Phytochemical Indicaxanthin Blocks the Onset of Oxidative Stress

By Kyle J. Norton


Oxidative stress is a  condition associated with the long-term imbalanced ratio of free radicals and antioxidants in the body, leading to protein, lipid, and cells damage that cause chronic illness such as heart disease, stroke, and diabetes.

In other words, the condition is caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host or both.

Antioxidants are either produced by the body or injected to the body from the outside sources such as consumptions of antioxidant-rich fruits and vegetables.

Free radicals are everywhere, including the air we breathe, the food we eat and the body daily functioning such as cell metabolism.

More precisely, any chemical compound which has an oxygen molecule can become free radical after entering our body.

In healthy individuals, the antioxidant produced by the host is more than enough to counter the bombards of free radicals. However, for people with a weakened immune system such as elderly and immature immune system such as baby may need the injection of antioxidants from the outside sources.

Particularly, people with a suppressive immune system due to chemotherapy may require to intake large amounts from antioxidant-rich food regularly.

Dr. Biller-Takahashi JD and colleagues wrote, "Reactive oxygen species (ROS) are reactive molecules containing oxygen, that form as byproducts of aerobic metabolism, including immune system processes. Too much ROS may cause oxidative stress".

And, " This study shows a relationship between oxidative stress and immunity, and, from a practical perspective, shows that improving immunity and health in pacu through the administration of selenium could improve their growth performance".

However, free radicals in moderate amount are needed for body functioning, including lower blood pressure, relax blood vessels to move blood, such as nitric oxide NO.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential ingredient for the prevention of disease associated with oxidative stress, researchers investigated the effect of indicaxanthin (Ind) on 7-KC-induced apoptosis of human monocyte/macrophage THP-1 cells.

Where 7-Ketocholesterol (7-KC) has been found to induce apoptosis of macrophages, a key event in the development of human atheromas.

Based on the tested analysis, 7-KC within 24 hours of injection within showed the pro-apoptotic activity observed by the early formation of intracellular reactive oxygen species over basal levels,  NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺, with progressive depletion of total thiols.

In other words, 7-KC induced oxidative stress in the human monocyte/macrophage THP-1 cells, leading to cytotoxicity.

Interestingly, 7-KCalso inhibited the process of the redox-sensitive NF-κB against oxidation in the tested cells.

Co-incubation of 2·5 μm of indicaxanthin completely prevented 7-KC-induced pro-apoptotic events.

The efficacy of indicaxanthin was attributed to the inhibition of NOX-4 basal activity and over-expression, inhibition of NF-κB activation.

More precisely indicaxanthin promoted the THP-1 cells redox balance and Ca homeostasis, thus preventing mitochondrial damage-induced apoptosis.

Based on the findings, researchers said, " Ind, a highly bioavailable dietary phytochemical, may exert protective effects against atherogenic toxicity of 7-KC at a concentration of nutritional interest".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC. (PubMed)

Carotenoids in Different Etiologies of Chronic Liver Diseases

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical condition characterized by the reducing partly or completely the function of the liver, including liver failure.

Most common types of liver disease in the US are
* Hepatitis C (26%) is a liver disease caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

* Alcoholic liver disease (21%) is a condition caused long-term excessive alcohol drinking. It is known that years of alcohol abuse can cause the liver to become inflamed and swollen. Over time, it has been found to induce the formation of liver scars, known as cirrhosis. Cirrhosis is the final stage of liver disease.

* Hepatitis C plus alcoholic liver disease (15%)

* Cryptogenic causes (18%) is a condition with no apparent underlying reason. However, most researchers suggested that many cases of cryptogenic cirrhosis are likely caused by non-alcoholic fatty liver disease (NAFLD), a condition of fat accumulated in the liver.

* Hepatitis B and  D (15%) are liver diseases caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

Most common symptoms of liver disease are jaundice, abdominal pain and swelling, swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, or bloody or tar-colored stool, chronic fatigue and nausea or vomiting.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a natural ingredient for the treatment of chronic liver diseases, researchers examined the effects of carotenoids against reactive oxygen species and oxidative damage associated with the onset of liver damage.

Overexpression of free radical-induced oxidative stress in the liver not only induced lipid and protein oxidation but also caused the alternation of the liver cell DNA, leading to reduced function of the liver.

Dietary carotenoids as antioxidants not only protected the liver cellular metabolism but also balanced the ratio of free radical in the liver, thus preventing the onset of liver oxidative stress, the major cause of chronic liver disease, including cancer.

In other words, carotenoids enhanced the liver functioning by inactivating reactive oxygen species and obstructing lipid and protein oxidative damage, the vital prophylactic strategic molecules.

In chemical differentiation,

*  β-Carotene supplementation enhanced the levels of antioxidants in the tested subject that act as free radical scavengers such as vitamin C, glutathione, and glutathione-related enzymes against liver toxicity caused by administration of aflatoxin-B1.

Furthermore, β-Carotene also inhibited liver disease associated with both HBV and HCV by suppressing the elevation of inflammatory and oxidative conditions in hepatocytes.

* Lycopene found abundantly in tomato and products of tomato possesses antioxidant, and detoxification abilities in many epidemiological and animal studies, thus preventing liver oxidative stress induced chronic diseases.

* Lutein, another phytochemical and bioactive compound found in carotenoids has been found epidemiologically to possess a strong antioxidant activity by promoting the production liver antioxdant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione,  against diseases associated with oxidative stress including antiviral activity against hepatitis B.

* Other carotenoids such as β-Cryptoxanthin, α-carotene, fucoxanthin, and zeaxanthin also show promising effects against chronic liver injury through their antioxidant activity.

 

Taken altogether, betacyanins used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination,
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Dietary Carotenoids in Different Etiologies of Chronic Liver Diseases By Uzma Latief and Riaz Ahmad

Herbal Coltsfoot(Tussilago farfara) Anti Bacterial and Cancer Remedy

By Kyle J. Norton

Cancer is a group of cell mutated diseases caused by the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At the early, most people with cancer are asymptomatic, however, at the later, due to the size and the tumor, patients may experience the general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort and loss of appetite and localized symptoms such as severe pain and bleeding.

The exact causes of cancer are not identified. As of today, researchers do not know why one person develops cancer and another doesn’t, even they share some common risk factors of the disease.

However, most prevalent factors associated with the cancer onset are age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the types of cancer.

Some researchers suggested that the causes of cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".

And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strong indicated the risk of cancer is increased substantially in obese.

Bacteria are single-celled organisms of which only a few have been found to cause infection.
The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has made many of them resistant to antibiotics.

There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.

Most common symptoms of bacterial infection include redness and heat, swelling, fever, pain at the site of infection.

In severe cases, the patient may also experience symptoms of swollen lymph glands.

Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.


There are many risk factors associated with the onset of bacterial infection, some researchers suggested that people with a weakened immune system may increase the prevalence of bacterial infection.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of chronic disease, researchers examined the anti-bacterial and cancer effects of sesquiterpenoids from the flower bud extract of Tussilago farfara by the silver and gold nanoparticles that had a characteristic surface plasmon resonance at 416 nm and 538 nm, respectively.

According to the tested analysis, the silver nanoparticles showed better antibacterial activity (two- to four-fold enhancement) on both Gram-positive and Gram-negative bacteria comapred to the extract alone.

Furthermore, the highest antibacterial activity was obtained against vancomycin-resistant Enterococci Van-A type Enterococcus faecium.

Gold nanoparticles exerted the highest cytotoxicity against cancer cell lines, compared silver nanoparticles, particularly in human pancreas ductal adenocarcinoma cells.

Based on the findings, researchers said, "both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications.".

Taken altogether, coltsfoot may be considered a remedy for the treatment of bacterial infection and cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)

Herbal Ashwagandha Processes Lowering Cholesterol Property

By Kyle J. Norton

Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.

Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.

 Blood cholesterol can be classified into
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.

In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.

The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.

Patients with hyperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of heart disease and stroke.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.

Some researchers suggested that the hyperlipidemic prevalence in the Western world may correlate to the promotion of a high-fat diet over the past few decades.

Dr. Karam I, the lead scientist in examing the said, "Hyperlipidemia, a group of metabolic disorders characterized by the elevated levels of lipids, is a major modifiable risk factor for atherosclerosis and cardiovascular disease [5]. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Increased levels of LDL are related to the development of atherosclerosis [15,16]. 

And, "The result showed that there was a significant increase in hyperlipidemia biomarker which includes TC, TG, LDL, and HDL. There were histological changes in organs which confirm the previous result of blood lipid. That mean high fat diet successfully induces hyperlipidemia in rats, to make disease model of hyperlipidemia.".

The life-long condition of hyperlipidemia is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of heart disease, researchers examined the effects of Ashwagandha on lowering the blood cholesterol.

The study included rats induced by a high-fat diet treated by aqueous extract of fruits of Withania coagulans for 7 weeks.

According to the tested analysis during the experiment, administration of the extract showed a significantly reduced elevated serum cholesterol, triglycerides and lipoprotein levels. 

In triton induced hypercholesterolemia., the aqueous extract of fruits of Withania coagulans exerted a significantly hypolipidemic activity.

Furthermore, according to the tested analysis on the liver tissues of treated hyperlipidemic rats, the extracts also inhibited the degenerative changes, compared to hyperlipidemic controls.

Based on the findings, researchers said, "The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora mukkul".

Taken altogether, Ashwagandha may be considered a functional herb for  lowering blood cholesterol, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withaniacoagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model by Shukla K, Dikshit P, Shukla R, Sharma S, Gambhir JK. (PubMed)
(2) Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats by Hemalatha S1, Wahi AK, Singh PN, Chansouria JP. (PubMed)
(2) Induce Hyperlipidemia in Rats Using High Fat Diet Investigating Blood Lipid and Histopathology by Karam I, Ma N, Yang Y-J, and Li J-Y. (The Journal of Hematology and Blood Disorders)

Herbal Turmeric Speeds Up Skin Wound Healing

By Kyle J. Norton


The skin wound is a condition that damage the layers of the skin.

Most cases of skin wound can be treated by washing and disinfecting the wound and applying pressure to control the bleeding following by a sterile dressing or bandage. Very minor wounds may heal without a bandage.

In more serious cases, stitched by the professionals may be needed to prevent excessive bleeding.

Mose cases of the skin wound are healed within a few days or weeks.

Skin wound can be classified into 2 types

1. Abrasion is a skin injury caused by rubbing or scraping against a rough or hard surface. 

Most cases of abrasion do not involve a lot of bleeding. However, skin care must be taken to prevent infection

2. A laceration is a deep cut or tearing of your skin caused by accidents with knives, tools. Deep lacerations can induce heavy bleeding which stitches are normally required.

Symptoms of a skin wound are bruising or swelling, itching and redness. Use of over counter pain medicine and applying ice on the wound can be helpful.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of skin wound, researchers examined the effect of topical curcumin on the healing of skin wounds produced by the CO(2) laser in an animal model.

A prospective, randomized study conducted by the University of Murcia included a total of 270 wounds were made (3 wounds by animal) of 90 mice assigned to three groups (30 animals per group), with the creation of 6-mm incisions in the skin of the dorsal region by means of the CO(2) laser.

Then all mice were assigned to
* Group I, (control group) with no product applied to the resulting wound
* Group II, vehicle 5 mg/day was applied to the wound and
* Group III, topical curcumin of 5 mg/day was applied to the wound

During the experiment, researchers found that

* Incomplete re-epithelialization was found in all wounds (treated or untreated) after 2 days

* After 7 days, 73.33% of the wounds treated with curcumin presented re-epithelialization covering the entire wound, with irregular thickness; nevertheless, compared to only 37.50% of the wounds in control group and 41.67% in the vehicle group.

In inflammatory perspective, there are no significant differences regarding the resolution of the inflammatory process in any of the study groups after 2, 7, and 14 days.

These results strongly suggested that topical curcumin speeds up the healing process after 7 days. 

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the treatment of skin, pending to the confirmation of the larger sample size and multicenter human study.

Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Topical curcumin for the healing of carbon dioxide laser skin wounds in mice by López-Jornet P1, Camacho-Alonso F, Jiménez-Torres MJ, Orduña-Domingo A, Gómez-García F. (PubMed)
(2) Beneficial effect of Curcumin Nanoparticles-Hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies by Kamar SS1, Abdel-Kader DH2, Rashed LA. (PubMed)

Bromelain Normalizes the Enzymes In Blood Clots.

By Kyle J. Norton

Fibrinolysis is the condition associated with the enzymatic breakdown of the fibrin in blood clots.

Where fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade of fibrinolysis.

In other words, fibrinolysis is a process that prevents blood clots from growing to induce certain health problems such as cardiovascular disease.

Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the cover of vascular injury. However, overexpression of platelet counts in the blood is problematic to human health.

In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition which causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medication with blood thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".

These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that the converts fibrinogen to fibrin.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of fibrinolysis, researchers examined the influence of bromelain on platelet count, platelet aggregation and platelet activity in vitro.

The study included blood samples taken from the antecubital vein of 10 healthy male non-smokers. 

According to the tested observation, platelet count decreased after incubation with 2.5 and 5 mg bromelain/ml.

The levels of ADP and TRAP-6 associated with platelet aggregation  were inhibited after incubation with 2.5 mg or 5 mg compared to control. 

Interestingly, according to the flow cytometry, the percentage of the total number of platelets or unstimulated CD62P positive platelets.

In other words, under normal condition, bromelain does not have any effect on unstimulated CD62P positive platelets even with higher incubation with 5 mg bromelain/ml compared to control.

However, after TRAP-6 stimulation with platelet aggregation, the incubation with 5 mg bromelain/ml led to a remarkable decrease, compared to the untreated control.

The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition.

Based on the findings, researchers said, "The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition".

These results suggested that bromelain have a strong effect on the prevention and treatment of cardiovascular disease associated with platelet aggregation.

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of fibrinolysis,, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Thrombin generation and fibrin clot structure by Wolberg AS. (PubMed)

Onion, the Best in the Management of Surgical Wounds

By Kyle J. Norton

Surgery is a medical practice that uses operative manual and instrumental techniques on a patient to investigate or treat an injury or disease

The aim of the medical procedure is to promote bodily function,

Most common types of surgery in the US
* Appendectomy is the common surgery that removes the appendix in patients with acute inflammation of the appendix due to infection.

* Breast biopsy. A biopsy that removes breast tissue to diagnose cancer.

* Carotid endarterectomy is used to remove the blockage from carotid arteries

* Cataract surgery is to remove the cloudy lens and replace it with a clear artificial lens.

* Cesarean section or c-section help to deliver a baby by making an incision through the mother's abdomen and uterus.

* Cholecystectomy is a surgery that to remove the gallbladder.

The Atlantic General Hospital in examining the benefits and risk of surgery wrote, 

"Benefits of having surgery
• Prevention of or improvements to medical conditions caused by a patient's obesity
• Surge in energy
• Increased life expectancy
• Increased self-esteem
• Weight loss 

Risks to having surgery:
• A blood clot in a vein (Deep venous thrombosis or DVT)
• Bleeding or infection
• Bowel obstruction caused by scar tissue
• Leakage of fluid (if opting for gastric banding)
• Adverse reaction to anesthesia
• Nausea and Vomiting
• Band slippage (if opting for gastric banding)
• Gallstones
• The overall risk of death".

Please make sure that you discuss all the health benefits and risk of having surgery with your surgeon ahead of the operation.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a natural compound for the reducing scar after surgery, researchers investigated the effects of onion extract-based topical gel (Mederma, Merz Pharmaceuticals, Greensboro, NC, USA) that has been marketed as a product to improve scar appearance and texture.

The randomized, double-blinded, split-scar study including 24 patients with new surgical wounds of at least 4 cm in length was divided into two equal portions with each half treated by either onion extract gel or petrolatum ointment at the time of suture removal by applying three times daily for 8 weeks.

By comparing the efficacy between the onion extract gel and a petrolatum-based emollient (Aquaphor, Beiersdorf, Inc., Wilton, CT, USA), researchers at the Harvard Medical School showed that

* According to patients evaluated at 2, 8, and 12 weeks following initiation of treatment and a follow-up telephone interview conducted at least 11 months postoperatively, onion extract gel improved the wound healing compared to those of petrolatum-based topical agents.

* According to the paired t-test and the Wilcoxon signed rank test at the end of the experiment, there was no statistically significant difference (p < .1) between the two treatment groups.

In other words, onion extract-based topical gel demonstrated a similar effect as those of petrolatum ointment but did not improve scar cosmesis or symptomatology.

Where Petrolatum ointment has been used in standard therapy in the management of postoperative wounds.

Taken altogether, onion may be considered a remedy in the management of postoperative wounds, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study by Chung VQ1, Kelley L, Marra D, Jiang SB. (PubMed)
(2) Risks & Benefits of Surgery by The Atlantic General Hospital