of phlegm(751), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing the function of all 12 channels.
Phytochemicals
1. Glycyrrhizic acid
2. 24-hydroxyglycyrrhetic acid
3. Licorice saponins A3
4. Licochalcone A
5. Licochalcone B
6. Licoflavone
7. Liquiritin
8. Liquiritigenin
9. Isoliquiritigenin
10. Ononins
11. 4′,7-dihydroxyflavone
12. Etc.
Gan Cao used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(759). In senile dementia, Gan Cao exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. In Alzheimer's disease (AD)
Vascular risk factors (VRF) has shown strong evidence in contribution to cognitive decline and the development of Alzheimer's disease (AD)(763) and dementia(761). Sini Decoction, a TCM formula containing Gan Cao enhanced cardiac function through significant suppression of lipid peroxidation(765) of myocardial homogenate(764), via scavenge oxygen free radicals activity(764). According to Korea Food Research Institute, Gan Cao attenuated the Amyloid beta protein (Abeta) involved in the progression ofAlzheimer's disease (AD), through inhibition of Acetylcholinesterase activity(762), probably via mediation antioxidant actions against oxidative stress(762).
2. In Parkinson's diseases(PD)
Kampo kami-shoyo-san (TJ-24), a Korean traditional herbal medicine, containing Gan Cao, significantly reduce tremor, disturbances in muscular movement in antipsychotic-induced parkinsonism(766). The formula also showed effectively in relieved symptoms of panic attacks, anticipatory anxiety(767). Liquiritin, a flavonoid extracted from Glycyrrhizae radix, significantly promoted the neurite outgrowth in dose dependant manners, through overexpression of neural related genes, such as neurogenin 3, neurofibromatosis 1, associated to Alzheimer's disease or Parkinson's disease(768).
3. In learning and memory
Oral administration of Glycyrrhizae radix (GR) in rat study, showed to reduce anxiety and promote learning and memory in rats, by attenuating the behavioral and neurochemical impairments caused by repeated stress-induced alterations(770). Palmul-chongmyeong-tang, containing Gan Cao used in used as herbal medicine against ischemia, may be a potential agent for treatment of vascular dementia as it significantly improved learning and memory and attenuated cognitive impairment through reduction of the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia in rat model(769).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)(759) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(760) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(761) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease by Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, Yan JC, Zhou HD; Chongqing Ageing Study Group.(PubMed)
) (762) Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice by Ahn J1, Um M, Choi W, Kim S, Ha T.(PubMed)
(763) Treatment of vascular risk factors is associated with slower decline in Alzheimer disease.by Deschaintre Y1, Richard F, Leys D, Pasquier F.(PubMed).
(764) [In vitro experiment on scavenging oxy-radical and suppressing myocardial lipid peroxidation with sini decoction].[Article in Chinese] by Wu W1, Luo H, Hou C.(PubMed)
(765) [Anti-lipid peroxidation effects of sini decoction and its components on ischemic myocardium and the dose- and time-effects].[Article in Chinese] by Wu W1, Hou C, Luo H, Jin W, Luo C.(PubMed)
(766) Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism by Ishikawa T1, Funahashi T, Kudo J.(PubMed)
(767) Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. by Mantani N1, Hisanaga A, Kogure T, Kita T, Shimada Y, Terasawa K.(PubMed)
(768) Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells by Chen ZA1, Wang JL, Liu RT, Ren JP, Wen LQ, Chen XJ, Bian GX.(PubMed)
(769) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Radix glycyrrhizae(Gan Cao)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Gan Cao, a sweet and neutral herb, also known as Licorice root, has been used in TCM as anti allergy(752), anti inflammation(751), anti ulcer(753), anti convulsion(754) agents and to treat stomach weakness(755), tired and lack of strength(756), enhance cardiac performance(757) and short of breath(758), cough with abundance of phlegm(751), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing the function of all 12 channels.
Phytochemicals
1. Glycyrrhizic acid
2. 24-hydroxyglycyrrhetic acid
3. Licorice saponins A3
4. Licochalcone A
5. Licochalcone B
6. Licoflavone
7. Liquiritin
8. Liquiritigenin
9. Isoliquiritigenin
10. Ononins
11. 4′,7-dihydroxyflavone
12. Etc.
Gan Cao used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(759). In senile dementia, Gan Cao exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).
1. In Alzheimer's disease (AD)
Vascular risk factors (VRF) has shown strong evidence in contribution to cognitive decline and the development of Alzheimer's disease (AD)(763) and dementia(761). Sini Decoction, a TCM formula containing Gan Cao enhanced cardiac function through significant suppression of lipid peroxidation(765) of myocardial homogenate(764), via scavenge oxygen free radicals activity(764). According to Korea Food Research Institute, Gan Cao attenuated the Amyloid beta protein (Abeta) involved in the progression ofAlzheimer's disease (AD), through inhibition of Acetylcholinesterase activity(762), probably via mediation antioxidant actions against oxidative stress(762).
2. In Parkinson's diseases(PD)
Kampo kami-shoyo-san (TJ-24), a Korean traditional herbal medicine, containing Gan Cao, significantly reduce tremor, disturbances in muscular movement in antipsychotic-induced parkinsonism(766). The formula also showed effectively in relieved symptoms of panic attacks, anticipatory anxiety(767). Liquiritin, a flavonoid extracted from Glycyrrhizae radix, significantly promoted the neurite outgrowth in dose dependant manners, through overexpression of neural related genes, such as neurogenin 3, neurofibromatosis 1, associated to Alzheimer's disease or Parkinson's disease(768).
3. In learning and memory
Oral administration of Glycyrrhizae radix (GR) in rat study, showed to reduce anxiety and promote learning and memory in rats, by attenuating the behavioral and neurochemical impairments caused by repeated stress-induced alterations(770). Palmul-chongmyeong-tang, containing Gan Cao used in used as herbal medicine against ischemia, may be a potential agent for treatment of vascular dementia as it significantly improved learning and memory and attenuated cognitive impairment through reduction of the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia in rat model(769).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)(759) Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits by Hou Y1, Wang Y2, Zhao J1, Li X1, Cui J1, Ding J2, Wang Y3, Zeng X1, Ling Y4, Shen X5, Chen S2, Huang C4, Pei G6.(PubMed)
(760) Traditional chinese medicine for senile dementia by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(761) Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease by Li J, Wang YJ, Zhang M, Xu ZQ, Gao CY, Fang CQ, Yan JC, Zhou HD; Chongqing Ageing Study Group.(PubMed)
) (762) Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice by Ahn J1, Um M, Choi W, Kim S, Ha T.(PubMed)
(763) Treatment of vascular risk factors is associated with slower decline in Alzheimer disease.by Deschaintre Y1, Richard F, Leys D, Pasquier F.(PubMed).
(764) [In vitro experiment on scavenging oxy-radical and suppressing myocardial lipid peroxidation with sini decoction].[Article in Chinese] by Wu W1, Luo H, Hou C.(PubMed)
(765) [Anti-lipid peroxidation effects of sini decoction and its components on ischemic myocardium and the dose- and time-effects].[Article in Chinese] by Wu W1, Hou C, Luo H, Jin W, Luo C.(PubMed)
(766) Effectiveness of the Kampo kami-shoyo-san (TJ-24) for tremor of antipsychotic-induced parkinsonism by Ishikawa T1, Funahashi T, Kudo J.(PubMed)
(767) Four cases of panic disorder successfully treated with Kampo (Japanese herbal) medicines: Kami-shoyo-san and Hange-koboku-to. by Mantani N1, Hisanaga A, Kogure T, Kita T, Shimada Y, Terasawa K.(PubMed)
(768) Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells by Chen ZA1, Wang JL, Liu RT, Ren JP, Wen LQ, Chen XJ, Bian GX.(PubMed)
(769) Neuroprotective effect of palmul-chongmyeong-tang on ischemia-induced learning and memory deficits in the rat. by Yun YJ1, Lee B, Hahm DH, Kang SK, Han SM, Lee HJ, Pyun KH, Shim I.(PubMed)
Saturday, 4 February 2017
The holistic Prevention, Management and Treatment of Dementia In TCM Herbal Medicine - Poria cocos(Fu Ling)
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Poria cocos(Fu Ling)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).
Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.
Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).
1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).
2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).
3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(711) [Chemical constituents of surface layer of Poria cocos and their pharmacological properties (I)].[Article in Chinese] by Feng YL1, Zhao YY, Ding F, Xi ZH, Tian T, Zhou F, Du X, Chen DQ, Wei F, Cheng XL, Lin RC.(PubMed)
(712) Chemical constituents and pharmacological properties of Poria cocos by Ríos JL1.(PubMed)
(713) Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. by Sun Y1.(PubMed)
(714) Antioxidant activity of carboxymethyl (1→3)-β-d-glucan (from the sclerotium of Poria cocos) sulfate (in vitro) by Wang Q1, Chen S2, Han L2, Lian M2, Wen Z2, Jiayinaguli T2, Liu L2, Sun R2, Cao Y3.(PubMed)
(715) [Clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping].[Article in Chinese] by Li YL1.(PubMed)
(716) Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes by Lee JH1, Lee YJ, Shin JK, Nam JW, Nah SY, Kim SH, Jeong JH, Kim Y, Shin M, Hong M, Seo EK, Bae H.(PubMed)
(717) Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure by Wu ZL1, Ren H2, Lai WY3, Lin S1, Jiang RY1, Ye TC1, Shen QB1, Zeng QC3, Xu DL4.(PubMed)
(718) Anti-rejection effect of ethanol extract of Poria cocos wolf in rats after cardiac allograft implantation by Zhang GW1, Liu HY, Xia QM, Li JQ, Lü H, Zhang QH, Yao ZF.(PubMed)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(720) Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature by May BH1, Lu C, Lu Y, Zhang AL, Xue CC.(PubMed)
(721) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(722) Traditional chinese medicine for senile dementia.by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(722a) Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines by Jesky R1, Hailong C.(PubMed)
(723) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(724) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(725) Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity by Oh MH1, Houghton PJ, Whang WK, Cho JH.(PubMed)
(726) Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. by Liu JP1, Feng L, Zhang MH, Ma DY, Wang SY, Gu J, Fu Q, Qu R, Ma SP.(PubMed)
(727) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y(PubMed)
(728) Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. by Hatip-Al-Khatib I1, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M.(PubMed)
(729) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(730) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(731) A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease by Jeon S1, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
TCM Herbal Medicine for Treatment of Dementia - Poria cocos(Fu Ling)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia(*).
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).
Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.
Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).
1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).
2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).
3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(*) Traditional Chinese Medicine for Senile Dementia by Zhihong Lin,1 Jie Gu,1 Jin Xiu,1 Tingyan Mi,1 Jie Dong,1 and Jyoti Kumar Tiwari2(Hindawi)
(711) [Chemical constituents of surface layer of Poria cocos and their pharmacological properties (I)].[Article in Chinese] by Feng YL1, Zhao YY, Ding F, Xi ZH, Tian T, Zhou F, Du X, Chen DQ, Wei F, Cheng XL, Lin RC.(PubMed)
(712) Chemical constituents and pharmacological properties of Poria cocos by Ríos JL1.(PubMed)
(713) Biological activities and potential health benefits of polysaccharides from Poria cocos and their derivatives. by Sun Y1.(PubMed)
(714) Antioxidant activity of carboxymethyl (1→3)-β-d-glucan (from the sclerotium of Poria cocos) sulfate (in vitro) by Wang Q1, Chen S2, Han L2, Lian M2, Wen Z2, Jiayinaguli T2, Liu L2, Sun R2, Cao Y3.(PubMed)
(715) [Clinical and experimental study on the treatment of children diarrhea by granule of children-diarrhea fast-stopping].[Article in Chinese] by Li YL1.(PubMed)
(716) Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes by Lee JH1, Lee YJ, Shin JK, Nam JW, Nah SY, Kim SH, Jeong JH, Kim Y, Shin M, Hong M, Seo EK, Bae H.(PubMed)
(717) Sclederma of Poria cocos exerts its diuretic effect via suppression of renal aquaporin-2 expression in rats with chronic heart failure by Wu ZL1, Ren H2, Lai WY3, Lin S1, Jiang RY1, Ye TC1, Shen QB1, Zeng QC3, Xu DL4.(PubMed)
(718) Anti-rejection effect of ethanol extract of Poria cocos wolf in rats after cardiac allograft implantation by Zhang GW1, Liu HY, Xia QM, Li JQ, Lü H, Zhang QH, Yao ZF.(PubMed)
(719) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(720) Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature by May BH1, Lu C, Lu Y, Zhang AL, Xue CC.(PubMed)
(721) Chinese herbs for dementia diseases by Hügel HM1, Jackson N, May BH, Xue CC.(PubMed)
(722) Traditional chinese medicine for senile dementia.by Lin Z1, Gu J, Xiu J, Mi T, Dong J, Tiwari JK.(PubMed)
(722a) Are herbal compounds the next frontier for alleviating learning and memory impairments? An integrative look at memory, dementia and the promising therapeutics of traditional chinese medicines by Jesky R1, Hailong C.(PubMed)
(723) Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. by de Caires S1, Steenkamp V.(PubMed)
(724) Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats by Ikarashi Y1, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y, Takeda S.(PubMed)
(725) Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity by Oh MH1, Houghton PJ, Whang WK, Cho JH.(PubMed)
(726) Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. by Liu JP1, Feng L, Zhang MH, Ma DY, Wang SY, Gu J, Fu Q, Qu R, Ma SP.(PubMed)
(727) Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors by Huang Y1, Zhang H, Yang S, Qiao H, Zhou W, Zhang Y(PubMed)
(728) Determination of the effectiveness of components of the herbal medicine Toki-Shakuyaku-San and fractions of Angelica acutiloba in improving the scopolamine-induced impairment of rat's spatial cognition in eight-armed radial maze test. by Hatip-Al-Khatib I1, Egashira N, Mishima K, Iwasaki K, Iwasaki K, Kurauchi K, Inui K, Ikeda T, Fujiwara M.(PubMed)
(729) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(730) A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Abeta(1-42) level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease by Seo JS1, Jung EY, Kim JH, Lyu YS, Han PL, Kang HW.(PubMed)
(731) A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease by Jeon S1, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS.(PubMed)
Friday, 3 February 2017
The holistic Prevention, Management and Treatment of Dementia In Herbal Medicine - Bacopa
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
Herbal Medicine forTreatment of Dementia - Bacopa
Commonly known as Waterhyssop or Water Hyssop, the herb is a semi-woody plants, genus of Hyssopus, belonging to the family Lamiaceae, native to the east Mediterranean to central Asia, used in traditional medicine as an antibiotic(660)(659), carminative, antispasmodic, antifungal(661), and antiseptic(661)(662) agents and to treat bronchitis(663), asthma(664), digestive ailments(665)(668), insomnia(666), diabetes(667), edema(669)(670), etc.
a. Increases Cerebral Blood Flow
In cerebral blood flow (CBF), Bacopa monnieri's promoted blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671). |Together with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).
b. Ethnobotanical treatment
Bacopa, ethnobotanically, may be used as brain tonification(676) and to treat various diseases(673), including Alzheimer's disease
through its phytochemicals in alleviation of AD pathology and associated symptoms(674). According to university System HSC College of Medicine, Bacopa monniera extract (BME), administered starting at 2 months of age for either 2 or 8 months on test mice, significant lowered Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes(675). Its natural products (galantamine and rivastigmine), also has been used pharmaceutically for cognitive and behavioural and psychological symptoms of dementia (BPSD)(673).
c. Cognitive performance, anxiety, and depression
In olfactory bulbectomized mice, alcoholic extract of Bacopa monnieri(L.) showed to ameliorate memory and emotional deficits(678) and enhanced cognitive performance(679) through its protection of cholinergic systems from OBX-induced neuronal damage(677). In normal healthy participants, the herb also attenuated stress reactivity and mood, through its adaptogenic and nootropic effects, probably via reduction in cortisol levels(680). According to National College of Natural Medicine, standardized dry extract of Bacopamonnieri, promoted the improvement depression scores, combined state plus trait anxiety scores,with few adverse events, primarily stomach(681)
6. Other potential herbs
Herbs used in the treatment and prevention of dementia(682)(683) in traditional medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress and neuro inflammation via neuroglial activation(683).
According to University of Wollongong, herbs and spices, containing high amount of phytochemicals in traditional history of use, with strong roles in cultural heritage, may have a distinguished effect in cognitive decline associated with ageing and the acute effects of psychological and cognitive function(684), probably through active ingredients of spices in modulation of neural response in the peripheral nervous system, via interaction with TRP channel/receptors(685).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(660) Use of the cryptogein gene to stimulate the accumulation of Bacopa saponins in transgenic Bacopa monnieri plants by Majumdar S1, Garai S, Jha S.(PubMed)
(661) Bacopa antifungal(PubMed)
(662) Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. by Chaudhuri PK1, Srivastava R, Kumar S, Kumar S.(PubMed)
(663) Bacopa asthma(PubMed)
(664) Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats by Dar A1, Channa S.(PubMed)
(665) Evaluation of memory enhancing clinically available standardized extract of Bacopa monniera on P-glycoprotein and cytochrome P450 3A in Sprague-Dawley rats. by Singh R1, Panduri J, Kumar D, Kumar D, Chandsana H, Ramakrishna R, Bhatta RS.(PubMed)
(666) Bacopa monniera Linn. as an antioxidant: mechanism of action. by Tripathi YB1, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP.(PubMed)
(667) Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic rats by Ghosh T1, Maity TK, Singh J.(PubMed)
(668) Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats by Dorababu M1, Prabha T, Priyambada S, Agrawal VK, Aryya NC, Goel RK.(PubMed)
(669) Anti-inflammatory activity of Bacopa monniera in rodents. by Channa S1, Dar A, Anjum S, Yaqoob M, Atta-Ur-Rahman.(PubMed)
(670) Anti-inflammatory activity of Bacopa monniera in rodents by Channa S1, Dar A, Anjum S, Yaqoob M, Atta-Ur-Rahman(PubMed)
(671) Effects of Ginkgo biloba in dementia: systematic review and meta-analysis by Stefan Weinmann,
1 Stephanie Roll,1 Christoph Schwarzbach,2 Christoph Vauth,2 and Stefan N Willich1(PMC)
(672) Neuropharmacological review of the nootropic herb Bacopa monnieri. by Aguiar S1, Borowski. T.(PubMed)
(673) An ethnobotanical survey of medicinal plants used in Terai forest of western Nepal by Singh AG1, Kumar A, Tewari DD.(PubMed)
(674) Ethnobotanical treatment strategies against Alzheimer's disease. by Howes MJ1, Houghton PJ.(PubMed)
(675) Bacopa monniera extract reduces amyloid levels in PSAPP mice. by Holcomb LA1, Dhanasekaran M, Hitt AR, Young KA, Riggs M, Manyam BV.(PubMed)
(676) Ethnobotany and research on medicinal plants in India by Jain SK1.(PubMed)
(677) Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems by Le XT1, Pham HT, Do PT, Fujiwara H, Tanaka K, Li F, Van Nguyen T, Nguyen KM, Matsumoto K.(PubMed)
(678) Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions by Mizuki D1, Qi Z, Tanaka K, Fujiwara H, Ishikawa T, Higuchi Y, Matsumoto K.(PubMed)
(679) An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract ofBacopa monnieri (CDRI 08) on sustained cognitive performance by Downey LA1, Kean J, Nemeh F, Lau A, Poll A, Gregory R, Murray M, Rourke J, Patak B, Pase MP, Zangara A, Lomas J, Scholey A, Stough C.(PubMed)
(680) An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri(CDRI 08) on multitasking stress reactivity and mood by Benson S1, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A.(PubMed)
(681) Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial by Calabrese C1, Gregory WL, Leo M, Kraemer D, Bone K, Oken B.(PubMed)
(682) Neuroprotective potential of phytochemicals by Kumar GP1, Khanum F.(PubMed)
(683) Neuroprotective herbs and foods from different traditional medicines and diets. by Iriti M1, Vitalini S, Fico G, Faoro F.(PubMed)
(684) Health benefits of herbs and spices: the past, the present, the future by Tapsell LC1, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE.(PubMed)
(685) Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices by Pezzoli M1, Elhamdani A1, Camacho S2, Meystre J1, González SM3, le Coutre J4, Markram H1.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
Herbal Medicine forTreatment of Dementia - Bacopa
Commonly known as Waterhyssop or Water Hyssop, the herb is a semi-woody plants, genus of Hyssopus, belonging to the family Lamiaceae, native to the east Mediterranean to central Asia, used in traditional medicine as an antibiotic(660)(659), carminative, antispasmodic, antifungal(661), and antiseptic(661)(662) agents and to treat bronchitis(663), asthma(664), digestive ailments(665)(668), insomnia(666), diabetes(667), edema(669)(670), etc.
a. Increases Cerebral Blood Flow
In cerebral blood flow (CBF), Bacopa monnieri's promoted blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671). |Together with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).
b. Ethnobotanical treatment
Bacopa, ethnobotanically, may be used as brain tonification(676) and to treat various diseases(673), including Alzheimer's disease
through its phytochemicals in alleviation of AD pathology and associated symptoms(674). According to university System HSC College of Medicine, Bacopa monniera extract (BME), administered starting at 2 months of age for either 2 or 8 months on test mice, significant lowered Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes(675). Its natural products (galantamine and rivastigmine), also has been used pharmaceutically for cognitive and behavioural and psychological symptoms of dementia (BPSD)(673).
c. Cognitive performance, anxiety, and depression
In olfactory bulbectomized mice, alcoholic extract of Bacopa monnieri(L.) showed to ameliorate memory and emotional deficits(678) and enhanced cognitive performance(679) through its protection of cholinergic systems from OBX-induced neuronal damage(677). In normal healthy participants, the herb also attenuated stress reactivity and mood, through its adaptogenic and nootropic effects, probably via reduction in cortisol levels(680). According to National College of Natural Medicine, standardized dry extract of Bacopamonnieri, promoted the improvement depression scores, combined state plus trait anxiety scores,with few adverse events, primarily stomach(681)
6. Other potential herbs
Herbs used in the treatment and prevention of dementia(682)(683) in traditional medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress and neuro inflammation via neuroglial activation(683).
According to University of Wollongong, herbs and spices, containing high amount of phytochemicals in traditional history of use, with strong roles in cultural heritage, may have a distinguished effect in cognitive decline associated with ageing and the acute effects of psychological and cognitive function(684), probably through active ingredients of spices in modulation of neural response in the peripheral nervous system, via interaction with TRP channel/receptors(685).
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(660) Use of the cryptogein gene to stimulate the accumulation of Bacopa saponins in transgenic Bacopa monnieri plants by Majumdar S1, Garai S, Jha S.(PubMed)
(661) Bacopa antifungal(PubMed)
(662) Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea. by Chaudhuri PK1, Srivastava R, Kumar S, Kumar S.(PubMed)
(663) Bacopa asthma(PubMed)
(664) Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats by Dar A1, Channa S.(PubMed)
(665) Evaluation of memory enhancing clinically available standardized extract of Bacopa monniera on P-glycoprotein and cytochrome P450 3A in Sprague-Dawley rats. by Singh R1, Panduri J, Kumar D, Kumar D, Chandsana H, Ramakrishna R, Bhatta RS.(PubMed)
(666) Bacopa monniera Linn. as an antioxidant: mechanism of action. by Tripathi YB1, Chaurasia S, Tripathi E, Upadhyay A, Dubey GP.(PubMed)
(667) Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic rats by Ghosh T1, Maity TK, Singh J.(PubMed)
(668) Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats by Dorababu M1, Prabha T, Priyambada S, Agrawal VK, Aryya NC, Goel RK.(PubMed)
(669) Anti-inflammatory activity of Bacopa monniera in rodents. by Channa S1, Dar A, Anjum S, Yaqoob M, Atta-Ur-Rahman.(PubMed)
(670) Anti-inflammatory activity of Bacopa monniera in rodents by Channa S1, Dar A, Anjum S, Yaqoob M, Atta-Ur-Rahman(PubMed)
(671) Effects of Ginkgo biloba in dementia: systematic review and meta-analysis by Stefan Weinmann,
1 Stephanie Roll,1 Christoph Schwarzbach,2 Christoph Vauth,2 and Stefan N Willich1(PMC)(672) Neuropharmacological review of the nootropic herb Bacopa monnieri. by Aguiar S1, Borowski. T.(PubMed)
(673) An ethnobotanical survey of medicinal plants used in Terai forest of western Nepal by Singh AG1, Kumar A, Tewari DD.(PubMed)
(674) Ethnobotanical treatment strategies against Alzheimer's disease. by Howes MJ1, Houghton PJ.(PubMed)
(675) Bacopa monniera extract reduces amyloid levels in PSAPP mice. by Holcomb LA1, Dhanasekaran M, Hitt AR, Young KA, Riggs M, Manyam BV.(PubMed)
(676) Ethnobotany and research on medicinal plants in India by Jain SK1.(PubMed)
(677) Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems by Le XT1, Pham HT, Do PT, Fujiwara H, Tanaka K, Li F, Van Nguyen T, Nguyen KM, Matsumoto K.(PubMed)
(678) Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions by Mizuki D1, Qi Z, Tanaka K, Fujiwara H, Ishikawa T, Higuchi Y, Matsumoto K.(PubMed)
(679) An acute, double-blind, placebo-controlled crossover study of 320 mg and 640 mg doses of a special extract ofBacopa monnieri (CDRI 08) on sustained cognitive performance by Downey LA1, Kean J, Nemeh F, Lau A, Poll A, Gregory R, Murray M, Rourke J, Patak B, Pase MP, Zangara A, Lomas J, Scholey A, Stough C.(PubMed)
(680) An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri(CDRI 08) on multitasking stress reactivity and mood by Benson S1, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A.(PubMed)
(681) Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial by Calabrese C1, Gregory WL, Leo M, Kraemer D, Bone K, Oken B.(PubMed)
(682) Neuroprotective potential of phytochemicals by Kumar GP1, Khanum F.(PubMed)
(683) Neuroprotective herbs and foods from different traditional medicines and diets. by Iriti M1, Vitalini S, Fico G, Faoro F.(PubMed)
(684) Health benefits of herbs and spices: the past, the present, the future by Tapsell LC1, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE.(PubMed)
(685) Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices by Pezzoli M1, Elhamdani A1, Camacho S2, Meystre J1, González SM3, le Coutre J4, Markram H1.(PubMed)
Thursday, 2 February 2017
The holistic Prevention, Management and Treatment of Dementia In Herbal Medicine - Huperzine A
Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
Herbal Medicine forTreatment of Dementia - Huperzine A
Huperzine A, a chemical made from the plant Huperzia serrata has been studied for its effect on patient of dementia with conflict results.
a. Cognitive effects
In induced Alzheimer's disease animal study, Huperzine A showed a significant effect in inhibited acetylcholinesterase, derived from forebrain, hippocampus, cortex and cerebellum(635), through neuron protective effects and enhanced glutamatergic functions(635). In mild to moderate vasculardementia (VaD) patients, the medicine also improved the cognitive function with serious adverse events(636). According to Beijing University of Chinese Medicinealthough Huperzine A showed a beneficial effects on improvement of cognitive function, daily living activity in global clinical assessment in participants with Alzheimer's disease, the findings should be interpreted with caution due to the poor methodological quality of the included trials(638). But according to University of California,, in a phase II trial of huperzine A, regardless to doses, huperzine A did not demonstrate cognitive effect in patients with mild to moderate AD(637).
b. Inhibition of amyloid plaque burden and oligomeric β-amyloid (Aβ)
Huperzine A, showed to reduce in Aβ levels and Aβ burden in AD brain, through activation of Wnt signaling(regulate cell-to-cell interactions) and targeting of the Wnt/β-catenin signaling pathway in various components in contribution to disease(639) through modulation of amyloidogenic and nonamyloidogenic pathways(640), and reduction of iron in the brain(641) via a multi-target mechanism(642).
c. Mild to moderate vascular dementia (VaD) and Alzheimer's disease
In patients with mild to moderate vascular dementia (VaD), Huperzine A significantly improved the cognitive function in mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores(643)(644).
In patients with Alzheimer's disease (AD), Huperzine A also showed improvement in memory function and cognitive enhancement at a dose of 0.4 mg using MMSE, MQ, ADAS-COG, and ADL tests(645); against organophosphate (OP) intoxication and reduction of glutamate-induced cell death(646). According to Georgetown University Hospital, the antioxidant and neuroprotective properties of Huperzine A may be useful as a disease-modifying treatment for Alzheimer's disease (AD)(647).
Due to data supporting its use are limited by weak study design, the Massachusetts College of Pharmacy and Health Sciences-Worcester/Manchester suggested that randomized, placebo-controlled trials are necessary to establish the role of huperzine A in the treatment of AD(648).
d. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(635) Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate by Ved HS1, Koenig ML, Dave JR, Doctor BP.(PubMed)
(636) Treatment with Huperzine A improves cognition in vascular dementia patients by Xu ZQ1, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ.(PubMed)
(637) A phase II trial of huperzine A in mild to moderate Alzheimer disease by Rafii MS1, Walsh S, Little JT, Behan K, Reynolds B, Ward C, Jin S, Thomas R, Aisen PS; Alzheimer's Disease Cooperative Study.(PubMed)
(638) Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials by Yang G1, Wang Y, Tian J, Liu JP.(PubMed)
(639) Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model by Wang CY1, Zheng W, Wang T, Xie JW, Wang SL, Zhao BL, Teng WP, Wang ZY.(PubMed)
(640) Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice by Wang Y1, Tang XC, Zhang HY.(PubMed)
(641) Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease by Huang XT1, Qian ZM2, He X3, Gong Q3, Wu KC3, Jiang LR4, Lu LN3, Zhu ZJ3, Zhang HY5, Yung WH3, Ke Y6.(PubMed)
(642) Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease by Wang R1, Tang XC.(PubMed)
(643) Treatment with Huperzine A improves cognition in vascular dementia patients by Xu ZQ1, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ.(PubMed)
(644) Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. by Xing SH1, Zhu CX2, Zhang R1, An L1.(PubMed)
(645) Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies by Ha GT1, Wong RK, Zhang Y.(PubMed)
(646) The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease by Zangara A1.(PubMed)
(647) An update on huperzine A as a treatment for Alzheimer's disease by Little JT1, Walsh S, Aisen PS.(PubMed)
(648) Role of huperzine a in the treatment of Alzheimer's disease by Desilets AR1, Gickas JJ, Dunican KC.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
Herbal Medicine forTreatment of Dementia - Huperzine A
Huperzine A, a chemical made from the plant Huperzia serrata has been studied for its effect on patient of dementia with conflict results.
a. Cognitive effects
In induced Alzheimer's disease animal study, Huperzine A showed a significant effect in inhibited acetylcholinesterase, derived from forebrain, hippocampus, cortex and cerebellum(635), through neuron protective effects and enhanced glutamatergic functions(635). In mild to moderate vasculardementia (VaD) patients, the medicine also improved the cognitive function with serious adverse events(636). According to Beijing University of Chinese Medicinealthough Huperzine A showed a beneficial effects on improvement of cognitive function, daily living activity in global clinical assessment in participants with Alzheimer's disease, the findings should be interpreted with caution due to the poor methodological quality of the included trials(638). But according to University of California,, in a phase II trial of huperzine A, regardless to doses, huperzine A did not demonstrate cognitive effect in patients with mild to moderate AD(637).
b. Inhibition of amyloid plaque burden and oligomeric β-amyloid (Aβ)
Huperzine A, showed to reduce in Aβ levels and Aβ burden in AD brain, through activation of Wnt signaling(regulate cell-to-cell interactions) and targeting of the Wnt/β-catenin signaling pathway in various components in contribution to disease(639) through modulation of amyloidogenic and nonamyloidogenic pathways(640), and reduction of iron in the brain(641) via a multi-target mechanism(642).
c. Mild to moderate vascular dementia (VaD) and Alzheimer's disease
In patients with mild to moderate vascular dementia (VaD), Huperzine A significantly improved the cognitive function in mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores(643)(644).
In patients with Alzheimer's disease (AD), Huperzine A also showed improvement in memory function and cognitive enhancement at a dose of 0.4 mg using MMSE, MQ, ADAS-COG, and ADL tests(645); against organophosphate (OP) intoxication and reduction of glutamate-induced cell death(646). According to Georgetown University Hospital, the antioxidant and neuroprotective properties of Huperzine A may be useful as a disease-modifying treatment for Alzheimer's disease (AD)(647).
Due to data supporting its use are limited by weak study design, the Massachusetts College of Pharmacy and Health Sciences-Worcester/Manchester suggested that randomized, placebo-controlled trials are necessary to establish the role of huperzine A in the treatment of AD(648).
d. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including dementia
and restore your health naturally with Chinese diet
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(635) Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate by Ved HS1, Koenig ML, Dave JR, Doctor BP.(PubMed)
(636) Treatment with Huperzine A improves cognition in vascular dementia patients by Xu ZQ1, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ.(PubMed)
(637) A phase II trial of huperzine A in mild to moderate Alzheimer disease by Rafii MS1, Walsh S, Little JT, Behan K, Reynolds B, Ward C, Jin S, Thomas R, Aisen PS; Alzheimer's Disease Cooperative Study.(PubMed)
(638) Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials by Yang G1, Wang Y, Tian J, Liu JP.(PubMed)
(639) Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model by Wang CY1, Zheng W, Wang T, Xie JW, Wang SL, Zhao BL, Teng WP, Wang ZY.(PubMed)
(640) Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice by Wang Y1, Tang XC, Zhang HY.(PubMed)
(641) Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease by Huang XT1, Qian ZM2, He X3, Gong Q3, Wu KC3, Jiang LR4, Lu LN3, Zhu ZJ3, Zhang HY5, Yung WH3, Ke Y6.(PubMed)
(642) Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease by Wang R1, Tang XC.(PubMed)
(643) Treatment with Huperzine A improves cognition in vascular dementia patients by Xu ZQ1, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ.(PubMed)
(644) Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. by Xing SH1, Zhu CX2, Zhang R1, An L1.(PubMed)
(645) Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies by Ha GT1, Wong RK, Zhang Y.(PubMed)
(646) The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease by Zangara A1.(PubMed)
(647) An update on huperzine A as a treatment for Alzheimer's disease by Little JT1, Walsh S, Aisen PS.(PubMed)
(648) Role of huperzine a in the treatment of Alzheimer's disease by Desilets AR1, Gickas JJ, Dunican KC.(PubMed)
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