The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Metals binding proteins

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.


Prevention and Management
B. Antioxidants and Dementia
B.2. Metals binding proteins
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood, plays a role iniron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).

2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload(233)(234). In a soluble and non-toxic form, the protein is transported to the body needs, including organs(236) for enhancement of the immune system in the presence of an infection(237), against proliferation of lymphoid and myeloid cells(235), cancer(238) and prevention of the infectious agent in attempt of binding iron to form free radicals(239) in most cellular oxidation reactions(239).

3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system(240) of the body used for fighting against foreign invasion of bacteria and virus(241)(242) and lipid oxidation(243) by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity(244).

4. Metallothionein
Metallothionein, a family of cysteine-rich(24), low molecular weight proteins binds both physiological heavy metals(245) through detoxified fraction of accumulation(245) by capturing harmful superoxide and hydroxyl radicals(246) through binding the metal ions(247)(248) bounded to cysteine(249).

5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) impeded to cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).

6. Hemoglobin
Hemoglobin, the protein molecule in red blood cells enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs(255)(256). During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radicals(259), probably through regulating NO(258) and auxin homeostasis(257).

7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin(260) through interaction with pathogens establishment of successful infection and survival is probably through peroxidase activity(261) in reducing the free radicals damage caused by oxidate stress(261)(262).

8. Etc.

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References
(233) Sulforaphane reduces the alterations induced by quinolinic acid: modulation of glutathione levels. by Santana-Martínez RA1, Galván-Arzáte S2, Hernández-Pando R3, Chánez-Cárdenas ME1, Avila-Chávez E4, López-Acosta G1, Pedraza-Chaverrí J5,Santamaría A6, Maldonado PD7.(PubMed)
(234) Ferritin in the red cells of normal subjects and patients with iron deficiency and iron overload. by Cazzola M, Arosio P, Barosi G, Bergamaschi G, Dezza L, Ascari E.(PubMed)
(235) New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. by Recalcati S1, Invernizzi P, Arosio P, Cairo G.(PubMed)
(236) CoCl2-induced biochemical hypoxia down regulates activities and expression of super oxide dismutase and catalase in cerebral cortex of mice. by Rani A1, Prasad S.(PubMed)
(237) Transferrin and ferritin response to bacterial infection: the role of the liver and brain in fish. by Neves JV1, Wilson JM, Rodrigues PN.(PubMed)
(238) The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis. by Alkhateeb AA1, Connor JR.(PubMed)
(239) The iron-binding protein Dps2 confers peroxide stress resistance on Bacillus anthracis. by Tu WY1, Pohl S, Gizynski K, Harwood CR.(PubMed)
(240) Antiviral properties of lactoferrin--a natural immunity molecule. by Berlutti F1, Pantanella F, Natalizi T, Frioni A, Paesano R, Polimeni A, Valenti P.(PubMed)
(241) Potential lactoferrin activity against pathogenic viruses. by Redwan EM1, Uversky VN2, El-Fakharany EM3, Al-Mehdar H4.(PubMed)
(242) The antimicrobial activity of lactoferrin: current status and perspectives. by Orsi N1.(PubMed)
(243) Role of lipid oxidation, chelating agents, and antioxidants in metallic flavor development in the oral cavity by Omür-Özbek P1, Dietrich AM, Duncan SE, Lee Y.(PubMed)
(244)Lactoferrin in infant formulas: effect on oxidation by Satué-Gracia MT1, Frankel EN, Rangavajhyala N, German JB.(PubMed)
(245) Contrasting metal detoxification in polychaetes, bivalves and fish from a contaminated bay.by Fan W1, Xu Z2, Wang WX3.(PubMed)
(246) Channa punctata brain metallothionein is a potent scavenger of superoxide radicals and prevents hydroxyl radical-induced in vitro DNA damage by Atif F1, Kaur M, Ansari RA, Raisuddin S.(PubMed)
(247) In vitro free radical scavenging activity of hepatic metallothionein induced in an Indian freshwater fish, Channa punctata Bloch by Atif F1, Kaur M, Yousuf S, Raisuddin S.(PubMed)
(248) Possible role of cutaneous metallothionein in protection against photo-oxidative stress--epidermal localization and scavenging activity for superoxide and hydroxyl radicals by Hanada K1, Baba T, Hashimoto I, Fukui R, Watanabe S.(PubMed)
(249) Quantitation of human metallothionein isoforms: a family of small, highly conserved, cysteine-rich proteins by Mehus AA1, Muhonen WW, Garrett SH, Somji S, Sens DA, Shabb JB.(PubMed)
(250) Nutritional immunity. Escape from bacterial iron piracy through rapid evolution of transferrin by Barber MF1, Elde NC2.(PubMed)
(251) Total iron binding capacity and transferrin concentration in the assessment of iron status by Kasvosve I1, Delanghe J.(PubMed)
(252) Fibrillation of transferrin by Booyjzsen C1, Scarff CA, Moreton B, Portman I, Scrivens JH, Costantini G, Sadler PJ.(PubMed)
(253) The formation of Fe3+-transferrin-CO3(2-) via the binding and oxidation of Fe2+ by Kojima N, Bates GW.(PubMed)
(254) Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein. by Lamb DJ1, Leake DS.(PubMed)
(255) Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids by Cabrales P1, Intaglietta M.(PubMed)
(256) Hemoglobin solutions and tissue oxygenation by Muir WW1, Wellman ML.(PubMed)
(257) Plant hemoglobin participation in cell fate determination by Huang S1, Hill RD1, Stasolla C1.(PubMed)
(258) The dual effects of nitrite on hemoglobin-dependent redox reactions. by Lu N1, Chen C2, He Y3, Tian R4, Xiao Q5, Peng YY6.(PubMed)
(259) Redox reactivity in propolis: direct detection of free radicals in basic medium and interaction with hemoglobin by Mot AC1, Damian G, Sarbu C, Silaghi-Dumitrescu R.(PubMed)
(260) Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets by Heemskerk JW1, Hoyland J, Mason WT, Sage SO.(PubMed)
(261) Molecular characterization of Clonorchis sinensis secretory myoglobin: delineating its role in anti-oxidative survival. by Ren M, He L, Huang Y, Mao Q, Li S, Qu H, Bian M, Liang P, Chen X, Ling J, Chen T, Liang C, Wang X, Li X1, Yu X.(PubMed)
(262) Molecular characterization of Clonorchis sinensis secretory myoglobin: delineating its role in anti-oxidative survival by Ren M, He L, Huang Y, Mao Q, Li S, Qu H, Bian M, Liang P, Chen X, Ling J, Chen T, Liang C, Wang X, Li X1, Yu X.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Antioxidant enzymes

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Prevention and Management

B. The Antioxidants
B.1. Antioxidant enzymes
Antioxidant enzymes, chemical substances found in plants, protect the body from damage of free radicals by terminating the chain reactions through removing free radical intermediates and inhibiting oxidation reactions.
1. Catalase
Catalase is an enzyme, found in most living organisms exposed to oxygen for action of converse hydrogen peroxide (free radicals)(226) to water and oxygen. The antioxidants showed to protect cells against the toxic effects of hydrogen peroxide in pathogenesis of oxidative stress-related diseases(222) inducted early stages of aggregation of the amyloid peptides(225), including neurodegeneration(224) such as Alzheimer's diseas(223).

2. Glutathione peroxidase
The function of glutathione peroxidase is to protect the organism from oxidative damage and induced neurodegenerative diseases, such as Alzheimer's disease(228) by removing lipid hydroperoxides(227), causes of oxidation of lipid cell membranes. probably through its major cellular peroxide scavenging enzyme(228) and maintaining the oxidative phosphorylation system and protecting mitochondria(229) and oxidative injury and amyloid toxicity of cortical neurons(230).

3. Glutathione reductase
Glutathione reductase, an antioxidant enzyme capable to regenerate Gglutathione (GSH) levels at 24h(233), and reduced pair of sulfur atoms glutathione to a organosulfur compound form of antioxidant (consisting of three amino acids joined by peptide bonds) may play an important role in prevention of damage of important cellular components induced neurodegenerative diseases such as PD(231)(232), caused by free radicalsand peroxides. probably through its antioxidant and anti-inflammatory properties(231)

4. Super oxide dismutase (both Cu-Zn and Mn)
Super oxide dismutase is an important antioxidant and immune defence(224) in nearly all cells exposed to oxygen by converting superoxide into oxygen and hydrogen peroxide, depending on the metal cofactor such as both Cu-Zn and Mn(225), probably through the attenuation of superoxide dismutases (SODs) and catalases (CATs)(225) in enhanced protection of biochemical/molecular/neurobiological function(226).

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References

(222) Human catalase, its polymorphisms, regulation and changes of its activity in different diseases. by Kodydková J1, Vávrová L1, Kocík M1, Žák A1.(PubMed)

(223) Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. by Cervellati C1, Romani A1, Seripa D2, Cremonini E1, Bosi C3, Magon S3, Bergamini CM1, Valacchi G4, Pilotto A5, Zuliani G3.(PubMed)

(224) Neurodegeneration through oxidative stress: monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors. by Koppenhöfer D1, Kettenbaum F1, Susloparova A1, Law JK1, Vu XT1, Schwab T1, Schäfer KH1, Ingebrandt S2.(PubMed)

(225) Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia. byTabner BJ1, El-Agnaf OM, Turnbull S, German MJ, Paleologou KE, Hayashi Y, Cooper LJ, Fullwood NJ, Allsop D.(PubMed)

(226) Development of a new catalase activity assay for biological samples using optical CUPRAC sensor. by Bekdeşer B1, Özyürek M1, Güçlü K2, Alkan FÜ3, Apak R1.(PubMed)

(227) Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. by Ariza J1, Steward C2, Rueckert F2, Widdison M2, Coffman R2, Afjei A2, Noctor SC3, Hagerman R4, Hagerman P5, Martínez-Cerdeño V6.(PubMed)

(228) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease byYoo MH1, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL.(PubMed)
(229) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. by Kono S1, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.(PubMed)
(230) Ceruloplasmin-ferroportin system of iron traffic in vertebrates. by Musci G1, Polticelli F1, Bonaccorsi di Patti MC1.(PubMed)
(231) Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. by Goldstein IM, Kaplan HB, Edelson HS, Weissmann G.(PubMed)
(232) Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice by Antunes MS1, Goes AT1, Boeira SP1, Prigol M1, Jesse CR2.(PubMed)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Do's and Do Not's list

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

Prevention and Management


A. The Do's and Do Not's list
1. Mediterranean diet
If you are typical American dieter, you are at increased risk for the development of dementia, in advanced age, as the diet is classified as one of the most unhealthy diet in the existence, according to studies. Mediterraneandiet, high monounsaturated fatty acids energy intake appeared to be associated with a high protection against cognitive decline and reduced the prevalence of AD in older people(208). Also recent research supports the hypothesis of calorie intake, among other non-genetic factors, in influence of the risk of clinical dementia.(209).

2. Yoga
Senile dementia is the mental deterioration, such as loss of intellectual ability associated with old age. Yoga is believed to have beneficial effects on cognition, probably through attenuation of emotional intensity and stress reduction. Yoga participation showed to improve the memory performance, and all other psychophysiological parameters, in patient with dementia, including intellect, attention, thinking, comprehension and personality, with preservation of normal level of consciousness(210), according to G.J. PatelAyurved College.

3. Aging of theory of mind
According to Aging of theory of mind, educational level and cognitiveprocessing are two factors, influencing the pattern of the aging. Younger and older group with equally high education showed to outperform the older group with less education in false-belief and faux-pas tasks, with younger group outperformed the other two groups in the cognitive processing tasks(211).

3. Moderate alcohol drinking
Moderate alcohol drinking of less than 2 cups for men and 1 cups of red wine for women are said to offers possible health benefits, but Binge drinking (ie,alcohol exceeding the amount of 5 bottles of beer or a bottle of wine on 1 occasion at least monthly) in midlife is associated with an increased risk ofdementia, according to the follow-up, 103 participants had developeddementia(212).

4. Stop Smoking or never smoke before
Smoking is a risk factor for several life-threatening diseases, but its long-term association with dementia is controversial and somewhat understudied. According to a total of 5367 people (25.4%), heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later(213).

5. Drink your tea and coffee
Caffeine in tea and coffee may enhance cognitive function acutely, but its link to dementia is somewhat inconsistent, but most studies support coffee's favourable and protective effects against cognitive decline, dementia or AD. Coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life(214).


6. Eat your fruits and veggies
Fruits and veggies containing high amounts of antioxidant enhance the immune system in fighting against forming of free radicals cause to damage to the brain cells in induced early onset of dementia. Vitamin E and vitamin C supplements in combination were associated with reduced prevalence and incidence of AD, according to The Johns Hopkins University(215).

7. Regular and moderate exercise for elder
Regular and moderate exercise may attenuate the cognitive dysfunction, but theirs' induced changes in cognition were not correlated with changes in mood/anxiety, probably through some separate neural systems mediation(216).

8. Avoid nutritional deficiency with balance diet
a. Beyond our believe, an excess of dietary carbohydrates, particularly fructose, alongside a relative deficiency in dietary fats and cholesterol,may lead to the development of Alzheimer's disease(217).
b. For more of Avoid nutritional deficiency with balance diet, please visit(218)

9. Avoid environment risk of dementia
Certain environment toxins produced as a result of industrialization or naturally have been linked to cognitive degenerative diseases. According to University of British Columbia, novel environmental toxins: steryl glycosides, a potential etiological factor for age-related neurodegenerative diseases, showed signs of mimicked ALS-PDC, including progressive deficits in motor, cognitive, and olfactory functions associated with neuron loss in the spinal cord, nigrostriatal system, cortex, hippocampus, and olfactory bulb in fed mice(219).

10. No illicit drug, please(220)
Illicit drug used may cause nervous system impairment as a result of direct and indirect effects on the integrity and function of nervous system tissue and, potentially, through immune effects, especially, up to 40% risk of nervous system impairment for patients with HIV-1 infection.

11. Prevent prolonged period of using certain drugs
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may cause increased risk of cognitive dysfunction causes of dementia-like symptoms(221).

12. Etc.

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Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References

(208) METABOLIC SYNDROME AND THE ROLE OF DIETARY LIFESTYLES IN ALZHEIMER’S DISEASE by Giulio Maria Pasinetti1 and Jacqueline A. Eberstein2(PubMed)
(209) Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.by Pasinetti GM1, Eberstein JA.(PubMed)
(210) Improvement in physiological and psychological parameters after 6 months of yoga practice. by Rocha KK1, Ribeiro AM, Rocha KC, Sousa MB, Albuquerque FS, Ribeiro S, Silva RH.(PubMed)
(211) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study. by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PubMed)
(212)  Aging of theory of mind: the influence of educational level and cognitive processing. by Li X1, Wang K, Wang F, Tao Q, Xie Y, Cheng Q.(PubMed)
(213)  Binge drinking in midlife and dementia risk. by Järvenpää T1, Rinne JO, Koskenvuo M, Räihä I, Kaprio J.(PubMed)

(214) Caffeine as a protective factor in dementia and Alzheimer's disease. by Eskelinen MH1, Kivipelto M.(PubMed)

(215) Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. by Zandi PP1, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT, Norton MC, Welsh-Bohmer KA, Breitner JC; Cache County Study Group.(PubMed)

(216) Differential effects of acute and regular physical exercise on cognition and affect. by Hopkins ME1, Davis FC, Vantieghem MR, Whalen PJ, Bucci DJ.(PubMed)

(217) Nutrition and Alzheimer's disease: the detrimental role of a high carbohydrate diet. by Seneff S1, Wainwright G, Mascitelli L.(PubMed)

(218) Delay Dementia - Deficiency Causes of Dementia by Kyle J. Norton

(219) Delay Dementia - Environment toxin causes of Dementia by Kyle J. Norton

(220) Substance Abuse Causes of Cognitive Impairment induced Dementia? by Kyle J. Norton

(221) Medication Causes of Dementia by Kyle J. Norton

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Complications

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.

B. The Complications
According to physical complications of patients with dementia occurred in the 12 months from April 2007 to March 2008 recorded in Ichinomiya CityHospital, Ichinomiya, the physical complications can be divided into two categories:
** Serious emergencies occurred with a possible high risk of mortality within a few days (e.g. pneumonia and upper airway obstruction); and
**Life-threatening complications arising required diagnosis and treatment by specialists from other medical departments (e.g. bone fracture andcancer)(202).

1. Pneumonia
Pneumonia is common among patients with advanced dementia, especially toward the end of life, due to microbial infection, according to Beth IsraelDeaconess Medical Center(203).

2. Obstructive Sleep Apnea Syndrome (OSAS)
The prevalence of OSAS increased with aging, occurring in up to 25% of older adults and up to 48% in patients with Alzheimer's disease, showed to induce symptoms of hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage, due to reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss(204)

3. Bone fracture
Bone mass and dementia in elderly hip fracture patients may be associated to levels of different aluminium concentrations in water supplies in the areas affecting the negative calcium balance of age-related osteoporosis together predispose to senile dementia.(205)

4. Urinary incontinence
Urinary incontinence is a common problem in dementia. Almost invariably, the person with dementia will develop incontinence as the diseaseprogresses. However, the primary reasons for incontinence are often not because of any significant pathology in the urinary system. Rather, it is due to factors outside the urinary system, including insertion of tube in assisting urinary flow(206)

5. Venous thromboembolism
Venous thromboembolism (VTE), caused by a blood clot breaking loose and traveling in the blood, in patients with dementia had a high incidence of fatal pulmonary embolism (PE) and fatal bleeding, according to the study of 37988 patients with 1316 (3.5%) having dementia(207).

6. Etc.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

References
(202) Physical complications for elderly inpatients with senile dementia in the Imaise Branch of Ichinomiya City Hospital by Ukai K1, Mizuno Y.(PubMed)
(203) Survival and comfort after treatment of pneumonia in advanced dementia. b Givens JL1, Jones RN, Shaffer ML, Kiely DK, Mitchell SL.(PubMed)
(204) [Obstructive sleep apnea and cognitive impairment in the elderly].[Article in French]by Onen F1, Onen H.(PubMed)
(205) Bone mass and dementia in hip fracture patients from areas with different aluminium concentrations in water supplies.by Wood DJ1, Cooper C, Stevens J, Edwardson J.(PubMed)
(206) Urinary incontinence in dementia - a practical approach. by Yap P1, Tan D.(PubMed)
(207) Venous thromboembolism in immobilized patients with dementia. Findings from the RIETE registry. by Nuñez MJ, Villalba JC, Cebrián E, Visoná A, Lopez-Jimenez L, Núñez M, Szwebel TA, Luque JM, Jaras MJ, Monreal M; RIETE Investigators.(PubMed)

http://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/suicide.pdf
http://www.sprc.org/basics

http://www.apa.org/education/ce/suicide.pdf

https://www.afsp.org/preventing-suicide/treatment

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - The Symptoms

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Dementia is a neuropsychiatric disorder induced of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, with a progressive loss of memory and other mental abilities, affecting a person's ability to perform usual tasks in everyday life.
A. Symptoms
A.1. Symptoms of Alzheimer's disease
Alzheimer's disease is a brain disorder, affecting over 1 million people in US alone with well known symptoms of lack of concentration (56%), tremors (56%), depression (44%), lack of cooperation (36%), and delusions (32%), psychotic symptoms (delusions, hallucinations, and delirium) and tremors, and emotional symptoms (tearfulness and apathy, lack of concentration and appetite change), according to Hospital de Cruces, Plaza de Cruces s/n, Barakaldo in a study of total of 1014 patients(177). Other symptoms include

1. Increasing forgetfulness(178)
2. Communication difficulty(179)
3. Anxiety(180)
4. Mood and personal change(181)
5. Delay recall(183)
6. Repeat question(183)
7. Memory loss(182)
8 Aberrant motor behavior (184)
9. Sleep problems (184)
10. Eating problems (184) and
11. Agitation/aggression (184)
10. Etc.

A.2. Symptoms of Diminished quality of acetylcholine
If the nerves located in front of the brain perish, diminished quality of acetylcholine, it can cause language difficulty, memory loss, concentration problem and reduce mobile skills because of lacking reaction in muscular activity and refection.
Symptoms of deficiency of acetylcholine include(185)
1. Difficulty remembering names and faces after meeting people
2. Difficulty remembering peoples birthdays and numbers
3. Difficulty remembering lists, directions or instructions
4. Forgetting common facts
5. Trouble understanding spoken or written language
6. Forget where I put things
7. Slowed and/or confused thinking
8. Difficulty finding the right words before speaking
9. Disorientation
10. Prefer to do things alone than in groups / social withdrawal
11. Rarely feel passionate
12. Feel despair and lack joy
13. Lost some of my creativity / lack imagination
14 Dry mouth
15. Etc.

A.3. Dementia due to long-term alcohol abuse
Dementia is common in patients with alcoholism. Most symptoms of alcohol dementia are also presented in other types of dementia, with a few qualitative differences(186) involved both cortical and subcortical pathology. According to the article, "What's alcohol-related dementia?" Alcohol dementia induced deterioration in intellectual function with memory not being specifically affected, such as disinhibition, loss of planning, and executive functionsand a blithe disregard for the consequences of their behaviour, affecting mostly of women in the ages between 30 - 70 with the better rates better than for Korsakoff's Psychosis(187).
Other symptoms in deficits are most frequently observed on tasks of visuospatial function, memory(188) and higher-order (executive) tasks(189)

A.4. Multi-infarct dementia
Also known as vascular dementia, is the second most common form of dementia after Alzheimer's disease in older adults, caused by different mechanisms, affecting the vascular lesions in the brain.with major neurovegetative symptoms of depression accompanied by depressed mood/anhedonia in patients with clinically-diagnosed Alzheimer's disease (AD) and multi-infarct dementia (MID)(190).
Symptoms include memory deficits(192) such as
1. Confusion
2. Memory problems
3. Wandering Getting lost
and
4. At least one of behavioural or psychological symptom, such as appetite disturbances irritability and anxiety and emotional suppresion(such as laughing inappropriately, crying inappropriately)
(193), and
5. Difficulty following instructions, and
6. Bladder incontinence
7. Bowel incontinence(191)

A.5. Dementia associated with Parkinson's disease
Parkinson disease (PD) is a disabling, progressive condition cause of cognitive deficits due to the interruption of frontal-subcortical loops that facilitate cognition and that parallel the motor loop, affecting motor function.These include olfactory deficit, sleep problems such as rapid eye movement behaviour disorder, constipation and male erectile dysfunction.(194).
Other symptoms due to dopamine (DA) deficiency, include, dysexecutive behaviors(196), such as planning, abstract thinking, flexibility and behavioural control and postural disabilities(197) and
1. Constipation
2. Difficulty swallowing
3. Choking, coughing, or drooling
4. Excessive salivation
5. Excessive sweating
6. Loss of bowel and/or bladder control(195)

A.6. Creutzfeldt-Jakob disease (CJD)
People who have eaten contaminated beef in many years, may be infected with Creutzfeldt-Jakob disease (CJD) without even knowing it. Creutzfeldt-Jakob disease is a quickly progressing and fatal disease, characterized by rapidly progressive dementia. Initially, individuals experience problems withmuscular coordination, personality changes, including impaired memory, judgment, and thinking and impaired vision. People with the disease also may experience insomnia, depression, or unusual sensations.(198).

A.7. Subdural hematoma
Subdural hemorrhages, the accumulation of blood beneath the outer cover of the brain resulted from the rupture of blood vessel may cause an increase in tracranial pressure, leading compression and damage to delicate brain tissue. Acute subdural hematoma has a high mortality rate.

A.8. Other symptoms include
1. Intermittent numbness and weakness of extremity(199) and
2. Loss of consciousness(201)
3. Irritability
4. Seizures
5. Pain
6. Headache
7. Dizziness
8. Disorientation
9. Weakness
10. Weakness or lethargy
11. Nausea or vomiting
12. Loss of appetite
13. Personality changes
14. Confused speech
15. Difficulty with balance or walking
16. Altered breathing patterns
17. Hearing loss or hearing ringing (tinnitus)
18. Blurred Vision
19. Deviated gaze, or abnormal movement of the eyes(200)

References

(177) Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment by Fernández M, Gobartt AL, Balañá M; COOPERA Study Group.(PubMed)
(178) Alzheimer's disease and age-related memory decline (preclinical).by Terry AV Jr1, Callahan PM, Hall B, Webster SJ.(PubMed)
(179) Communication Difficulty and Relevant Interventions in Mild Cognitive Impairment: Implications for Neuroplasticity by Johnson M1, Lin F2.(PubMed)
(180) Anxiety and depression in family caregivers of people with Alzheimer disease: the LASER-AD study. by Mahoney R1, Regan C, Katona C, Livingston G.(PubMed)
(181)  Dehydroepiandrosterone (DHEA) supplementation for cognition and well-being. by Huppert FA1, Van Niekerk JK, Herbert J.(PubMed)

(182) How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. by Richardson A1, Galvan V2, Lin AL3, Oddo S4(PubMed)

(183) Evaluation of a Japanese version of the Mini-Mental State Examination in elderly persons. by Ideno Y1, Takayama M, Hayashi K, Takagi H, Sugai Y.(PubMed)

(184) Prevalence of neuropsychiatric symptoms in Alzheimer's disease: a cross-sectional descriptive study in Thailand. by Charernboon T, Phanasathit M.(PubMed)

(185) Behavioral and psychological symptoms of dementia and bipolar spectrum disorders: review of the evidence of a relationship and treatment implications by Dorey JM1, Beauchet O, Thomas Antérion C, Rouch I, Krolak-Salmon P, Gaucher J, Gonthier R, Akiskal HS.(PubMed)

(186) Acetylcholine deficiency(Nutrition healing)

(187) All about dementia(healthcare net)

(188) Association of alcohol drinking with verbal and visuospatial memory impairment in older adults: Clinical Research Center for Dementia of South Korea (CREDOS) study.by Byeon H1, Lee Y2, Lee SY2, Lee KS3, Moon SY4, Kim H5, Hong CH4, Son SJ6, Choi SH7.(PubMed)

(189) Alcohol-related dementia: an update of the evidence. by Ridley NJ1, Draper B2, Withall A3.(PubMed)

(190) [Vascular dementia: big effects of small lesions].[Article in French] by Gold G1, Kövari E.(PubMed)
(191) Symptoms of Multi-Infarct Dementia(Right diagnosis)
(192) The role of neurosonology in the diagnosis of vascular dementia.by Tsivgoulis G1, Katsanos AH2, Papageorgiou SG3, Dardiotis E4, Voumvourakis K3, Giannopoulos S2.(PubMed)
(193) Behavioural and Psychological Symptoms in Poststroke Vascular Cognitive Impairmentby Meena Gupta,* Abhijit Dasgupta, Geeta Anjum Khwaja, Debashish Chowdhury, Yogesh Patidar, and Amit Batra(PubMed)
(194) Non-motor symptoms of Parkinson's disease: diagnosis and management by Salawu FK1, Danburam A, Olokoba AB.(PubMed)
(195) Parkinson’s Disease and Parkinson’s Dementia(Helpguide.org)
(196) Anterior cingulate dopamine turnover and behavior change in Parkinson's disease.by Gallagher CL1, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE.(PubMed)
(197) Biomarkers of Parkinson's disease: present and future. by Miller DB1, O'Callaghan JP2.(PubMed)
(198) Creutzfeldt-Jakob Disease Fact Sheet(NIH)
(199) Chronic subdural hematoma presenting with symptoms of transient ischemic attack (TIA): a case report by Wilkinson CC1, Multani J, Bailes JE.(PubMed)
(200) Subdural hematoma(Medline plus)
(201) COGNITIVE LOSSES ASSOCIATED WITH ALZHEIMER’S(The brain from top to bottom)

The 2nd edition of The holistic Prevention, Management and Treatment of Dementia under The Microscope of Conventional Medicine - Genetic Mutation Causes of dementia

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Abstract
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies. The aim of this essay is to provide accurate information of how effective of holistic medicine in prevention, management and treatment of dementia through searching data base of PubMed.
This is the third time, a research paper has been written this way to general public that you will not find any where in the net.

Causes of dementia

I..Genetic Mutation causes of dementia
Genetic mutation is a condition of changes of DNA structure and alteration in the inherited nucleic acid sequence of the genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their children.


1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26
Genetic mutation of chromosome 2q35-q36 Lewy bodies (DLB) are multiplex, due to its complex mechanism than generally monogenic disorders. Identifying the first familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)

2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high risk of cognitive decline due to the recurrent R155Hmutation, according to University of Genova(171).


3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid precursor protein (APP ) gene, presenillin gene (PSEN-1), and presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).

4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation was found to associate to significantly decreased cerebral blood flow (CBF) affecting brain capillaries(173) and contributing to the early on set of dementia.

5. Mutations in the NOTCH3
Mutations in the NOTCH3 gene are responsible for hereditary stroke disorder, contributed to an adult onset of hereditary ischemic stroke, vascular dementia and psychiatric disorders(174).

6. Etc.

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References
(169) (169) Smoking: effects on multiple sclerosis susceptibility and disease progression by Dean M. Wingerchuk(PMC)
(170) Comprehensive genetic and mutation analysis of familial dementia with Lewy bodies linked to 2q35-q36 by Meeus B1, Nuytemans K, Crosiers D, Engelborghs S, Peeters K, Mattheijssens M, Elinck E, Corsmit E, De Deyn PP, Van Broeckhoven C, Theuns J.(PubMed)
(171) Inclusion body myopathy, Paget's disease of the bone and frontotemporal dementia: recurrence of the VCP R155H mutation in an Italian family and implications for genetic counselling by Viassolo V1, Previtali SC, Schiatti E, Magnani G, Minetti C, Zara F, Grasso M, Dagna-Bricarelli F, Di Maria E.(PubMed)
(172) About Dementia Types of Dementia Genetic Mutations(Dementia guide)
(173) Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI. by Lunau L1, Mouridsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P; FReJA Consortium.(PubMed)
(174) Novel mutation of the notch3 gene in arabic family with CADASIL. by Bohlega S1.(PubMed)