Monday, 19 May 2014

Herbal Catnip (Nepeta cataria)

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family Lamiaceae, native to Europe and Asia. It has been used in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

1. Herbal Catnip (Nepeta cataria) and anti-microbial activity
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The benefits
 Chemical composition of essential oil from N. cataria including the chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) were effective in exerting theirs anti microbial activity against all tested bacteria at concentrations of 0.125-4 μL/mL. and inhibited the growth of Candida species at a concentration less than 1 μL/mL. Other in the study of the anti bacterial effect of some herbs, including Catnip, found that Lavender oil is more effective in exhibition of antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic values of essential oil components.


2. Herbal Catnip (Nepeta cataria) and memory
Central nervous system include is the part of the nervous system of the brain and spinal cord with function of integrates information it receives from for the entire nervous system, and control all the workings of your body.

Evidences emerged in the research community that certain ingredients plants and vegetable may  improve the cognitive function by enhancing theirs antioxidant activity. Study of the effects of menthoides aqueous extract on memory retention and retrieval of mice using passive avoidance apparatus, the result showed that the extract has exerted its antioxidant effect by enhancing the  memory retention and retrieval, these may be a result of the effects of the herb's rosmarinic acid, caffeic acid and phenolic acids.

References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi,  and Reza Khashei(PubMed)
(2) Chemical composition and antimicrobial activities of essential oil of nepeta cataria L. Against common causes of oral infections by Zomorodian K1, Saharkhiz MJ2, Rahimi MJ1, Shariatifard S3, Pakshir K1, Khashei R4.(PubMed)
(3)  Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods, by Miladinović DL, Ilić BS, Mihajilov-Krstev TM, Nikolić ND, Miladinović LC, Cvetković OG.(PubMed)
(4) Croton zehntneri: possible central nervous system effects of the essential oil in rodents`by Batatinha MJ, de Souza-Spinosa H, Bernardi MM(PubMed)
(5) `Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice`by Massoco CO, Silva MR, Gorniak SL, Spinosa MS, Bernardi MM(PubMed)
 



3. Herbal catnip as repellent
Catnip may be used as repellent agent in protect skin against insect and may be used to as  mosquito repellent against several Aedes and Culex species, both topically and spatially and can be considered as a relatively safe repellent, which may cause minor skin irritation.(1).
In Stomoxys calcitrans (L.) (Diptera: Muscidae) study, chemical compound from catnip oil tsuch as isolongifolenone, 2-methylpiperidinyl-3-cyclohexen-1-carboxamide and (1S,2'S)-2-methylpiperidinyl-3-cyclohexen-1-carboxamide, showed to effective a significant effect in repellency against stable flies(2).
But in the study by Chemicals Affecting Insect Behavior Laboratory, catnip oil and nepetalactone isomers are significantly less effective when compare with the repellents N,N-diethyl-3-methylbenzamide (deet) and chiral (1S,2'S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220)(3).


References
(1) Efficacy and safety of catnip (Nepeta cataria) as a novel filth fly repellent by Zhu JJ1, Zeng XP, Berkebile D, DU HJ, Tong Y, Qian K.(PubMed)
(2) Nepetalactones from essential oil of Nepeta cataria represent a stable fly feeding and oviposition repellent by Zhu JJ1, Berkebile DR, Dunlap CA, Zhang A, Boxler D, Tangtrakulwanich K, Behle RW, Baxendale F, Brewer G.(PubMed)
(3) Feeding deterrent effects of catnip oil components compared with two synthetic amides against Aedes aegypti by Chauhan KR1, Klun JA, Debboun M, Kramer M.(PubMed)

3. Catnip and Anti inflammatory effect
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

Herbal catnip may be used as anti inflammatory agonist in treating chronic related inflammation disease. 4aα,7α,7aβ-nepetalactone and 1,8-cineole, a chemical compound from catnip, found in the main concentrated components of NP essential oil, showed to alleviate symptoms of  both the acute and chronic forms of nociception, through its anti inflammatory effect in does depending manner, ibn rat study(1). In support of the above, the Tarbiat Modares University study showed that Nepeta crispa essential oil enhances anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw oedema in all applied doses(2).
The coincidence of the proven inflammatory effect with insistence of herbalist may be due to its  inhibition of calcineurin; an important regulator of T-cell mediated inflammation that has received little attention in ethnopharmacological research, Dr. Prescott TA and the research team at the Royal Botanic Gardens suggested(3).

4. Etc.


References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(3) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA, Veitch NC, Simmonds MS.(PubMed)

4. Catnip as Antioxidants
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.

Beside containing anti inflammatory effect, Catnip may also act as antioxidants in fighting against forming of free radicals. In fact, the study at the found that catnip and other plants used in folk medicine in the Mediterranean basin in the experiment showed to exhibit  the deduction of reactive oxygen species produced by neutrophils, such as the superoxide anion and the hydroxyl radical, could be implicated in the overall reduction of inflammation(1).
The testing of herbal medicine Teucrium chamaedrys L. and Nepeta cataria L. (Lamiaceae) used in traditional medicine in treatment of  related nflammation, also support the antioxidant effect of catnip, through inhibition of calcineurin; an important regulator of T-cell mediated inflammation that has received little attention in ethnopharmacological research(2).


References
(1) Anti-inflammatory, anti-oxidant, and apoptotic activities of four plant species used in folk medicine in the Mediterranean basin by Amira S, Dade M, Schinella G, Ríos JL.(PubMed)
(2) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA1, Veitch NC, Simmonds MS(PubMed)



Side effects 

1. Overdose of Catnip may cause central nervous system depression.
2. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased the susceptibility to seizures.
3. Catnip may interacts with other medication if used  on a daily basis.



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Herbal Cayenne as Antioxidants

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge. The unpaired electrons cause radicals to be highly chemically reactive in the human body, leading to aging and cancers.

Ingredients
The chemical constituents of Cayenne include capsaicin,  capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

According to the Texas A&M University, the antioxidant activities of cayenne may be due to its
rich source of diverse bioactive compounds, including : hexane, ethyl acetate, acetone, methanol, and methanol:water. In high concentrations, the extracts exerted different measures of antioxidant activity, with DPPH radical-scavenging activity was strongly correlated with total bioactive compounds such as capsaicinoids, carotenoids, flavonoids and total phenolics(1). The study consisted Four cultivars (Bronowicka Ostra, Cyklon, Tornado, and Tajfun) of pepper fruit Capsicum annuum L., phenolics contents, showed a positive effect of the compounds in exerting its antioxidant activities through elucidated in heat-induced oxidation in the beta-carotene-linoleic acid system(2).
The Universidad Complutense de Madrid suusgested that the antioxidants exerted by cayenne may be due to the amount released from the food matrix by the action of digestive enzymes, about 75% for total polyphenols, up to 49% for both beta-carotene and zeaxanthin, and up to 41% for beta-cryptoxanthin.(3).
Other research suggested Organic growing showed to increased the level of antioxidant compounds such as carotenoids, phenolic compounds and vitamin C in sweet bell pepper, another member family of Capsicum annuum(4).

The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.


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References
(1) Variation of antioxidant activity and the levels of bioactive compounds in lipophilic and hydrophilic extracts from hot pepper (Capsicum spp.) cultivars by Bae H1, Jayaprakasha GK, Jifon J, Patil BS.(PubMed)
(2) Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L) by Materska M1, Perucka I.(PubMed)
(3) Bioactive compounds of four hot pepper varieties (Capsicum annuum L.), antioxidant capacity, and intestinal bioaccessibility by Hervert-Hernández D1, Sáyago-Ayerdi SG, Goñi I.(PubMed)
(4) Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems by Hallmann E1, Rembiałkowska E.(PubMed)

Herbal Catnip Anti inflammatory effect

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia. It has been use in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

Herbal catnip may be used as anti inflammatory agonist in treating chronic related inflammation disease. 4aα,7α,7aβ-nepetalactone and 1,8-cineole, a chemical compound from catnip, found in the main concentrated components of NP essential oil, showed to alleviate symptoms of  both the acute and chronic forms of nociception, through its anti inflammatory effect in does depending manner, ibn rat study(1). In support of the above, the Tarbiat Modares University study showed that Nepeta crispa essential oil enhances anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw oedema in all applied doses(2).
The coincidence of the proven inflammatory effect with insistence of herbalist may be due to its  inhibition of calcineurin; an important regulator of T-cell mediated inflammation that has received little attention in ethnopharmacological research, Dr. Prescott TA and the research team at the Royal Botanic Gardens suggested(3).

Side effects1. Overdose of Catnip may cause central nervous system depression.
2. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased the susceptibility to seizures.
3. Catnip may interacts with other medication if used  on a daily basis
4. Etc.



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References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(3) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA, Veitch NC, Simmonds MS.(PubMed)

Phytochemical Allyl isothiocyanate and Prostate Cancer

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

In PC-3 human prostate cancer xenografts, ATIC found abundantly in cruciferous vegetables exhibited its anti prostate cancer effect inhibits through inducing apoptosis and reducing cell proliferative activity(1). The University of Pittsburgh School of Medicine study also supported the above but insisted ATIC inhibit prostate cancer through cell cycle arrest (G2/M)and induced apoptosis(2) and The State University of New Jersey, showed the inhibition through ERK and JNK signaling pathways(cellular processes in regulation of Proliferation, Differentiation, Survival and Apoptosis) involvement in the regulation of activator protein 1 and cell death(3).

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References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.(PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis vy Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV.(PubMed)
(3) ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu C1, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.(PubMed)
 

Simple and easy Recipe - Tomato-Bacon Nibbles

Recipe by Quick and easy family favorites (by Vickie and JoAnn)

A 1/4 teaspoon measuring spoon is just right for scooping out tiny tomatoes for stuffing.
24 to 30 cherry tomatoes
16 oz. pkg. bacon crispy cooked and crumbled
2 T. fresh parsley chopped
1/2 cup green onions finely chopped
3 T. grated parmesan cheese
1/2 cup mayonnaise
Cut a thin slice off the top of each tomatoes and if desired, cut a thin slice from bottom of each tomatoes( so the tomatoes will stand up right); scoop out and discard tomato pulp. Place tomatoes upside-down on a paper towel to drain for 10 minutes.
Mix bacon and remaining 4 ingredients in a small bowl, stuff tomatoes. Serve immediately or chill up to 2 hours. Make 2 to 21/2 dozen

Anna Mcmaster
Porland OR


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Sunday, 18 May 2014

Herbal Cinnamon and Alzheimer's Diseases

Kyle J. Norton

Adding spicy cinnamon into your diet may reduce risk of Alzheimer's Diseases, new study suggested. Although, cinnamon is best known for its anti diabetic effect, it has also consisted certain chemical constituents associated to prevent Insulin resistance causes of complication such as obesity(1) and neurodiseases(2).

The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal. 

According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease. It may be a result of  cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity)(10)

In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), Cinnamon (CN) showed to alleviate the increases in mRNA associated with Alzheimers such as PTEN, Tau and amyloid precursor protein, through its neuroprotective associated with improved whole body insulin sensitivity and related changes in the brain.(4). Its aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protect tau from abnormal modifications, according to the University of California(5).

PTEN, is a tumor suppressor gene through the action of its phosphatase protein  involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules has been found in patients with Alzheimer's Diseases.
Amyloid precursor protein, plays an important role in formation of synapses between neurons in the nervous system, showed to generate beta amyloid (Aβ) in patients with Alzheimer's diseases

In cognitive impairment in Alzheimer's disease animal models, caused by accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ), oral administration of cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).

Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).

Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndrome such as obesity and diabetes. According to DR. Georgakopoulou EA(7),  Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(1)(7).

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References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ.(PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS.(PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL.(PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)

Phytochemical Allyl isothiocyanate and Colorectal Cancer

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.

In HT-29 colorectal cell line, phytochemical Allyl isothiocyanate, showed to inhibit the proliferation of cancer cells by induced blocking cell division associated with disruption of alpha-tubulin(1). The phytochemical also found to inhibit the same cell line through suppresses aberrant crypt foci in the  the mucus layer that lines the intestinesof rats(2).
Dr. Musk SR. and Dr. Johnson IT. at the AFRC Institute of Food Research, Norwich Laboratory suggested that AITC showed to exert its cytotoxic and cytostatic effects against the development of colorectal cancer by selectively inhibiting the growth of transformed cell clones within the gastrointestinal mucosa(3).


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References
References
(1) Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells by Smith TK1, Lund EK, Parker ML, Clarke RG, Johnson IT.(PubMed)
(2) Allyl isothiocyanate selectively kills undifferentiated HT29 cells in vitro and suppresses aberrant crypt foci in the colonic mucosa by Smith T1, Musk SR, Johnson IT.(PubMed)
(3) Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29 by Musk SR, Johnson IT.(PubMed)