Thursday, 3 August 2023

#RedCabbage Processes Anti-Mammalian #Cancer Activity through Activiting the Cytototic and Inflammatory Pathways Induced Cancer Cell's DNA Damage

Kyle J. Norton

Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where the cancer begins.

As of today, researchers do not know what are the exact causes of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.

Genetic mutation of BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and the alternation of gene PTEN.that suppress the growth of tumors also increases the risk of cancers.

According to the statistic provided by the UK Cancers Research, in 2012, an estimated 14.1 million new cases of cancer occurred worldwide.

Sadly, more than 4 in ten cancers occurring worldwide are in countries at a low or medium level of the Human Development Index (HDI).

The four most common types of human cancer, occurring worldwide are
* Lung Cancer

Lung cancer is a medical condition characterized by irregular cell growth in the tissues of the lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistics, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.

* Female breast cancer
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

* Colorectal cancer
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of the cell's DNA.

Colorectal cancer is a relatively very common and slowly growing and progressing cancer.

The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.

* Prostate cancer
Prostate cancer is defined as a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth which spread to distant parts of the body. Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.
Kale is a species of Brassica Oleracea, belongings to the family Brassicaceae, native to coastal southern and western Europe. The veggie leave is highly nutritious and cultivated as foods in most parts of Europe.

In finding a potent compound for the prevention and treatment of cancers, researchers examined, in vitro cytotoxic effects and the mode of interaction of biologically synthesized Ag and Au nanoparticles (NPs) using Brassica oleracea L. var. capitata f. Rubra (BOL) against HT-1080 cancer cells and bacterial cells.

According to the tested analysis,* The Ag NPs showed a stronger free radical scavenging activity in vitro compared to the Au NPs.
* Both nanoparticles (NPs) exerted cytotoxic effects mediated through nuclear morphological changes and DNA damage.

* Intracellular localization of Ag and Au NPs induced HT-1080 cancer cell apoptosis.

These results strongly suggested that the Ag and Au NPs have easily entered and accumulated into the cytosol and nucleus to activate the inflammatory and apoptosis pathways to induce damage in cancer cell DNA.

Most importantly, Ag and Au NPs showed no clear toxic effects and no nuclear abnormalities in peripheral blood cells


Taken altogether, red cabbage may be considered a functional food for the treatment of mammalian cancer, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Interaction of silver and gold nanoparticles in mammalian cancer: as a real topical bullet for wound healing- A comparative study by Sivakumar AS1, Krishnaraj C2, Sheet S3, Rampa DR4, Kang DR1, Belal SA1, Kumar A5, Hwang IH6, Yun SI2, Lee YS3, Shim KS. (PubMed)

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