Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday, 25 January 2015

The best recipe for Diabetes: Courgettes with Garlic and Parsley

Saturday, 24 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Herbal Treatments: Other Potential Herbs

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
B. In herbal medicine perspective
6. Other potential herbs
Herbs used in the treatment and prevention of dementia(682)(683) in traditional medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress and neuro inflammation via neuroglial activation(683).
According to University of Wollongong, herbs and spices, containing high amount of phytochemicals in traditional history of use, with strong roles in cultural heritage, may have a distinguished effect in cognitive decline associated with ageing and the acute effects of psychological and cognitive function(684), probably through active ingredients of spices in modulation of neural response in the peripheral nervous system, via interaction with TRP channel/receptors(685).

Phytochemicals have been studied intensively including
1. Cannabinoids (e.g. cannabidiol) from Cannabis sativa, may be emerging as potential therapeutic agents for treatment of symptoms of dementia(686)(687). In Alzheimer's disease. the phytochemicals have found effectively against multifactorial illnesses as Alzheimer's disease, through inhibition of BuChE(689) and AChE(690) enzymes by a non-competitive or mixed mechanism(688).

2. Resveratrol (occurs in various plants) showed to improved cognition and reduces oxidative stress, by promoting learning and memory ability in vascular dementia(692) and decreased malonyldialdehyde levels(691). In Alzheimer's Disease, the phytochemical exerted its neuroprotective effect(694)(695), in decreased Aβ accumulation, tau protein phosphorylation, oxidative stress(693), and may be used for aging population in the prevention of various age-related neurological disorders(694).

3. Curcumin (from turmeric [Curcuma longa]), in pharmacological activities, besides promoted cognition and mood in a healthy older population(695), it also exhibited beneficial role in several neurodegenerative disorders(696) against administered streptozotocin (STZ)induced dementia model(696)(698), probably through its antioxidant effect(697). In Alzheimer's Disease, The herb also showed in reversed cognitive deficits, through its function in decreased GSK-3β levels(Glycogen synthase kinase 3, a protein) related to onset of Alzheimer's Disease(699)), and increased promoter activity of the TCF/LEF in binding DNA(600) and cyclin-D1(a protein) in regulating cell cycle progression(701).

4. Crocetin, a phytochemical found in Saffron (Crocus sativus), protected cerebrocortical and hippocampus neurons against ischemia, by improving spatial learning memory after chronic cerebral hypoperfusion in animal study(703) through its antioxidant effects(704) in decreased oxidative stress(704). According to The University of Tokyo, the effectiveness of the herbal phytochemicals crocetin and crocin, also enhanced learning behaviour and promoted memory recall(705). In severe Alzheimer's Disease and mild-to-moderate Alzheimer's disease patients, saffron extract showed to be comparable with memantine in reducing cognitive decline in 1 year(706) and reduce cognitive decline in 22 weeks administration(707), respectively.

Herbs
5. Ginseng (Panax species), showed to be beneficiary on age-related cognitive impairments
through the activities of its members of ginsenosides(708) and Non-ginsenoside nicotinic agents(709).

6. Sage (Salvia species), may also be used as a potential novel natural treatments for the relief of some diseases including dementia, according to Shahid Beheshti University of Medical Sciences(710).

But according to Jodrell Laboratory, the use of such remedies in complex mixtures of different plants in traditional folk medicine may induce complication in interpretation of pharmacological activity and challenges for quality control(702).

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Sources
(682) http://www.ncbi.nlm.nih.gov/pubmed/23055633
(683) http://www.ncbi.nlm.nih.gov/pubmed/20657497
(684) http://www.ncbi.nlm.nih.gov/pubmed/17022438
(685) http://www.ncbi.nlm.nih.gov/pubmed/25359561
(686) http://www.ncbi.nlm.nih.gov/pubmed/24828945
(687) http://www.ncbi.nlm.nih.gov/pubmed/24624670
(688) http://www.ncbi.nlm.nih.gov/pubmed/24378710
(688) http://www.medscape.com/viewarticle/424604_5
(689) http://www.ncbi.nlm.nih.gov/pubmed/24378710
(690) http://www.ncbi.nlm.nih.gov/pubmed/25206513
(691) http://www.ncbi.nlm.nih.gov/pubmed/25206513
(692) http://www.ncbi.nlm.nih.gov/pubmed/24660032
(693) http://www.ncbi.nlm.nih.gov/pubmed/25525597
(694) http://www.ncbi.nlm.nih.gov/pubmed/19090994
(695) http://www.ncbi.nlm.nih.gov/pubmed/25315300
(694) http://www.ncbi.nlm.nih.gov/pubmed/25281824
(695) http://www.ncbi.nlm.nih.gov/pubmed/25277322
(696) http://www.ncbi.nlm.nih.gov/pubmed/20026275
(697) http://www.ncbi.nlm.nih.gov/pubmed/19705549
(698) http://www.ncbi.nlm.nih.gov/pubmed/21195590
(699) http://en.wikipedia.org/wiki/GSK-3
(700) http://en.wikipedia.org/wiki/TCF/LEF_family
(701) http://en.wikipedia.org/wiki/Cyclin_D1
(702) http://www.ncbi.nlm.nih.gov/pubmed/21639405
(703) http://www.ncbi.nlm.nih.gov/pubmed/23988025
(704) http://www.ncbi.nlm.nih.gov/pubmed/21774008
(705) http://www.ncbi.nlm.nih.gov/pubmed/10815004
(706) http://www.ncbi.nlm.nih.gov/pubmed/25163440
(707) http://www.ncbi.nlm.nih.gov/pubmed/19838862
(708) http://www.ncbi.nlm.nih.gov/pubmed/10189953
(709) http://www.ncbi.nlm.nih.gov/pubmed/21639405
(710) http://www.ncbi.nlm.nih.gov/pubmed/24860730

The best recipe for Diabetes: Cabbage with capers and Balsamic Vinegar

Friday, 23 January 2015

(Preview) Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoarthritis: The Preventive Antioxidants

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By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs)

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time.
Most common Musculo-Skeletal Disorders include
1. Musculoskeletal pain .
2. A shoulder disorder
3. rheumatoid arthritis and osteoarthritis (OA) of the hand, hip, and knee.

Types of Musculo-Skeletal disorders in ages of 50 plus(2)
1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain

Osteoarthritis

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
VI. Antioxidants and Osteoporosis
Dietary and endogenous antioxidants were consistently lower in patients with osteoporosis, according to University of Perugia, leading to decrease antioxidant defenses and promoting pathogenesis of osteoporosis(32).

2. Selenium plus vitamins E and C
In rabbits study, combination of vitamins E and C given partially prevented this bone tissue destruction on the progress of osteoporosis. When combine with sodium selenite given together with vitamins E and C to the osteoporosis model rabbits, the long bone tissue of osteoporosis rabbits had almost the same structure as in normal rabbits(33).

3. Vitamin C
According to the study epidemiologic studies, correlate low vitamin C intake and genetic deletion of enzymes involved in de novo vitamin C synthesis are associated to bone loss and severe osteoporosis, respectively(34).

4. Calcium and vitamin D
Calcium supplements showed to reduce the rate of bone loss in osteoporotic patients. According to SENECA study, calcium treatment not only on bone mass but also on fracture incidence and vitamin D insufficiency is frequent in elderly populations in Europe. Supplementations with daily doses of 400-800 IU of vitamin D, given alone or in combination with calcium, are able to reverse vitamin D insufficiency, to prevent bone loss and to improve bone density in the elderly, according to University of Siena(35)
5. Etc.

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References
(32) http://www.ncbi.nlm.nih.gov/pubmed/12679433
(33) http://www.ncbi.nlm.nih.gov/pubmed/14677021
(34) http://www.ncbi.nlm.nih.gov/pubmed/23056580
(35) http://www.ncbi.nlm.nih.gov/pubmed/11683549

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Musculoskeletal disorders (MSDs) - Osteoarthritis by Kyle J. Norton

The best recipe for Diabetes: Brussels Sprouts with Shallots

Thursday, 22 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Herbal Treatments: Bacopa

By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
A. In herbal medicine perspective

5. Bacopa

Commonly known as Waterhyssop or Water Hyssop, the herb is a semi-woody plants, genus of Hyssopus, belonging to the family Lamiaceae, native to the east Mediterranean to central Asia, used in traditional medicine as an antibiotic(660)(659), carminative, antispasmodic, antifungal(661), and antiseptic(661)(662) agent and to treat bronchitis(663), asthma(664), digestive ailments(665)(668), insomnia(666), diabetes(667), edema(669)(670), etc.
a. Increases Cerebral Blood Flow
In cerebral blood flow (CBF), Bacopa monnieri's promoting blood flow through its procognitive effect in comparison via dose-dependent hypotensive actions (671), with Ginkgo biloba and donepezil(671)may be a potential attenuation of dementia, Parkinson's disease, and epilepsy(672).

b. Ethnobotanical treatment

Bacopa, ethnobotanically, may be used as brain tonification(676) and to treat various diseases(673), including Alzheimer's disease

through its phytochemicals in alleviation of AD pathology and associated symptoms(674). According to university System HSC College of Medicine, Bacopa monniera extract (BME), administered starting at 2 months of age for either 2 or 8 months on test mice, significant lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes(675). Its natural products (galantamine and rivastigmine), also has been used pharmaceutically for cognitive and behavioural and psychological symptoms of dementia (BPSD)(673).

c. Cognitive performance, anxiety, and depression

In olfactory bulbectomized mice, alcoholic extract of Bacopa monnieri (L.) showed to ameliorate memory and emotional deficits(678) and enhanced cognitive performance(679) through its protection of cholinergic systems from OBX-induced neuronal damage(677). In normal healthy participants, the herb also attenuated stress reactivity and mood, through its adaptogenic and nootropic effects, probably via reduction in cortisol levels(680). According to National College of Natural Medicine, standardized dry extract of Bacopa monnieri, promoted the improvement depression scores, combined state plus trait anxiety scores,with few adverse events, primarily stomach(681)

d. Etc.

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources

(659) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017840/

(660) http://www.ncbi.nlm.nih.gov/pubmed/22733208

(661) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa++antifungal

(662) http://www.ncbi.nlm.nih.gov/pubmed/15022161

(663) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa+asthma

(664) http://www.ncbi.nlm.nih.gov/pubmed/23195581

(665) http://www.ncbi.nlm.nih.gov/pubmed/?term=Bacopa+digestive+ailments

(666) http://www.ncbi.nlm.nih.gov/pubmed/8792640

(667) http://www.ncbi.nlm.nih.gov/pubmed/21154199

(668) http://www.ncbi.nlm.nih.gov/pubmed/15088689

(669) http://www.ncbi.nlm.nih.gov/pubmed/16343831

(670) http://www.ncbi.nlm.nih.gov/pubmed/16343831