Monday, 14 November 2016

Antioxidants: Neurodegenrative diseases - Lou Gehrig's diseases: The Effects of Antioxidants on Lou Gehrig's disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.

                      

                 Neurodegenrative diseases

Neurodegeneration is defined as a health conditions of the progressive loss of structure or function of neurons, including death of neurons, includingParkinson’s, Alzheimer’s, and Huntington’s diseases due to genetic mutations, most of which are located in completely unrelated genes.


                                         Lou Gehrig's diseases 

Lou Gehrig's diseases is defined as a condition of neurological disorders that selectively affect the motor neurones caused by the degeneration of neurons located in the two separate anatomical structures of the spinal cord and the cerebral cortex that provide activity of carrying nerve impulses from receptors to the central nervous system.

The Effects of Antioxidants on Lou Gehrig's disease

a. Vitamin B12 (methylcobalamin)
Researcher found that high doses of vitamin B12 (25 mg) as an antioxidant have been shown to improve or slow muscle wasting in the later stages of patients with ALS disease.

b. Vitamin E
Vitamin E beside helps to protect cell membranes from lipid peroxidation damage that reduce the risk of breakdown of the cell membrane, causing ALS.

c. Superoxide dismutase enzyme
Research found that mutations in the superoxide dismutase enzyme can increase the risk ALS in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide.

d. Cerebral cortex
Researcher found that oxidative protein damage and DNA alternation were found in elevating levels in the cerebral cortex of those with sporadic ALS.

e. Amino acids
study found that diet high in amino acids as antioxidants have shown some promising effect in treating ALS.

f. Etc.

Antioxidants: Neurodegenrative diseases - Lou Gehrig's diseases: The Effects of Free radicals on Lou Gehrig's disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.

                      

                 Neurodegenrative diseases

Neurodegeneration is defined as a health conditions of the progressive loss of structure or function of neurons, including death of neurons, includingParkinson’s, Alzheimer’s, and Huntington’s diseases due to genetic mutations, most of which are located in completely unrelated genes.


                                         Lou Gehrig's diseases 

Lou Gehrig's diseases is defined as a condition of neurological disorders that selectively affect the motor neurones caused by the degeneration of neurons located in the two separate anatomical structures of the spinal cord and the cerebral cortex that provide activity of carrying nerve impulses from receptors to the central nervous system.

The Effects of Free radicals on Lou Gehrig's disease

Researchers found that glutamate in the synapses enhances the production of free radicals compounds only in motor nerve cells but spares other nerve cells such as cells control senses and other body functions, causing to more production of free radicals and leading to disrupting of the surrounding support cells, called astrocytes, which regulate glutamate levels.

Saturday, 12 November 2016

Antioxidants: Neurodegenrative diseases - Lou Gehrig's diseases: The Causes

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.

                      

                 Neurodegenrative diseases

Neurodegeneration is defined as a health conditions of the progressive loss of structure or function of neurons, including death of neurons, includingParkinson’s, Alzheimer’s, and Huntington’s diseases due to genetic mutations, most of which are located in completely unrelated genes.


                                         Lou Gehrig's diseases 

Lou Gehrig's diseases is defined as a condition of neurological disorders that selectively affect the motor neurones caused by the degeneration of neurons located in the two separate anatomical structures of the spinal cord and the cerebral cortex that provide activity of carrying nerve impulses from receptors to the central nervous system.

                                                          The Causes

a. Glutamate
Some theories suggested that ALS is a result of the diminish of glutamate in the synapses, causing the build up of plague due to overflow of calcium into motor neurons.

b. Gene alternation
Gene alternation of superoxide dismutase enzyme will reduce the functions in catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide.

c. Genetic defect
An inherited genetic defect on the coding for superoxide dismutase (chromosome 21) is associated with approximately 20% of familial cases of ALS.

d. Environmental factors
Prolonged exposure to a dietary neurotoxin called BMAA (a neurotoxin found in the seeds of the cycad) produced by cyanobacteria is one suspected risk factor to cause ALS.

e. Toxic exposure
There is another epidemiologic association suggested a link of toxins and ALS.

f. Other theories have been proposed that may cause ALS, including autoimmune disorders, heavy metal poisoning, and even viral infection.

g. Etc.

Friday, 11 November 2016

Antioxidants: Neurodegenrative diseases - Lou Gehrig's diseases : The Symptoms

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.

                      

                 Neurodegenrative diseases

Neurodegeneration is defined as a health conditions of the progressive loss of structure or function of neurons, including death of neurons, includingParkinson’s, Alzheimer’s, and Huntington’s diseases due to genetic mutations, most of which are located in completely unrelated genes.


                                         Lou Gehrig's diseases 

Lou Gehrig's diseases is defined as a condition of neurological disorders that selectively affect the motor neurones caused by the degeneration of neurons located in the two separate anatomical structures of the spinal cord and the cerebral cortex that provide activity of carrying nerve impulses from receptors to the central nervous system.

                                         The Symptoms

1.1. Initial Symptoms
a. Muscle weakness affecting an arm or a leg
b. Slurred and nasal speech.
c. Tripping or stumbling
d. Difficulty speaking clearly or swallowing
e. Loss of tongue mobility
f. Affect intercostal muscles that support breathing
g. Uncontrollable laughter, crying or smiling
h. Etc.
1.2. Progressive symptoms
a. Unable to stand or walk
b. Unable to use their hands and arms
c. Unable to swallow and chew and eat normally
d. Mild problems with word-generation, attention, or decision-making
e. poor breathing
f. Etc.

Thursday, 10 November 2016

Regular Walking Reduced Risk of Early Onset, Progression and Symptoms of Alzheimer's disease in Older Adults

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named Health Tweets: The 50 Best Healthy Living And Fitness Tweeters In Canada - Huffington Post
TWEETER: Kyle J.Norton, health researcher and writer 
TWEETS ABOUT: Health articles, industry updates — overall, one source to get several types of health news 
FOLLOW: @kylejnorton
by Huffington Post, Canada
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of reduced risk and progression of Alzheimer's disease in the younger and older elderly patient have been lacking, probably due to in reversibility in disease controlling(1) and in most cases in older adults(2).

Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal, due to progression of formation of plaques and tangles.

Strengthening immune system fights against inflammation, reduce high blood pressure, lower cholesterol levels and healthy diet will help to prevent Alzheimer's disease(3).

New study conducted by the São Paulo State University, multimodal exercise, including walking intervention on frontal cognitive functions and kinematic gait parameters may be effective to prevent the progression in patients with Alzheimer's disease(4).

According to a study of the performance of exercise program such as walking, of 134 ambulatory patients with mild to severe AD, significantly improved ability to perform activities of daily living (ADLs), physical performance, and nutritional and decreasing behavioral disturbance and depression in patients(5).

In support of regular walking in improvement of cognitive and physical function in AD patients, Dr. Vreugdenhil A and colleagues at the University of Tasmania, said, " participation in a community-based exercise programme can improve cognitive and physical function and independence in ADL in people with Alzheimer's disease,.... under the supervision of their carer.(6),
In fact, regular walking in elderly exercise program also showed to slow the rate of functional deterioration in mild AD and reduce falls and disease progression(8) in patients suffering from advanced AD(7), a major concern of caregivers, through improvement of balance performance(8).

Dr. Ryan SM and colleagues in the study of examined exercise-mediated effects on AD pathology, cognitive function, hippocampal neurogenesis and neuroinflammation in transgenic mouse models of AD, concluded, "exercise presents a promising non-pharmacological option to potentially delay the onset of or slow down the progression of AD"(9) through " induced effects on hippocampal neurogenesis, cognitive function and neuroinflammation, and considerexercise as a potential pro-neurogenic and anti-inflammatory intervention for cognition"(10)

Some researches suggested that the effectiveness of exercise in delay the onset of or slow down the progression of AD by preventing amyloid-β (Aβ) load, probably is the results of exercise induced protection against AD-related mitochondrial dysfunction and phenotypic deterioration(11).

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References
(1) iPSCs: On the Road to Reprogramming Aging by Soria-Valles C1, López-Otín C2.(PubMed)
i(2) Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study BY Burnham SC1, Bourgeat P2, Doré V3, Savage G4, Brown B5, Laws S6, Maruff P7, Salvado O2, Ames D8, Martins RN9, Masters CL10,Rowe CC11, Villemagne VL12; AIBL Research Group.(PubMed)
(3) Regular Walking of 50+ to the World of Diseases Free and Longevity(Research and Studies) by Kyle J. Norton
(4) Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: a controlled trial by Coelho FG1, Andrade LP, Pedroso RV, Santos-Galduroz RF, Gobbi S, Costa JL, Gobbi LT.(PubMed)
(5) Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial BY Rolland Y1, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, Rivière D, Vellas B.(PubMed)
(6) A community-based exercise programme to improve functional ability in people withAlzheimer's disease: a randomized controlled trial by Vreugdenhil A1, Cannell J, Davies A, Razay G.(PubMed)
(7) Effects of Exercise on Functional Performance and Fall Rate in Subjects with Mild or Advanced Alzheimer's Disease: Secondary Analyses of a Randomized Controlled Study by Öhman H1, Savikko N, Strandberg T, Kautiainen H, Raivio M, Laakkonen ML, Tilvis R, Pitkälä KH.(PubMed)
(8) Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer's disease: protocol for a randomised trial by Hill KD1, LoGiudice D, Lautenschlager NT, Said CM, Dodd KJ, Suttanon P.(PubMed)
(9) Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease by Ryan SM1, Kelly ÁM2.(PubMed)
(10) Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: canexercise compensate? Ryan SM1, Nolan YM2.(PubMed)
(11) Exercise-induced neuroprotection of hippocampus in APP/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase by Bo H1, Kang W2, Jiang N3, Wang X3, Zhang Y3, Ji LL4.(PubMed)

Regular Walking Reduces Early Onset and Complications of Atherosclerosis in 50+ Adults

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named Health Tweets: The 50 Best Healthy Living And Fitness Tweeters In Canada - Huffington Post
TWEETER: Kyle J.Norton, health researcher and writer 
TWEETS ABOUT: Health articles, industry updates — overall, one source to get several types of health news 
FOLLOW: @kylejnorton
by Huffington Post, Canada
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, the joint study led by Universidade Federal de Minas Gerais, showed that regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases(1). But regular walking contribution of reduced risk of atherosclerosis in the younger and older elderly have been lacking, probably due to the effectiveness of medication in reduced cholesterol build up on the inner wall of arteries.

Atherosclerosis is a condition of hardening and narrowing of the arteries as a result of plaques of fatty cholesterol on inner wall, leading to reduce oxygen-rich blood flow to the organs and other parts of the body.

According to the joint study led by the University of Shizuoka, off-site walking program of a prospective, 12-week, randomized and controlled study of Fifty-two women aged 32 to 57 years suggested, the program may decrease fibrinogen levels which was found to be a trigger cardiac events in patients with atherosclerosis(3).

In fact, regular leg exercise not only reduced the complications of patients with atherosclerosis(3) but also induced expansive arterial remodelling in corresponding improvements in risk factors for atherosclerosis in healthy men of of different ages(4). Dr. Rauramaa R and colleagues in a randomized clinical trial in overweight men, insisted that regular exercise (walking to slow jogging) significantly inhibited secondary platelet aggregation from 27% to 36% of that induced protective effects in the initiation of atherosclerosis(5).

Dr. Kovacić L said, "The criteria for physical active person were walking three times a week for 30 minutes at least .... in prevention of many health problems, like obesity, arterial hypertension, diabetes, hearth diseases, atherosclerosis, osteoporosis and others"(2).


In support of regular exercise in lowering the risk of Atherosclerosis, Dr. Ali Al-Mamari said, "physical activity has been recognized as a preventive measure for atherosclerosis" and " moderately vigorous exercise resulted in a substantial reduction in mortality from all causes by 23% and from CHD by 41% compared with sedentary classmates.59 Maintaining or increasing physical activity level in late middle age was associated with a reduction in mortality rates, and light activities appeared to be sufficient to produce this benefit in older men"(6), probably due to its contribution in the reduced abnormalities in lipid and lipoprotein metabolism(7) and serum TG concentration(8).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesityand restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer


References(1) Physical Activity and Lipid Profile in the ELSA- Brasil Study.[Article in English, Portuguese] by Silva RC1, Diniz MF1, Alvim S2, Vidigal PG1, Fedeli LM3, Barreto SM1.(PubMed)

(2) [Physical inactivity as public health problem].[Article in Croatian] by Kovacić L1(PubMed)
(3) Effects of an off-site walking program on fibrinogen and exercise energy expenditure in women by Furukawa F1, Kazuma K2, Kojima M3, Kusukawa R4.(PubMed)
(4) Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men by Dinenno FA1, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR.(PubMed)
(5) Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men by Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V.(PubMed)
(6) Atherosclerosis and Physical Activity by Ali Al-Mamari(Oman Med J.)
(7) Regular Walking Reduces Risk and Complications of hyperlipidemia in Older Adults
by Kyle J. Norton
(8) Regular Walking Reduces Risk of high triglyceride level Significantly in 50 plus Adults by Kyle J. Norton

Wednesday, 9 November 2016

Regular Walking Reduces Early Onset and Complications of Atherosclerosis in 50+ Adults

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named Health Tweets: The 50 Best Healthy Living And Fitness Tweeters In Canada - Huffington Post
TWEETER: Kyle J.Norton, health researcher and writer 
TWEETS ABOUT: Health articles, industry updates — overall, one source to get several types of health news 
FOLLOW: @kylejnorton
by Huffington Post, Canada
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.



Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, the joint study led by Universidade Federal de Minas Gerais, showed that regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases(1). But regular walking contribution of reduced risk of atherosclerosis in the younger and older elderly have been lacking, probably due to the effectiveness of medication in reduced cholesterol build up on the inner wall of arteries.

Atherosclerosis is a condition of hardening and narrowing of the arteries as a result of plaques of fatty cholesterol on inner wall, leading to reduce oxygen-rich blood flow to the organs and other parts of the body.

According to the joint study led by the University of Shizuoka, off-site walking program of a prospective, 12-week, randomized and controlled study of Fifty-two women aged 32 to 57 years suggested, the program may decrease fibrinogen levels which was found to be a trigger cardiac events in patients with atherosclerosis(3).

In fact, regular leg exercise not only reduced the complications of patients with atherosclerosis(3) but also induced expansive arterial remodelling in corresponding improvements in risk factors for atherosclerosis in healthy men of of different ages(4). Dr. Rauramaa R and colleagues in a randomized clinical trial in overweight men, insisted that regular exercise (walking to slow jogging) significantly inhibited secondary platelet aggregation from 27% to 36% of that induced protective effects in the initiation of atherosclerosis(5).


Dr. Kovacić L said, "The criteria for physical active person were walking three times a week for 30 minutes at least .... in prevention of many health problems, like obesity, arterial hypertension, diabetes, hearth diseases, atherosclerosis, osteoporosis and others"(2).


In support of regular exercise in lowering the risk of Atherosclerosis, Dr. Ali Al-Mamari said, "physical activity has been recognized as a preventive measure for atherosclerosis" and " moderately vigorous exercise resulted in a substantial reduction in mortality from all causes by 23% and from CHD by 41% compared with sedentary classmates.59 Maintaining or increasing physical activity level in late middle age was associated with a reduction in mortality rates, and light activities appeared to be sufficient to produce this benefit in older men"(6), probably due to its contribution in the reduced abnormalities in lipid and lipoprotein metabolism(7) and serum TG concentration(8).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesityand restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer


References(1) Physical Activity and Lipid Profile in the ELSA- Brasil Study.[Article in English, Portuguese] by Silva RC1, Diniz MF1, Alvim S2, Vidigal PG1, Fedeli LM3, Barreto SM1.(PubMed)

(2) [Physical inactivity as public health problem].[Article in Croatian] by Kovacić L1(PubMed)
(3) Effects of an off-site walking program on fibrinogen and exercise energy expenditure in women by Furukawa F1, Kazuma K2, Kojima M3, Kusukawa R4.(PubMed)
(4) Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men by Dinenno FA1, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR.(PubMed)
(5) Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men by Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V.(PubMed)
(6) Atherosclerosis and Physical Activity by Ali Al-Mamari(Oman Med J.)
(7) Regular Walking Reduces Risk and Complications of hyperlipidemia in Older Adults
by Kyle J. Norton
(8) Regular Walking Reduces Risk of high triglyceride level Significantly in 50 plus Adults by Kyle J. Norton