Kyle J.Norton
Skin aging is one of most visible process
which occurs constantly in our skin organ. According to the Clinical
Centre of Nis, certain plant extracts may have the ability to scavenge
free radicals, to protect the skin matrix through the inhibition of
enzymatic degradation, or to promote collagen synthesis in the skin,
affect skin elasticity and tightness(a). Other suggested that free
radicals induced domino effects in production of reactive oxygen
species, can react with DNA, proteins, and fatty acids, causing
oxidative damage and impairment of antioxidant system, leading
injuries damage regulation pathways of skin, including wrinkles,
roughness, appearance of fine lines, lack of elasticity, and de- or
hyperpigmentation marks(b).
Vitamin D is a fat-soluble secosteroids found in small amount in
few foods, including salmon, mackerel, sardines and tuna. The vitamin
plays an important role in modulation of cellular proliferation,
apoptosis induction, tumor growth suppression and promotion in
absorption of minerals, including calcium, iron, magnesium, phosphate
and zinc.
1. Plasma of vitamin D
Levels of 25-hydroxyvitamin D levels [25(OH)D]
was associated to risk of skin aging as the study at
Universitätsklinikum des Saarlandes showed. UV-radiation exerts
both skin aging -promoting and -inhibiting effects on skin aging. Altered mineral homeostasis caused by a high vitamin D activity, exhibited the premature aging
that include, such as short lifespan, retarded growth, ectopic
calcification, immunological deficiency, osteoporosis, atherosclerosis,
hypogonadism, skin and general organ atrophy but in laboratory investigations, vitamin D compounds protects the skin against the hazardous effects of various skin aging-inducing
agents, including ultraviolet (UV) radiation(1). Therefore optimal
serum concentration are necessary due to its U-shaped risk(2). The
Stanford University School of Medicine study indicated that vitamin D
deficiency enhanced low scores for specific photodamage parameters
including erythema/telangiectasias, hyperpigmentation, and wrinkling(3),
specially, the skin from aging subjects can decrease by greater than twofold the capacity of the skin to produce previtamin D3(4).
2. The effects
According to Treviglio-Caravaggio Hospital, daily supplementation of
vitamin D indicated is about 800-1,000 IU/day but may increase up to a
maximum dose of 2,000 IU/day in conditions of severe vitamin D deficiency
with a concomitant reduced or no sun exposure, reduced dietary intake
and reduced calcium absorption(5)(6). Some researchers suggested that
intrinsic skin aging may reflects the reduction processes that are common in internal organs, as the reduced production of sex hormones influence skin morphology and functions, skin permeability, wound healing, sebaceous lipogenesis, and the metabolism of skin
cells in both sex and Vitamin D administered and antioxidant treatment
may be beneficial(7). In postmenopausal health, low levels of vitamin D
may induce obesity, malabsorption syndromes, medication use (e.g.
anticonvulsants, antiretrovirals), skin aging.
According to Universidad de Zaragoza, Increased level of the vitamin
D through regular sunlight exposure (without sunscreens) for 15 min, 3-4
times a week, in the middle of the day in summer may be beneficial, but
supplementation intake of vitamin D2 (ergocalciferol) or vitamin D3
(cholecalciferol) should be monitored depending on the dose used and the
presence of concomitant medical conditions such as renal disease(8). Dr Johnson MA at the University of Georgia, insisted " Diminished synthesis of vitamin D in the skin that occurs with aging and poor dietary intake contribute to the high prevalence of poor vitamin D
status in older adults"(9). Cutaneous
vitamin D3 synthesis declines with age, it would require input of an
additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that
97.5% of older women have 25(OH)D values at or above desirable
levels (10).
Taken altogether, optimal serum concentration was found to interact in
enhancing production of sex hormones and reducing
photodamage parameters including erythema/telangiectasias,
hyperpigmentation, and wrinkling due to aging. As always, all articles
written by Kyle J. Norton are for information & education only,
please consult your Doctor & Related field specialist before
applying
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References
(1) Unravelling of hidden secrets: The role of vitamin D in skin aging by Reichrath J.(PubMed)
(2) Vitamin D and aging by Tuohimaa P.(PubMed)
(3) Association of facial skin aging and vitamin D levels in middle-aged white women by Chang AL1, Fu T, Amir O, Tang JY.(PubMed)
(4) Aging decreases the capacity of human skin to produce vitamin D3 by MacLaughlin J, Holick MF.(PubMed)
(5) Vitamin D: role and opportunity to prescribe by Resmini G1, Tarantino U, Iolascon G.(PubMed)
(6) Vitamin D and aging by Gallagher JC.(PubMed)
(7) Hormonal therapy of intrinsic aging by Zouboulis CC1, Makrantonaki E.(PubMed)
(8) EMAS position statement: Vitamin D and postmenopausal health by Pérez-López FR1,
Brincat M, Erel CT, Tremollieres F, Gambacciani M, Lambrinoudaki I,
Moen MH, Schenck-Gustafsson K, Vujovic S, Rozenberg S, Rees M(PubMed)
(9) Nutrition and aging--practical advice for healthy eating by Johnson MA(PubMed)
(10) Barriers to optimizing vitamin D3 intake for the elderly by Heaney RP.(PubMed)
Friday, 4 April 2014
Herbal Calendula and Atherosclerosis
Calendula is also known as pot marigold, a annual or perennial herbaceous
plants of about 12–20 species of genus Calendula, belonging to the
family Asteraceae, native to Southern Europe. It has been used in herbal
medicine as spasmolytic, spasmogenic, inflammatory effects and to treat
abdominal cramps, wound healing, skin diseases, colitis, constipation,
etc.
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Atherosclerosis is a condition of thickening of an artery wall as a result of the accumulation of cholesterol and triglyceride.
The study of natural products including botanicals for both therapy of clinical manifestations of atherosclerosis and reduction of atherosclerosis risk, showed a positive effects of herbal Caendula in reduced risk of atherosclerosis and progression of the disease(1). Inflaminat, a composition of (calendula, elder, and violet), which possesses anti-cytokine activity, showed to cause the regression of carotid atherosclerosis(2). Other composition, including calendula, elder, and pansy showed to enhanced maximum antiinflammatory activity. Thus can be used for pathogenetic therapy of various inflammatory diseases, including atherosclerosis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Anti-atherosclerotic therapy based on botanicals by Orekhov AN1, Sobenin IA, Korneev NV, Kirichenko TV, Myasoedova VA, Melnichenko AA, Balcells M, Edelman ER, Bobryshev YV.(PubMed)
(2) Direct anti-atherosclerotic therapy; development of natural anti-atherosclerotic drugs preventing cellular cholesterol retention by Orekhov AN(PubMed)
(3) Use of natural products in anticytokine therapy by Gorchakova TV1, Suprun IV, Sobenin IA, Orekhov AN(PubMed)
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Atherosclerosis is a condition of thickening of an artery wall as a result of the accumulation of cholesterol and triglyceride.
The study of natural products including botanicals for both therapy of clinical manifestations of atherosclerosis and reduction of atherosclerosis risk, showed a positive effects of herbal Caendula in reduced risk of atherosclerosis and progression of the disease(1). Inflaminat, a composition of (calendula, elder, and violet), which possesses anti-cytokine activity, showed to cause the regression of carotid atherosclerosis(2). Other composition, including calendula, elder, and pansy showed to enhanced maximum antiinflammatory activity. Thus can be used for pathogenetic therapy of various inflammatory diseases, including atherosclerosis(3).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Anti-atherosclerotic therapy based on botanicals by Orekhov AN1, Sobenin IA, Korneev NV, Kirichenko TV, Myasoedova VA, Melnichenko AA, Balcells M, Edelman ER, Bobryshev YV.(PubMed)
(2) Direct anti-atherosclerotic therapy; development of natural anti-atherosclerotic drugs preventing cellular cholesterol retention by Orekhov AN(PubMed)
(3) Use of natural products in anticytokine therapy by Gorchakova TV1, Suprun IV, Sobenin IA, Orekhov AN(PubMed)
Phytochemical allicin and pancreatic cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.
The health benefits
Allicin found in garlic and onion has drawn many interest in scientific community in finding a natural potent agent with little and no side effects in preventing and treating cancers. Garlic preparations inhibition of cancer cell-growth has been attributed to a group of structurally-related organosulfur compounds, such as allicin, diallyl disulfide and diallyl trisulfide. Combined treatment with recombinant interleukin-2 (rIL-2) on pancreatic cancer and explored the potential immunological mechanism in mice, showed a significant suppression of cells growth and prolonged survival time in the combined treatment with allicin and rIL-2 group, with increased mature Th cells express the surface protein CD4 and CD8, natural killer cell (NK cell) and Serum levels of interferon-gamma.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.
The health benefits
Allicin found in garlic and onion has drawn many interest in scientific community in finding a natural potent agent with little and no side effects in preventing and treating cancers. Garlic preparations inhibition of cancer cell-growth has been attributed to a group of structurally-related organosulfur compounds, such as allicin, diallyl disulfide and diallyl trisulfide. Combined treatment with recombinant interleukin-2 (rIL-2) on pancreatic cancer and explored the potential immunological mechanism in mice, showed a significant suppression of cells growth and prolonged survival time in the combined treatment with allicin and rIL-2 group, with increased mature Th cells express the surface protein CD4 and CD8, natural killer cell (NK cell) and Serum levels of interferon-gamma.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
Phytochemical Piperine and Asthma
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
The effects
Study of bacterial infections causes of frequent respiratory infections, including bacterial infections provoke asthma attack, showed a positive effect of Piper Longum L. Extract (20% Piperine) in exhibition of a moderate activity antibacterial activity against selected strains, such as Haemophilus influenzae , Streptococcus pneumoniae , Streptococcus pyrogene and Staphylococcus aureus. In the study of antioxidant defenses of asthma patient, Piper longum extract (20% Piperine) showed a potent antioxidant activiy by scavenging Nitric oxide to prevent the bronchial inflammation in asthmatic patients.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.
The effects
Study of bacterial infections causes of frequent respiratory infections, including bacterial infections provoke asthma attack, showed a positive effect of Piper Longum L. Extract (20% Piperine) in exhibition of a moderate activity antibacterial activity against selected strains, such as Haemophilus influenzae , Streptococcus pneumoniae , Streptococcus pyrogene and Staphylococcus aureus. In the study of antioxidant defenses of asthma patient, Piper longum extract (20% Piperine) showed a potent antioxidant activiy by scavenging Nitric oxide to prevent the bronchial inflammation in asthmatic patients.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
Thursday, 3 April 2014
Skin aging in Vitamin C points of view
Kyle J. Norton
Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support. In skin aging, the vitamin may improve solar radiation protection and epidermal aging(1) through production of collagen due to its antioxidant activity(2)(3).
Epidemiological studies, linking vitamin C in prevention of skin damage and aging have produced some certain results(3a)(3b)(3c), but the large sample size and multi canters studies are necessary to validate it effectiveness.
1. Plasma levels of vitamin C
L-ascorbic acid, was known for its effects on skin-whitening and against anti-oxidation causes of skin aging. During the aging process, levels of vitamin C was found slowly deplete, according to Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice turnover during 3 to 30 months of aging(4). Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes, through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).
Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6) and the 1Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise(7).
2. The effects
According to the Minghsin University of Science and Technology, in doses dependent manner, concentration of L-ascorbic acid, induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up the spots(8). Ascorbic acid (AA) is essential in stimulation for collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). The Chiang Mai University study also supported the effects of ascorbic acid in anti-aging process through exhibition pro and active MMP-2 inhibitory(10). Other study suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). The Bruce and Associates study also insisted the effectiveness of vitamin C application over 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with 100% of satisfied overall appearance of tested subject skin(14).
Taken altogether, vitamin C was found to be effective in slowdown skin aging regardless to the cause, through its antioxidant status, down regulated the expression of Matrix metalloproteinase (MMPs) and enhanced production of collagens. Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(15)(16). As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Active ingredients against human epidermal aging by Lorencini M1, Brohem CA2, Dieamant GC2, Zanchin NI3, Maibach HI(PubMed)
(2) CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C? by Barbosa NS1, Kalaaji AN2.(PubMed)
(3) The science behind vitamins by Linder J.(PubMed)
(3a) Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skin by Xu TH1, Chen JZ, Li YH, Wu Y, Luo YJ, Gao XH, Chen HD(PubMed)
(3b) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(3c) Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein by Akhtar N1, Yazan Y(PubMed)
(4) Ascorbic acid levels in various tissues, plasma and urine of mice during aging by Iwama M1, Amano A, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(5) Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells by Xu P1, Lin Y, Porter K, Liton PB(PubMed)
(6) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis by Chaganti RK1, Tolstykh I2, Javaid MK3, Neogi T4, Torner J5, Curtis J6, Jacques P7, Felson D4, Lane NE8, Nevitt MC9; Multicenter Osteoarthritis Study Group (MOST)(PubMed)
(7) Trade-offs between anti-aging dietary supplementation and exercise by Mendelsohn AR1, Larrick JW(PubMed)
(8) [The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(9) Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts by Kishimoto Y1, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(10) Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of Longkong (Lansium domesticum Correa) leaf extracts for anti-aging by Manosroi A1, Kumguan K, Chankhampan C, Manosroi W, Manosroi J.(PubMed)
(11) Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations by Gianeti MD1, Gaspar LR, Camargo FB Jr, Campos PM.(PubMed)
(12) Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. by Segall AI1, Moyano MA.(PubMed)
(13) Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy by Raschke T1, Koop U, Düsing HJ, Filbry A, Sauermann K, Jaspers S, Wenck H, Wittern KP.(PubMed)
(14) Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin by Bruce S1, Watson J(PubMed)
(15) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
Skin aging is one of most visible ageing process which occurs constantly in our skin organ. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a). Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support. In skin aging, the vitamin may improve solar radiation protection and epidermal aging(1) through production of collagen due to its antioxidant activity(2)(3).
Epidemiological studies, linking vitamin C in prevention of skin damage and aging have produced some certain results(3a)(3b)(3c), but the large sample size and multi canters studies are necessary to validate it effectiveness.
1. Plasma levels of vitamin C
L-ascorbic acid, was known for its effects on skin-whitening and against anti-oxidation causes of skin aging. During the aging process, levels of vitamin C was found slowly deplete, according to Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice turnover during 3 to 30 months of aging(4). Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes, through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).
Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6) and the 1Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise(7).
2. The effects
According to the Minghsin University of Science and Technology, in doses dependent manner, concentration of L-ascorbic acid, induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up the spots(8). Ascorbic acid (AA) is essential in stimulation for collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). The Chiang Mai University study also supported the effects of ascorbic acid in anti-aging process through exhibition pro and active MMP-2 inhibitory(10). Other study suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). The Bruce and Associates study also insisted the effectiveness of vitamin C application over 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with 100% of satisfied overall appearance of tested subject skin(14).
Taken altogether, vitamin C was found to be effective in slowdown skin aging regardless to the cause, through its antioxidant status, down regulated the expression of Matrix metalloproteinase (MMPs) and enhanced production of collagens. Daily ingestion of high-dose vitamin C may be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(15)(16). As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Active ingredients against human epidermal aging by Lorencini M1, Brohem CA2, Dieamant GC2, Zanchin NI3, Maibach HI(PubMed)
(2) CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C? by Barbosa NS1, Kalaaji AN2.(PubMed)
(3) The science behind vitamins by Linder J.(PubMed)
(3a) Split-face study of topical 23.8% L-ascorbic acid serum in treating photo-aged skin by Xu TH1, Chen JZ, Li YH, Wu Y, Luo YJ, Gao XH, Chen HD(PubMed)
(3b) Use of topical ascorbic acid and its effects on photodamaged skin topography by Traikovich SS.(PubMed)
(3c) Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein by Akhtar N1, Yazan Y(PubMed)
(4) Ascorbic acid levels in various tissues, plasma and urine of mice during aging by Iwama M1, Amano A, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(5) Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells by Xu P1, Lin Y, Porter K, Liton PB(PubMed)
(6) High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis by Chaganti RK1, Tolstykh I2, Javaid MK3, Neogi T4, Torner J5, Curtis J6, Jacques P7, Felson D4, Lane NE8, Nevitt MC9; Multicenter Osteoarthritis Study Group (MOST)(PubMed)
(7) Trade-offs between anti-aging dietary supplementation and exercise by Mendelsohn AR1, Larrick JW(PubMed)
(8) [The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy].[Article in Chinese] by Yang BW1, Lin YM, Wang SY, Yeh DC.(PubMed)
(9) Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts by Kishimoto Y1, Saito N, Kurita K, Shimokado K, Maruyama N, Ishigami A.(PubMed)
(10) Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of Longkong (Lansium domesticum Correa) leaf extracts for anti-aging by Manosroi A1, Kumguan K, Chankhampan C, Manosroi W, Manosroi J.(PubMed)
(11) Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations by Gianeti MD1, Gaspar LR, Camargo FB Jr, Campos PM.(PubMed)
(12) Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. by Segall AI1, Moyano MA.(PubMed)
(13) Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy by Raschke T1, Koop U, Düsing HJ, Filbry A, Sauermann K, Jaspers S, Wenck H, Wittern KP.(PubMed)
(14) Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin by Bruce S1, Watson J(PubMed)
(15) Fatal vitamin C-associated acute renal failure by McHugh GJ, Graber ML, Freebairn RC.(PubMed)
(16) Ascorbic acid overdosing: a risk factor for calcium oxalate nephrolithiasis by Urivetzky M, Kessaris D, Smith AD.(PubMed)
Herbal Calendula and Neuroprotective effects
4. Herbal Calendula and Neuroprotective effects
Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Neuro protective effect is defined of a protection against harmful of the brain.
In 3-NP-induced neurotoxicity in rats, Calendula officinalis Linn. flower extract (COE) showed asignificantly attenuated behavioral alterations, oxidative damage and striatal neuronal loss, probably through its antioxidant, anti-inflammatory and estrogenic properties(1). Monosodium glutamate (MSG) a popular flavour enhancer used in food industries may cause neurotoxicity if excess intake.
In neurotoxic mice induced by excess intake of MSG, the similar extract also significantly attenuated behavioral alterations, oxidative stress, and hippocampal damage(2)
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats by Shivasharan BD1, Nagakannan P, Thippeswamy BS, Veerapur VP, Bansal P, Unnikrishnan MK(PubMed)
(2) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats by Shivasharan BD, Nagakannan P, Thippeswamy BS, Veerapur VP(PubMed)
Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Edema is a condition of accumulation of fluid in the interstitial spaces, causes of swelling in the feet, ankles and legs.
Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Neuro protective effect is defined of a protection against harmful of the brain.
In 3-NP-induced neurotoxicity in rats, Calendula officinalis Linn. flower extract (COE) showed asignificantly attenuated behavioral alterations, oxidative damage and striatal neuronal loss, probably through its antioxidant, anti-inflammatory and estrogenic properties(1). Monosodium glutamate (MSG) a popular flavour enhancer used in food industries may cause neurotoxicity if excess intake.
In neurotoxic mice induced by excess intake of MSG, the similar extract also significantly attenuated behavioral alterations, oxidative stress, and hippocampal damage(2)
Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way
If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats by Shivasharan BD1, Nagakannan P, Thippeswamy BS, Veerapur VP, Bansal P, Unnikrishnan MK(PubMed)
(2) Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats by Shivasharan BD, Nagakannan P, Thippeswamy BS, Veerapur VP(PubMed)
Phytochemical allicin and Osteosarcoma
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.
The health benefits
Phytochemical compounds derived from garlic such as Allicin, diallyl thiosulfinate, have been drawn of interest in cancer treatment research. In the study of the effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo, found that treatment with artesunate and allicin enhanced the synergistic effects on osteosarcoma cell proliferation and apoptosis. diallyl sulfide (DAS) derived from allicin, in the study of its effect on proliferation of human osteosarcoma
MG-63 cells, showed to significantly suppress the growth of MG-63
tumor-bearing tissue. Immunohistochemistry in different concentrations
(20 and 40 μg/mL) and decrease microvessel density (MVD) of MG-63
tumor-bearing tissue by suppressing the expression of Vascular
endothelial growth factor (VEGF) mRNA.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)
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