Friday, 25 November 2016

The holistic Prevention, Management and Treatment of Dementia - Types of dementia

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

                           Types of dementia

1. Alzheimer's disease
Alzheimer's disease is a brain disorder named for German physician Alois Alzheimer(1). Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal(2). Over 1 million people in US alone are currently afflicted by Alzheimer's disease because of degeneration of hippocampus and cerebral cortex(3) of the brain where memory, language and cognition(4) are located. With this mental disorder, brain cells gradually die and generate fewer and fewer chemical signals day by day resulting in diminished of functions. Overtime memory thinking as well as behavior deteriorates. Today, there is no known cure.

2. Absence of acetylcholine
If the nerves located in front of the brain perish(5), caused by diminished quality of acetylcholine due long term alcohol abused may result of cognitive dysfunction(6) causes of language difficulty, memory loss, concentration problem, and anxiety- and depression-like behaviors(8),reduced moblile skills because of lacking reaction in muscular activity and refection(7).

3. Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism(9). Most classic is the Korsakoff's dementia resulted in extremely poor short term memory(10) and often associated with the memory losses of confabulations due to diminished processing resources and/or an encoding or retrieval deficit(11).

4. Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults caused by different mechanisms all results in vascular lesions(12) of the brain(13).

5. Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition, causes of cognitive deficits due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop(15)(16) due to loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons(14).

6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef(18) for many years may be infected without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease consisted of dementia(19), muscle abnormal functions(17).

7. Subdural hematoma
It is the accumulation of blood beneath the outer cover of the brain resulted from the rupture of blood vessel(20)(21). Subdural hemorrhages may increase intracranial pressure(22), causing compression and damage to delicate brain tissue. Acute subdural hematoma has a high mortality rate(23).

Other types of dementia include metabolic disorders, dementia due to long-term substance abuse, hypothyroidism, and hyperethyroidism.


References
(1) Alzheimer's disease (Wikipedia)
(2) Understanding dementia in the sociocultural context: a review by Cipriani G1, Borin G2.(PubMed)
(3) What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus by Fjell AM1, McEvoy L2, Holland D3, Dale AM4, Walhovd KB5; Alzheimer's Disease Neuroimaging Initiative.(PubMed)
(4) Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? by Docherty AR1, Hagler DJ Jr2, Panizzon MS3, Neale MC4, Eyler LT5, Fennema-Notestine C6, Franz CE3, Jak A7, Lyons MJ8, Rinker DA9, Thompson WK10, Tsuang MT11, Dale AM12, Kremen WS13.(PubMed)
(5) Acetylcholine facilitates recovery of episodic memory after brain damage by Croxson PL1, Browning PG, Gaffan D, Baxter MG.(PubMed)
(6) Postsynaptic activity reverses the sign of the acetylcholine-induced long-term plasticity of GABAA inhibition by Domínguez S1, Fernández de Sevilla D2, Buño W3.(PubMed)
(7) Induction of dystrophin-associated proteins together with nicotinic acetylcholine receptors by denervation in the absence of dystrophin in skeletal muscles of mdx mice by Mitsui T1, Kawai H, Kawajiri M, Kunishige M, Aki K, Saito S.(PubMed)
(8) Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia by Semenova S1, Contet C, Roberts AJ, Markou A.(PubMed)
(9) Magnetic resonance imaging in alcoholic Korsakoff's syndrome: evidence for an association with alcoholic dementia by Emsley R1, Smith R, Roberts M, Kapnias S, Pieters H, Maritz S.(PubMed)
(10) Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome by Kopelman MD.(PubMed)
(11) Non-verbal, short-term forgetting in the alcoholic Korsakoff syndrome and Alzheimer-type dementia by Kopelman MD1.(PubMed)
(12) Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain by Thal DR1, Grinberg LT, Attems J.(PubMed)
(13) Pathology and pathogenesis of vascular cognitive impairment-a critical update by Jellinger KA1.(PubMed)
(14) What causes the death of dopaminergic neurons in Parkinson's disease? by Surmeier DJ1, Guzman JN, Sanchez-Padilla J, Goldberg JA.(PubMed)
(15) Frontal-subcortical circuitry and behavior Circuitos fronto-subcorticales y conducta Circuits fronto-sous-corticaux et comportement, Raphael M. Bonelli, MD; DMedSc*
Raphael M. Bonelli, Department of Psychiatry, Graz Medical University, Graz, Austria ;
Jeffrey L. Cummings, MD,
Jeffrey L. Cummings, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA;(PubMed)
(16) The Frontal Lobes and Neuropsychiatric Illness, edited by Stephen P. Salloway, Paul F. Malloy, James D. Duffy
(17) [A case of Creutzfeldt-Jakob disease presenting with arm levitation as an initial symptom].
[Article in Japanese] by Kamogawa K1, Ninomiya S, Okuda S, Matsumoto Y, Tomita H, Okamoto K, Okuda B.(PubMed)
(18) Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: how safe is eating beef? by Roma AA1, Prayson RA.(PubMed)
(19) Immune responses in rapidly progressive dementia: a comparative study of neuroinflammatory markers in Creutzfeldt-Jakob disease, Alzheimer's disease and multiple sclerosis by Stoeck K, Schmitz M, Ebert E, Schmidt C, Zerr I.(PubMed)
(20) Acute subdural hematoma from bridging vein rupture: a potential mechanism for growth by
Miller JD1, Nader R.(PubMed)
(21) Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhage by
Patel PV1, FitzMaurice E, Nandigam RN, Auluck P, Viswanathan A, Goldstein JN, Rosand J, Greenberg SM, Smith EE.(PubMed)
(22) Acute spontaneous subdural hematoma: an unusual form of cerebrovacular accident by Naama O1, Belhachmi A, Ziadi T, Boulahroud O, Abad Elasri C, Elmostarchid B, Boucetta M.(PubMed)
(23) Fatal deterioration of delayed acute subdural hematoma after mild traumatic brain injury: two cases with brief review by Chen S1, Xu C, Yuan L, Tian H, Cao H, Guo Y.(PubMed)

Thursday, 24 November 2016

Antioxidants: The Summary

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
                      
              
                                         The Summary



Aging is a natural process, no one can stop but delay it. Over last 20+ years, researchers found that free radicals have played a majors role in the progression of aging process as they damage every cells of the whole body. One of the majoy cause of free radical is that of setting a chain reaction, if left unchecked, it can cause death of the cells, triggering the attack to the adjacent cells. At the middle age, due to weakened immune system, damage of body organs and reduced levels of antioxidants, our health is deteriorate and aging progressed at a fast rate, it is up to you to delay it by eating healthy, living a healthy style, exercise, etc. if you want to look younger than you biological age, live longer, healthier and diseases free.


Wednesday, 23 November 2016

Antioxidants: The immune system - The Effects of antioxidants on immune system

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
                      
              
                                         The immune system

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, virus, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

    The Effects of antioxidants on immune system

Enzyme antioxidants, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase are best known to defense our body in fighting or scavenging against forming of free radicals by neutralizing them. Other antioxidants include
a. Zinc
Zinc, as a antioxidant is essential mineral in ading immune system by enhancing the peoper function of T cells which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals.

b. Selenium
Selenium is one of the powerful antioxidant. In the extracellular space, it helps to influence immune processes by proliferating the response to mitogen, and macrophages, leukotriene.

c. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including lymphocyte activation and proliferation, T-helper-cell differentiation, the production of specific antibody isotypes and regulation of the immune response.

d. Vitamin C
Researchers found that vitamin C raised the concentration in the blood of immunoglobulin A, M that promotes the ability of antibodies and phagocytic cells to clear pathogens.

e. Vitamin E
In aged mice study showed that Vitamin E beside increased both cell-dividing and IL-producing capacities of naive T cells it also enhances the immune functions in association with significant improvement in resistance to influenza infection.

f. Carotenoids
Carotenoids reduces oxidation damage to cells and protects LDL cholesterol from oxidation, thus reducing the risk of aging and chronic diseases caused by damaging free radicals.

g. Etc.

Tuesday, 22 November 2016

Antioxidants: The immune system - How free radicals affect Immune system

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
                      
              
                                         The immune system

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, virus, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.


            How free radicals affect Immune system

There are many factors which affect immune system as we age. Hormone declining such as human growth hormone and Dehydroepiandrosterone (DHEA) are the major influences. In factor, some researchers suggested free radicals is one of major contribution to the declining of immune system.
a. Thymus
The declining of the thymus function contributes a direct effect on the immune system due to diminish of quantity of T cells and immune factors.

b. Lipid peroxidation
Researchers found that lipid peroxidation are able to attack immune cells membrane, leading to the impediment of cells membrane activities, causing susceptibility diseases found in aging person.

c. NADHP oxidase
NADHP oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) is a membrane-bound enzyme complex found in the plasma membrane. Free radicals cause damage to membrane, leading to diminish of its function in fighting against foreign invasion.

d. Cytokine
Free radicals damage immune cells that affect the function of cytokines in transmitting intercellular signals, leading to many disease states and conditions ranging from major depression and Alzheimer's disease to cancer.

e. Etc.
 


Monday, 21 November 2016

Antioxidants: The immune system - Types of free radicals utilized by Immune system

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
                      
              
                                         The immune system

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, virus, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

Types of free radicals utilized by Immune system

Free Radicals play an important role in the function of the Immune System. The immune systen produce free radicals to kill foreign microbes, but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals that stimulate the formation of more free radicals, leading to even more damage, until they are brought to stop.


a. Nitric oxideNitric oxide is also generated by phagocytes of immune system as part of the human immune response. It is produced as free radicals and toxic to bacteria, that helps the immune system in regulating the armamentarium of phagocytes that play a role in inflammation.
Nitric oxide can contribute to reperfusion injury if excessive amount produced during reperfusion and reacts with superoxide to produce the damaging oxidant peroxynitrite.

b. Superoxide
Superoxide is a compound that possesses the superoxide anion with the chemical formula O2−. It is biologically quite toxic and is deployed by the immune system to kill invading microorganisms produced in large quantities by the enzyme NADPH oxidase.
If over produce, superoxide may contribute to the pathogenesis of many diseases , such as radiation poisoning and hyperoxic injury and aging as aresult of oxidation.

c. Neutrophils
Neutrophils, the phagocytes can internalize and kill microbes, but each phagocytic event causes the formation of a phagosome into which reactive oxygen species (ROS) and hydrolytic enzymes are secreted, leading to respiratory burst, resulting in activating the enzyme NADPH oxidase, which produces large quantities of superoxide.

d. Chain reaction
Since free radicals are caused by the body’s own natural processes by stealing oxygen electron from other cell, its chain effect result in production of even more free radicals. These aditional free radicals continue until they are stopped, leading to toxins, radiation, etc. that weakens the immune system.

e. Etc.

Sunday, 20 November 2016

Antioxidants: The immune system - functioning

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
                      
              
                                         The immune system

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, virus, parasites, etc. and tumor cells, including irregular cells growth, cancer cells to keep us healthy. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.


                Immune system and functioning

Although immune system have done a great job in protecting us against foreign invasion, but unfortumately, during process od their functions, they may induce the production of free radicals and chain of free radicals that can be harmful to our body.
a. Red and white blood cells
During the process, the tissue of bone marrow of the long bone produce stem cells which will evolve into progenitor cells. This progenitor cells finally differentiate into white and redblood cells. While the red blood cells deliver oxygen (O2) and nutrients to the body tissues via the blood flow through the circulatory system, the white blood cells or leukocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials.

b. Thymus gland
The thymus gland a specialized organ form part of the immune system. It helps in the production and functioning of T-lymphocytes (T cells), which are critical cells of the adaptive immune system by providing an inductive environment for development of T-lymphocytes from hematopoietic progenitor cells. The thymus gland starts to shrink from the time when we was born and by age of 60, it had shriveled away to almost nothing.
Beside it is important to the functions of above, it also produced varies protein hormones, such as IL-2, is a protein manufactured by lymphocytes. Peripheral blood obtained from patients with chronic hepatitis B and viral infections responded to THF with increased production of IL-2. This suggests a possible antiviral role for this thymic hormone, and is one of the reasons we should replace thymic hormone as we pass the second decade.

c. Lymphatics system
The lymphatic system form part of the immune system comprising a network of conduits called lymphatic vessels that carry a clear fluid called lymph unidirectionally toward the heart. Beside having a function of removing interstitial fluid from tissues, absorbing and transporting fatty acids and fats from the circulatory system and transporting immune cells to and from the lymph nodes into the bones, it also enhances the immune system of the body by defending the body against the infections and spread of tumors due to its connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes.

d. Spleen
Spleen formed part of immune system, is imporant in the filtration process of removal of old or damaged red blood cells from the circulation and filters out bacteria of the blood. The immunological function of spleen in human body is looked after by the white pulp which consists of aggregates of lymphoid tissue. Abnormal function of spleen can result in enlarged organ due to its inability to perform function of removing of old or damaged red blood cells, leading to accumulation or trapping of red blood cells, causing major turmoils in immune system.

Saturday, 19 November 2016

Antioxidants: Arthritis - The Effects of Antioxidants on Arthritis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.                     
               
                                         Arthritis


There are over 100 different forms of arthritis, including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and related autoimmune diseases. Arthritis is defined as a health condition with characteristics of redness, swelling, accompanied with pain and loss of function due to inflammation that occurs around the joint, damage to the joint.

The Effects ofn Antioxidants on Arthritis

a. Vitamin C
Vitamin C beside is vital in restoring the antioxidants vitamin E in scavenging the free radicals before they can become harmful to the body, it also protects the capillaries by preventing them from breaking off, triggering an inflammatory reaction. Other study found that vitamin C also reduces the risk of cartilage loss and developing knee pain.

b. Vitamin E and fish oil
In genetically altered mice study, researcher found that diet included fish oil plus vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum.

c. Glucosamine
Since glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans, and they are a major component of joint cartilage. Study found that supplemental glucosamine may help to prevent cartilage degeneration and treat arthritis.

d. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid. Researchers found that DLPA effectively reduces arthritis pain and joint inflammation in many patients.

e. Glucosamine and Methylsulfonylmethane
In a double-blind, placebo-controlled study with osteoarthritis of the knee were given a combination of glucosamine and MSM, or placebo. After 12 weeks, the results suggested combination of MSM and glucosamine may improve arthritis symptoms as compared to placebo.

f. Etc.