Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Sunday 19 May 2019

Whole Food Tomato Suppresses the Onset of Pulmonary Diseases

By Kyle J. Norton

Pulmonary diseases are a class of disease associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.

In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.

Most common pulmonary diseases are

* Asthma

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

* Pneumothorax

Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.

* Bronchitis

Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.

* COPD (chronic obstructive pulmonary disease)

** Emphysema is a type of COPD with a long term and progressive condition that cause shortness of breath, depending to the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.

** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that cause the increased production of mucus in the lung associated with the difficulty of breathing.

*Lung cancer

Lung cancer a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers are derived from epithelial cells

* Pneumonia

Pneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumoniae or influenza viruses in most cases.

* Pulmonary edema

Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that lead to difficulty of breathing and respiratory failure.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.

Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected to the study underwent necropsy at P7d or raised in room air until adulthood (P56d). A subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.

In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.

Futhermore, in P56d, TJ increased TAC, decreased oxidative stress and reversed the hyperoxia-induced the increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.

Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".

In other words, TJ protects the lung against injury by stimulating the expression of circulation of antioxidant concentration.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)

Saturday 18 May 2019

Herbal Turmeric Enhances the Ratio of Human Gut Microbiota

By Kyle J. Norton

Gut microbiota is a community of microbes living in the gastrointestinal tract.
Believe it or not, there are over trillions of microorganisms, including at least 1000 different species of known bacteria with more than 3 million genes.

In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.

In other words, emotional problems, use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.

Dr. Ruth K. Dudek-Wicher, the lead scientists wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".

And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".

More precisely, imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.

* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obese complication.

* Failure to control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

On finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin in the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.

According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacterias.

Futhermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).

According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.

Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.

More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.

In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacterias in the colon.

Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".

Taken altogether, turmeric may be considered supplements for the prevention and treatment of imbalanced ratio of gut microbiome composition, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,

Adam Junka, and Marzenna Bartoszewicz. (PMC)

Whole Food Tomato Improves Glucose Tolerance in Diabetics in Vivo

By Kyle J. Norton

Glucose intolerance is a condition of the cluster of metabolic conditions associated with a higher than normal blood glucose levels.

Glucose tolerance is a test that examines how fast glucose is cleared from the blood.

Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the conditions of elevated blood glucose that is below the diabetes

* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L

* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.

Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.

Most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,

Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.

Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".

And "The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes induced by a high-saturated-fat (HSF) diet in vivo.

The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.

According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found non-DTP treated groups.

In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance through increasing insulin sensitivity in the tested subject.

Also, in high-fat diet (HF)-induced obese mice treated by tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.

More precisely, TVB exerted anti-diabetic effect by TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, associated with the enhanced glucose metabolism in obese mice.

The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.

Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the improvement of glucose tolerance, pending to large sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, PhD, RD. (PubMed)

Bromelain Protects the tissues On Chronic Wound Healing

By Kyle J. Norton

A chronic wound is a wound that does not heal within a predictable period of time.

It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.

In other words, any wound that does not heal with 3 months is considered a chronic wound.

According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds.

Additionally, every year, more than 305 million cases of acute, traumatic and burn wounds are treated globally.

Believe it or not, chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.

Some researchers suggested that pressure, trauma and/or lower extremity wounds, increased the bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potential causes of the conditions.

More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of the chronic wound, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.

The study included 24 patients with chronic wounds of different aetiologies.

According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.

17/24 patients showed the responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.

There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".

In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell and fibroblast proliferation moderately.

The inhibition of cell proliferation was not associated with cell apoptosis but cell cycle arrest in the G0 phase.

In the comparable tested, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.

In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.

Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".

Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of chronic wounds, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)

Phytochemical Alliin, the Best Free Radical Scavenger Against the Onset of Oxidative Stress

By Kyle J. Norton

Free radical scavengers are antioxidants that inhibit free radicals before they can cause damage to the tissues and organs.

Free radicals are unstable and high reactive atoms with a single electron in the outermost ring. Therefore, in order to maintain stable, free radicals are ready to steal or donate a single electron from other stable atoms in the body, leading to a cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

In the body, free radical is produced by cell metabolism that provides energy for body needs. Outside of the body, free radicals can be anywhere including the air we breathe and the foods we eat.

In other words, any chemical compound containing oxygen atoms can be free radicals during the process of a chemical reaction.

Most common types of free radical scavengers include

* Bilirubin
Bilirubin is a prosthetic group which breaks down molecules into smaller units to release energy, excrete them through bile and urine.

* Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria.

* Flavonoids
Flavonoids neutralize many of reactive oxygen species (ROS), including singlet oxygen, hydroxyl, and superoxide radicals.

* Thiols (R-SH)
Chemically, thiol, an organosulfur compound have strong odors resembling that of garlic plays an important in the functioning of enzyme regulation, control of gene expression, protein trafficking, and receptor signaling.

* Coenzyme Q10
Coenzyme Q10 enhances energy production by promoting the process of the production of ATP then serving as fuel for the cells and acts an antioxidant to prevent the generation of free radicals during this process.

* Vitamin A, C, E. D.
**Vitamin A
Vitamin A plays an important role that scavenges free radicals in the lining of the mouth and lungs. The vitamin also boosts the immune system in controlling free radicals, preventing oxidation of LDL and enhances the productions of insulin pancreas.

** Vitamin C
Vitamin C, an antioxidant and water soluble vitamin, vitamin C can be easily carried in the blood, The vitamin not only restores the vitamin E but also fights against the forming of free radicals.

** Vitamin E
Vitamin E not only protects muscle weakness, repairs damaged tissues, lowers blood pressure and induce blood clotting in healing wound, but also moves into the fatty medium to prevent lipid peroxidation.

** Vitamin D
vitamin D, a group of fat-soluble secosteroids is also a membrane antioxidant with the ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers examined the alliin ability to inhibit osteoclast differentiation and fusion on osteoporosis.

According to the results of the experiment, alliin showed significant effects in improvement of bone density in osteoporotic patients by inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast fusion and differentiation.in bone resorption by blocking the signaling pathway activation.

Additional differentiation of the alliin osteoporosis protective activity, researchers found that alliin decreased the generation of reactive oxygen species (ROS) by inhibiting the expression enzyme involved in the generation of free radicals.

In other words, alliin protects the bone density by decreasing the bone reabsorption and oxidative stress in the bone tissues.

Based on the findings, researchers wrote, "The overall results revealed that alliin could be a potential therapeutic agent in the treatment of osteoporosis".

Taken altogether, alliin may be considered supplements as a free radical scavenger against the onset of oxidative stress, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(2) Comparative studies of bioactive organosulphur compounds and antioxidantactivities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.) by Kim S1, Kim DB1, Jin W1, Park J1, Yoon W1, Lee Y1, Kim S1, Lee S1, Kim S1, Lee OH2, Shin D1, Yoo M. (PubMed)

Friday 17 May 2019

Herbal Turmeric Protects the Endocrine Function Naturally

By Kyle J. Norton

Scientists may have found a bioactive ingredient which protects the endocrine system integrity with no side effects, according to studies.

The endocrine system is made up of glands that produce and secrete hormones with an aim to regulate the activity of cells or organs.

In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.

Any disruption of the endocrine system can cause abnormal production of the hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.

The most common cause of endocrine dysfunction is exposure to men-make xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.

There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimic naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient which promotes the endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production of the body glands.

According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions, and signal pathways by

* Inhibiting the high levels of some hormones such as T4, leptin or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body needs.

* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.

* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress induced hormone imbalance.

* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.

The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.

Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".

Taken altogether, turmeric combined with ginger may be considered supplements for the prevention and treatment of endocrine dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)

3,3'-Diindolylmethane Suppresses the Progression of Non-alcoholic Steatohepatitis (NASH)

By Kyle J. Norton

Non-alcoholic steatohepatitis (NASH) is an advanced form of inflammatory non-alcoholic fatty liver disease (NAFLD) caused by a buildup of fat in the liver.

NASH has been found to induce the formation of scars of the liver, a leading cause of cirrhosis associated with the onset of liver cancer and liver failure.

The progression of NASH has been a leading cause of liver transplant.

Patients with NASH are asymptomatic. However, some patients may experience vague pain and discomfort in the abdomen.

The causes of NAFLD are identified. Some researchers suspected that long-term unhealthy diet accompanied by physical inactivity may have a strong impact in accelerating the onset of the disease.

Dr. Kristen Stephenson in the investigation of the western diet in the risk NAFLD, wrote, "Nonalcoholic fatty liver disease (NAFLD) is a disease of increasing interest, as its prevalence is on the rise. NAFLD has been linked to metabolic syndrome, which is becoming more common due to the Western diet".

And, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

On finding the natural ingredient for the treatment of nonalcoholic steatohepatitis (NASH), researchers at the joint investigation led by the Fudan University examined the effects of 3, 3'-diindolylmethane (DIM) on methionine-choline-deficient (MCD)-diet induced mouse nonalcoholic steatohepatitis (NASH).

NASH mice were administrated with or without DIM at different concentrations for 8 weeks

In vivo, DIM treatment alleviated hepatic steatosis and inflammation and restored the Treg/Th17 imbalance from MCD diet-induced Th17 dominance to Treg dominance.

In-vitro, instead of suppressing the expression of Th17m, DIM not only significantly promoted the expression of the mRNAs that purify spleen CD4(+) T cells, but also enhanced the immunosuppressive function of these Treg cells.

In MCD-diet mice, DIM significantly exhibited the function of CYP1A1 and CYP1B1 in metabolizing liver toxicity, whereas down-regulated those of TLR4 on CD4(+) T cells in the promotion of autoimmune inflammation, leading to Treg/Th17 imbalance.

In other words, DIM treated NASH by dramatical induction of Treg dominance to alleviate intra-hepatic inflammation.

Dr. Liu Y, the lead scientist wrote, "dietary cruciferous vegetables (containing abundant DIM) might exist as a protective factor for patients with NASH-related liver diseases".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of nonalcoholic steatohepatitis (NASH), pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance by Liu Y1, She W1, Wang F1, Li J2, Wang J1, Jiang W. (PubMed)
(2) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)