Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday 1 May 2019

Phytochemical Alliin Isolated from Garlic Gobbles Up Breast Cancer Cells in Vitro

By Kyle J. Norton

Breast cancer is the medical condition caused the irregular cell growth in the breast tissue due to the alternation of cell DNA.

According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Most cases of breast cancer begin in the cells on the surface of inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the early stage, breast cancer is a painless lump in the breast or armpit. However, at the later stage, most women with breast cancer may experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple, persistent tenderness of the breast and
unusual breast pain or discomfort.

According to statistic, the 5 years survival rate of early diagnosed breast cancer is closed to 100%.

However, in the rare case aggressive inflammatory breast cancer (IBC) that induces the growth in sheets instead of lumps and invades nearby skin, the whole breast may go suddenly red and feel hot, resembling an inflammation.

The disease only occurs in 1-6% of all breast cancer cases in the USA. Women with IBC are first treated with chemotherapy before surgery. On average, the 5-year survival rate of women diagnosed with inflammatory breast cancer is 34% compared to the early stage of breast cancer of 100%.

Out of many risk factors associated with the risk of breast cancer, the genetic proposition is one of the factors that may predict the onset of the disease.

Dr. Turnbull C, the lead scientist said, "BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional cloning. Mutational screening of genes functionally related to BRCA1 and/or BRCA2 has revealed four genes, CHEK2, ATM, BRIP1, and PALB2; mutations in these genes are rare and confer an intermediate risk of breast cancer".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, and a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural potential for the treatment of breast cancer, researchers examined the combination of garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) effect on breast adenocarcinoma MCF-7 cells.

According to Western blotting assay, alliin and PTX worked synergistically to promote and potentiate apoptosis in MCF-7 cells by inhibiting the altered expression of importin-9 (IPO9) involved in transcription, cell signaling, and cell cycle regulation.

Furthermore, the inhibition of the IPO9 expression was also found to correlate with a significant reduction in the apoptotic cell population as well as with a decrease in F-actin content in the cancer cells, leading to alteration of cell DNA and in the cortical and nuclear/perinuclear areas of the cells.

Simultaneously, the inhibition of IPO9 by alliin and PTX was also accompanied by the increased post-translational expression of CFL1 associated with the reduction of cell proliferation and metastasis.

In other words, garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) induced breast cancer MCF-7 cells death by inhibiting the protein associated with cell differentiation and division through the reduction of cell proliferation and metastasis.

The combined compound exhibited anti-MCF-7 cells activity by targeting modulating the cytoskeleton present in the cytoplasm of cancer cells through some aforementioned mechanisms.

Taken altogether, alliin used alone or combined with primary medicine may be used for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel by Izdebska M1, Grzanka D2, Gagat M1, Hałas-Wiśniewska M1, Grzanka A. (PubMed)
(2) Genetic predisposition to breast cancer: past, present, and future by Turnbull C1, Rahman N. (PubMed)

Herbal Turmeric's Curcumin, Protects the Blood Vessels Against the Onset of Stroke, in Vivo

By Kyle J. Norton

A stroke is a medical condition caused by poor blood flow to the brain, leading to the death of the neurons.

Besides cancer and heart diseases, stroke is the third leading cause of death in the US. According to the statistics, approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.

The causes of stroke are either associated with plaque build-up on the arteries, leading to reduce blood flow to the brain, depending on the location of an obstruction or the breaking of small blood vessels in the brain.

In other words, strokes can be classified into 2 types
* Ischemic stroke caused by a clot or other blockage within an artery which leads to the brain.
* Hemorrhagic stroke caused by the vessel in the brain rupturing that results in blood leaking into the brain.

Stroke is caused by a number of factors. Epidemiological studies suggested high blood pressure, medical conditions such as diabetes, heart disease, smoking, age, gender ethnicity and personal or family history of stroke are some of the prevalent risk factors.

Some researchers in the examination of the rise of stroke in North American suggested that stroke may be associated with the promotion of the Western diet over the past few decades.

The American Heart Association wrote, "Western" diets consisting of red and processed meats, refined grains, sweets, and desserts may be associated with a greater risk of stroke, according to a study published in this week's rapid access issue of Stroke: Journal of the American Heart Association".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of stroke prevention scientists evaluated the protective effects of curcumin, the best-known member and is mainly extracted from turmeric preventive effect on stroke.

The study included stroke-prone spontaneously hypertensive rats (SHRsp) randomly divided into either a control group (n = 10, saline or curcumin (100 mg/kg/day)) or curcumin group (n = 10) administrated daily.

According to the tested assays, administration of curcumin significantly delayed the onset of stroke and increased the survival of SHRsp by decreasing the expression of ROS and improving endothelial-dependent relaxation of carotid arteries.

However, according to the RT-PCR and immunoblotting, curcumin showed no statistical significance in the presence of UCP2 inhibitor genipin by blocking the decrease of ROS and increase of NO production.

Where genipin is a chemical compound found in gardenia fruit extract.

In other words, in order for curcumin to exert its stroke preventive activity, curcumin cannot be consumed together with gardenia fruit.

Additionally, in the study to examine the curcumin effect during the stroke, researchers found that curcumin encapsulated in exosomes, nano-vesicles (<200 nm), shows therapeutic effects in brain diseases, such as stroke.

Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of stroke, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

(1) Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function by Lan C1,2, Chen X1,2,3, Zhang Y1,2, Wang W1,2, Wang WE1,2, Liu Y1,2, Cai Y1,2,4, Ren H1,2, Zheng S1,2, Zhou L5,6, Zeng C. (PubMed)
(2) Epigenetic impact of curcumin on stroke prevention by Kalani A1, Kamat PK, Kalani K, Tyagi N. (PubMed)
(3) Western' Diets May Be Linked To Greater Stroke Ris by the American Heart Association. (Science Daily)

Ginger, A Natural Treatment of Post-Stroke Urinary Incontinence

By Kyle J. Norton

Scientists may have found a natural ingredient for the treatment of poststroke urinary incontinence with no side effects, according to study.

Post-stroke is a condition in which a patient continues to recovery from stroke by making changes in the physical, social and, emotional aspects of his/her life.

Urinary incontinence is a condition of leakage of urine involuntarily caused by the loss or weakened of the urinary sphincter.

In other words, a person urinates when he/she does not want to.

According to the statistic, urinary incontinence affects over 30 percent of females aged 30-60 compared to 1.5-5 percent of men.

The exact cause of the loss control of urinary sphincter is not identified. However, epidemiological studies suggested gender, smoking, obesity, and persistent stress are some of the potential risk factors associated with the condition.

Treatment of urinary incontinence is totally depending on the severity of the syndrome. Bladder control such as delaying the event, double voiding and toilet timetable and floor exercise have been found to be effective to many patients urinary incontinence.

Some patients may require the assistance of medication, including anticholinergics and Imipramine accompanied by bladder control and floor exercise.

Some researchers suggested the increase in age may be correlated to the onset of UTI as a large percentage of older adults were found to have UTI compared to the general population.

Dr. George A. Kuchel, the lead scientist wrote, "The prevalence of urinary incontinence (UI) increases with age. Moderate to severe UI affects 7% of women 20 to 39 yr of age, 17% 40 to 59 yr of age, 23% 60 to 79 yr of age, and 32% 80 yr of age".

And, "Nursing home residents have especially high rates of UI, ranging from 60 to 78% in women and 45 to 72% in men".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural ingredient for the treatment of urinary incontinence in post-stroke patients researchers evaluated the efficacy and safety of ginger-salt-indirect moxibustion for urge urinary incontinence after stroke.

The study included cases of cerebral apoplexy, including cerebral infarction and cerebral hemorrhage, with urination disorders induced by neurogenic bladder at the restoration stage.

Patients were randomly divided into a treatment group treated with ginger-salt-partitioned moxibustion at Shenque (CV 8) and routine acupuncture, and a control group treated with routine acupuncture.

The treatment was given 5 times each week and the therapeutic effects were observed after treatment of 3 consecutive weeks.

39 cases in the treatment group and 36 cases in the control group completed all treatments.

The ginger-salt-partitioned moxibustion treatment group showed an improvement of urinary times of each day compared to control.

The mean times on awakening of the nursing personnel at night, and mean times of urgent urinary incontinence at day for the patients, were significantly lower in the treatment group.

Furthermore, cases-times of urinary incontinence of the patient at night, and increasing degree of urinary incontinence was better than that of the control group.

In other words, the ginger-salt-partitioned moxibustion treatment group was more superior in improving all parameters associated with urination disorders in post-stroke patients

Take all together, ginger used alone or combined with other alternative therapy may be considered a functional alternative for the treatment of urinary incontinence in post-stroke patients, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Post stroke UTI
Sources
(1) Efficacy and safety of ginger-salt-indirect moxibustion for urge urinary incontinence after stroke: protocol for a pilot multicentre randomised controlled trial by Wang L1, Wang L1, Shi G1, Zeng L2, Yang Y1, Zhang T1, Liu H1. (PubMed)
(2) [Randomized controlled study on ginger-salt-partitioned moxibustion at shenque (CV 8) on urination disorders poststroke].[Article in Chinese] by Liu HL1, Wang LP. (PubMed)
(3) Chapter 30: Urinary Incontinence in the Elderly by George A. Kuchel* and Catherine E. DuBeau. (University of Connecticut Health Center)

Whole Food Tomato, The Potent Inhibitor Against Platelet Aggregation in Vitro and Vivo

By Kyle J. Norton

Platelet aggregation is a condition of platelets clumping together in the blood. The process also is also necessary for the cover of vascular injury.s

In other words, after sensing the bodily injury or damage, the immune system of the first line of defense stimulates the production of blood platelets to cover the site of injury with an aim to reduce the risk of infection.

Platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition which causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medication with blood thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find the natural ingredient for the treatment of platelet aggregation, researchers examined the anti-human platelet aggregation induced by ADP, collagen or arachidonic acid in aqueous extract of tomato.

The study included sugar-free tomato extract (TE) obtained by a heat-stable fraction with molecular mass <1,000 Da from tomatoes.was tested against the human plasma and rabbit lung.

100 g tomatoes produced 72.2 ± 4.7 mg of TE used in the experiment inhibited platelet aggregation in a dose-dependent manner.

The TE maximum effect in the inhibition of platelet aggregation was found to be at an IC50 value of was 0.4 ± 0.02 mg/ml,

Furthermore, compared to the efficacy of TE, Fruitflow(®)-2 showed similar amounts of catechin also exerted a similar inhibitory potency against platelet aggregation activity.

In order to find more information about tomato anti-cardiovascular disease activity, researchers at the University of Newcastle examined the effect of an aqueous tomato fraction (tomato extract) against platelet aggregation in vitro.

According to the tested results from assays, platelet-rich plasma prepared from human blood incubated in the presence of tomato extract, collagen-induced, and adenosine diphosphate-induced platelet aggregation was significantly inhibited by the extract, compared to those with nontreatment plasma without affecting the basal cAMP levels in platelets.

Where cAMP plays a critical role in the regulation and signaling in platelets.

Interestingly, the extract inhibition of platelet aggregation was found to be dose-dependent and increased with longer incubation times.

However, the extract showed no effect anti-platelet aggregation induced by the presence of arachidonic acid.

In other words, the tomato extract inhibits platelet aggregation associated with other mechanisms involved in cathepsin G-induced human platelet activation such as the phospholipase C/protein kinase C pathway instead of cAMP levels.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of platelet aggregation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tomato extract in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Tomato extract inhibits human platelet aggregation in vitro without increasing basal cAMP levels by Lazarus SA1, Garg ML. (PubMed)
(2) Effects of tomato extract on human platelet aggregation in vitro by Dutta-Roy AK1, Crosbie L, Gordon MJ. (PubMed)
(3) Types of platelet function disorders. Hereditary platelet function disorders can be divided into five groups depending on the type of abnormality by the Canadian Hemophilia Society

Tuesday 30 April 2019

Turmeric Protects the Nerves Against the Onset of Diabetic Neuropathy

By Kyle J. Norton

Diabetic neuropathy is a complication of patients with diabetes associated with nerves damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.

Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.

Diabetic neuropathy can be classified into 4 main types, including.

* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.

* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs and eyes.

* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks or legs.

* Mononeuropathy, or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso) or leg.

The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage of nerves and blood vessels in the affected area has been found to induce by over time, uncontrolled high blood sugar.

In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.

Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days".

In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve.” There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of de-oxygenated blood".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined the turmeric antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property.

According to the results of the experiment, turmeric inhibited the pathogenesis of diabetic neuropathy by improving the antioxidant in the reduction of the level of oxidative stress associated with the occurrence of the present complication.

Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.

In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in the antioxidant, anti-inflammatory and antibacterial activity.

In order to review more information about turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.

The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment of 12 weeks.

Selected rats were randomly divided into group I (Control) vehicle treated consists of 6 rats and

group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone and Epalrestat respectively.

Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by High Fat High Fructose diet. After confirmation of the development of diabetes; rats divided into six groups as the aforementioned division.

Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.

Taken altogether, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)

(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)

(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019

Phytochemical Betanin, the Potent Anti Prostate Cancer Remedy

By Kyle J. Norton

Prostate cancer is a medical condition associated with cell growth disorderly in the tissue of the prostate.

The prostate is a reproductive gland in men that have shape and size of a walnut located between the bladder and the penis found in front of the rectum.

The gland has a unique function in the making of prostate fluid, one of the components of semen.

Prostate cancer is one of the slowest growth of cancer in men. Prostate cancer may take years to develop before affecting the patients with symptoms.

Most cases of prostate cancer are found in older men. However,
The disease also affects men before the ages of 40.

Believe it or not, about 1 man in 9 will be diagnosed with prostate cancer during his lifetime. According to the statistics, about 6 cases in 10 are diagnosed in men aged 65 or older.

In the US, approximately 1,700,000 new cases are diagnosed every year. Prostate cancer also causes the death of 609,640 patients.

The 5-year survival rate for diagnosed at local or regional prostate cancer is nearly 100%.

Although there are many risk factors involved in the onset of the condition, some researchers suggested the widespread prostate cancer over the past few decades may correlate to the promotion of a high-fat diet in the US.

Dr. Amir Bagheri, the lead scientists in the cancer team wrote, "Prostate cancer is one of the most common types of cancer with a high mortality rate".

And, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

The findings strongly suggested that men who follow the Western diet pattern are associated with an increased risk of prostate cancer compared to those who do not.

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find an effective compound for the treatment of prostate cancer, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the androgen-independent human prostate cancer cells (PC-3).

According to the tested assays, both doxorubicin and the beetroot extract exhibited similarly a dose-dependent cytotoxic effect in the two cancer cell lines.

The cytotoxicity of the beetroot extract was significantly lower when compared to doxorubicin, however, the extract continued to decrease the growth rate of the PC-3 cells by 3.7% in 3 days vs. 12.5% in 7 days at the concentration of 29 µg/ml, compared to those of doxorubicin, at the same concentration level.

In further analysis, researchers found that the anti-prostate cancer effects of beetroot extract were attributed to the presence of betanin, the major betacyanin constituent in the exhibition of cytotoxicity.

Dr. Kapadia GJ, the lead scientists suggested the beetroot extract (B) when used alone or in combination with doxorubicin (D) may process chemopreventive potentials to mitigate the toxic side-effects of the latter.

In order to reveal more information of red beetroot (Beta vulgaris L.) anti-cancer activity researchers examined the beetroot extract (B), approved by Food and Drug Administration and European Union as red food color E162 against cancers.

In pancreatic (PaCa), breast (MCF-7) and prostate (PC-3) tumor cells of human origin, D showed an overall positive reduction in drug concentration when combined with B in its cytotoxicity profile.

The synergistic cytotoxicity was best when the B:D ratio of 1:5 was used in PaCa cells at IC50, IC75, and IC90 dose levels.

The findings strongly supported the potential use of red beetroot extract-doxorubicin combination in treating human prostate cancer.

In other words, red beetroot extracts not only processed the potential to improve the anti-cancer effects of doxorubicin through reduced volume used in prostate cancer treatment but also inhibited the doxorubicin's adverse effects.

Taken altogether, betanin used alone or combined with other medicines may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

(2) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. (PubMed)

(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, 1 , 2 Seyed Mostafa Nachvak, 1 ,* Mansour Rezaei, 3 Mozhgan Moravridzade, 1 , 2Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Bromelain Protects the Inner Lining of Colon Against Colitis

By Kyle J. Norton

Colitis is a medical condition associated with the inflammation of the inner lining of the colon.

The causes of colitis can be results of infection, inflammatory bowel disease, including Crohn's disease and ulcerative colitis, ischemic colitis, allergic reactions, and microscopic colitis.

Most common systems of colitis are total depending on the types of condition, including abdominal pain, cramping, diarrhea, with or without blood in the stool.

Some patients with colitis also experience symptoms of fever, chills, fatigue, dehydration, eye inflammation.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

According to the statistics, in the US, 1.6 million Americans are living with inflammatory bowel disease, about 907,000 of them have ulcerative colitis.

Also, according to the study by the Catholic University of the Sacred Heart, the most common types of colitis include

* Microscopic colitis is an inflammation of the large intestine (colon) that causes persistent watery diarrhea.

* Ischemic colitis is inflammation and injury of the large intestine that results from the inadequate blood supply.

* Segmental colitis is an inflammation of the colonic luminal mucosa.

* Radiation enteritis is inflammation of the intestines caused by radiotherapy.

* Diversion colitis is an inflammation of the colon associated with the complication of ileostomy or colostomy.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a natural compound for the treatment of colitis, researchers examined whether long-term dietary supplementation with pineapple (supplied as juice) could decrease colon inflammation in neoplasia in Il10(-/-) mice with chronic colitis, compared to bromelain derived from the stem.

The experiment included colitis Il10(-/-) mice induced by exposure to the non-steroidal anti-inflammatory drug piroxicam followed by supplemented with fresh vs. boiled pineapple juice or bromelain purified (14 mg bromelain) from the stem for up to 6 months.

During the study, daily treatment of fresh juice had a decreased histologic colon inflammation scores and a lower incidence of inflammation scores, compared to those treated with bromelain purified (14 mg bromelain).

Futhermore, both treatments showed fewer neoplastic lesions/colon. However, fresh juice lower incidence of inflammation-associated colonic neoplasia by 35% compared to 66% of those treated with bromelain purified (14 mg bromelain).

According to the flow cytometric analysis of murine splenocytes in vitro, fresh pineapple juice demonstrated a proteolytic removal of cell surface molecules that can affect leukocyte trafficking and activation, compared to those treated with bromelain purified.

The finding strongly supported the long-term use of pineapple juice with proteolytically active bromelain enzymes for the treatment of inflammatory induction of colitis.

Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".

Taken altogether, pineapple (supplied as juice) processed a high amount of bioactive compound bromelain may be considered supplements for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Sources
(1) Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease by Hale LP1, Greer PK, Trinh CT, Gottfried MR. (PubMed)
(2) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)