#Herbal #Garlic Extracts Inhibit Pathways Associated with Abnormal Hemostasis and Thrombosis, According to Studies

Kyle J. Norton

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Several sulfur-containing compounds, isolated from garlic may be very effective in the inhibition of platelet aggregation, a recent study suggested.

Antiplatelet activity is the effect of decreased platelet aggregation and inhibited thrombus formation.

According to Ochanomizu University, sulfur-containing compounds in garlic not only inhibited arachidonic acid metabolism but also suppressed aggregation in association with the function of the platelet plasma membrane.

In vitro, garlic mechanisms of action may be comparable to that of the clinically used drug clopidogrel, as the herb exerts antiaggregatory effects. Garlic extracts are acting by inhibiting the ADP pathway, an important physiological agonist of normal hemostasis and thrombosis.

Dr. MacDonald JA lead researcher said, " The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented to establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation"

Besides the sulfur compound, Ajoene, (E, Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, isolated from alcoholic extracts of garlic reversibly inhibited platelet aggregation through platelet deposition on severely damaged vessel wall but not affected platelet adhesion.
In fact, in the comparison of the effect of the Garlic Pill with Plavix on Platelet Aggregation and Bleeding Time, groups treated with 1200 or 2400 mg garlic inhibited platelet aggregation substantially, through an increased time of bleeding.

The use of garlic supplements should be taken with care for patients who are taking Anticoagulants as garlic may increase risk of bleeding. Also, patients with ulcers should consult with their doctors.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Sources
(1) Improving upon the in vitro biological activity of antithrombotic disulfides by MacDonald JA1, Marchand ME, Langler RF. (PubMed)
(2) Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets by Lim H1, Kubota K, Kobayashi A, Seki T, Ariga T.(PubMed)
(3) Antiplatelet activity of Allium ursinum and Allium sativum by Hiyasat B1, Sabha D, Grotzinger K, Kempfert J, Rauwald JW, Mohr FW, Dhein S.(PubMed)
(4) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel walls in an in vivo porcine experimental model by Apitz-Castro R1, Badimon JJ, Badimon L.(PubMed)

#Ginger and #Turmeric Mixture Are Associated with the Treatment of RA #Rheumatoid Arthritis Severity and Complications, Researchers Show

Kyle J. Norton

Ginger may have a potential effect on the prevention and treatment of rheumatoid arthritis, some scientists suggested.
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with the immune system that mistakenly attacks the joint tissue.

According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.

As of today, researchers do not know what triggers the immune system to make antibodies that attack the joint tissue. Why are people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.

However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.

In fact, lifestyle is a preventable risk factor that has been found to elevate the risk of RA in the Western world.

Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.

The Doctor's team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".

And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.

These results indicated a significant change in RA risk just by quitting cigarette smoking.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.

Application of Z. officinale extract at doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.

Continued administration for 26 days of Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.

The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.

The extract also reduced the immune system in the production of an antibody against the joint tissue.

Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.

Dr. Fouda AM, in the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".


In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.

Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.

Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.

Further analysis suggested that the protective effects of GTaq are attributed to increasing food intake and decreasing systemic inflammation and antioxidant activity in the inhibition of oxidative stress.

The finding supported the use of a ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.

However, further data collection large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)

#Avocado Oil Inhibits Parameters Associated with #HighBloodCholesterol, According to Studies

Kyle J. Norton

Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.

Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aiding the digestive tract in absorbing the nutrients for our body needs.

However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart disease and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.

People who follow the Western diet high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).

The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.

Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.

It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.

The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.

The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.

The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.


Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ, and protein expression of PPAR-γ in mediating the expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.


The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.

In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.

* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.

* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.

Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".

Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Kkarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)

#Bromelain, in the Form of Nanoparticles (NPs) Inhibits the Genes and Proteins Associated with the Risk of Skin Cancer In Vitro

Kyle J. Norton

Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.

Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.

Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.

Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risks of sun and tanning exposure.

Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size, or feel or that bleeds, a small lesion with an irregular border, and portions that appear red, pink, and white, blue or blue-black.

There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spreads and kills but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.

* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.

* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell that produced dark pigment for your skin.

Some researchers suggested that by seeking shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, and using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.

The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.

According to the tested assays, BL-loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.

In the tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.

Furthermore, the administration of NPs also exerted a significant effect on reducing the percent mortality rate and the average tumor volume.

More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to their capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.

Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".

Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect to the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.

In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.

Taken together, bromelain may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)

#Bakkenolide Isolated Herbal #Butterbur and Its #Extract Exhibit A Cytotoxic Effect Against the Onset of #Cancers, According to Studies

Kyle J. Norton

Scientists may have found a medicinal remedy for the prevention and treatment of cancer with no side effects, according to studies.

Cancer is a class of diseases in which a group of cells grow and multiply in disordered and uncontrollable ways in our body, due to the change of cellular DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ. At the 0 stage, due to the very small size of the tumor, most patients do not experience any symptoms.

However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.

Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Symptoms of cancer at this stage are totally dependent on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive-related cancers.

Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.

Some researchers in the investigation of weakened immune function in the risk of cancer suggested people with a weakened immune system lost the function
1) to stimulate the T cells' inactivation of the B cells in the production of p53, a tumor suppressor gene, or antioncogene that inhibits the cancer cell proliferation and tumor development and

2) to stimulate the production of pro-inflammatory cytokines to kill off the DNA alternated damage cells in the acute phase of inflammation.

In other words, if you have a strong immune system, your risk of cancer is substantially lower compared to the general public.

Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere. the herbal plant has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petition and iso-S-petition, etc.

The Shandong University at Weihai, on finding a natural compound for the treatment of cancer with no side effects examined a new bakkenolide isolated from Butterbur anti-cancer effects.

The new bakkenolide exerted a potent cytotoxic activity against a number of cultured human cancer cells, including human cervical carcinoma (HeLa), human breast cancer (MCF-7), and murine Lewis lung carcinoma (LLC) cell lines.

According to the National Veterinary Research and Quarantine Service in vitro methanol extract from the leaves in the rat liver epithelial cells. significantly decreased spontaneous beta-galactosidase activity and beta-galactosidase activity induced by a mutagen.

Elevated beta-galactosidase (beta-gal) enzyme activity is an indication of the tumor and metastatic expression.

All doses of the extract (0.08-100 mg/plate) decreased the reversion frequency induced by benzo (alpha)pyrene (BaP) in S. Typhimurium TA 98 of the Salmonella typhimurium.

In an additional analysis of the experiment, PJ extract showed greater cytotoxic effects on the human stomach, colon, and uterus cancer cells than on other cancer cell types and normal rat liver epithelial cells.

Furthermore, PJ significantly increased the number of gap junction proteins associated with tumor suppression in a dose-dependent manner.

Dr. the lead scientist said, "Based on these findings, PJ is suggested to contain antimutagenic and anticarcinogenic compounds".

Taken together, herbal Butterbur may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tatewakianus by Dong XW, Li RJ, Gao X, Row KH.(PubMed)
(2) Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves by Kang HG, Jeong SH, Cho JH.(PubMed)
(3) Interactions between the tumor suppressor p53 and immune responses by Menendez D1, Shatz M, Resnick MA. (PubMed)

#Herbal #Bilberry Inhibits #Obesity by Suppressing Visceral Fat Accumulation and Hyperglycemia, According to Studies

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have a herbal remedy that visceral fat accumulation in obesity, according to studies.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity is a medical condition caused by excess body fat accumulated to an extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.

Dr. Maximilian Tremmel, the lead scientist in the investigation of the economic burden of obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".

And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".

The findings strongly suggested that widespread obesity has caused significant pressure on the public health care system and an impact on the financial and economic burden.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in Aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.


During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.

Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.

Bilberry lowered the mesenteric adipose tissue mass.

Bilberry also exerted the equivalently inhibited increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.

The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity by suppressing visceral fat accumulation and hyperglycemia.

In order to reveal more information about bilberry's anti-obesity properties, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.

Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega-3 fatty acids.

According to the urinary assay, in the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.

In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.

Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.

The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma, and considered a measurement of obesity and health beyond BMI.

Taken together, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

#Tomato Protects Diabetes Against Complications Through Its Antioxidant Activity, Researchers Say

Kyle J. Norton

Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period of overexpression free radicals compared to reduced levels of antioxidants.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.

Antioxidants are stable molecules that inhibit oxidation.

Diabetes is a chronic condition of insufficient insulin entering the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged-up by cholesterol.

In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antioxidant either produced by the body or the intake of antioxidant chemical compounds from dietary sources.

Free radicals can enter our body from environmental factors, such as the air we breathe, and the foods we eat.

Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals most likely occurred in people with a weakened immune system such as the elderly due to aging.

Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".

And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural compound for the treatment of diabetes with no side effects, researchers examined the beneficial effect of tomatoes in diabetics.

Participants in the type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.

Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and a very high lipid peroxidation rate compared to the control group.

According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.

Once again, in a total of 90 subjects including type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.

Patients with type 2 diabetes have significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before the application of lycopene.

Long-term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.

In other words, long-term tomato injection protects diabetics against complications associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Effect of short-term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long-term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile, and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)