Monday 19 May 2014

Phytochemical Allyl isothiocyanate and Prostate Cancer

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

In PC-3 human prostate cancer xenografts, ATIC found abundantly in cruciferous vegetables exhibited its anti prostate cancer effect inhibits through inducing apoptosis and reducing cell proliferative activity(1). The University of Pittsburgh School of Medicine study also supported the above but insisted ATIC inhibit prostate cancer through cell cycle arrest (G2/M)and induced apoptosis(2) and The State University of New Jersey, showed the inhibition through ERK and JNK signaling pathways(cellular processes in regulation of Proliferation, Differentiation, Survival and Apoptosis) involvement in the regulation of activator protein 1 and cell death(3).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca     


References
(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.(PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis vy Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV.(PubMed)
(3) ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu C1, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.(PubMed)
 

Simple and easy Recipe - Tomato-Bacon Nibbles

Recipe by Quick and easy family favorites (by Vickie and JoAnn)

A 1/4 teaspoon measuring spoon is just right for scooping out tiny tomatoes for stuffing.
24 to 30 cherry tomatoes
16 oz. pkg. bacon crispy cooked and crumbled
2 T. fresh parsley chopped
1/2 cup green onions finely chopped
3 T. grated parmesan cheese
1/2 cup mayonnaise
Cut a thin slice off the top of each tomatoes and if desired, cut a thin slice from bottom of each tomatoes( so the tomatoes will stand up right); scoop out and discard tomato pulp. Place tomatoes upside-down on a paper towel to drain for 10 minutes.
Mix bacon and remaining 4 ingredients in a small bowl, stuff tomatoes. Serve immediately or chill up to 2 hours. Make 2 to 21/2 dozen

Anna Mcmaster
Porland OR


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca      

Sunday 18 May 2014

Herbal Cinnamon and Alzheimer's Diseases

Kyle J. Norton

Adding spicy cinnamon into your diet may reduce risk of Alzheimer's Diseases, new study suggested. Although, cinnamon is best known for its anti diabetic effect, it has also consisted certain chemical constituents associated to prevent Insulin resistance causes of complication such as obesity(1) and neurodiseases(2).

The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal. 

According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease. It may be a result of  cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity)(10)

In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), Cinnamon (CN) showed to alleviate the increases in mRNA associated with Alzheimers such as PTEN, Tau and amyloid precursor protein, through its neuroprotective associated with improved whole body insulin sensitivity and related changes in the brain.(4). Its aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protect tau from abnormal modifications, according to the University of California(5).

PTEN, is a tumor suppressor gene through the action of its phosphatase protein  involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules has been found in patients with Alzheimer's Diseases.
Amyloid precursor protein, plays an important role in formation of synapses between neurons in the nervous system, showed to generate beta amyloid (Aβ) in patients with Alzheimer's diseases

In cognitive impairment in Alzheimer's disease animal models, caused by accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ), oral administration of cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).

Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).

Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndrome such as obesity and diabetes. According to DR. Georgakopoulou EA(7),  Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(1)(7).

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Researched articles - Points of view of Vitamins, Foods and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca



References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ.(PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS.(PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL.(PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)

Phytochemical Allyl isothiocyanate and Colorectal Cancer

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.

In HT-29 colorectal cell line, phytochemical Allyl isothiocyanate, showed to inhibit the proliferation of cancer cells by induced blocking cell division associated with disruption of alpha-tubulin(1). The phytochemical also found to inhibit the same cell line through suppresses aberrant crypt foci in the  the mucus layer that lines the intestinesof rats(2).
Dr. Musk SR. and Dr. Johnson IT. at the AFRC Institute of Food Research, Norwich Laboratory suggested that AITC showed to exert its cytotoxic and cytostatic effects against the development of colorectal cancer by selectively inhibiting the growth of transformed cell clones within the gastrointestinal mucosa(3).


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 


Back to Most common Types of Cancer  http://kylejnorton.blogspot.ca/p/blog-page.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   
References
References
(1) Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells by Smith TK1, Lund EK, Parker ML, Clarke RG, Johnson IT.(PubMed)
(2) Allyl isothiocyanate selectively kills undifferentiated HT29 cells in vitro and suppresses aberrant crypt foci in the colonic mucosa by Smith T1, Musk SR, Johnson IT.(PubMed)
(3) Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29 by Musk SR, Johnson IT.(PubMed)

Herbal Cat's claw and Osteoarthritis

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae. It has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

Ingredients
The chemical constituents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

 Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.

In the study to understand the effect of Cat's claw isolated active compounds against the pivotal molecular targets involved in inflammation and the joint destruction process and to summarize their toxicities and efficacy,  showed a positive effect in alleviation pain with no adverse effect(1).
Dr. Chrubasik S. at Institut für Rechtsmedizin der Universität Freiburg, in the study of Cat's claw analgesics, found a the positive effect of the herb extract (Doloteffin (extraction solvent water))in relieving symptoms of chronic pain with at least 50 mg harpagoside in the daily dose(2).
Further more, the reviews of 16 clinical studies (11 randomized, placebo-controlled clinical trials, three crossover trials, one case-controlled study, and one open-label study) at Bethesda North Hospital Pharmacy, showed the support of cat's claw alone or in combination for OA in 3 studies(3).

These effectiveness may be coincided with the use of herb in herbal medicine over thousand of year in treating disorders such as arthritis, gastritis and osteoarthritis(4).

Unfortunately, the study in reviews the data base by the University of Southampton, showed a doubt
of the methodological quality of the existing clinical trials and insisted that clinical evidence to date cannot provide a definitive answer to the two questions posed: (1) Does it work? And (2) is it safe?, although these trials may provide certain supports for effectiveness of the herb(5).


Side effects
1. It may cause allergic reaction, including itching, rash and allergic inflammation of the kidneys, etc. to certain people, according to the article of `Uncaria Tomentosa`by Wikipedia(a)
2. If you are taking blood pressure medicines, blood-thinning medications, hormones, or insulin do not take cat's claw
3. Do not take Cat's claw if you are pregnant or breast feeding with out approval of your related field specialist
4. Do not take cat’s claw if you have low blood pressure or an autoimmune disease (such as lupus or multiple sclerosis) or have had an organ or bone marrow transplant.
5. Etc.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 


Back to Most common Types of Cancer  http://kylejnorton.blogspot.ca/p/blog-page.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca    
References
(1) Current nutraceuticals in the management of osteoarthritis: a review by Akhtar N1, Haqqi TM.(PubMed)
(2) [Devil's claw extract as an example of the effectiveness of herbal analgesics].[Article in German]

 by Chrubasik S.(PubMed)
(3) Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis by Rosenbaum CC1, O'Mathúna DP, Chavez M, Shields K.(PubMed)
(4) Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis by Hardin SR.(PubMed)
(4) Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety by Brien S1, Lewith GT, McGregor G.(PubMed)

Easy and Quick recipe - Party Tortilla Wraps

Recipe by Quick and easy family favorites( by Vickie and JoAnn)

Talk about versatile. These wraps are a great go-to for a tasty appetizer. a special treat for the lunch box or a handy afternoon snack.
8 oz. container chive cream cheese
4(10 inches) flour tortillas
1 Lb. sliced cooked ham
8 oz. pkg. shredded American cheese
Spread craem cheese evenly over tortillas. Place several slices of ham on each tortilla, sprinkle with shredded cheese
Roll up tortillas. Place in refrigerator for 15 minutes. Cut into one-inch piece. make 40 appetizers.

Manly Hardy
Middleville, MI

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca      

Saturday 17 May 2014

Food therapy - Avocado and Prostate Cancer

Avocados are a commercially valuable fruit cultivated in tropical climates throughout the world. The fruit has a green-skinned, pear-shaped fruit that ripens after harvesting, native to the Caribbean, Mexico, South America and Central America, belonging to the flowering plant family Lauraceae.
Nutrients
1. Vitamin K
2. Dietary fiber
3. Vitamin B6
4. Vitamin C
5. Folate
6. Copper
7. Potassium
8. Amino acid
9. Others
a) Vitamin A
b) Vitamin B1, B2, B3, B12
c) Vitamin D
d) Vitamin E
e) Carotenoid
f) Pantothenic acid
g) Calcium
h) Chromium
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol; fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).

Intake of dietary MUFA from whole fruit of avocado are associated to reduced risk and treatment of prostate cancer, the new study at the University of the West Indies suggested(1). In support of the above, the University of California study showed that the anti prostate cancer effect are not as result of a single ingredient such as related carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit in combination with other det-derived phytochemicals through cell cycle arrest and  G(2)/M cell cycle arrest accompanied by an increase in p27 protein which involves function as tumor suppressor in controlling the cell cycle progression, in incubated PC-3 cells(3). The Purdue University study in the evaluation of the anti cancers effect of avocado also showed a positive effect of the whole fruit in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(4).

Side effects
 1. Skin product of avocado oils may contain latex which can cause skin side effect in certain people with hypersensitivity to latex, leading to symptoms of reddening of the skin, itching, hives, or eczema.
2. Liver damage
Certain types of avocado may cause liver damage as a result of collagen accumulation in the liver
3. Breastfeeding
Some types of Avocado may be unsafe during breastfeeding as it can cause problems of upset stomachs in babies.
4. Drugs
Avocado may decrease the effect of "blood thinning" or anti-inflammatory medications.
5. It may cause symptoms of gastrointestinal irritation, vomiting, diarrhoea, respiratory distress, congestion, fluid accumulation due to toxic fatty acid derivative, Persin.
6. Etc.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months 


Back to Most common Types of Cancer  http://kylejnorton.blogspot.ca/p/blog-page.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca   
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
12. Avocado and Skin health
13. Avocado and Cadiovascular diseases