#Allicin Suppresses the growrh of #PancreaticCancer Cells and Prolongs the Survival Rate in Vivos, Researchers Show

Kyle J. Norton

Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.
Cancer of the pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.

Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originating in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.

At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.

In Canada, the 5-year net survival including all stages of pancreatic cancer is 8%. In other words, 92% of people diagnosed with pancreatic cancer will die after 5 years.

According to the statistic provided by the American Cancer Society, every year, approximately an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.

Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet and a certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.


Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patients with a family history of the disease, compared to others.


Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".

And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. Increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".


Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

In finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.

The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized and assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin, and rIL-2 group.


Mice in each group were treated with saline, rIL-2, allicin, or a combination of rIL-2 and allicin by weekly i.v injection for four weeks.


Treatment with the allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, the combined therapy group exerted the most amounts of apoptotic cells.

The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, killing cancer cells and natural killer cells.

Furthermore, allicin and rIL-2 also increased the levels of Interferon-gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.

Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".

Taken together, allicin isolated from garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for the treatment of pancreatic cancer.

However, intake of allicin in the form of a supplement should be taken with extreme care in the prevention of overdose toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI. (PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)