Kyle J. Norton
The good news for aging people with neurodegenerative diseases, Andrographis paniculata possesses potent anti-inflammatory activity in the expression of neurodegeneration a study by a renowned institute suggested.
Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,......
Andrographolide, a major phytochemical isolated from Andrographis paniculata, exerted significant anti-neuro deficits in reduced infarct volume with a maximum reduction of approximately 50% at a dose of 0.1 mg·kg(-1).
According to the National University of Singapore, the efficacy of the chemical compound in neuroprotective effects is the result of the suppression of NF-κB, a protein in regulated cell survival and function of microglia in the activated response to brain injuries and immunological stimuli together with the reduction in the production of inflammatory cytokines.
Dr. Chan SJ, the lead research said, "Andrographolide, given i.p. 1 h after pMCAO, reduced infarct volume with a maximum reduction of approximately 50% obtained at 0.1 mg·kg(-1)".
Octodon degus (degu) is the only wild-type South American rodent that develops Alzheimer's-like pathology with age. the progression of AD in these animals is associated with aging on the loss of cognitive function, causing a decrease in the synaptic functions and an increase in the main hallmarks of Alzheimer's disease (AD).
Natural product (Andrographolide, ANDRO), administered to aged degus (56-month old) for 3 months, in compared 2 control groups (young degus: 12-month old and aged degus: 56-month old), showed a recovery of spatial memory and learning performance, synaptic basal transmission; and enhancing the neuroprotective effect, through reduced phosphorylated tau protein and reduced amyloid beta aggregate maturation in involving neurodegeneration in Alzheimer's disease (AD) in Andrographolide, ANDRO treated subjects.
Taken together, Andrographis could be used as a functional food in potential therapy for AD-associated neural damage due to aging processes and neuropathological hallmarks of aging-related diseases such as AD.
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Sources
(1) Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischemia by Chan SJ1, Wong WS, Wong PT, Bian JS(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
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