Chamomile is also known as camomile, common name of
many species daisy-like plants in the family Asteraceae. The herb has
been used in traditional medicine as antispasmodic and anti-inflammatory
constituents and to treat menstrual cramps and sleep disorders, reduce
cramping and spastic pain in the bowels, relieve excessive gas and
bloating in the intestine, etc.
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (=
desacetoxymatricarin), corresponding C-11
stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid
(cis-GMCA), chlorogenic acid,
(E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA),
quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside,
apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin
7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene
(tonghaosu)(b).
According to the Canadian mental health association, Anxiety disordered is a result of a combination
of biological, psychological, and other individual factors(1a).
Anxiety is the most commonly reported psychiatric conditions and frequently occur as comorbid disorders.
In a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract on generalized anxiety
disorder (GAD) showed to be effective of modest anxiolytic activity with
patient mild to moderate GAD(1). The University of Ottawa study of Matricaria recutita (German chamomile)
and Humulus lupulus (hops) showed significant inhibition of GAD
activity at doses of 0.11-0.65 mg/mL(2). The study containing 57
participants in the 2009 trial, 19 had anxiety with comorbid depression; 16 had anxiety with a past history of depression; and 22 had anxiety
with no current or past depression, chamomile showed a clinically
meaningful antidepressant activity to its previously observed anxiolytic
activity(3). Apigenin, a component of Matricaria recutita flowers, in
in mice study, exerted its anxiolytic and slight sedative effects
through the central benzodiazepine receptors(4).
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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and
use of partial least-square discriminant analysis to differentiate
chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder by Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(PubMed)
(2) Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system by Awad R1, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT.(PubMed)
(3) Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study by Amsterdam JD1, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB.(PubMed)
(4) Apigenin, a component of Matricaria recutita flowers, is a central
benzodiazepine receptors-ligand with anxiolytic effects by Viola H1, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, Medina JH, Paladini AC.(PubMed)
Thursday 22 May 2014
Quick Recipe - Chestnut topping
Recipe By 4 Ingredients by Kim McCosker and Rachael Bermingham (Atria Books))
Serve 2
3 tsp. butter
1 tsp. brown sugar
4 - 5 ounces cooked peeled chestnuts, finely chopped
Melt butter in a small skillet. Add brown sugar and stir until dissolved. Add chestnuts and sauté until barely browned.
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Herbal Cayenne and Non Allergic Rhinitis
Cayenne is also known as Cayenne Pepper, a red, hot
chili pepper, belonging to Capsicum annuum, the family Solanaceae,
native to sub-tropical and tropical regions. It has been used in
traditional medicine to increases metabolism, enhance circulatory
system and stomach and the intestinal tract, adjust blood pressure,
lower LDL cholesterol and triglycerides, treat frostbite, muscles,
arthritis, rheumatism, low back pain, strains, sprains, bruises and
neuralgia, etc.
Nonallergic rhinitisis defined as condition with symptoms resemble an allergy causes of ahiitis but without a known cause. Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis(1).
Ingredients
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
Non allergic rhinitis
ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, showed to exhibit significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain in patients with Nonallergic rhinitis(2).
The intranasal capsaicin spray, also showed a significant and long-term reduction of symptoms in nonallergic noninfectious perennial rhinitis patients, and five treatments of capsaicin on a single day at least is comparable to five treatments of capsaicin in 2 weeks, in a 30 nonallergic noninfectious perennial rhinitis patients randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals(3).
The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)
Nonallergic rhinitisis defined as condition with symptoms resemble an allergy causes of ahiitis but without a known cause. Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis(1).
Ingredients
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
Non allergic rhinitis
ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, showed to exhibit significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain in patients with Nonallergic rhinitis(2).
The intranasal capsaicin spray, also showed a significant and long-term reduction of symptoms in nonallergic noninfectious perennial rhinitis patients, and five treatments of capsaicin on a single day at least is comparable to five treatments of capsaicin in 2 weeks, in a 30 nonallergic noninfectious perennial rhinitis patients randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals(3).
The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
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References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)
Wednesday 21 May 2014
Food Therapy - Avocado and Cholesterol
Avocado is a commercially
valuable fruit and are cultivated in tropical climates throughout the
world, it is a green-skinned, pear-shaped fruit that ripens after
harvesting and native to the Caribbean, Mexico, South America and
Central America, belonging to the flowering plant family Lauraceae.
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place.
Avocado may be one of best fruit used to reduced the accumulation of bad cholesterol in the blood, as it processes body fat lowering capacity. The fruit was also found to reduced risk of metabolic syndrome(1), including obesity(2) and cardiovascular diseases(3). According to Dr. Monika P, and Dr. Geetha A., hydro-alcoholic fruit extract of P. americana (HAEPA) in a period of 14 weeks rat study, showed a significantly decreased body mass index (BMI), total fat pad mass and adiposity index. Levels of reduced glutathione, adiponectin, mRNA expression of adiponectin were significant lower in rats fed a high-fat diet (HFD)(4). The study of the level of expression of adiponectin and PPAR-γ in rats, Persea americana (avocado) fruit extract enhanced the HAEPA exhibition of hypolipidemic activity probably by increasing the mRNA, which is RNA messenger expression of adiponectin, a protein with function in regulating glucose levels as well as fatty acid breakdown. and PPAR-γ, a protein with function in regulation of cellular metabolism (carbohydrate, lipid, protein), and tumorigenesis, which reduce the risk of hyperlipidemia and obesity(5). In support of the view of above, researchers at the Potchefstroom University for Christian Higher Education, suggested that consumption of 200 g/d of avocado within an energy-restricted diet does not compromise weight loss when substituted for 30 g of mixed dietary fat. Serum lipid concentrations, plasma fibrinogen, arterial compliance, and systolic and diastolic blood pressures were not affected by weight loss or avocado intake(6).
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References
(1) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ.(PubMed)
(2) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(3) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)
(4) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(5) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(6) Substitution of high monounsaturated fatty acid avocado for mixed dietary fats during an energy-restricted diet: effects on weight loss, serum lipids, fibrinogen, and vascular function by Pieterse Z1, Jerling JC, Oosthuizen W, Kruger HS, Hanekom SM, Smuts CM, Schutte AE.(PubMed)
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place.
Avocado may be one of best fruit used to reduced the accumulation of bad cholesterol in the blood, as it processes body fat lowering capacity. The fruit was also found to reduced risk of metabolic syndrome(1), including obesity(2) and cardiovascular diseases(3). According to Dr. Monika P, and Dr. Geetha A., hydro-alcoholic fruit extract of P. americana (HAEPA) in a period of 14 weeks rat study, showed a significantly decreased body mass index (BMI), total fat pad mass and adiposity index. Levels of reduced glutathione, adiponectin, mRNA expression of adiponectin were significant lower in rats fed a high-fat diet (HFD)(4). The study of the level of expression of adiponectin and PPAR-γ in rats, Persea americana (avocado) fruit extract enhanced the HAEPA exhibition of hypolipidemic activity probably by increasing the mRNA, which is RNA messenger expression of adiponectin, a protein with function in regulating glucose levels as well as fatty acid breakdown. and PPAR-γ, a protein with function in regulation of cellular metabolism (carbohydrate, lipid, protein), and tumorigenesis, which reduce the risk of hyperlipidemia and obesity(5). In support of the view of above, researchers at the Potchefstroom University for Christian Higher Education, suggested that consumption of 200 g/d of avocado within an energy-restricted diet does not compromise weight loss when substituted for 30 g of mixed dietary fat. Serum lipid concentrations, plasma fibrinogen, arterial compliance, and systolic and diastolic blood pressures were not affected by weight loss or avocado intake(6).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
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References
(1) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ.(PubMed)
(2) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(3) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)
(4) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(5) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(6) Substitution of high monounsaturated fatty acid avocado for mixed dietary fats during an energy-restricted diet: effects on weight loss, serum lipids, fibrinogen, and vascular function by Pieterse Z1, Jerling JC, Oosthuizen W, Kruger HS, Hanekom SM, Smuts CM, Schutte AE.(PubMed)
Health Benefits of Phytochemical Allyl isothiocyanate
By Kyle J. Norton
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
1. Phytochemical Allyl isothiocyanate and Brain Cancer
Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating is not very common. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone.
The benefits
Allyl isothiocyanate (AITC) found in various cruciferous vegetables, beside has shown the inhibition of leukemia HL-60, bladder cancer UM-UC-3 and colon cancer HT-29 cells in vitro, it also significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner. Allyl isothiocyanate (AITC) may be another potential source of anti-human brain malignant glioma drug. Other study insisted that intake of Allyl isothiocyanate (AITC) may reduce the risk of cancer but AITC at high-dose levels also exhibit a low degree of cytotoxicity and genotoxicity, but unlikely in humans exposed to dietary levels of AITC.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)
2. Phytochemical Allyl isothiocyanate and Bladder Cancer
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is most common type of cancer that effect men twice as frequently as it effects women. Usually it starts from the lining the bladder caused by several types of malignant growths of the urinary bladder cells.
The benefits
Allyl isothiocyanate (AITC) found in Cruciferous vegetables and celecoxib effects in modulate cyclooxygenase-2 (Cox-2) oncogenic activity has been well documented in bladder cancer and other cancers. The combination showed the effectiveness in reduced risk of bladder cancer due to their associated with depletion of prostaglandin E2, a key downstream signaling molecule of Cox-2, caspase activation and downregulation of vascular endothelial growth factor in the tumor tissues. In other study, the N-acetylcysteine conjugate (NAC-AITC) is found to be significant inhibition of cell growth and proliferation in human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM.
References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
3. Allyl isothiocyanate and liver cancers
Liver cancer is defined as a condition of irregular cell growth in the liver.
In SK-Hep1 human hepatoma cells, Allyl isothiocyanate (AITC) showed to exhibit anti liver cancer effect through suppressing tumor cell migration and cell behaviors via MMP expression(1). The phytochemical together with its N-acetylcysteine conjugate also showed the reversal of transcriptase polymerase chain reaction in dose-dependent manner also through inhibition of MMP-2/-9 messenger RNA levels(2). Unfortunately, some researchers suggested that Organosulfur compounds, may induced histone acetylation expression and thereby favor cell differentiation(3).
References
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH.(PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ.(PubMed)
(3) Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide by Lea MA1, Randolph VM.(PubMed)
4. Allyl isothiocyanate and Colorectal Cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
In HT-29 colorectal cell line, phytochemical Allyl isothiocyanate, showed to inhibit the proliferation of cancer cells by induced blocking cell division associated with disruption of alpha-tubulin(1). The phytochemical also found to inhibit the same cell line through suppresses aberrant crypt foci in the the mucus layer that lines the intestinesof rats(2).
Dr. Musk SR. and Dr. Johnson IT. at the AFRC Institute of Food Research, Norwich Laboratory suggested that AITC exert its cytotoxic and cytostatic effects against the development of colorectal cancer by selectively inhibiting the growth of transformed cell clones within the gastrointestinal mucosa(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells by Smith TK1, Lund EK, Parker ML, Clarke RG, Johnson IT.(PubMed)
(2) Allyl isothiocyanate selectively kills undifferentiated HT29 cells in vitro and suppresses aberrant crypt foci in the colonic mucosa by Smith T1, Musk SR, Johnson IT.(PubMed)
(3) Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29 by Musk SR, Johnson IT.(PubMed)
5. Allyl isothiocyanate and Prostate Cancer
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
In PC-3 human prostate cancer xenografts, ATIC found abundantly in cruciferous vegetables exhibited its anti prostate cancer effect through apoptosis and reducing cell proliferative activity(1). The University of Pittsburgh School of Medicine study also supported the above but insisted that ATIC inhibits prostate cancer through cell cycle arrest (G2/M)and induced apoptosis(2) and The State University of New Jersey, showed the inhibition through ERK and JNK signaling pathways(cellular processes in regulation of Proliferation, Differentiation, Survival and Apoptosis) involvement in the regulation of activator protein 1 and cell death(3)
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.(PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis vy Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV.(PubMed)
(3) ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu C1, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.(PubMed)
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
1. Phytochemical Allyl isothiocyanate and Brain Cancer
Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating is not very common. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone.
The benefits
Allyl isothiocyanate (AITC) found in various cruciferous vegetables, beside has shown the inhibition of leukemia HL-60, bladder cancer UM-UC-3 and colon cancer HT-29 cells in vitro, it also significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner. Allyl isothiocyanate (AITC) may be another potential source of anti-human brain malignant glioma drug. Other study insisted that intake of Allyl isothiocyanate (AITC) may reduce the risk of cancer but AITC at high-dose levels also exhibit a low degree of cytotoxicity and genotoxicity, but unlikely in humans exposed to dietary levels of AITC.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)
2. Phytochemical Allyl isothiocyanate and Bladder Cancer
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is most common type of cancer that effect men twice as frequently as it effects women. Usually it starts from the lining the bladder caused by several types of malignant growths of the urinary bladder cells.
The benefits
Allyl isothiocyanate (AITC) found in Cruciferous vegetables and celecoxib effects in modulate cyclooxygenase-2 (Cox-2) oncogenic activity has been well documented in bladder cancer and other cancers. The combination showed the effectiveness in reduced risk of bladder cancer due to their associated with depletion of prostaglandin E2, a key downstream signaling molecule of Cox-2, caspase activation and downregulation of vascular endothelial growth factor in the tumor tissues. In other study, the N-acetylcysteine conjugate (NAC-AITC) is found to be significant inhibition of cell growth and proliferation in human bladder cancer UM-UC-3 cells or rat bladder cancer AY-27 cells with NAC-AITC at 15 μM.
References
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
3. Allyl isothiocyanate and liver cancers
Liver cancer is defined as a condition of irregular cell growth in the liver.
In SK-Hep1 human hepatoma cells, Allyl isothiocyanate (AITC) showed to exhibit anti liver cancer effect through suppressing tumor cell migration and cell behaviors via MMP expression(1). The phytochemical together with its N-acetylcysteine conjugate also showed the reversal of transcriptase polymerase chain reaction in dose-dependent manner also through inhibition of MMP-2/-9 messenger RNA levels(2). Unfortunately, some researchers suggested that Organosulfur compounds, may induced histone acetylation expression and thereby favor cell differentiation(3).
References
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH.(PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ.(PubMed)
(3) Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide by Lea MA1, Randolph VM.(PubMed)
4. Allyl isothiocyanate and Colorectal Cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
In HT-29 colorectal cell line, phytochemical Allyl isothiocyanate, showed to inhibit the proliferation of cancer cells by induced blocking cell division associated with disruption of alpha-tubulin(1). The phytochemical also found to inhibit the same cell line through suppresses aberrant crypt foci in the the mucus layer that lines the intestinesof rats(2).
Dr. Musk SR. and Dr. Johnson IT. at the AFRC Institute of Food Research, Norwich Laboratory suggested that AITC exert its cytotoxic and cytostatic effects against the development of colorectal cancer by selectively inhibiting the growth of transformed cell clones within the gastrointestinal mucosa(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells by Smith TK1, Lund EK, Parker ML, Clarke RG, Johnson IT.(PubMed)
(2) Allyl isothiocyanate selectively kills undifferentiated HT29 cells in vitro and suppresses aberrant crypt foci in the colonic mucosa by Smith T1, Musk SR, Johnson IT.(PubMed)
(3) Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29 by Musk SR, Johnson IT.(PubMed)
5. Allyl isothiocyanate and Prostate Cancer
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
In PC-3 human prostate cancer xenografts, ATIC found abundantly in cruciferous vegetables exhibited its anti prostate cancer effect through apoptosis and reducing cell proliferative activity(1). The University of Pittsburgh School of Medicine study also supported the above but insisted that ATIC inhibits prostate cancer through cell cycle arrest (G2/M)and induced apoptosis(2) and The State University of New Jersey, showed the inhibition through ERK and JNK signaling pathways(cellular processes in regulation of Proliferation, Differentiation, Survival and Apoptosis) involvement in the regulation of activator protein 1 and cell death(3)
References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.(PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis vy Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV.(PubMed)
(3) ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu C1, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.(PubMed)
Simple and Easy Recipe - Broil pears with yogurt
Recipe Contributed by 4 Ingredients by Kim McCosker and Rachael Bermingham (Atria Books))
Serve 2
2 pears, halved lengthwise and cored
1/4 cup of yogurt (flavor of your choice)
Preheat the broiler. Broil pears cut sides up to 3 minutes or until soft. Top with yogurt.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Serve 2
2 pears, halved lengthwise and cored
1/4 cup of yogurt (flavor of your choice)
Preheat the broiler. Broil pears cut sides up to 3 minutes or until soft. Top with yogurt.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Herbal Chamomile and anti inflammatory effect
Chamomile is also known as camomile, common name of
many species daisy-like plants in the family Asteraceae. The herb has
been used in traditional medicine as antispasmodic and anti-inflammatory
constituents and to treat menstrual cramps and sleep disorders, reduce
cramping and spastic pain in the bowels, relieve excessive gas and
bloating in the intestine, etc.
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
In the study at Case Western Reserve University, chamomile showed to exhibit its potential anti-inflammatory mechanisms, through inhibited NO production and iNOS gene expression via inhibiting RelA/p65 activation(1). The study of whether chamomile interferes with the COX-2 pathway, showed a positive effect of the herb in inhibition of COX-2 enzyme activity and causation of reduction in LPS-induced COX-2 mRNA and protein expression(2),
The study of supplement containing 2 flavonoids (>95% pure), luteolin (100 mg/capsule, from chamomile) and quercetin (70 mg/capsule), and the quercetin glycoside rutin (30 mg/capsule) from the Sophora japonica leaf, formulated in olive kernel oil to increase oral absorption, suggested that that the combination of the flavonoids luteolin and quercetin seemed to be effective in reducing ASD symptoms, with no major adverse effects through it anti inflammatory activities(3)
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
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References
(1) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N1, Shukla S, Srivastava JK, Gupta S.(PubMed)
(2) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity by Srivastava JK1, Pandey M, Gupta S.(PubMed)
(3) An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders by Taliou A1, Zintzaras E, Lykouras L, Francis K.(PubMed)
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
In the study at Case Western Reserve University, chamomile showed to exhibit its potential anti-inflammatory mechanisms, through inhibited NO production and iNOS gene expression via inhibiting RelA/p65 activation(1). The study of whether chamomile interferes with the COX-2 pathway, showed a positive effect of the herb in inhibition of COX-2 enzyme activity and causation of reduction in LPS-induced COX-2 mRNA and protein expression(2),
The study of supplement containing 2 flavonoids (>95% pure), luteolin (100 mg/capsule, from chamomile) and quercetin (70 mg/capsule), and the quercetin glycoside rutin (30 mg/capsule) from the Sophora japonica leaf, formulated in olive kernel oil to increase oral absorption, suggested that that the combination of the flavonoids luteolin and quercetin seemed to be effective in reducing ASD symptoms, with no major adverse effects through it anti inflammatory activities(3)
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Women Health http://kylejnorton.blogspot.ca/p/women-health.html
Back to Kyle J. Norton Home Page http://kylejnorton.blogspot.ca
References
(1) Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity by Bhaskaran N1, Shukla S, Srivastava JK, Gupta S.(PubMed)
(2) Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity by Srivastava JK1, Pandey M, Gupta S.(PubMed)
(3) An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders by Taliou A1, Zintzaras E, Lykouras L, Francis K.(PubMed)
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