Herbal Cat's claw and Cancers

Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae. It has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Ingredients
The chemical constustuents of Cat's claw include, ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine, etc.

The benefits
Cat's claw (Uncaria tomentosa), the popular herb has emerged in scientific community in searching of organic chemical constistuents in treating cancers. Study of ethanol extract from the bark of the herb in different concentrations is found to be effective  in inhibiting proliferation of cervical carcinoma, breast carcinoma and lung carcinoma (A-549) with little of adverse effects. In the isolation of pentacyclic oxindole alkaloid mitraphylline from the dried inner bark of Cat's claw, concentrations of mitraphylline (5 microM to 40 microM) inhibited the proliferation of human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines in a dose-dependent manner. With that result in mind, the herb may be a potential agent in treating certain types of human cancers in the future.



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Side effects
1. It may cause allergic reaction, including itching, rash and allergic inflammation of the kidneys, etc. to certain people, according to the article of `Uncaria Tomentosa`by Wikipedia(a)
2. If you are taking blood pressure medicines, blood-thinning medications, hormones, or insulin do not take cat's claw
3. Do not take Cat's claw if you are pregnant or breast feeding with out approval of your related field specialist
4. Do not take cat’s claw if you have low blood pressure or an autoimmune disease (such as lupus or multiple sclerosis) or have had an organ or bone marrow transplant.
5. Etc.

References
(1) Topical plant data base (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)

Herbal Catnip (Nepeta cataria) and anti-microbial activity

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia. It has been use in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

The benefits
 Chemical composition of essential oil from N. cataria found that the chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) were effective in exerting theirs anti microbial activity against all tested bacteria at concentrations of 0.125-4 μL/mL. and inhibited the growth of Candida species at a concentration less than 1 μL/mL. Other in the study of the anti bacterial effect of some herbs, including Catnip, found that Lavender oil is more effective in exhibition of antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic values of essential oil components.

Side effects
 1. Overdose of Catnip may cause central nervous system depression.
2. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased the susceptibility to seizures.
3. Catnip may interacts with other medication if used  on a daily basis
4. Etc.


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References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi,  and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)

Herbal Cayenne and weight loss

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

Ingredients
The chemical constituents of Cayenne include capsaicin,  capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

The benefits
The prevalence of obesity is widespread in the Western world. In US, approximately 68% of the population are either over weight or obese. Weight loss with little or no side effects of organic chemical compound from plants have gone under extensive research. Capsaicinoids are a group of chemicals found in Cayenne, may have a potential benefits in relation to weight management. In fact, Capsaicinoids has exerted induced weight loss activities through increased energy expenditure, increased lipid oxidation and reduced appetite of which may be caused stimulation of the TRPV1 receptor. Other in the study of the same, suggested that a minimum dose of 2mg of capsaicinoids is needed to contribute to reductions in ad libitum energy intake and daily consumption of capsaicinoids may contribute to weight management through reductions in energy intake.

The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.
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References
(1) "Severe pepper allergy in a young child" by Gimenez L, Zacharisen M(PubMed))
(2) Mechanisms underlying the hypertensive response induced by capsaicin" by Dutta A, Deshpande SB.(PubMed)
(3) Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures" by Gupta PJ.(PubMed)
(4) Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence by Whiting S, Derbyshire E, Tiwari BK.(PubMed)
(5) Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data.

Whiting S¹, Derbyshire EJ², Tiwari B³.(PubMed)

Herbal Arctostaphylos uva-ursi and Gastric Cancer

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to the northern North America, Asia and Europe. The herb has been used in traditional medicine as diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

Stomach cancer or gastric cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins,  phenolic glycosides and flavonoids.

The benefits
Ursolic acid, extracted from bearberry has found to exert its effect in inhibition of cell growth and induction of apoptosis in gastric cancer. The induction of gastric cell apoptosis through a a translocation of cofilin-1 protein (involved in the translocation of actin-cofilin complex) from the cytoplasm (the substance that fills the cell.) to the mitochondria (The power sources) to promoted the release of cytochrome c (a small heme protein found loosely associated with the inner membrane of the mitochondrion) from the mitochondria to the cytoplasm, thereby activating the caspase cascade (routes from cell surface and the other from mitochondria) and finally inducing apoptosis of gastric cancer BGC-823 cell line. These suggested that the mitochondrial translocation of cofilin-1 might play a crucial role in the promotion of apoptosis and might be a key target for future treatment of human gastric cancer.

The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medicine, including diuretic
3. Do not use the herb in new born, children or if you are pregnant or breast feeding without approval from the related field specialist.
4. Etc.

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References
(1) Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid by Tang Q, Ji Q, Tang Y, Chen T, Pan G, Hu S, Bao Y, Peng W, Yin P.(PubMed)

Herbal Arctostaphylos uva-ursi and Diabetes Symptoms

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to the northern North America, Asia and Europe. The herb has been used in traditional medicine as diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins,  phenolic glycosides and flavonoids.

The benefits
Arctostaphylos uva-ursi, one of the herbal plant used in treating diabetes was tested in streptozotocin diabetic mice with treatments supplied as 6.25% by weight of the diet for 9 days, showed to counter some of the symptoms of streptozotocin diabetes, as the herb retarded the body weight loss but treatments showed no significantly altered plasma glucose or insulin concentrations and without affecting glycemic control.


The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medicine, including diuretic
3. Do not use the herb in new born, children or if you are pregnant or breast feeding without approval from the related field specialist.
4. Etc.



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References
(1) Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice by Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR.(PubMed)

Serum Potassium and nonalcoholic fatty liver disease

Dietary Minerals are the group of minerals essential for our body to sustain normal functions and physical health.
In General, potassium is a very essential mineral to the human body for maintaining to build proteins and muscle, break down carbohydrates, maintain normal body growth and normal heart electricity, etc.
Fatty liver disease.
Fatty liver disease is defined as a condition of accumulation of fat in the liver, including people who drink little or no alcohol (Non alcohol fatty disease) or who are excessive alcohol drinking (Alcohol fatty liver disease). The disease can even occur after a short period of heavy drinking (acute alcoholic liver disease). More than 15 million people in the U.S. either abuse or overuse alcohol with fatty liver diseases with fat makes up 5-10 percent of liver weight.
Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of clinical conditions, actually representing an emerging disease of great clinical interest(4).

The benefits
Nonalcoholic fatty liver disease (NAFLD) are associated to increased risk of metabolic syndrome. In the study of in 8592 subjects with NAFLD (30·3%) and gradually decreased across serum potassium quartiles, to investigate the association of serum potassium with the risk of prevalent NAFLD. The result showed a significant relation between serum potassium level and NAFLD in women, younger subjects, those with insulin resistance and central obesity. Other in the study to investigate the association between NAFLD and primary aldosteronism (PA), and to identify determinants of NAFLD in this condition, showed that Serum potassium was lower in primary aldosteronism (PA) than in LREH patients with NAFLD (P < 0.001), while it was similar in PA and LREH patients without NAFLD.


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References
(1) Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabolic disorders by Sun K, Lu J, Jiang Y, Xu M, Xu Y, Zhang J, Xu B, Sun J, Sun W, Ren C, Liu J, Wang W, Bi Y, Ning G.(PubMed)
(2) Nonalcoholic fatty liver disease in primary aldosteronism: a pilot study by Fallo F, Dalla Pozza A, Tecchio M, Tona F, Sonino N, Ermani M, Catena C, Bertello C, Mulatero P, Sabato N, Fabris B, Sechi LA.(PubMed)
(3) Review article: the diagnosis of non-alcoholic fatty liver disease -- availability and accuracy of non-invasive methods by Festi D, Schiumerini R, Marzi L, Di Biase AR, Mandolesi D, Montrone L, Scaioli E, Bonato G, Marchesini-Reggiani G, Colecchia A.(PubMed)

Antioxidant Melatonin and Non alcoholic fatty liver disease

Melatonin supplement, a synthetic product of the vertebrate pineal gland was sfound to have significantly broader actions including oncostatic effects (Blask et al., 2002), immunesystem stimulation (Guerrero & Reiter, 2002)and anti-inflammatory functions.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

The benefits
In the study to investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease (NAFLD), Melatonin was ineffective in reverse the abnormal action of lipid accumulation and in enhancing normal lipidemic serum markers, but it enhanced the antioxidant effects by protecting the liver against the peroxidation and oxidative stress in liver tissue as well as a significant increasing of glutathione.

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The side effects of Melatonin may include nightmares, nausea, abdominal issues, an altered sleep pattern, etc.

References
(1) Melatonin as an antioxidant: biochemical mechanisms andpathophysiological implications in humans (Acta, Biochimica, Polonica)
(2) Melatonin attenuates high fat diet-induced fatty liver disease in rats by Hatzis G, Ziakas P, Kavantzas N, Triantafyllou A, Sigalas P, Andreadou I, Ioannidis K, Chatzis S, Filis K, Papalampros A, Sigala F.(PubMed)