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Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women. Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Medicine Perspective
While conventional medicine focus of using synthetic medication to induce ovulation and assisted artificial insemination for infertility couple, if the medicine fail, traditional Chinese medicine views polycystic ovarian syndrome in different approaches. Polycystic ovary syndrome, according to traditional Chinese medicine is a medical condition characterized by accumulative of fluid over a prolonged period of time causes of dampness and phlegms(1247a)(1247b) build up on the ovaries due to the effects of vary differentiations, affecting not only the women’s menstrual cycle, but also ovulation and fertility(1247a)(1247b).
PCOs Treatment according traditional Chinese medicine
Depending to differentiation, most common diagnosis of polycystic ovary syndrome can be classified into
Spleen yang deficiency
Spleen yang deficiency is a serve form of spleen qi deficiency, characterized by a condition of inability of spleen in distribution of fluid and nutrient to the body organs, in removal and descend the turbids(2072), causing malfunctions functions of the organs and fluid retention. Prolong period of spleen yang deficiency may induce the development of phlegm, including women with PCOs.
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....
Women with PCOs diagnosed by spleen yang deficiency may also experience yang vacuity impelled cold expression of additional symptoms of abdominal pain(2074), lack of appetite(2076), fatigue(2075), lightheadedness(2075) and headache(2075), weakness of the four limbs(2077), diarrhea(2073)(2076), chilliness(2077), edema(2074), pale, swollen, wet tongue(2076) and weak, slow, deep pulse(2072),....
In the review of the Data base provided by PubMed, spleen qi deficiency may alter certain metabolic pathways, such as the energy, protein, and glycolytic metabolisms(2078), body weight and motor behavior(2079), skeletal muscle function(3080), blood glucose, lipid metabolism and fat-islet axie.(2081),.....
Foods for Spleen yang deficiency
Spleen yang deficiency can be managed and treated in part with a diet of fresh and cooked warming foods.
4. Coriander
Coriander is an annual herb, genus Coriandrum in the family Apiaceae, native to southern Europe and North Africa to Southwestern Asia. All parts of the plant are edible, but the fresh leaves and the dried seeds are the parts most commonly used in cooking. It has been found to process certain health effects on skin(2083)(2084) and menstrual disorder(2085)(2086)[due to high concentration of carotenoids], oxidative stress(2087)(2088), liver damage(2089)(2090), cognitive degeneration(2091) and degenerative symptoms(2092)(2093)[such as anxiety, depression and memory loss], impairment(2091)(2092), cholesterol(2094)(2095), gastrointestinal disorders(2096)(2097)(2098), hypertension(2096), infection(2099) and inflammation(2098)(2099), anemia(2100), immune respond(2101),...........
.
Phytochemical constituents
1. Monoterpenes
2. α-pinene,limpnene
3. γ- terpinene
4. P-cymene
5. Borneol
6. Citronellol
7. Camphor
8. Peraniol
9. Pyrazine
10. Pyridine
11. Isocoumarins
12. Coriandrin
13. Dihydrocoriandrin
14. Flavonoids,
15. Phenolic acids
16. Sterols(2082).
17. Etc.
Epidemiological studies suggested that coriander may comprise a strong evidence as the food to be used for treatment of metabolic syndrome(2102) and its complications of diabetes(2102)(2110) and cardiovascular disease(2102) due to its antioxidants(2104)(2106), anti inflammatory(2107)(2108) and immunomodulatory(2109) effects in hypoglycemia(2102)(2103)(2104) and hypolipidemia(2102)(2104)(2105), glucose level(2102), insulin resistance(2102), hypertensive(2096), obesity(2111)....
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of Jiangsu province of polycystic ovarian syndrome correlation distribution of traditional Chinese medicine syndrome type and improper diet]. [Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary study on relationship of disease-syndrome-symptom of ovulatory disorder infertility based on factor analysis]. [Article in Chinese] by Li M, Ma K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(2072) Spleen, Earth
(2073) [Research on building method of spleen kidney Yang deficiency diarrhea rats model]. [Article in Chinese] by Pan X, Hu CJ, Geng YY, Zhao L, Wu WH, Wu XQ, Zhong ZD.(PubMed)
(2074) Treatment of an elderly patient with acute abdominal pain with traditional Korean medicine by Son CG1.(PubMed)
(2075) Shenzhu Tiaopi granule combined with lifestyle intervention therapy for impaired glucose tolerance: a randomized controlled trial by Fang Z1, Zhao J2, Shi G3, Shu Y3, Ni Y3, Wang H3, Ding L3, Lu R3, Li J3, Zhu X3, Cheng S4, Zhang X3, Liu Y5, Wang J6, Luo Y3, Fan Q3, Guo C3, Jiang T3, Wu Q3, Fan L3, Ling H3, Cui L3, Luo Y3, Yang H3, Anderson RM7.(PubMed)
(2075) Direct moxibustion to treat spleen qi and yang deficiency fatigue: a pilot study by Thorne TL1, Hanes DA2, Wild H3, Colbert A4.(PubMed)
(2076) [Clinical observation on fuzhong (supporting the middle-jiao) manipulation of tuina for infantile anorexia]. [Article in Chinese] by Wang YY, Liu XY.(PubMed)
(2077) [Effect of umbilicus moxibustion therapy on physical conditions of yang-deficiency volunteers]. [Article in Chinese] by Zhang YY1.(PubMed)
(2078) Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using (1)H-NMR-based metabonomics by Zheng XF1, Tian JS2, Liu P3, Xing J1, Qin XM1.(PubMed)
(2079) [1H NMR based metabolomics study of bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model]. [Article in Chinese] by Chen L, Xiang H, Xing J, Tian JS, Qin XM, Du GH.(PubMed)
(2080) Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease by Dong Y1,2, Li Y3,4,5, Sun Y6, Mao J7, Yao F8, Tian Y9, Wang L10, Li L11, Li S12,13,14, Li J15,16,17(PubMed)
(2081) [Clinical observation on obesity and hyperlipidemia of liver qi stagnation and spleen deficiency pattern in female patients treated with combined therapy of acupuncture and tapping method]. [Article in Chinese] by Wu B, Liu ZC, Xu B.(PubMed)
(2082) Phytopharmacological Properties of Coriander Sativum as a Potential Medicinal Tree: An Overview by Pathak Nimish L, Kasture Sanjay B, Bhatt Nayna M and Rathod Jaimik D.(The Journal of Applied pharmaceutical Science)
(2083) Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression by Hwang E1, Lee DG, Park SH, Oh MS, Kim SY.(PubMed)
(2084) Coriander alleviates 2,4-dinitrochlorobenzene-induced contact dermatitis-like skin lesions in mice by Park G1, Kim HG, Lim S, Lee W, Sim Y, Oh MS.(PubMed)
(2085) [Study of an antioxidant dietary supplement "Karinat" in patients with benign breast disease]. [Article in Russian] by Bespalov VG, Barash NIu, Ivanova OA, Krzhivitskiĭ PI, Semiglazov VF, Aleksandrov VA, Sobenin NA, Orekhov AN.(PubMed)
(2086) Carrot juice junkies and big bangs by Martin-Du Pan R, Herrmann W.(PubMed)
(2087) Effects of hydroalcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazole-induced seizures in rats by Karami R1, Hosseini M2, Mohammadpour T3, Ghorbani A4, Sadeghnia HR4, Rakhshandeh H4, Vafaee F3, Esmaeilizadeh M5.(PubMed)
(2088) In vitro free radical scavenging and DNA damage protective property of Coriandrum sativum L. leaves extract by Harsha SN1, Anilakumar KR1.(PubMed)
(2089) Antioxidant and hepatoprotective potential of essential oils of coriander (Coriandrum sativum L.) and caraway (Carum carvi L.) (Apiaceae) by Samojlik I1, Lakić N, Mimica-Dukić N, Daković-Svajcer K, Bozin B.(PubMed)
(2090) Effect of coriander on thioacetamide-induced hepatotoxicity in rats by Moustafa AH1, Ali EM2, Moselhey SS1, Tousson E3, El-Said KS2.(PubMed)
(2091) Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1-42) rat model of Alzheimer's disease by Cioanca O1, Hritcu L, Mihasan M, Hancianu M.(PubMed)
(2092) Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1-42) rat model of Alzheimer's disease by Cioanca O1, Hritcu L2, Mihasan M3, Trifan A1, Hancianu M1.(PubMed)
(2093) Reversal of memory deficits by Coriandrum sativum leaves in mice. Mani V1, Parle M, Ramasamy K, Abdul Majeed AB.(PubMed)
(2094) The cholesterol lowering property of coriander seeds (Coriandrum sativum): mechanism of action by Dhanapakiam P1, Joseph JM, Ramaswamy VK, Moorthi M, Kumar AS.(PubMed)
(2095) Petroselinic acid from dietary triacylglycerols reduces the concentration of arachidonic acid in tissue lipids of rats by Weber N1, Richter KD, Schulte E, Mukherjee KD.(PubMed)
(2096) Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities by Jabeen Q1, Bashir S, Lyoussi B, Gilani AH.(PubMed)
(2097) The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study by Vejdani R1, Shalmani HR, Mir-Fattahi M, Sajed-Nia F, Abdollahi M, Zali MR, Mohammad Alizadeh AH, Bahari A, Amin G.(PubMed)
(2098) Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells by Zaidi SF1, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W, Sugiyama T.(PubMed)
(2099) Coriander (Coriandrum sativum L.) and its bioactive constituents by Laribi B1, Kouki K2, M'Hamdi M3, Bettaieb T2.(PubMed)
(2100) Enhancement of folate content and its stability using food grade elicitors in coriander (Coriandrum sativum L.) by Puthusseri B1, Divya P, Lokesh V, Neelwarne B.(PubMed)
(2101) Effects of different levels of coriander (Coriandrum sativum) seed powder and extract on serum biochemical parameters, microbiota, and immunity in broiler chicks by Hosseinzadeh H1, Alaw Qotbi AA1, Seidavi A1, Norris D2, Brown D2.(PubMed)
(2102) Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats by Aissaoui A1, Zizi S, Israili ZH, Lyoussi B.(PubMed)
(2103) Postprandial glycaemia and inhibition of α-glucosidase activity by aqueous extract from Coriandrum sativum by Brindis F1, González-Andrade M, González-Trujano ME, Estrada-Soto S, Villalobos-Molina R.(PubMed)
(2104) Antioxidant, antihyperglycemic, and antihyperlipidemic effects of Coriandrum sativum leaf and stem in alloxan-induced diabetic rats by Sreelatha S1, Inbavalli R.(PubMed)
(2105) Hypolipidemic effect of Coriandrum sativum L. in triton-induced hyperlipidemic rats by Lal AA1, Kumar T, Murthy PB, Pillai KS.(PubMed)
(2106) Green synthesis of multifunctional carbon dots from coriander leaves and their potential application as antioxidants, sensors and bioimaging agents by Sachdev A1, Gopinath P.(PubMed)
(2107) Evaluation of coriander spice as a functional food by using in vitro bioassays by Zhang CR1, Dissanayake AA1, Kevseroğlu K2, Nair MG3.(PubMed)
(2108) Anti-granuloma activity of Coriandrum sativum in experimental models by Nair V1, Singh S, Gupta YK.(PubMed)
(2109) [Contributions to the chemical study of the essential oil isolated from coriander fruits (Sandra cultivar)]. [Article in Romanian] by Trifan A1, Aprotosoaie AC, Spac A, Hăncianu M, Miron A, Stănescu U.(PubMed)
(2110) Antioxidant potential of Coriandrum sativum L. seed extract by Deepa B1, Anuradha CV.(PubMed)
(2111) Optimising aroma quality in curry sauce products using in vivo aroma release measurements by Hatakeyama J1, Davidson JM2, Kant A2, Koizumi T3, Hayakawa F4, Taylor AJ2.(PubMed)
1 Takahide Ikeda,1 Kazuo Kajita,1 Kei Fujioka,1 Ichiro Mori,1 Hideyuki Okada,1 Yoshihiro Uno,1 and Tatsuo Ishizuka.(