Aged Garlic Extract (AGE) processes Anti #Hypertension Activity, Researchers Say

Kyle J. Norton

Garlic may be used as a chemopreventive and treatment agent against hypertension. In hypertension of 80-90% of patients with excess glucocorticoid levels, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.


Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.


In adult men and women, who participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up to 26%.


In support of the above, a randomized, placebo-controlled, clinical trial conducted on 56 CAD patients, aged 25 - 75 years old also suggested that treatment with garlic-based drugs can be an effective treatment for controlling BP in CAD patients and has no interaction with other drugs that CAD patients take, after 3 months of administration.


Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, "Aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"

In fact, in Traditional Chinese Medicine, Food Therapy, and Hypertension Control, garlic is the food recommended to be used to facilitate hypertension control. Based on a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.

Taking all together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that the garlic anti-hypertension effect may result from its anticoagulant property.


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Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3.(PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)