Monday, 2 December 2013

Hydrocephalus Treatment In Traditional Chinese medicine perspective

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

Treatments
In Traditional Chinese medicine perspective
 According to the article of Hydrocephalus posted on Dicovery TCM, Hydrocephalusis a result of

1. Deficiency of the kidney qi
a. Main symptoms and signs 
Marked enlargement of skull, widened fontanel with separation of sutures,sluggish expression, dimness in the eyes, dropping eyeballs like "the setting sun", large anteverted head with thin neck, strabismus, vomiting and convulsion in severe cases, whitish complexion, poor appetite, loose stools, pale tongue with a little fur, weak pulse and bluish superficial venule of index finger. 
b. Therapeutic method   
Tonifying  the kidney and marrow. 
c. Prescription and drugs  The prescription used is the modified Bushen Dihuang Pill (Rehmannia Pill for Tonifying the kidney) composed of 10 g of Shudihuang ( Radix Rehmanniae Praeparata ), 10 g of Shanyao (Rhizoma Dioscoreae ), 10 g of Shanzhuyu ( Fructus Corni), 10 g of Fuling (Poria), 10 g of Zexie (Rhizoma Alismatis), 10 g of Mudanpi ( Cortex Moutan Radicis), 6 g of Niuxi (RadixAchyranthis Bidentatae), 6 g of Lujiaojiao (colla Comus Cervi) (melted) and 6 g of Danggui ( Radix Angelicae Sinensis ) 
Modification  For the patients with concurrent talantropia, strabismus or blurred vision, 10 g of Gouqizi (Fructus Lycii), 8 g of Tusizi (Semen Cuscutae), 10 g of Juemingzi ( Semen Cassiae ) and 10 g of Juhua ( Flos Chrysanthemi) are added.
2. Hyperactivity of the liver due to asthenia of the kidney
a. Main symptoms and signs  
Separation of skull sutures, large and wide anterior fontanel, dropping eyeballs with more white than black, brightless eyes, dry mouth, dysphoria, feverish palms and soles, muscular twitching and cramp, occasional scream, red tongue,deep, thready and rapid pulse and purplish superficial venule of index finger
b.Therapeutic methods  
Nourishing the kidney yin, calming the liver yang to stop wind. 
c. Prescription and drugs The prescription used is the modified Zhibai Dihuang Pill in combination with Sanjia Fumai Decoction composed of 6 g of Shudihuang (Radix Rehmanniae Praeparata), 10 g of Shanyao (Rhizoma Dioscoreae), 8 g of Shanzhuyu (Fructus Corni), 10 g of Fuling ( Poria ), 6 g of Zexie ( Rhizoma Alismatis ), 10 g of Guiban ( Plastrum Testudinis) ( to be decocted first), 6 g of Zhimu (Rhizoma Anemarrhenae), 3 g of Huangbai ( Cortex Phellodendri), 6 g of Ejiao ( Colla COrii Asini) and 12 g of Baishaoyao (Radix Paeoniae Alba ). 
Modification  For the patients with fever due to yin deficiency, 6 g of Yuzhu (Rhizoma Polygonati Odorati) and 6 g of Baiwei (Radix Cynanchi Atrati ) are added; for the patients with dysphoria, 3 g of Hupofen (powder of Succinum) (taken separately) and 15 g of Zhenzhumu (Concha Margaritifera Usta) (to be decocted first) are included; for patients with muscular twitching and cramp, or occasional scream, 6 g of Tianma ( Rhizoma Gastrodiae ), 10 g of Gouteng ( Bamulus Uncariae cum Uncis) (to be decocted later) and 10 g of Baijiangcan (Bombyx Batryticatus) are added.
3. Water retention due to asthenia of the spleen
a. Main symptoms and signs Wide and large fontanel, separation of fontanel sutures, whitish complexion,lassitude, poor appetite, loose stools, epigastric and abdominal distension, pale tongue with whitish and thin or whitish and greasy fur, thready and weak pulse and light red superficial venule of index finger.
b. Therapeutic method  
Warming the spleen to promote water metabolism.
c. Prescription and drugs  The prescription used is the modifided Fuzi Lizhong Decoction (Aconite Decoction for Regulating the Middle Energizer) in combination with Wuling Powder (Five-ingredient Powder with Poria) composed of 3 g of Renshen (Radix Ginseng), 10 g of Baizhu (Rhizoma Atractylodis Macrocephalae), 6 g of Ganjiang (Rhizoma Zingiberis), 3 g of Zhifuzi ( Radix Aconiti Praeparata) (to be decocted first), 10 g of Zhuling (Polygorus Umbellatus), 10 g of Fuling (Poria), 6 g of Zexie (Rhizoma Alismatis ) and 6 g of Guizhi ( Ramulus Cinnamomi )
Modification  For the patients with poor appetite, 10 g of Jiaoshanzha (carbonized Fructus Crataegi), 10 g of Jiaomaiya (carbonized Fructus Hordei Germinatus ) and 10 g of Jiaoshenqu (carbonized Massa Fermentata Medicinalis) are added; for the patients with loose stools,6 g of Cheqianzi ( Semen Plantaginis) (to be wrapped) and 10 g of Shanyao (Rhizoma Dioscoreae) are included; for the patients with vomiting, 6 g of Banxia (Rhizoma Pinelliae ) and 6 g of Zhuru ( Caulis Bambusae in Taeniam) are added; for the patients with yang deficiency of the spleen and kidney, poor appetite and loose stools,Kidney-regulating Powder may be applied. The powder is composed of 10 g of Shanyao (Rhizoma Dioscoreae), 3 g of Renshen (Radix Ginseng), 10 g of Baifuling (Poria), 10 g of Fushen (Poria cum Ligno Hospite ), 10 g of Baizhu (Rhizoma Atractylodis Macrocephalae), 12 g of Baishaoyao (Radix Paeoniae Alba ), 6 g of Shudihuang (Radix Rehmanniae Praeparata), 8 g of Danggui (Radix Angelicae Sinensis ), 10 g of Huangqi (Radix Astragall seu Hedysari), 6 g of Chuanxiong (Rhizoma Ligustici Chuanxiong) , 3 g of Zhigancao (Radix Glycyrrhizae Praeparata) and 10 g of Shichangpu ( Rhizoma Acori Graminei). The ingredients are ground into fine powder, 10 g of which is decocted with ginger and Chinese dates to be taken each time.
4. Stagnation of preponderant heat and toxin
a. Main symptoms and signs Gradual enlargement of skull, prominent and distending fontanel, closure of fontanel sutures with recurrent separation, dropping eyes, fever, short breath, dysphoria with cry and tantrum, flushed complexion with red lips or strabismus, spasm of limbs, dark and scanty and deep yellow urine, constipation, red tongue with yellowish fur, taut and rapid pulse, purple and sluggish superficial venule of index finger. 
b. Therapeutic methods   
Clearing away heat and removing toxin, removing blood stasis and dredging collaterals. 
c. Prescription and drugs The prescription used is the modified Xidi Qingluo Decoction (Decoction of Rhinoceros Horn and Rehmannia Root for Clearing away Heat from Collaterals) composed of 15g of Shuiniujiaopian (slices ofcornu Bubali) (to be decocted first), 10 g of Shengdihuang ( Radix Rehmanniae ), 10 g of Lianqiao ( Fructus Forsythiae ), 3 g of Dengxincao ( Medulla Junci), 10 g of Mudanpi ( Cortex Moutan Radicis ),10 g of Chishaoyao ( Radix Paeoniae Rubra ), 6 g of Taoren (Semen Persicae ) and 10 g of Baimaogen (Rhizoma Imperatae ) . 
Modification For the patients with stagnation of phlegm and heat, chest distress with nausea, red tongue with yellowish fur, 6 g of Danxing (Arisaema cum Bile), 10 g of Shichangpu ( Rhizoma Acori Graminei ) ,6 g of Dilong ( Lumbricus ) and 10 g of Tianzhuhuang (concretio silicea Bambusae ) are added; for the patients with clonic convulsion, 6 g of Quanxie (Scorpio), 10 g of Gouteng (Bamulus Uncariae cure Uncis) (to be decocted later) and 12 g of Baishaoyao (Radix Paeoniae Alba) are included. For enlargement of skull, separation of fontanel sutures without closure, visible local bluish superficial venules, tongue with ecchymosis, or deafness and dumbness, hypophrenia and paralysis of limbs resulted from the fact that blood stasis obstructs cerebral collaterals, constricts cerebral marrow and blocks cerebral orifices, the therapeutic method is removing blood stasis to eliminate obstructive orifices. The prescription used is the modified Tongqiao Huoxue Decoction (Decoction for Removing Obstruction from Orifices and Activating Blood Circulation) composed of 10 g of Danggui (Radix Angelicae Sinensis ), 8 g of Chuanxiong ( Rhizoma Ligustici Chuanxiong), 10 g of Chishaoyao (Radix Paeoniae Rubra), 6 g of Taoren ( Semen Persicae), 6 g of Honghua (Flos Carthami ), 10 g of Danshen ( Radix Salviae Miltiorrhizea), 8 g of Dilong (Lumbricus), O. 05 g of Shexiang (artificial Moschus) (to be infused separately),8 g of Niuxi (RadixAchyranthis Bidentatae) and 10 g of Fuling (Poria).
For more information of TCM in treating please visit  (66)

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Optimal Health And Loose Weight

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Sources
(66) http://tcmdiscovery.com/TCMDisease/Paediatrics/info/D-Treatment/20081010_231.html 

Hydrocephalus Treatment In Herbal medicine perspective

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

There is no specific herbs formula or herbs 
According to the article of Hydrocephalus by Dherbs, Hydrocephalus is a result of the building up of toxins cause of accumulations of fluid on the brain as he provide each step
1. Toxins removal
a. Blood and Lymphatic with ECHINACEA ANGUSTIFOLIA, BEET ROOT, DRAGONS BLOOD, SPIRULINA, DANDELION, BURDOCK, MANJISTHA, BITTER MELON, RED CLOVER, CHICKWEED, SASSAFRAS, AMLA FRUIT, CLEAVERS, VIDANGA, INDIGO, POKE ROOT, NETTLE, IRON WEED, CAPSICUM, RED ROOT, YELLOW DOCK, PAU D’ARCO, ANANTAMUL, SOLOMON SEAL, OLIVE LEAF, GOLDENSEAL.

b.  Cardiovascular with GARLIC, CAPSICUM, HAWTHORN BERRIES, LILY OF THE VALLEY, ARJUNA, SIBERIAN GINSENG, REISHI MUSHROOM, MOTHERWORT, DANDELION LEAF, MYRRH, GINGER, BALA, PUNARNAVA, MISTLETOE, GINGKO BILOBA, PRICKLY ASH, MULBERRY.

c. Liver and Gallbladder with MANJISTHA ROOT, ANANTAMUL, SCHIZANDRA, BEET ROOT, DANDENLION, BHUMYAMALAKI, ARTICHOKE, ROSEMARY, TURMERIC, LICORICE, BUPLEURUM, AMALAKI FRUIT, PIPPALI FRUIT, MILK THISTLE SEEDS, PEONY ROOT, BHRINGARAJ, RHUBARB, FENUGREEK, GOLDENSEAL.


d. Lungs and Respiratory with GOKSHURA FRUIT, JUNIPER BERRY, GUDUCHI, CORN SILK, CORIANDER SEED, FENNEL SEED, PUNARNAVA, UVA URSI, ASPARAGUS, BUCHU, CRANBERRY, TRIBULUS, CLEAVERS, GOLDENROD, CELERY SEED, ANANTAMUL, PARSLEY LEAF, GRAVEL ROOT, PIPSISSEWA, HORSETAIL, NETTLE.

e. Colon and Digestive Tract with SENNA LEAVES AND PODS, OAT BRAN, BARLEY GRASS, SLIPPERLY ELM, BLACK PEPPER, CASCARA SAGRADA, CARBON (ACTIVATED CHARCOAL), BUCKTHORN, HARITAKI, TURMERIC, PSYLLIUM HUSK, IRISH MOSS, ALOE VERA, GINGER, CLAY BENTONITE, POKE ROOT, CAYENNE PEPPER, HINGVASTAK.

f. Carbon (also known as Activated Charcoal) is not a formula but the residue of burnt plant matter (Willow bark) that is carbon and copper-based and therefore ELECTRICAL

2. 10 DAYS ELECTRIC GREENS COMBO REGIMEN
 10-day Cleanse that helps cleanse, build, and nourish the body at the same time. It is a unique cleanse consisting of a mix of super green foods such as alfalfa, nettle, kamut grass, blue green algae, spirulina, chlorella, and wheat grass to name a few.

3. Soften and dissolve hardened, stubborn mucus and phlegm of which can cause toxins accumulation with LICORICE, CALENDULA, MULLEIN LEAVES, RED CLOVER, QUASSIA, PLANTAIN, FENUGREEK.

4. Enhance circulation with HAWTHORNE BERRY, CAYENNE (40,000), CINNAMON, AND GINGER.

5. Release fluid with UVA URSI, LILY OF THE VALLEY, DANDELION LEAF & ROOT, CORN SILK, BILBERRY, ANISE, CELERY, FENNEL, BLACK COHOSH, MULLEIN LEAF, ROSEMARY, QUEEN OF THE MEADOW, PARSLEY, AND BURDOCK ROOT.

6. Nourish, strengthen, and tone the veins and venous system with HORSE CHESTNUT, BILBERRY, ORANGE PEEL, BUTCHER’S BROOM, GOTU KOLA, MANJISTHA, CINNAMON, GINGER, HORSETAIL, WHITE OAK BARK, LEMON PEEL, AND CALENDULA.

7. Colon and intestinal complaints and helps to maintain overall colon and intestinal health and wellbeing! with SENNA LEAVES, CHAMOMILE, GINGER, PEPPERMINT, LICORICE, and STEVIA .

8. Etc.
For more information of DHerbssolution, please visit (65). You can follow the instruction of above or prefer to my previous articles of detoxification in the general health section at this link

http://kylejnorton.blogspot.ca/p/general-health.html 

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca  


Sources
(65) http://dherbs.com/articles/hydrocephalus-439.html 

Hydrocephalus Treatment In Conventional medicine perspective

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Preventions
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

Treatment
A. In Conventional medicine perspective
A.1. Surgical treatment
In general, treatment of Hydrocephalus involves the placement of a tube made of silastic, into the cerebral ventricles to bypass the flow obstruction and drain the excess fluid into other body cavities, where the fluid can be reabsorbed. In the study of Lumboperitoneal shunts for the treatment of normal pressure hydrocephalus, Dr. Bloch O,  and Dr.McDermott MW. indicated that Studies have reported shunt complication rates up to 38%, with subdural hemorrhage rates as high as 10%. Lumboperitoneal (LP) shunts with horizontal-vertical valves (HVV) are an alternative for cerebrospinal fluid (CSF) diversion that avoids direct cerebral injury and may reduce the risk of overdrainage. They also showed that
 in 33 patients with LP-HVV shunts inserted for the treatment of iNPH from 1998 to 2009. Patients were evaluated for improvements in gait, urinary function, and dementia after shunt placement. All patients had evidence of ventriculomegaly and a positive response to pre-operative lumbar puncture or extended lumbar drainage. All 33 (100%) patients had pre-operative gait dysfunction, 28 (85%) had incontinence, and 20 (61%) had memory deficits. Mean follow-up time was 19 months. Following shunt placement, 33/33 (100%) patients demonstrated improved gait, 13/28 (46%) had improvement in incontinence, and 11/20 (55%) had improvement in memory. Shunt failures requiring revision occurred in nine patients (27%), with an average time to failure of 11 months. Infections occurred in two patients (6%). There were no neurologic complications, including no hemorrhages. Thus, LP-HVV shunt placement is a safe and effective alternative to ventriculoperitoneal shunting for iNPH, resulting in significant symptomatic improvement with a low risk of overdrainage. It should be considered as an option for the treatment of patients with iNPH who demonstrate clinical improvement following lumbar drainage(61).
Other cautioned of The incidence of infection and malfunction with an LP shunt is significantly lower than that with a VP shunt. An LP shunt is also indicated for pediatric patients, although a relatively higher incidence of malfunction is noted compared to adults(62)

A.2. Non Medical treatment
1. Occupational therapy and physical therapy
In the study to examine effectiveness of standardized occupational therapy and physical therapy assessments in detecting functional changes and predicting clinical improvement in patients with suspected normal pressure hydrocephalus undergoing cerebrospinal fluid drainage, indicated that specific occupational therapy and physical therapy assessments demonstrate sensitivity to change and predictive value with patients with suspected normal pressure hydrocephalus undergoing cerebrospinal fluid drainage(63).

2. Psycological and Speech therapy
In the review of the literature on psychic disturbance in normal pressure hydrocephalus, showed that in the 26 cases of CSF drainage, impairment of memory and concentration were always present in normal pressure hydrocephalus; behaviour disorders were very frequent and characterized by both types of frontal behaviour; the mental picture also comprised difficulties of calculation, writing, visuoconstructive praxis and, less frequently, impaired speech and reading ability. CSF drainage brought clinical improvement in 73% of the cases. Disorders of consciousness, mental function and behaviour regressed generally progressively as soon as the operation had been performed(64).

3. Etc.

Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

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Sources
(60) http://medicaladvisorjournals.blogspot.ca/2012/05/dementia-preventions-antioxidants.html
(61) http://www.ncbi.nlm.nih.gov/pubmed/22705135
(62) http://www.ncbi.nlm.nih.gov/pubmed/2362678
(63) http://www.ncbi.nlm.nih.gov/pubmed/18843422
(64) http://www.ncbi.nlm.nih.gov/pubmed/749513 

Hydrocephalus Preventions - The Antioxidants

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Preventions
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

Antioxidants to prevent Hydrocephalus(60)
D.1. Antioxidant enzymes
Antioxidant enzymes are chemical substances found in plants that can protect the body from damage of free radicals by terminating the chain reactions by removing free radical intermediates and inhibiting other oxidation reactions.
1. Catalase
Catalase is an enzyme, found in most living organisms that are exposed to oxygen helped to converse hydrogen peroxide (free radicals) to water and oxygen as a rate of 40 million molecules of hydrogen peroxide to water and oxygen each second, using either an iron or manganese cofactor.

2. Glutathione peroxidase
The function of glutathione peroxidase is to protect the organism from oxidative damage by reducing lipid hydroperoxides, an oxidation of lipid cell membranes which can easily break and form free radicals of the form RO and converting free hydrogen peroxide to oxygen and water.

3. Glutathione reductase
Glutathione reductase, an enzyme reduces pair of sulfur atoms glutathione to the a organosulfur compound form of antioxidant (consisting of three amino acids joined by peptide bonds) which helps to prevent damage of important cellular components caused by free radicals and peroxides.

4. Super oxide dismutase (both Cu-Zn and Mn)
Super oxide dismutase is an important antioxidant defense in nearly all cells exposed to oxygen by converting superoxide into oxygen and hydrogen peroxide depending on the metal cofactor such as both Cu-Zn and Mn.

D.2. Metals binding proteins 
1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood plays a role in iron metabolism. It prevents the oxidation that leads to the forming of oxidation from Fe2+ (ferrous iron) into Fe3+ (ferric iron) by exhibiting a copper-dependent oxidase activity, causing mutations in the ceruloplasmin gene cause of iron overload in the brain, liver, pancreas, and retina.

2. Ferritin
Ferritin, the protein produced by almost all living organisms, acts as a component to fight against iron deficiency and iron overload, keep in a soluble and non-toxic form and transport it to the body needs, including organs. It enhances the immune system in the presence of an infection or cancer and prevent the infectious agent attempts to bind iron to become free radicals by migrating from the plasma to within cells.

3. Lactoferrin
Lactoferrin, a multifunctional protein of the transferrin family, is one of the components of the immune system of the body by fighting against foreign invasion of bacteria and virus and lipid oxidation by inhibiting oxidation in a concentration-dependent manner even at concentrations beyond its capacity.

4. Metallotheinein
Metallotheinein, a family of cysteine-rich, low molecular weight proteins helps to bind both physiological heavy metals through the organosulfur compound of its cysteine residues. It also captures harmful superoxide and hydroxyl radicals by liberating the metal ions which were bound to cysteine.

5. Transferrin
Transferrin is a glycoprotein that binds iron very tightly but reversibly. It enhance the immune system in fighting against infection, inflammation by creating an environment low in free iron that impedes bacteria survival and cell oxidation.

6. Hemoglobin
Hemoglobin is the protein molecule in red blood cells that enhances the carrying of oxygen from the lungs to the body's tissues and return CO2 from the tissues to the lungs.
During oxidate stress, the cell membrane is protected by intraerythrocytic hemoglobin from the forming of free radical.

7. Myoglobin
Myoglobin is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates. The binding of oxygen by myoglobin is unaffected by the oxidation or chain of oxidative reaction in the surrounding tissue, thus reducing the free radicals damage caused by oxidate stress.

8. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve 
Optimal Health And Loose Weight

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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Hydrocephalus Preventions - The Phytochemicals

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Preventions
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

Phytochemicals to prevent Hydrocephalus 
C.1. Rosemarinol, is a phytochemical monophenols, found in essential oil of labiate herbs like Rosemary and also in variety of other plants.
1. Chemical stabilization of fish oil
In the study of fish oil undergoes multiple changes in its physical properties and its autoxidation occurred found that rosemary extract rich in carnosic acid to ternary blends of tocopherols, ascorbyl palmitate and lecithin or Citrem significantly retarded autoxidation, according to "Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage" by Pop F.

2. Anti-inflammatory effects
In the research of the extract of rosemary leaves from supercritical fluid extraction and its anti inflammatory effects found that the yield of 3.92% and total phenolics of 213.5 mg/g extract obtained from the most effective extraction conditions showed a high inhibitory effect on lipid peroxidation (IC(50) 33.4 μg/mL). Both the SC-CO(2) extract and CA markedly suppressed the LPS-induced production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α), as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), phosphorylated inhibitor-kappaB (P-IκB), and nuclear factor-kappaB (NF-κB)/p65 in a dose-dependent manner, according to the study of "Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves" by Kuo CF, Su JD, Chiu CH, Peng CC, Chang CH, Sung TY, Huang SH, Lee WC, Chyau CC.(51)

3. Supercritical fluid
In the investigation of rosemary extract could enhance antioxidant defenses and improve antioxidant status in aged rats found that rosemary extract produced a decrease in antioxidant enzyme activity, lipid peroxidation and ROS levels that was significant for catalase activity in heart and brain, NOS in heart, and LPO and ROS levels in different brain tissues. These observations suggest that the rosemary supplement improved the oxidative stress status in old rats, according to "Protective effect of supercritical fluid rosemary extract, Rosmarinus officinalis, on antioxidants of major organs of aged rats" by Posadas SJ, Caz V, Largo C, De la Gándara B, Matallanas B, Reglero G, De Miguel E.(52)

C.2. Gingerole
Gingerole, is also known as gingerol, a phytochemical of Flavonoids (polyphenols) found in fresh ginger. and in variety of other plants. The herb has been used to treat nausea and vomiting of pregnancy, motion sickness, rheumatoid arthritis, relieve migraine, etc.
1. Antioxidant and anti-inflammatory effects
In the investigation of the effectiveness of chemical constituents of Zingiber officinale Rosc. (Zingiberaceae)in treating oxidative stress found that compounds [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol of the herb scavenges of 1,1-diphenyl-2-picyrlhydrazyl (DPPH), superoxide and hydroxyl radicals, inhibitsof N-formyl-methionyl-leucyl-phenylalanine (f-MLP) induced reactive oxygen species (ROS) production in human polymorphonuclear neutrophils (PMN), lipopolysaccharide induced nitrite and prostaglandin E(2) production in RAW 264.7 cells, according to the study of "Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol" by Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN(53)

2. Dementia
In the study of Ginger effectiveness in treating dementia in South Asia with A 70% aqueous/methanolic extract of dried ginger (Zo.Cr) was used. Zo.Cr tested positive for the presence of terpenoids, flavonoids, secondary amines, phenols, alkaloids and saponins found that
specific inhibition of butyrylcholinesterase (BuChE) rather than acetylcholinesterase enzyme. Different pure compounds of ginger also showed spasmolytic activity in stomach fundus, with 6-gingerol being the most potent. 6-Gingerol also showed a specific anti-BuChE effect, according to "Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia" by Ghayur MN, Gilani AH, Ahmed T, Khalid A, Nawaz SA, Agbedahunsi JM, Choudhary MI, Houghton PJ.(54)

C.3.  Naringenin
Naringenin, a flavanone, belonging to the red, blue, purple pigments of Flavonoids (polyphenols) found predominantly in citrus fruits is considered as one of powerful antioxiant with many health benefits.
1. Antioxidant, radical scavenging and biomolecule activity
In the affirmation of the capacity of flavonoid naringenin and its glycoside naringin in the comparison of theirs antioxidant capacities, radical scavenging and biomolecule activities found that naringenin exhibited higher antioxidant capacity and hydroxyl and superoxide radical scavenger efficiency than naringin and both flavanones were equally effective in reducing DNA damage. However, they show no protective effect on oxidation of GSH, according to the study of "Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study" by Cavia-Saiz M, Busto MD, Pilar-Izquierdo MC, Ortega N, Perez-Mateos M, Muñiz P.(55)

2. Anti-inflammatory effects
In the evaluation of the mechanisms of action of the effective compounds. Flavone, the isoflavones daidzein and genistein, the flavonols isorhamnetin, kaempferol and quercetin, the flavanone naringenin, and the anthocyanin pelargonidin amd theirs anti-inflammatory effects found that they inhibited iNOS protein and mRNA expression and also NO production in a dose-dependent manner, according to "Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages" by Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E.(56)

3. Immunity
In the unvestigation of Naringenin, a flavonoid in grapefruits and citrus fruits and its effec in immune system found that naringenin potently suppressed picryl chloride (PCl)-induced contact hypersensitivity by inhibiting the proliferation and activation of T lymphocytes. In vitro, both of the activated hapten-specific T cells and the T cells stimulated with anti-CD3/anti-CD28 showed growth arrest after naringenin treatment, according to "A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression" by Fang F, Tang Y, Gao Z, Xu Q.(57)

C.4.  Tangeritin
Tangeritin, one of the flavones, is found in tangerine and many citrus peels
1. Neuroprotective effects
In the evaluation of neuroprotective effects of a natural antioxidant tangeretin, a citrus flavonoid and its effect on Parkinson's disease found that tangeretin crosses the blood-brain barrier. The significant protection of striato-nigral integrity and functionality by tangeretin suggests its potential use as a neuroprotective agent, according to "Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease" by Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT.(58)

2. Antioxidants
In the comparison of hand-pressed juice of polymethoxylated flavones (PMFs) and flavanone glycosides (FGs) and the peeled fruit of 'Sainampueng' tangerines ( Citrus reticulata Blanco cv. Sainampueng) antioxidant effects found that hand-pressed juice of C. reticulata Blanco cv. Sainampueng serves as a rich source of PMFs, FGs, carotenoids, and antioxidants: 4-5 tangerine fruits ( approximately 80 g of each fruit) giving one glass of 200 mL hand-pressed juice would provide more than 5 mg of nobiletin and tangeretin and 36 mg of hesperidin, narirutin, and didymin, as well as 30 mg of ascorbic acid, >1 mg of provitamin A active beta-cryptoxanthin, and 200 microg of alpha-tocopherol, according to "Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand" by Stuetz W, Prapamontol T, Hongsibsong S, Biesalski HK.(59)

C.5. Etc.  


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Sources

(51) http://www.ncbi.nlm.nih.gov/pubmed/21375325
(52) http://www.ncbi.nlm.nih.gov/pubmed/19289162
(53) http://www.ncbi.nlm.nih.gov/pubmed/19833188
(54) http://www.ncbi.nlm.nih.gov/pubmed/18812031
(55) http://www.ncbi.nlm.nih.gov/pubmed/20394007
(56) http://www.ncbi.nlm.nih.gov/pubmed/18274639
(57) http://www.ncbi.nlm.nih.gov/pubmed/20471963
(58) http://www.ncbi.nlm.nih.gov/pubmed/11726811
(59) http://www.ncbi.nlm.nih.gov/pubmed/20420369 

Hydrocephalus Preventions - The Diet

Hydrocephalus, also known as "water in the brain" is defined as complex and multifactorial neurological disorders of accumulation of cerebrospinal fluid (CSF) in the cavity of brain of that can lead to intracranial pressure inside the side, resulting of brain trauma, stroke, infection, tumor, etc.
Preventions
Other than structures abnormalities caused by genetic defects, accidence, etc., most acquired hydrocephalus can be prevented by enhancing the immune system in fighting against forming of free radicals causes of irregular cells growth and foreign invasion such virus and bacteria and reduce the risk of diseases cause of Hydrocephalus, such as dementia.

Diet to prevent Hydrocephalus
The aims of the diet is to provide sufficient nutrients to body and enhance the immune function in fighting against inflammation and weakened immune system causes of Hydrocephalus
B.1. Black beans (Phaseolus)
1. Antioxidant effect
In the evaluation of the indigestible fraction (IF)of the cooked seeds of three pulses (black bean, chickpea and lentil) and their antioxidant effect found that Condensed tannins were retained to some extent in the IF that exhibited significant antioxidant capacity. The total IF of the three pulses produced short chain fatty acids (SCFA) after 24 h of in vitro fermentation by human colonic microflora. IF from black bean and lentil were best substrates for the fermentative production of butyric acid, according to "In vitro fermentability and antioxidant capacity of the indigestible fraction of cooked black beans (Phaseolus vulgaris L.), lentils (Lens culinaris L.) and chickpeas (Cicer arietinum L.)" by Hernández-Salazar M, Osorio-Diaz P, Loarca-Piña G, Reynoso-Camacho R, Tovar J, Bello-Pérez LA.(42)

2. Molybdenum
Molybdenum cofactor is vital for human enzymes, including xanthine oxidase, sulfite oxidase, and aldehyde oxidase, Deficiency may cause
a. Prenatal brain disruption, according to the study of "Prenatal brain disruption in molybdenum cofactor deficiency" by Carmi-Nawi N, Malinger G, Mandel H, Ichida K, Lerman-Sagie T, Lev D.(43)

3. Nervous system
Protein is essential for the brain in transmitting information between themselves and cells in the other parts of the body, thus reducing the blood sugar levels from rising too rapidly after a meal, reducing the risk of nervous symptoms cause of anxiety, stress and depression, etc., according to the study of "The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function" by Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SH, Abrous DN, Montcouquiol M, Sans N, posted in PubMed (44)

B.2. Brown rice
1. Selenium
Oat contains trace minerals selenium which is essential for the healthy function of the thyroid and immune system as it increases the antioxidant defense system by fighting against the forming of free radicals and reduce the risk of irregular cells growth causes of tumor and cancer, according to the study of "Selenium in the immune system" by Arthur JR, McKenzie RC, Beckett GJ.(45)

2. Antioxidants
Beside containing high levels of magnesium which is necessary for the synthesis of fatty acids to produce energy for our body needs, it also is one of the important component of antioxidant enzyme of which increases the body in fighting against the forming of free radical, according to the study of "Analysis of antioxidant enzyme activity and magnesium level in chronic obstructive pulmonary disease (COPD)" by Kurys E, Kurys P, Kuźniar A, Kieszko R., posted in PubMed(46) 

B.3.  Asparagus 
1. Immunomodulatory activity
In the research of Roots of Asparagus racemosus Willd (Shatavari in vernacular) and its effect on immunostimulation found that asparagus racemosus root aqueous extract (ARE) also showed higher antibody titres and DTH responses. ARE, in combination with LPS, Con A or SRBC, produced a significant proliferation suggesting effect on activated lymphocytes and suggested that mixed Th1/Th2 activity of ARE supports its immunoadjuvant potential, according to "Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity: implications for immunoadjuvant potential" by Gautam M, Saha S, Bani S, Kaul A, Mishra S, Patil D, Satti NK, Suri KA, Gairola S, Suresh K, Jadhav S, Qazi GN, Patwardhan B.(47)  

2. Antioxidants
Asparagus contains some kinds of antioxidant that help to improve the immune system in fighting against the forming of radicals, thus promoting synthesis DNA and regulates cell division, according to "The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile" by Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, Di Benedetto G, Pezzino S, Bernardini R.(48) 

B.4. Leek
1. Vitamin K
Since leak contains a measure amount of vitamin K, it helps to protect against aging diseases and the under layers of the skin, thus reducing the risk of wrinkle due to aging and enhances the absorption of calcium, thus promoting the formation of healthy bones, according to the study of "Vitamin K, osteoporosis and degenerative diseases of ageing" by Vermeer C, Theuwissen E., researchers found that According to the triage theory, long-term vitamin K inadequacy is an independent, but modifiable risk factor for the development of degenerative diseases of ageing including osteoporosis and atherosclerosis.(49)  

2. Antioxidant activities
In the investigation of the methanol extract of dried skin of Allium cepa and its isolation of quercetin-3'-O-beta-D-glucoside [1] found that the antioxidant activity of 1 was evaluated in the oxygen radical absorbance capacity assay; it showed 3.04 micromol Trolox equivalents/mmol. 1 was shown to be a promising ingredient that could be useful for treating hyperpigmentation and for protecting against oxidative stress, according to "Melanin biosynthesis inhibitory and antioxidant activities of quercetin-3'-O-beta-D-glucoside isolated from Allium cepa" by Arung ET, Furuta S, Ishikawa H, Tanaka H, Shimizu K, Kondo R.(50)

B.5. Etc.   

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Sources
(42) http://www.ncbi.nlm.nih.gov/pubmed/20549791
(43) http://www.ncbi.nlm.nih.gov/pubmed/21285035
(44) http://www.ncbi.nlm.nih.gov/pubmed/20660256
(45) http://www.ncbi.nlm.nih.gov/pubmed/12730442
(46) http://www.ncbi.nlm.nih.gov/pubmed/11977322
(47) http://www.ncbi.nlm.nih.gov/pubmed/19038322
(48) http://www.ncbi.nlm.nih.gov/pubmed/18826565 
(49) http://www.ncbi.nlm.nih.gov/pubmed/21427421
(50) http://www.ncbi.nlm.nih.gov/pubmed/21812337

Sunday, 1 December 2013

Thyroid disease: Euthyroid sick syndrome as a result of Sepsis - The Risk Factors

Euthyroid sick syndrome
Euthyroid sick syndrome is defined as a condition of  low T3 low T4 syndrome. According ot the study by the Mayo Clinic, in  other word this is the abnormalities of thyroid hormone concentrations seen commonly in a wide variety of nonthyroidal illnesses, resulting in low triiodothyronine, total thyroxine, and thyroid stimulating hormone concentrations(a). Decreased triiodothyronine (T3) levels are most common. Patients with more severe or prolonged illness also have decreased thyroxine (T4) levels. Serum reverse T3 (rT3) is increased. Patients are clinically euthyroid and do not have elevated thyroid-stimulating hormone (TSH) levels(b). Causes of euthyroid sick syndrome include a number of acute and chronic conditions, including pneumonia, fasting, starvation, sepsis, trauma, cardiopulmonary bypass, malignancy, stress, heart failure, hypothermia, myocardial infarction, chronic renal failure, cirrhosis, and diabetic ketoacidosis and inflammatory bowel disease(c). Others, in the study of classified SES into 3 subgroups according to the different alterations seen in the values of T3, T4, FT3, FT4, TSH, rT3 and TBG suggested that in SES type I the diseases seen, in order of frequency, were: obstructive chronic bronchopneumopathy with acute respiratory failure, diabetic ketoacidosis, neoplasms, ischemic heart disease, cardiac failure, chronic renal failure, liver diseases, acute cerebral vasculopathies, sepsis and collagenopathies. The disease seen in the 2 cases of SES type II was obstructive chronic bronchopneumopathy with acute respiratory failure. In SES type III the diseases seen were, in order of frequency: diabetic ketoacidosis, lung diseases, ischemic heart disease, cardiac failure, peripheral arteriopathies, acute cerebral vasculopathies, neoplasms, liver diseases, acute renal failure(d).

Euthyroid sick syndrome as a result of Sepsis  
 Sepsis is defined as a condition caused by chemicals released into the bloodstream to fight the infection trigger inflammation throughout the body as a result of severe infection(a)(b). according to the study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world. Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).
The Risk factors of Sepsis 
1.  Term infants, while very low birth weight (VLBW) and preterm infants
According to the study by the  Taipei City Hospital, total of 109 episodes of sepsis were identified in 100 neonates. The incidence of sepsis was 4.06% among all NICU admissions. Most neonates with early-onset sepsis were term infants, while very low birth weight (VLBW) and preterm infants accounted for the majority of cases of late-onset sepsis(14).

2. Obesity, operative vaginal delivery and age <25 years
In the study to describe the risk of maternal sepsis associated with obesity and other understudied risk factors such as operative vaginal delivery, found that ontrolling for mode of delivery and demographic and clinical factors, obese women had twice the odds of uncomplicated sepsis (OR 2.12; 95% CI 1.14-3.89) compared with women of normal weight. Age <25 years (OR 5.15; 95% CI 2.43-10.90) and operative vaginal delivery (OR 2.20; 95% CI 1.02-4.87) were also significant predictors of sepsis. Known risk factors for maternal sepsis were also significant in this study (OR for uncomplicated and severe sepsis respectively): multiparity (OR 6.29, 12.04), anaemia (OR 3.43, 18.49), labour induction (OR 3.92 severe only), caesarean section (OR 3.23, 13.35), and preterm birth (OR 2.46 uncomplicated only)(15).

3. Elder
If you are elder, you are at increased risk of sepsis

4. Patient in intensive care and with weakened immune system
Intra-abdominal infections are a common problem for the general surgeon and major sources of morbidity and mortality in the intensive care unit(16). Other indicated that severe sepsis has emerged as a major cause of admission and mortality for hospitalized HIV/AIDS patients, significantly affecting short- and longer-term survival of critically ill HIV/AIDS patients(17).

5. Invasive devices
There is a study of indwelling intravenous polyethylene catheters as factors influencing the risk of microbial colonization and sepsis(18).

6. Obesity and alcpholism
A multivariate analysis revealed that obesity (adjusted odds ratio [aOR] 21.4; 95% confidence interval [CI] 1.8-257.5) and alcoholism (aOR 6.5; 95% CI 1.3-32.8) were important predictive factors for spinal sepsis(18a).

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Use The Revolutionary Findings To Achieve 
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Sources
(a) http://en.wikipedia.org/wiki/Sepsis
(b) http://www.mayoclinic.com/health/sepsis/DS01004 
(c) http://www.ncbi.nlm.nih.gov/pubmed/24082613 

(d) http://www.ncbi.nlm.nih.gov/pubmed/8028742
(14) http://www.ncbi.nlm.nih.gov/pubmed/19579754 
(15) http://www.ncbi.nlm.nih.gov/pubmed/22251396 
(16) http://www.ncbi.nlm.nih.gov/pubmed/23153889 
(17) http://www.ncbi.nlm.nih.gov/pubmed/20698966
(18) http://www.ncbi.nlm.nih.gov/pubmed/4931311
(18a) http://www.ncbi.nlm.nih.gov/pubmed/19632847