Phytochemical Sulforaphane (Dithiolthiones), the Best for the Prevention and Treatment of Lung Diseases

By Kyle J. Norton

Scientists may have found a bioactive compound for the prevention and treatment of lung diseases with no side effects, according to studies.

Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

People with lung diseases have breathing problems, preventing them to get enough oxygen for the body needs.

According to the statistic from the World Health Organization, respiratory diseases are leading causes of death and disability in the world. chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.

3 million people die from the chronic obstructive pulmonary disease (COPD)  each year, making it the third leading cause of death worldwide. And 14% of 334 million people suffer from asthma are children.

Long-term smoking is considered one of the leading risk factor of lung diseases. Other risk factors associated with the onset of lung diseases include radon, Asbestos, second-hand smoke, and air pollution.

Depending on the are of the respiratory system effect. Lung diseases can be classified to 

* Lung disease affecting the airway include asthma and COPD.

*Lung diseases affecting the air sac include pneumonia and tuberculosis.

* Lung diseases affecting the interstitium include interstitial lung disease.

* Lung diseases affecting the blood vessel include pulmonary embolism (PE).

* Lung diseases affecting the pleura include pleural effusion.

* Lung affecting the chest wall include obesity

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

With an aim to find a natural compound for the treatment of lung diseases researchers examined the effects of sulforaphane (SF) in the protein Nuclear factor-like 2 (Nrf2) in mice from arsenic-induced toxicity.
Where Nuclear factor-like 2 has been found to protect the body against a broad spectrum of diseases induced by environmental exposure to harmful substances through its detoxed activity.

Selected mice were exposed to 2 weeks of arsenic-containing dust. At the end of 2 weeks, tested mice showed pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung.

Pretreatment of sulforaphane activated the expression of Nrf2 only blocked the alternation caused by arsenic-containing dust but also restored all the damages induced by the substances. 

Furthermore, SF-mediated activation of Nrf2 also alleviated inflammatory responses by modulating cytokine production, thus reducing the oxidative stress in the tested mice.

These results clearly suggested that dietary intervention which targets the Nrf2 activation may have a significant effect in the reduction of adverse health effects associated with arsenic exposure.

In the mouse model, activation of NRF2 protein was also found to regulate the rhythmic expression of antioxidant genes involved in glutathione redox homeostasis in the mouse lung.

Moreover, in vivo bleomycin-induced lung fibrosis model, pretreatment of SF restored the lung function by blocking the phenotype caused by bleomycin.

According to the observation of the lungs of the arrhythmic Clock(Δ19) mice, SF increased the levels of NRF2 and glutathione, the antioxidants enzymes produced by the host mice.

The results suggested that NRF2 activated by SF not only inhibited the oxidative damage but also protect the tested mice lung against fibrositis.

Dr. Pekovic-Vaughan V, the lead scientist, after taking into account co and confounders, said, "Our findings reveal a pivotal role for the circadian control of the NRF2/glutathione pathway in combating oxidative/fibrotic lung damage, which might prompt new chronotherapeutic strategies for the treatment of human lung diseases, including idiopathic pulmonary fibrosis".

However, in wildtype neonatal mice exposed to hyperoxia. SF also found to activated Nrf2 activation through induced expression of anti-oxidant genes but did not attenuate alveolar growth arrest caused by exposure to hyperoxia.

These discovery strong suggested that activation of activated Nrf2 may have a certain limit in protecting the lung and lung tissues against alveolar growth exposed to an excess supply of oxygen (O2) or higher than the normal partial pressure of oxygen.

Taken altogether, depending on the types of lung diseases, bioactive compound sulforaphane may be used for the prevention and combined with the primary therapy for the treatment of lung diseases with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. by Zheng Y1, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. (PubMed)
(2) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status by McGrath-Morrow SA1, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S.(PubMed)
(3) The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis by Pekovic-Vaughan V1, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ.(PubMed)

Phytochemical Allicin, the Bioactive Compound with Anti Gastric Cancer Potential

By Kyle J. Norton

Scientists may have found a natural and single ingredient for the prevention and treatment of gastric cancer with no side effects, according to the studies.

Gastric cancer is a condition caused by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

At the later stage, liver cancer cells may travel a distance away from the liver to infect other healthy tissue, leading to secondary metastasis through blood and fluids circulation.

According to the American Cancer Society, every year, approximately 26,000 cases of stomach cancer will be diagnosed (16,000 in men and 9,000 in women). The cancer causes the death of over10,000 people, including 6,000 men and 4,000 women).

The cause of gastric cancer is a result of the alternation of cell DNA in the stomach. Researchers do not know what causes the cell DNA alternation, but they do know certain risk factors such as smoking, family history, genetic preposition, certain diseases associated with the stomach and previous stomach surgery are involved the onset of the disease.

However, some researchers suggested that infection caused by Helicobacter pylori is the most important risk factor for gastric cancer.

Dr. Lydia E. Wroblewski, the lead author examined the effects of Helicobacter pylori in the risk of gastric cancer wrote, "Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer".

And, "Infection with H. pylori is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide".

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

With an aim to find the natural compound for the treatment of gastric cancer with no side effects, researchers evaluated the allicin, an active compound derived from garlic anti-cancer effects.

Allicin injection reduced cell viability in a dose- and time-dependent manner, partly through induction of apoptosis in gastric cancer cells.

At the molecular level, allicin induced cancer death through degradation of cancer cells through activation of the proteins associated with the stimulation of cell apoptosis, including the caspase-3, -8, and -9 and Bax and fas expression.

Allicin treatment also inhibited proliferation and induced apoptosis in SGC-7901 cancer cells.

Dr. the lead researcher said, "Data from the current study demonstrated that allicin should be further investigated as a novel cancer preventive or therapeutic agent in control of gastric cancer, with potential uses in other tumor types".

In a total of patients with progressive gastric adenocarcinoma, whose diagnosis was by gastroscopy and pathological examination assigned to 2 groups, 40 in each group, researchers examined the effects of local application of allicin via gastroscopy on progressive gastric carcinoma.

Allicin group showed the cell apoptosis rate of 9.60 +/- 1.52%, the percentage of cell in G0/G1 phase of 72.12 +/- 8.35%, in G2/M phase 9.54 +/- 3.20%, and PI 27.80 +/- 8.35, compared to the rate of 2.20 +/- 0.58%, 69.56 +/- 5.15%, 13.20 +/- 3.05%, and 30.40 +/- 5.15 in control.

The efficacy of allicin was attributed to the inhibition of the function of a protein (gene Bcl-2) associated with cancer cell anti-apoptosis and exhibition of the function of proteins (gene Bax and Fas) associated with the pro-apoptosis.

These results suggested that local application of allicin via gastroscopy can inhibit the cell growth and proliferation of progressive gastric carcinoma, and can also promote gastric carcinoma cell apoptosis, according to the final report by Fourth Affiliated Hospital of Hebei Medical University.

Taken altogether, phytochemical allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of gastric cancer

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
(3) Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk by Lydia E. Wroblewski,1,* Richard M. Peek, Jr.,1,2,3 and Keith T. Wilson. (PMC)

Phytochemicals Phytic Acid, the Anti Prostate cancers Bioactive Compound

By Kyle J. Norton

Phytochemicals phytic acid may be the next generation natural ingredient for the prevention and treatment of prostate cancer, some scientists found.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body.

As cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cell can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

 Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and  6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction.

Symptoms which are not found in enlarged prostate include blood in the urine and blood in the seminal fluid.

If you are experiencing  some of the above symptoms, please check with your doctor to rule out the possibility of prostate cancer

The causes of prostate cancer are unknown.  The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome and genetic proposition are some risks actors associated with the onset of the disease.

Some researchers suggested that a poor diet is one of the major risk factor found in patients with the disease.

Dr. Amir Bagher, the lead scientist evaluated the dietary patterns and risk of prostate cancer wrote, "After adjustment for potential confounders, a healthy dietary pattern was associated with decreased risk of prostate cancer (highest versus lowest tertile OR:0.24; 95% CI: 0.07-0.81; trend p: 0.025). An unhealthy dietary pattern was related to increased risk of prostate cancer(highest versus lowest tertile OR:3.4; 95% CI: 1.09-10.32; trend p: 0.037)".

And, "an unhealthy dietary pattern was associated with an increased risk of prostate cancer. However, a healthy dietary pattern was associated with a decreased risk of prostate cancer".

The results strongly suggested that by following a healthy diet pattern, one can substantially reduce the risk of prostate cancer.

Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

On finding a natural ingredient for the treatment of prostate cancer with no side effects, researchers assessed the effects of phytic acid (inositol hexakisphosphate (IP6)) on the activation of phosphoinositide 3-kinase (PI3K)-Akt pathway in promoting survival, proliferation, and angiogenesis in human prostate cancer cells.

In invasive human prostate cancer, PC-3 and C4-2B cells, IP6 treatment of cells suppressed proliferation, induced apoptosis through protein associated with the apoptotic and cell death programming pathways.

Phytic acid also inhibited cancer cells through protein associated with cancer cell growth, proliferation, differentiation, motility.

Furthermore, IP6 inhibited transcription and cell migration. through cell cycle arrest at the G1 phase.

Dr. Gu M, the lead scientist, after taking into account co and confounders said, " IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective".

In advanced and androgen-independent human PCa PC-3, Treatment of PC-3 cells with 2 mM IP6 strongly inhibited both growth and proliferation and decreased cell viability; similar effects were also observed in other human PCa DU145 and LNCaP cells.

IP6 also caused a strong apoptotic death of PC-3 cells through proteins associated with the activation of cell death programming and induced apoptosis.

The inhibition of PC-3 cancer cell line by IP6 also is associated with the inhibition of the protein involved cells proliferation, differentiation, similar to that of the above study.

Interestingly, researchers also discovered that IP6 also inhibited the transcription factor activity in promoting cancer cell growth and reproduction and regeneration

Where a transcription factor (TF) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA.

Taken altogether, phytochemicals phytic acid may be considered a bioactive compound for the prevention and combined with the primary therapy for the treatment of prostate cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target by Gu M, Roy S, Raina K, Agarwal C, Agarwal R.(PubMed)
(2) Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. by Gu M, Raina K, Agarwal C, Agarwal R.(PubMed)
(3) Dietary patterns and risk of prostate cancer: a factor analysis study in a sample of Iranian men by Amir Bagheri, Seyed Mostafa Nachvak, Mansour Rezaei, 3 Mozhgan Moravridzade, Mahmoudreza Moradi, 4 and Michael Nelson. (PMC)

Chinese Celery, the Prominent Post Stroke Treatment Functional Food

By Kyle J. Norton

Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients and without inducing any side effects, according to studies.

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain with inducing permanent damage.

Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.

Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.

In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.

Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".

The statement clearly suggested that a healthy diet rich in fruits and vegetable and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.

The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China. 

Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.

After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).

Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.

Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.

In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.

In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.

However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.

Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".

Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)

Ginger, Relieves Pain and Reduced Disability of Patients with Osteoarthritis

By Kyle J. Norton

Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complication of reduced quality of life in patients with osteoarthritis, some scientists suggested.

Osteoarthritis (OA) is a chronic condition of a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to “wear and tear” of joints over time.

Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.

According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% in men and 13% in women.

Epidemiological strongly suggested that obese and overweight which have a strong impact on the weight-bearing joints, genetic preposition of a patient can make such patient more susceptible to the disease compared to others do not, people with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.

The most common symptoms of osteoarthritis are joint pain and stiffness.

Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role for the onset of the disease.

In the dietary aspect in the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, the bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".

And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).

The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.

Out of 122 retrieved references, 117 were discarded, only 5 five trials (593 patients) were selected for meta-analyses.

All 5 remained studies suggested that ginger intake scored a statistically significant pain reduction. 

Furthermore, application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.

However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.

Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine the ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.

120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).

Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg starch.


At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.

After 3 months, GG showed a significant reduction of cytokines compared to the PG.

In the final report, the research team wrote, "ginger supplementation may have promising benefits for knee osteoarthritis".

These results reconfirming the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)

Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases

By Kyle J. Norton

Honey may the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.

Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.

After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.

In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.

In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.

Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.

Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.

In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.

Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).

Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.

Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.

At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.

Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.

During the stud, Manuka honey treated group displayed a significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.

Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.

Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and plasma of proinflammatory cytokines.

Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".

Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)

Green Banana, the Best for the Prevention and Treatment of Diarrhea

By Kyle J. Norton

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

Diarrhea is a condition of frequent bowel movements with three loose or liquid each day. A prolonged period of diarrhea may result in dehydration due to fluid loss. 

Infections by bacteria such as Salmonella or Escherichia coli are the most common causes of acute diarrhea. Patients with acute diarrhea usually are recovered within a week or 2 with or without medication.

However, patients with some bowel diseases such as such as irritable bowel syndrome or inflammatory bowel disease also frequently experience the chronic condition, which can not be cured unless the diseases are treated.

In some case, chronic frequent and severe diarrhea can be a sign of intestinal disease or a functional bowel disorder.

Most common symptoms diarrhea include loose, watery stools. abdominal pain and gastrointestinal discomforts. In the severe case, patients may also experience symptoms of fever and blood in the stool.

Some researchers suggested that symptoms of diarrhea accompanied by blood in the stool is also a sign of colon cancer.

Dr. Jia Cai, the lead scientist at the First Affiliated Hospital of Chongqing Medical University, in the differentiated the incidence of colon polyps, cancer, and colitis for the chronic abdominal pain, chronic diarrhea, and constipation suggested that there are no significant difference was found in the positive rate of colon polyps, cancer and ulcerative colitis among these 2 groups divided by symptoms.

The team continued, "The incidence of colon polyps, cancer, and colitis for chronic abdominal pain, chronic diarrhea, and constipation group are 20.8%, 57.1%, 42.9% respectively. The incidence of colon polyps and cancer increases with age. Among the age groups 13-39 years old, 40-59 years and > 60 years, the incidence is 7.9%, 13.6%, 22.4% respectively".

Therefore, if you have diarrhea with symptoms of chronic abdominal pain, please check with your doctor to rule out the possibility of colon polyps, cancer, and ulcerative colitis.

Most cases of acute and chronic diarrhea can be treated successfully by natural whole foods and herbal remedies with no side effects.

On finding a natural source with no side effects for the treatment of diarrhea associated with enteral feedings remains a problem for clinicians, researchers evaluated the effects of flakes in controlling diarrhea in critically ill patients receiving enteral feedings.

The study includes 31 patients with diarrhea and receiving enteral feedings randomized to receive either banana flakes or medical treatment for diarrhea.

Both banana flakes and medical treatments reduced the severity of diarrhea in critically ill tube-fed patients.

Over the course of treatment, the banana flake group scored diarrhea mean of 21.64 +/- 7.81 compared to 25.41 +/- 9.76 to the medical group. Both groups achieved similar levels of nutrition support.

The banana flake group had less diarrhea clinically, with 57% of the subjects diarrhea free on their last study day as opposed to 24% of the medically treated subjects.

This occurred despite a threefold increase in the number of patients testing positive for Clostridium difficile toxin in the banana flake group.

Dr. Emery EA, the lead author said, " banana flakes can be used as a safe, cost-effective treatment for diarrhea in critically ill tube-fed patients".

Moreover, in order to understand the anti-diarrhea effect of banana, researchers evaluated the therapeutic effects of green banana or pectin in children with persistent diarrhea.

The double-blind trial, 62 boys, age 5-12 months, were randomly given a rice-based diet containing either 250 g/L of cooked green banana (n = 22) or 4 g/kg pectin (n = 19) or the rice-diet alone (control, n = 21), providing 54 kcal/dL daily for 7 days.

The results of stool analysis showed that
* Most children (60%) had no pathogens isolated from stools, 17% had rotavirus, 5% Vibrio cholerae, 4% Salmonella group B, and 11% had enterotoxigenic Escherichia coli infections.

* By day 3 posttreatment, significantly (P < 0.001) more children recovered from diarrhea receiving pectin or banana compared to control and by day 4, these proportions correspondingly increased to 82%, 78%, and 23%, respectively.

These results strongly indicated green banana and pectin significantly reduced amounts of stool, oral rehydration solution, intravenous fluid, and numbers of vomiting, and diarrheal duration.

Dr. Rabbani GH, the lead scientist wrote in the final report, "Green banana and pectin are useful in the dietary the management of persistent diarrhea in hospitalized children and may also be useful to treat children at home".

 In support to the above results, the Hospital Universitario de Maracaibo strongly suggested that green plantain showed to be effective in the dietary management of persistent diarrhea, in a prospective, in-hospital controlled trial, two different treatments were administered to a sample of 80 children of both sexes, with ages ranging from 1 to 28 months.

Taken altogether, green banana may be considered a functional food for the prevention and treatment of  diarrhea with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Banana flakes control diarrhea in enterally fed patients by Emery EA1, Ahmad S, Koethe JD, Skipper A, Perlmutter S, Paskin DL. (PubMed)
(2) Clinical studies in persistent diarrhea: dietary management with green banana or pectin in Bangladeshi children by Rabbani GH1, Teka T, Zaman B, Majid N, Khatun M, Fuchs GJ. (PubMed)
(3) Beneficial role of green plantain [Musa paradisiaca] in the management of persistent diarrhea: a prospective randomized trial by Alvarez-Acosta T1, León C, Acosta-González S, Parra-Soto H, Cluet-Rodriguez I, Rossell MR, Colina-Chourio JA. (PubMed)