Honey, the Best for treatment of First and Second Degrees of Burns

By Kyle J. Norton

Scientists may have found a whole fruit for speeding up the healing of burns, according to studies.

Burn is skin and skin tissue damage due to heat, cold, electricity, chemicals, friction, or radiation. The condition is the most prevalent injury in the household, particularly in children.

Most cases of skin burn are healed within a few days or weeks, depending on the degree and size of the burns.

Depending on the severity, complications of deep or widespread burns may include bacterial infection (in some cases can lead to sepsis), hypovolemia (fluid loss), hypothermia (low body temperature) and breath difficulty due to the intake of hot air or smoke.

In some cases, patients with deep or widespread burns can be life-threatening. According to statistics, from Dr. ISHTIAQ AHMED CHAUDHARY in the study of burns and mortality, there is 100% mortality rate in patients with 70% total body surface area burns compared to the 100% survival rate in patients with less than 30%.

Most cases of first and second-degree burns that affect only the top layer of skin can be treated under cool running water or cool water for 15 minutes until pain subsides or taking a pain reliever and applying antibiotic cream.

Other higher degrees of burns should call 911 immediately.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers with an aim to develop a strategy for making the alginate base hydrogel components against burned wound infection examined the effect of honey in the biofilm forming bacteria colonization in burned patients.

Following the collection of the honey from three different provinces of Iran, an alginate base hydrogel was prepared by the use of calcium chloride.

In vivo, the healing activities of prepared ointment were compared in infected burned rat models. 75% diluted thymol based honey collected from Damavand province showed the greatest inhibition of bacteria in wound compared to others.

The hydrogel was also the better healing activity in rats burned wound against the bacteria biofilm-forming bacteria colonization compared to the honey application.

Additionally, in order to reveal more activities of honey, researchers investigated the medicinal honey antibacterial and immunomodulatory properties in the treatment for infected wounds.

Ras-induced burn wound selected to the study were randomly allocated into 4 experimental groups: control (C), PBM super pulsed 904 nm laser treated (PBMT), honey treated (HT) and combined treatment (CT).

The CT group demonstrated synergistically attenuated inflammation, pain and enhanced cell adhesion, migration compared to other treatment groups.

The efficacy of CT was attributed to the inhibition of the production of pro-inflammatory cytokines such as TNF-α, NF-κB, IL-1β and exhibition of molecules in the promotion of wound healing by spreading of platelets at the site of injury, fibroblasts, and endothelial cells into the wound region.

The findings strongly supports the use of the combination of medicinal honey and PBMT in accelerating the repair process of burn wounds.

Taken altogether, honey used alone or combined with other therapeutic agents may be used for speeding up wound healing with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Construction and analysis of alginate-based honey hydrogel as an ointment to heal of rat burn wound related infections by Mirzaei B1,2, Etemadian S3, Goli HR1, Bahonar S1, Gholami SA1, Karami P1, Farhadi M1, Tavakoli R. (PubMed)
(2) Combination of medicinal honey and 904 nm superpulsed laser-mediated photobiomodulation promotes healing and impedes inflammation, pain in full-thickness burn by Yadav A1, Verma S1, Keshri GK1, Gupta A. (PubMed)
(3) BURNS: FREQUENCY AND MORTALITY RELATED TO VARIOUS AGE GROUPS by Dr. ISHTIAQ AHMED CHAUDHARY 

Ginger, the Potential Anti-Aging Remedy with No Side Effects, According to Scientists

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have a vegetable with anti-aging potential, according to studies.

Aging is a natural process of becoming older. Antiaging is a term that relates to delay aging. In other words, anti-aging is an action that makes your appearance looked younger than your biological age.

The cause of aging has many theories, including the theory of the accumulation of damage due to oxidative stress in the initiation of DNA oxidation and the programmed aging concept due to DNA methylation.

However, regardless of the theories, the decrease in hormone production gradually found in the human body may be one of the major cause of aging progression.

In fact, reduced production of hormone affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.

Some researchers suggested that improved nutrients intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.

Dr. Simpson SJ, the lead scientist in the joint study led by the University of Sydney wrote, "Nearly a century of research has shown that nutritional interventions can delay aging and age-related diseases in many animal models and possibly humans".

And, "Nutritional geometry provides new perspectives on the relationship between nutrition and aging by focusing on calories, macronutrients and their interactions across a landscape of diets, and taking into account compensatory feeding in ad libitum-fed experiments".

The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, macronutrients, you may delay the process of biological aging.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural ingredient which processes anti-aging property examined the ameliorative effects of two antioxidant supplements, ginger and alpha lipoic acid (ALA), on hepatic ultrastructural alterations in old rats by evaluating the livers of young (4 months) and old (24 months) Wistar rats.

Before administration of ginger and ALA, livers of old rats showed sinusoidal collapse and congestion, endothelial thickening and defenestration, and inconsistent perisinusoidal extracellular matrix deposition and aged hepatocytes associated with the reduced liver functioning.

Injection of ginger and ALA supplementation completely normalized all the alternation due to aging in the tested old rats.

The findings strongly suggested the use of ginger and ALA as an anti-aging product for the improvement of based on their amelioration of ultrastructural alterations in livers of old rats.

Additonally, in order to get more information about ginger antiaging effects, researchers examined the anti-aging natural products, the active constituent 6-shogaol isolated from the ginger.

Application of the tested compound showed to the lifespan-extending effect in a dose-dependent manner in Caenorhabditis elegans.

The anti-aging activity effects were attributed to 6 gingerols in increasing oxidative stress tolerances via antioxidant enzymes induction.

In the depth differentiation, researchers surprisingly found that 6-shogaol inhibits the aging process independent from other aging-related factors of C. elegans.

Taken altogether, ginger processed high levels 6 gingerols may be considered a functional anti-aging  remedy, pending to the confirmation of larger sample sized and multicenter human study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans by Lee EB1,2, Kim JH1, Kim YJ1, Noh YJ1, Kim SJ1, Hwang IH1, Kim DK3. (PubMed)
(2) Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver by Mahmoud YI1, Hegazy HG1. (PubMed)
(3) Dietary protein, aging and nutritional geometry by Simpson SJ1, Le Couteur DG2, Raubenheimer D3, Solon-Biet SM4, Cooney GJ4, Cogger VC2, Fontana L. (PubMed)

Bilberry, Protects the Heart and Blood Vessels Against Cardiovascular Diseases

By Kyle J. Norton

Scientists may have found a whole fruit for the prevention and treatment of cardiovascular diseases, according to studies.

Cardiovascular diseases (CVD) are a group of conditions associated with blood vessels and the heart.

According to the statistics provided by the World Health Organization, cardiovascular diseases are the number 1 cause of death globally. Approximately, 17.9 million people died from CVDs in 2016, representing 31% of all global deaths.

Most common risk factors associated with CVD are an unhealthy diet, physical inactivity, smoking, and excessive alcohol drinking.

Patients with CVD mostly were found to have some intermediate conditions such as high blood pressure, cholesterol, and glucose and being overweight and obese.

Most common symptoms of CVD include persistent chest pain, chest tightness, chest pressure and chest discomforts, and conditions associated with lower blood circulation due to narrowing blood vessels such as shortness of breath, numbness, weakness or coldness in your legs or arms.

Some people before having a CVD may also experience symptoms of pain in the neck, jaw, throat, upper abdomen or back.

If you experience some of the symptoms aforementioned, please check with your doctor to rule out the possibility.

Some researchers suggested that people inherited the mutated gene from the parent are also at a higher risk of CVD.

Dr. Sunil K. Nadar the lead scientist in the investigation of the genetics of CVD wrote, "The term ‘cardiovascular disease’ (CVD) encompasses a wide spectrum of diseases—including ischaemic heart disease (IHD), congenital structural heart disease and various inherited arrhythmias and cardiomyopathies—each of which has its own etiology and pathogenesis".

And, "Our present understanding seems to suggest that it is not one gene on its own that leads to CVD, but rather an interaction between the effects of various genes".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the differentiation of natural compounds for the treatment of cardiovascular disease (CVD), researchers in a joint study led by the Slovak University of Agriculture in Nitra examined the effects of regular consumption of bilberries on CVD risk reduction.

Women (n=25) and men (n=11) included in the study were asked to consume 150 g of frozen stored bilberries 3 times a week for 6 weeks.

At the end of the study, the consumption of bilberries showed a significant decrease of risk factors associated with the onset of CVD, including total cholesterol (P=.017), LDL-C (P=.0347), TG (P=.001), glucose (P=.005), albumin (P=.001), γ-glutamyltransferase (P=.046), and a positive increase in HDL-C (P=.044).

In men, larger favorable changes were found in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C (P=.009) compared to women.

Interestingly, injection of bilberry over the period was not induced the favorable change but increase of LDL-C.

Dr, Habanova M, the lead scientist after taking into co and confounders, said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".

Furthermore, in order to find more information about the bilberry anti CVD effects, researchers investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).

The randomized controlled trial included participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.

Injection of bilberry juice resulted in a significant decrease in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG).

However, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) involved in the acute phase of systematic inflammation was also observed in the bilberry group.

Bilberry juice exerted a significant effect in modulating the protein associated with pro-inflammatory cytokines, through activation of a transcription factor, a crucial protein (nuclear factor- kappa B (NF-kappaB)) associated with chronic inflammatory diseases.

Interestingly, injection of bilberry juice did not induce the change of other clinical parameters, including oxidative stress or antioxidant status.

The findings suggested that bilberry reduced risk CVD by modulating the inflammation processes.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD by Karlsen A1, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, Erlund I, Laake P, Tonstad S, Blomhoff R. (PubMed)
(3) Genes and Cardiovascular Disease. Where do we go from here? by Sunil K. Nadar1,* and Kully Sandhu. (PMC)

Herbal Artichoke Improves Liver Functioning

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a herbal remedy for improvement of liver functioning, according to studies.

The liver function plays a critical role in filtering blood come from the intestinal before passing them to other organs and tissues. The reddish-brown organ also detoxes toxic chemicals and metabolizes medicine and secrete bile to the intestine for breaking down food and absorbing nutrients.

Additionally, the liver is found to process the ability to secrete proteins such as albumin, fibrinogens, and apolipoproteins into the blood for the regulation of the oncotic pressure, blood clotting, and lipoprotein metabolism, respectively.

There are many factors can disrupt the liver function including viral infection, alcohol use or obesity, leading to scar formation in the liver tissue.

Long-term untreated chronic liver infection that causes the replacement of normal liver tissue by scar tissues eventually lead to cirrhosis, a non-reversible, dangerous condition that can lead to liver failure and cancer.

At the early stage of liver disease, most patients are asymptomatic. However, as the disease progression patients may experience unspecific symptoms of loss of appetite, fatigue, general malaise, gastrointestinal discomforts or weight loss.

At the advanced stage severe on the right side of the abdomen, jaundice, pale stool, harden urine color, spiderlike blood vessels on the skin, redness in the palms of the hands.

Liver damage at this stage may cause loss of period in some women and loss of sex drive, breast enlargement or testicular atrophy in men.

In the severe case, patients also have symptoms of confusion, drowsiness and slurred speech.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

On finding a natural compound for enhancing the liver function, researchers at the Laboratoire de pharmacology examined the liver protective effects of artichoke (Cynara scolymus) leaf extract.

Injection of artichoke extract improved the liver function in the production of bile and liver lipid production and lipid recycling by lowering blood cholesterol.

In animal models, the liquid extracts of the roots and leaves of artichoke also found to demonstrate an ability to protect the liver, with possibly in enhancing liver cells regenerate.

Furthermore, administration of artichoke extract reduced the risk of cardiovascular disease by lowering risk factors associated with liver function in regulating cholesterol and triglycerides.

According to the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH), artichoke improved the function of the liver by improving liver enzymes which were significantly reduced in NASH.

Taken altogether, artichoke may have a strong implication in improving the liver function in many aspects, pending to the validation of larger sample size and multicenter studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits by Ben Salem M1, Affes H2,3, Ksouda K1, Dhouibi R1, Sahnoun Z1, Hammami S1, Zeghal KM. (PubMed)

Bilberry Cuts Off the Energy Supply to Cancers, Studies Found

By Kyle J. Norton 

Bilberry may process a unique function in blocking the formation of the new blood vessels to fuel the tumor growth, according to studies.

Angiogenesis is the development of new blood vessels from the existing vasculature. The process has occurred throughout life in human in forms of health and disease.

Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients,

In a tumor, the availability of nutrients is limited, therefore, for the tumor to survive and to grow continuously, the tumor cells induce the formation a new blood supply from the preexisting vasculature by stimulating the protein associated with the pro-angiogenesis and facilitation of angiogenesis, such as vascular endothelial growth factor.

In other words, if we can cut off the blood vessels that provide nutrients to the tumor, we may cure cancers.

Dr. Adair TH, the lead scientists in the investigation of the angiogenesis in diseases and cancer said, "Stimulation of angiogenesis can be therapeutic in ischemic heart disease, peripheral arterial disease, and wound healing. Decreasing or inhibiting angiogenesis can be therapeutic in cancer, ophthalmic conditions, rheumatoid arthritis, and other diseases".

And, "Capillaries grow and regress in healthy tissues according to functional dem bands. Exercise stimulates angiogenesis in skeletal muscle and heart. A lack of exercise leads to capillary regression. Capillaries grow in adipose tissue during weight gain and regress during weight loss.

The results strongly suggested that by allowing or blocking the growth of new blood vessels, angiogenesis may be used as a primary target for the treatment of chronic diseases and cancers

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound which blocks the progression of cancer examined the anti-angiogenic activity of berry anthocyanins.

Six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry) included in the study were analyzed the anti-angiogenic (the ability to reduce unwanted growth of blood vessels, which can lead to varicose veins and tumor formation) properties.

Formula OptiBerry IH141, including all berries used in the study, demonstrated superior anti-angiogenic properties compared to the other combinations tested.

OptiBerry significantly inhibited free radical and proinflammatory cytokines in the expression of VEGF (Vascular Endothelial Growth Factor) associated with the formation of the new blood vessels.

According to the Matrigel assay using human microvascular endothelial cells, OptiBerry reduced the new blood vessel formation by impairing angiogenesis.

Futhermore, endothelioma cells pretreated with OptiBerry showed a diminished ability to form hemangioma and markedly decreased tumor growth by more than 50% through its anti-angiogenic, and anti-carcinogenic properties.

In order to reveal more information about berries anti-angiogenic activity to prevent and treat cancer, researchers investigated the six berry extracts (wild blueberry, bilberry, cranberry, elderberry, raspberry seed, and strawberry) and a grape seed proanthocyanidin extract (GSPE) against the formation of new blood vessels for cancer proliferation.

Wild bilberry and blueberry extracts possessed the highest antioxidant activity observed by the ORAC values compared to other berries.

In other words, wild bilberry and blueberry extracts inhibited the overexpression of free radicals and proinflammatory cytokines in stimulating the production of VEGF (Vascular Endothelial Growth Factor) in enhancing angiogenesis.

Interestingly, these activities of wild bilberry and blueberry extracts were not shared by other antioxidants such as alpha-tocopherol or GSPE but were commonly shared by pure flavonoids.

Taken altogether, bilberry used alone or combined with other berries may be considered functional remedies for the prevention of angiogenesis and treatment of cancer cells proliferation by stimulating the formation of a new blood vessel, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula by Bagchi D1, Sen CK, Bagchi M, Atalay M. (PubMed)
(2) Anti-angiogenic property of edible berries by Roy S1, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. (PubMed)
(3) Chapter 1Overview of Angiogenesis by Adair TH, Montani JP.. (NCBI)

Artichoke, the Potential Anti Thyroid Cancer Herbal Remedy with No Side Effects, Scientists Reveal

By Kyle J. Norton

Scientists may have found a herbal remedy for the treatment of thyroid cancer with no side effect, according to studies.

Thyroid cancer is a chronic and medical condition characterized by irregular cell growth in the thyroid gland due to the alternation of cell DNA.

Most cases of thyroid cancer start in the cells on the surface of the inner lining of the gland, affecting the thyroid function in hormone production in the early stage.

About 45% of thyroid cancer is found in the population over the age of 45. According to the statistic, approximately over 53,000 adults in the United States are diagnosed with thyroid cancer every year.

In other words, the risk of thyroid cancer is about 4% a year, according to the data from 2005 to 2014. Overall, the 5-year survival rate for people with thyroid cancer is 98%.

The exact causes of thyroid cancer are unknown. Epidemiological studies suggested that people who have a family history of goiter, exposure to high levels of radiation, and certain hereditary syndromes are at an increased risk of the incidence.

Some researchers suggested that if you are female, your risk of thyroid cancer is increased substantially compared to the male counterpart.

Dr. Reza Rahbari, the lead scientist in the study to examine the thyroid cancer gender disparity, said, "Thyroid cancer is one of the fastest growing cancer diagnoses worldwide. It is 2.9-times more common in women than men".

And, "Recent studies on estrogen receptor status in thyroid cancer show a difference in the receptor subtypes expressed based on the histology of thyroid cancer. Moreover, the response to estrogen is dependent on the specific estrogen receptor expressed in thyroid cancer cells".

The results clearly suggested that the risk of thyroid cancer is 2.9 higher in the female, probably due to the response to the hormone estrogen.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural chemo compound for the treatment of thyroid cancer examined the antithyroid cancer activity of the sesquiterpene lactone cynaropicrin, a major constituent of the artichoke leaves extracts.

The aim of the study was to investigate the effects of cynaropicrin, a major compound from the sesquiterpenes on the grown of three human thyroid carcinoma cell lines.

Injection of cynaropicrin showed to inhibit the viability of CAL-62, 8505C and SW1736 cells in a dose- and time-dependent way, with an EC50 of about 5 mM observed after 48 h of treatment.

In the cellular growth assays, cynaropicrin inhibited the cell proliferation through the arrest of the cell cycle, mainly in the G2/M phase, observed by the presence of a significant percentage of necrotic cells.

Furthermore, the differentiation after 48 h of treatment with 10 mM of cynaropicrin suggested that the compound induced cell apoptosis also through the inhibition of the proteins associated with cellular survival and cell cycle division.

Moreover, the application also reduced the free radical activity in exhibiting the expression of lipid peroxidation, without any significant effect on the reactive oxygen species production.

These results clearly suggested that cynaropicrin exhibited the function of free radical in exerting the cytotoxic effect against the thyroid cancer without causing harm to the healthy nearby cells through its antioxidant activity.

Taken altogether, artichoke processed abundantly bioactive compound sesquiterpene lactone cynaropicrin may be considered a functional remedy for the prevention and treatment of thyroid cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Antiproliferative effects of cynaropicrin on anaplastic thyroid cancer cells by Lepore SM1, Maggisano V1, Lombardo GE1, Maiuolo J1, Mollace V1, Bulotta S1, Russo D1, Celano M. (PubMed)
(2) Thyroid cancer gender disparity by Reza Rahbari,1 Lisa Zhang,1 and Electron Kebebew. (PMC)

3,3'-Diindolylmethane, the Phytochemical Which Gobbles Up Liver Cancer Cells

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of liver cancer with no side effects, according to studies.

The liver is the largest internal organs in the human body which plays a critical role for maintaining the integrity of cells wall, production of vitamin D and steroid hormone and aiding the digestive system in absorption of nutrients, through the production of cholesterol.

Additionally, the liver also filters out waste from the blood coming from the digestive system before passing them to the other parts of the body.

Liver cancer is a medical condition caused by irregular cell growth in the tissues of the liver.

Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissues before penetrating into deeper layers of the liver.

At the early stage due to the small size of the tumor and lack of nerve tissues, most patients are asymptomatic.

However, at the advanced stage, cancer cells can travel a distance away from the liver to infect other healthy tissues and organs, leading to secondary metastasis.

Patients at this stage may experience the general symptoms of cancers such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue accompanied by the symptoms of persistent upper abdominal pain, abdominal swelling, jaundice, and chalky stools.

If you have some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

Out of many risk factors associated with the onset of liver cancer, some researchers suggested that people who carry hepatitis viral may have a substantially higher risk of the disease.

Dr. Marc Ringehan, the lead researcher said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause of HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year". 

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".


Scientists in seeking potential and bioactive compounds for the treatment of liver cancer examined 3'3-Diindolylmethane (DIM, the major product of the acid-catalyzed oligomerization of indole-3-carbinol anti-liver cancer properties.

In two HCC cell lines SMMC-7721 and MHCC-97H, injection of DIM inhibited the proliferation, migration, and invasion of cancer cells.

In nude mice, DIM significantly decreased the volumes of SMMC-7721 orthotopic liver tumor and suppressed lung metastasis.

Furthermore, DIM decreased the level of phospho-FAK (Tyr397) which is found elevated in both vitro and in vivo.

The DIM anti-cancer cells efficacy on proliferation, migration, and invasion are probably due to the inhibition of the expression of matrixes (MMP2-9) associated with the promotion of cancer cells growth and invasion.

Dr. Li WX, the lead scientist wrote, "These results demonstrated that DIM blocks HCC cell metastasis by suppressing tumor cell migration and invasion".

Moreover, in order to reveal more information about DIM anti-liver cancer activity, researchers investigated whether diindolylmethane effect on HA59T cells. 

At concentrations of 10-75 μM, diindolylmethane killed cells in a concentration-dependent manner, particularly, in diindolylmethane (25-50 μM) induced apoptosis in a concentration-dependent manner.

The cytotoxic effect of diindolylmethane against the tested liver cancer cell line was not reversed by chelating cytosolic Ca(2+).

Where Calcium (Ca2+) ions are important for cellular signaling. Its flow plays an essential role in regulating several secondary messenger systems in neural adaptation for visual, auditory, and the olfactory system. 

The results suggested that DIM inhibited the onset and progression of liver cancer through a number of mechanisms, including proteins involved in anti-cell proliferation and migration, and promotion of apoptosis.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling by Li WX1, Chen LP2, Sun MY1, Li JT1, Liu HZ1, Zhu W. (PubMed)
(2) Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells by Cheng JS1, Shu SS, Kuo CC, Chou CT, Tsai WL, Fang YC, Kuo LN, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Chai KL, Jan CR. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)