Asparagus, the Veggie with Anti Oral Cancer Cells Properties

Kyle J. Norton, Master of Nutrition

Whole food(herbal medicine) used as medical treatment, linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.

But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency.

Oral cancer is a medical condition characterized by irregular cells growth in the oral cavity. In the early stage, the abnormal cells only appear in the surface lining of the cavity. However, in the late stage, the infectious cells may travel a distance away from the original site to invade other cells and tissue.

Early diagnosed oral cancer may have a close to 100% recovery(3).

According to the cancer society, the 5 survival rate of oral cancer is about 60% plus without taking into consideration of the stage of cancer.

According to the Oral Cancer Foundation in the article of "Oral Cancer Fact", in US, approximately,  50000 Americans will be diagnosed with oral pharyngeal cancer this year. It will cause about 10,000 deaths.

The early symptoms of oral cancer include lip or mouth sores and persistent pain,.... Check with dentist, if you experience the above unexplained or persistent symptoms, particularly, if sore mouth does not heal in 2 weeks.

Although, the causes of oral cancers are still debatable, some researchers suggested that age, smoking, alcohol,  gender, diet,....... HPV and sun exposure are considered as  prevalent risk factors in contribution to the early onset of the cancer(3).

Dr.Payal Garg and Freny Karjodkar in the study of " “Catch Them before it Becomes Too Late”—Oral Cancer Detection. Report of Two Cases and Review of Diagnostic AIDS in Cancer Detection", said, "(Dentists and Doctors should the region with appearance of ) A red or white patch or a change in color, texture, size, contour, mobility, or function of intraoral, perioral, or extraoral tissue should arouse suspicion of the presence of malignant or premalignant lesions in these regions"

Regular intake of Asparagus may have a reduced risk and development of oral cancer, some scientists suggested.

Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia.

The veggie has been used in early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Treatment of oral cancer in conventional medicine involved immune suppressors such as chemo drugs may contribute to complications of patients with oral cancer, such as infection.

According to University of Florida, asparagus use currently in cancer prevention rather than treatment.of oral cancer probably due to mechanism of action for bioactive compounds, such as epigallocatechin, epicatechin-3-gallate,....

Dr. the lead author said, " Preclinical and clinical evidence for the use of green tea, raspberry, asparagus, and cannabis extracts,...... diet changes, supplementation with antioxidants, high-dose vitamin C therapy, and cannabinoid use have been suggested to decrease cancer cell replication and increase chance of remission"

In the study of blood sample of 40 oral cancer patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, researchers found that arsparagus racemosus Willd. exerted a strong effect against infection caused by Staphylococcus aureus (23.2%), Escherichia coli (15.62%), Staphylococcus epidermidis (12.5%), Pseudomonas aeruginosa (9.37%), Klebsiella pneumonia (7.81%), Proteus mirabilis (3.6%), Proteus vulgaris (4.2%) and the fungal pathogens Candida albicans (14.6%), Aspergillus fumigatus (9.37%).

Researchers at the institute also suggested, oral cancer patients were neutropenic with abnormally low level of neutrophils and and prone to secondary micro infection.. Asparagus may be used as antimicrobial agent to check the secondary infections in cancer patients.

Taking altogether, asparagus has shown to exert a significant anti progression, complications and treatment of oral cancer, but further multi centers and large sample size studies are necessary to validate this claim.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer by Godsey J1, Grundmann O1.(PubMed)
(2) In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases by Panghal M1, Kaushal V, Yadav JP.(PubMed)

The Best Detoxification Diet, That Works, Scientists Suggest

American diet contains high saturated, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic.

Some researchers suggested that diet and exposure to environmental toxins can damage function of the mitochondria in cells in converting food to energy, affecting the organs function in protection of the body in all aspects.

The damage to mitochondria can increase over expression of free-radicals in induction of cytotoxicity to cells and tissue though a negative chain reaction

Foods that can detoxify our body against cytotoxicity include

1. Spinach
Spinach contains 

* High levels of vitamin A, E, C , the free radical scavengers with function in reduced oxidative stress by improving production of  antioxidant enzymes(1)(2).

* Numbers of trace minerals act as antioxidant in inhibited ROS species such as iron, potassium, magnesium, zinc and calcium(2). The presences of trace minerals in equate amount  are vital for a healthy heart. 

* Antioxidants,  such as lutein and beta carotene(3) strengthen our immune system and fight against the forming of free radicals. 

People with kidney disease should not eat spinach, because it is rich with oxalates.

Without drinking a lot of water or juice, intake of the veggie will increase risk of kidney stones formation.

2. Broccoli
Broccoli is high in vitamin C(1), an antioxidant that has a property in reduced the risk of inflammation and prevented forming of free radicals caused by toxins in our body. 

Study shows that some of the chemicals such as indole 3, selenium and diindolymethane have anti cancer properties and help to prevent and repair DNA damaging cells(4)(9).

3. Garlic
Garlic is a super natural food. Besides having proven record in preventing heart diseases, lower cholesterol level, elevate blood pressure(5),  it also contains high amounts of allicin, an antibody that helps to reduce inflammation and fight off degeneration caused by virus, bacteria, strengthening our immune system(6) and forming of free radicals(7).

The sulfur element helps to rejuvenate our body by increasing the function of liver in removing toxins(7).

4. Black berry
Besides vitamins C and E(1) blackberry contains anthocyanins and ellagic acid that work together in preventing inflammation, improving mental performance as well as strengthening the immune system(8). Its antioxidant function also remove accumulation of heavy metal toxins in our body(9).

5. Mellon
Mellon contains high amounts of antioxidant enzyme(9), minerals(2) and the powerful antioxidant chlorophyll(9), which is rich in antioxidants, vital minerals such as magnesium, iron, potassium, calcium, and essential fatty acids(2) with functions in removed heavy metals accumulated in the brain and toxins in our kidney(10)

6. Green tea
Green tea  balances the PH level(11) in the blood, it also contains polyphenolic catechins, a powerful antioxidant that strengthens the immune system(9), fights against free radicals building up and detoxes our body though urinary secretion(9)(12).

7.  Cooked Tomato
Tomatoes contain high amounts of alpha and beta carotene that help to strengthen the body's immune system fight off inflammation from bacteria and virus causing many types of chronic diseases(3). 

The vegetable also contains lycopene(13), a powerful antioxidant that prevents the forming of free radicals caused by accumulation of toxic substances in the body when work together with lutein(3). Be sure that the veggie is well cooked(14).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats by Michael J. Ryan,1 Holly J. Dudash,1 Megan Docherty,1 Kenneth B. Geronilla,1,2 Brent A. Baker,2G. Gregory Haff,1 Robert G. Cutlip,2 and Stephen E. Alway(PubMed)

(2) Vitamins and minerals functioning as antioxidants with supplementation considerations Lee R. McDowell1 , Nancy Wilkinson, Rachel Madison and Tara Felix Department of Animal Sciences University of Florida

(3) Potential Role of Carotenoids as Antioxidants in Human Health and Disease by Joanna Fiedor* and Květoslava Burda(PubMed)

(4) Nutritional Epigenetic Regulators in the Field of Cancer by Michael Schnekenburger1, Marc Diederich2, in Epigenetic Cancer Therapy, 2015

(5) Garlic and Cardiovascular Disease: A Critical Review 

Khalid Rahman Gordon M. Lowe, The Journal of Nutrition, Volume 136, Issue 3, 1 March 2006, Pages 736S–740S,https://doi.org/10.1093/jn/136.3.736S

(6) The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention by Georgia Schäfer1 and Catherine H. Kaschula(PubMed)

(7) The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins by Rabinkov A1, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L(PubMed)

(8) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days by Stoner GD1, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X(PubMed)

(9) Free radicals, antioxidants and functional foods: Impact on human health byV. Lobo, A. Patil, A. Phatak, and N. Chandra(PubMed)

(10) Toxicity, mechanism and health effects of some heavy metals by Monisha Jaishankar, Tenzin Tseten, Naresh Anbalagan, Blessy B. Mathew, and Krishnamurthy N. Beeregowda(PubMed)

(11) Evaluation of the pH and titratable acidity of teas commercially available in Brazilian market ORIGINAL | ORIGINAL Avaliação do pH e titrabilidade ácida de chás comercialmente disponíveis no mercado brasileiro 

(12) 5 Kidney Cleansing Drinksby Dr. Group by Dr. Edward Group DC, NP, DACBN, DCBCN, DABFM

(13) Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview by Jalil Pirayesh Islamian, Ph.D.* and Habib Mehrali, M.Sc(PubMed)

(14) Cooking Tomatoes Boosts Disease-Fighting Power, Date:April 23, 2002 (by Cornell University)

A Beverage, That Suppresses the Incidence of Rheumatoid Arthritis (RA)

Kyle J. Norton, Master of Nutrition


Total caffeinated coffee intake daily is associated to non risk factor but attenuated risk of incidence of rheumatoid arthritis, the joint study by the Harvard Medical School and Brigham and Women's Hospital, Boston and a Asian study, suggested, respectively.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Rheumatoid Arthritis is a chronic immune disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues in the body.

In other words, the synovial membrane that protects and lubricates joints are inflamed, causing pain and swelling. But what trigger these attacks are still debatable.

The disease affects more women than men and generally occurs after the ages of 40, causing diminished physical activity and quality of life of many people.

According to statistic, 1% of the global population are affected by the disease. In the US, based on rates of RA from a 1995 Minnesota study and 2005 Census data, the prevalent risk  is lower with  approximately 1.29 million or 0.6% of the population.

Some researchers suggested that  Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). 

According to a cross-sectional population-based study of 1042 patients with rheumatoid arthritis, researchers showed that RA patients had an increased risk of death from various causes(5).

The joint study conducted lead by the University of Texas Southwestern Medical Center and Victoria Hospital, the misdiagnosis of the atypical infections versus inflammatory conditions of the hand due to some similarity to inflammatory conditions regarding their clinical and imaging finding is rare but delay diagnosis can increase risk of severe bone and joint destruction, and higher morbidity(6).

Truly, some reseachers believed that habitual coffee consumption are associated to risk of RA. 

Women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Dr. Mikuls TR, the lead author said, "Decaffeinated coffee intake is independently and positively associated with RA onset" and "Further investigations of decaffeinated coffee and tea intake as arthritis risk factors are needed to verify these findings and explore their biologic basis".

However, according to the study of Korea University Anam Hospital, caffeinated or decaffeinated coffee consumption are not risk factors of RA.

In the follow up study of 83,124 women, completed the FFQ at baseline, the diagnosis of incident RA(between 1980 and 2000) with a food frequency questionnaire (FFQ) completed every 4 years, from baseline in 1980 through 1998, researchers found that
* Decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) showed no subsequent risk of incident RA.

* There was no relationship of incidence of RA or reduced incidence RA in caffeinated coffee consumption, regardless to numbers of cup intake daily.

* Total coffee and total caffeine consumption were also not associated with the risk of RA.

And coffee intake showed a statistically clinical value in attenuated risk of RA.

According to the Korea University College of Medicine, the numbers of coffee intake daily in reduced RA incidence were substantially different in number studies.

The highest category of coffee intake in Heliovaara et al. cohort study from Finland was up to 13 cups per day, while US studies was > 4 cups coffee intake per day.

The study also emphasized that caffeine showed no significant association of RA incidence in compared to caffeinated coffee consumption in ameliorated risk RA incidence.

Furthermore, the study in valuated coffee, tea, and caffeine consumption and risk factors for rheumatoid arthritis (RA) onset among older women, indicated that risk of RA is reduced substantially with drinking > 3 cups/day of decaffeinated coffee in compared to non drinkers.

Interestingly, women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Collectively, the finding evidences suggested that caffeinated coffee intake is not an independent risk factor but a reduced risk parameters for onset of rheumatoid arthritis (RA) incidence, depending to numbers of cup consumption per day.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.



Sources
(1) Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis by Lee YH1, Bae SC, Song GG.(PubMed)
(2) Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study by Mikuls TR1, Cerhan JR, Criswell LA, Merlino L, Mudano AS, Burma M, Folsom AR, Saag KG.(PubMed)
(3) Coffee consumption and risk of rheumatoid arthritis by Karlson EW1, Mandl LA, Aweh GN, Grodstein F.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(5) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)

(6) Atypical Infections versus Inflammatory Conditions of the Hand: The Role of Imaging in Diagnosis by Soldatos T1, Omar H, Sammer D, Chhabra A.(PubMed)

Beware of The Major Side Effect of Kidney Beans Intake - Severe Intestinal Atrophy, Medline Studies Reveal

By Kyle J. Norton, Scholar, Master of Nutrition


The use of plants for healing purposes have been predated long before the existence of modern medicine.

Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intestinal atrophy is the abnormality of small intestine mucous membrane, in most cases caused by bacterial infection.

However, certain diseases such as Celiac disease may precipitate the occurrence of intestinal atrophy.

If  a patient incidentally consume foods containing the protein gluten, the allergic foods may trigger immune over expression in attacking the intestinal villi.


Intestinal atrophy can also be caused by intake of certain medication, including immune suppressors, such as imuran, antibiotics such as neomycin, and the anti-inflammatory medication such as colcrys,........

Patients in the early stage of the condition may only experience some abdominal discomforts.

As the infection progress, infectious persons may develop diarrhea, weight loss, abdominal pain, and fatigue.

Some researchers suggested, intestinal atrophy is a serious condition, as the ‘villi’ or ‘microvilli’, damage to some extents, the condition may increase risk of  intestinal permeability and most autoimmune diseases.

According to the Josai University, glutathione (GSH), an antioxidant found in plants, animals, fungi, and some bacteria and archaea may have a profound effect in reduced expression through enhances jejunal regenerative potential to minimize intestinalmucosal atrophy by diminishing fasting-mediated ROS generation and intestinal lining cells apoptosis and enhancing cell proliferation(4)..

These result suggested that oral glutathione (GSH) administration processes a strong activity in alleviated the effects of fasting-induced intestinal atrophy in the small intestinal mucosa.

Intake of kidney beans may result in increased risk of the developed intestinal atrophy, some scientists suggested.

Kidney beans with kidney shape, strong flavor and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the University of Utrecht, animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association to lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.


In compared to control, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.

Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".

In randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.


The study also showed that phytohaemagglutinin with high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of hormone in regulated gastric acid (HCl).

In fact, the effects of lectins cause of significant gastric trophy on the small intestine and colon may be vary between different sites in the gastrointestinal tract.

In support to the above analysis, the Christian-Albrechts-Universität study with 30 day old male rats pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, researchers found that oral administration of phytohaemagglutinin (PHA) in rats dose dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.

The result of phytohaemagglutinin (PHA) intake in exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in stimulated additional release of bile into the intestine.

Taking together, intake of kidney bean should be taken with care with patients with digestive problems as level of lectin may induce intestinal atrophy.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)

Detoxification - How to Detox and Nourish Your Colon for Optimal Health

By Kyle J. Norton

Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

Environment natural occurring compounds such as lead; mercury; radon, formaldehyde; benzene; and cadmium.and man made compounds such as BPA phthalates and pesticides accumulated without notices by the host also can cause endocrine disruption and organs failure.

Toxins can also be accumulated due to long term intake of certain conventional medicine such as Amiodarone (Cordarone), antibiodicts, diuresis,.... and betablockers, anti-depressants and cytotoxic drugs or cytostatics used for treatment of cancers.

These types of harmful substances are toxic. In order to protect and maintain normal function of out body, everyday, our body's detoxifying organs must work overtime to get rid of them.

However, if they fail, these toxins may cause a disruption of hormone production, damage of our body's detoxification organs and weakening of our immune system, resulting in hormone imbalance and development of chronic illness.

Herbal medicine have a strong effect in colon cleansing, including

1. Flax seed
Flax seed containing high amounts of omega 3 fatty acid, fiber and lignan not only helps in controlling cholesterol in the blood stream and provides essential nutrition to our body, its fiber also  soften the stool and promote bowel movements for relief of constipation by removing all toxins accumulated in the colon.

According to the study by the Mercer University, Atlanta, flax seed with abundant Omega-3 fatty acids, such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), exerted a significant effect in protect the colon health through heightening colonic free fatty acid receptor 4 (FFAR4) and actin expression with function in mobility and contraction of cells during cell division, and reducing expression of the pro-inflammatory cytokine TNF-α compared to animals fed control diets(1).

Dr. Gomides AF, at the Federal University of Juiz de Fora in the investigation of the effect in
defatted flaxseed meal and risk precancerous colon lesions in C57BL/6 mice said, 'The rats consuming defatted flaxseed meals showed lesions with lower multiplicity and a reduced incidence of lesions".

Some researchers also suggested that adding a portion of flaxseed (Linum usitatissimum L.) and its total non-digestible fraction may have a strong effect in inhibited azoxymethane (AOM)-induced colon (toxicity) cancer in Sprague Dawley rats(3).

2. Psyllium Psyllium
Psyllium Psyllium contains about 70% soluble fiber and 30% insoluble fiber.

Besides having proven record in Chinese medicine in treating high levels of cholesterol, its fiber portion also are used to treat constipation by softening stools and easing bowel movements .

According to the joint study lead by the Institute for Genomics and Multiscale Biology, in the investigation of interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice showed that application of all tested fibers reduces the severity of colitis in SPF mice, but not in GF mice or mice given antibiotics.

In compared to other tested fiber, psyllium fiber reduced the severity of colitis effects through improvement of microbiota-dependent and microbiota-independent mechanisms.

If used combinatorial perturbations to dietary casein protein, psyllium fiber exerted a significant effect in reduced intestinal permeability, gut microbial density, and development of intestinal inflammation.

Truly, higher intakes of dietary fiber are linked to improvement of gut health.

Some researchers also suggested, "fiber undergoes partial or total fermentation in the distal small bowel and colon leading to the production of short-chain fatty acids and gas, thereby affecting gastrointestinal function and sensation"(5).

3. Bentonite clay or liquid clay
Bentonite clay is a natural clay that comes from volcanic ash.

 Taken internally, the adsorbent action of bentonite eliminates and removes toxic material from the intestine.

According to the study by Shiraz University of Medical Sciences, bentonite clay may be used as a detoxifying agent because of its poly-cationic nature(6),

In T-2 is a trichothecene mycotoxin, injection of bentonite for 2 weeks before T-2 toxicosis, showed a a significant increase in fecal excretion of this toxin(6)

Further more,  bentonite may be used in humans as a dietary intervention to prevent and cure aflatoxin toxicity.if it does not affect the serum concentrations of important vitamins and nutrient minerals in humans(6).

4. Buckthorn bark
Buckthorn bark is native to Europe and parts of western Asia.

The herb contains anthraquinones that stimulate intestinal movement by easing water to the intestines. These results suggested that uckthorn bark may resulti have a strong impact in softened stool and removed toxins accumulated in the intestine.

In the article posted at the Whole Health Chicago, the author wrote, "(anthraquinones) ease constipation. The compounds in buckthorn bark increase the colon’s ability to spontaneously contract. They also reduce water absorption by the intestines, which means more liquid is left in the colon. This produces larger volume and softer stools, which in turn eases constipation"(7)


5. Cascara sagrada
Cascara sagrada is known to tone the relaxed intestinal muscles in the digestive system.

Intake of cascare sagrada promotes the digestive process in prevention of  digestive dyfunction such as chronic constipation.

In the study to assess aloe-emodin anthrone (AEA), the major compound found in sascara sagrada in the rat colonic mucosa using a Ussing-type chamber, researcher showed that AEA is effective in absorption of enhancers such as pyrilamine, histamine H(1) receptor antagonist and ketotifen without damage of the colon membrane and causing cytotoxicity(8).

Dr. Kai M, the lead scientist, after taking into account of other co and con founders, said, " AEA stimulates mast cells within the colonic mucosa to release histamine, which probably bind to the H(1) receptor. The intracellular PKC route activated by H(1) receptor activation enhances the permeability of water-soluble and poorly permeable drugs via opening of tight junctions in rat colonic membrane"(8).

Finally, intake of herbal supplements should be taken with extreme care as acute liver toxicity has been reported in numbers of case. Please consult with your herbalist before applying.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon by Cheshmehkani A#1, Senatorov IS#1, Kandi P1, Singh M1, Britt A1, Hayslett R1, Moniri NH(PubMed)
(2) Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice by Gomides AF1, Paula SO, Rosa DD, Oliveira LL, Comastri DS, Peluzio Mdo C(PubMed)
(3) Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats by Hernández-Salazar M1, Guevara-González RG, Cruz-Hernández A, Guevara-Olvera L, Bello-Pérez LA, Castaño-Tostado E, Loarca-Piña G(PubMed).
(4) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice by Llewellyn SR1, Britton GJ1, Contijoch EJ1, Vennaro OH1, Mortha A2, Colombel JF3, Grinspan A3, Clemente JC1, Merad M4, Faith JJ(PubMed)
(5) Fiber and functional gastrointestinal disorders by Eswaran S1, Muir J, Chey WD(PubMed)
(6) Bentonite Clay as a Natural Remedy: A Brief Review by Maryam MOOSAVI(PMC)
(7) Buckthorn Bark, Whole Health Chicago
(8) Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa by Kai M1, Hayashi K, Kaida I, Aki H, Yamamoto M(PubMed)

Infectious Diseases: The Herbs That Suppress Over Growth of Candida, Scientists Say

By Kyle J. Norton, Scholar, Master of Nutrition

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.


Herbalism or phytotherapy is a traditional medicine used botany and plants for treatment of a variety of ailments. Today, it has become increasingly important for many scientists who intent to find the natural agents with the same effectiveness as conventional medicine without inducing serious side effects.

However, the finding of these whole food medication have been facing many obstacles including limited financial support, because, the discovery of such plants will provide no commercial benefit and patent right to producers.

According to Dr. Marjorie Murphy Cowan in the study of "Plant Products as Antimicrobial Agents" said, "While 25 to 50% of current pharmaceuticals are derived from plants, none are used as antimicrobials. Traditional healers have long used plants to prevent or cure infectious conditions" and " Plants are rich in a wide variety of secondary metabolites, such as tannins, terpenoids, alkaloids, and flavonoids, which have been found in vitro to have antimicrobial properties"(a).

Western medicine is trying to duplicate herbal successes with the synthetic version for patent right without using the whole herb ingredients which have caused over expression of serious adverse effects.

ROS species have duo functions that are well documented for playing an important role in our body as both beneficial and deleterious molecules in expression of cytotoxicity against abnormal cells alternation and initiation of chronic ailments such as over growth of candida by causing imbalance of the ratio among antioxidants and free radicals, respectively.

In free radical over expression initiated over growth candida, certain herb-derived compounds exerted a strong antioxidant effect that target Candida and restore health and balance.

According to the Jamia Millia Islamia, diallyldisulphide (DADS), an important organosulphur compound found in garlic inhibited the over growth of candida through decreasing activity of all antioxidant enzymes except catalase in Candida species antioxidant system.

These result suggested that application of diallyldisulphide (DADS) caused increase of oxidative stress and damage to the fungal cells(b).

The Anti Over Growth of Candida Herbal Medicine
1. Berberis
Berberis is a genus of about 450-500 species of deciduous and evergreen shrubs from 1-5 m tall with thorny shoots, belongings to the family Berberidaceae, native to the temperate and subtropical regions of Europe, Asia, Africa, North America and South America. Europe has a few species, and North America only two. The stem, root bark, and fruit of barberry containing alkaloids and berberine have been used in traditional medicine or dietary supplement, to treat fungal infections(270), candida albicans(270), yeast(271), parasites, and bacterial/viral infections(270).

Berberine may also enhance the immune system through its antioxidant activity(272) by preventing candida yeasts from producing lipase(273)(274), an enzyme used to help them in colonization(274) and induced infection(274).

2. Clover(Trifolium)
Clover used as a spice in cuisines all over the world, is the aromatic dried flower buds of a tree in the Syzygium, belongings to the family Myrtaceae, native to Indonesia. Tellimagrandin II, in clover oil exhibited significantly anti-herpesvirus(275) and anti-oxidant(275)(276) properties and antiseptic property through phytochemical eugenol(277) used in dentistry to relieve pain(277), prevent bacterial infection(278) and boost immune system(279).

3. Goldenseal((Hydrastis Canadensis)
Goldenseal is a perennial herb in the species of Hydrastis canadensis, belongings to the family Ranunculaceae, native to southeastern Canada and northeastern United States, used widely in traditional medicine to treat functional disorders of gastrointestine(280), including atonic dyspepsia, chronic constipation, liver toxicity(281), etc.

Berberine, a compound found in goldenseal has demonstrated significant anti-fungal activity(282)(283)(284) by preventing candida yeasts from producing lipase, an enzyme involved in colonization.

4. Oregano(Origanum vulgare) Oil
Oregano is a common species of Origanum, belongings to the family Lamiaceae, native to warm-temperate western and southwestern Eurasia and the Mediterranean region.

Carvacrol, a monoterpenoid phenol phytochemical found in oregano oil inhibited the growth of several bacteria strains(285), including candida albicans due to its antimicrobial properties that disrupt the bacteria membrane(286).

5. Cinnamon
Cinnamon is a spice obtained from the inner bark of trees from the genus Cinnamomum, belongings to the family Lauraceae, used in traditional medicine to treat digestive system disorder(287)(289), insulin sensitive(288)(290) and enhance the immune system in regulated cells growth due to its antioxidant activity(290).

The cinnamon essential oil has antimicrobial properties(291)(292), which can prevent, limit or destroy the fungal overgrowth(293).

6. Allspice
Allspice also called Jamaica pepper is a spice of dried unripe fruit of Pimenta dioica, belongings to the family Myrtaceae, native to the southern Mexico and Central America. The herb has been used in folk medicine in relieving indigestion and gas(294) and as a deodorant.

Phenylpropene found in allspice volatile oils has shown to exhibit an antimicrobial property(295), including candida albicans(296)

7. Lavender(Lavandula angustifolia)
The lavender is a genus Lavandula of flowering plants in the mint family Lamiaceae, originated in Asia, used in herbal medicine to treat microbial infection(297) for the skin and reduce inflammation(298)(299).

Its essential oil components linalool and linalyl acetate showed both fungistatic and fungicidal activity(300)(301) against C. albicans strains in reducing fungal progression and the spread of infection in host tissue(301).

8. Chamomile
Chamomile is a common name for several daisy-like plants, genus Matricaria belongings to the family Asteraceae, native to Europe and western Asia used in traditional medicine to aid sleep(302), treat diarrhea(303) and reduce oxidative stress(304). Chamomile containing high amount of flavonoids is best known for its antioxidant(303), such as anti septic and anti biotic properties against virus bacteria invasion(305)(306(307)) including candida ablicans(308).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(a) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)
(b) Effect of diallyldisulphide on an antioxidant enzyme system in Candida species by Yousuf S1, Ahmad A, Khan A, Manzoor N, Khan LA(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)
(270) Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla by Freile ML1, Giannini F, Pucci G, Sturniolo A, Rodero L, Pucci O, Balzareti V, Enriz RD.(PubMed)
(271) Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. Musumeci R1, Speciale A, Costanzo R, Annino A, Ragusa S, Rapisarda A, Pappalardo MS, Iauk L.(PubMed)
(272) In vitro biological assessment of Berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects. Abd El-Wahab AE, Ghareeb DA1, Sarhan EE, Abu-Serie MM, El Demellawy MA.(PubMed)
(273) Inhibition of biofilm formation and lipase in Candida albicans by culture filtrate of Staphylococcus epidermidis in vitro. Bhattacharyya S1, Gupta P2, Banerjee G2, Jain A2, Singh M2.(PubMed)
(274) Differential Candida albicans lipase gene expression during alimentary tract colonization and infection. Schofield DA1, Westwater C, Warner T, Balish E.(PubMed)
(275) Medicinal Plants in Australia Volume 4: An Antipodean Apothecary
(276) Ellagitannin(Wikipedia)
(2377) Oil of clover(Wikipedia)
(278) Anti-virulence potential of eugenyl acetate against pathogenic bacteria of medical importance by Musthafa KS1, Voravuthikunchai SP.(PubMed)
(279) Immunomodulatory activity of geranial, geranial acetate, gingerol, and eugenol essential oils: evidence for humoral and cell-mediated responses. Farhath S1, Vijaya P1, Vimal M2.(PubMed)
(280) Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni by Cwikla C1, Schmidt K, Matthias A, Bone KM, Lehmann R, Tiralongo E.(PubMed)
(281) Protective effects of goldenseal (Hydrastis canadensis L.) on acetaminophen-induced hepatotoxicity through inhibition of CYP2E1 in ratsby Yamaura K1, Shimada M, Nakayama N, Ueno K.(PubMed)
(282) In vitro antifungal activity of the berberine and its synergism with fluconazole by Iwazaki RS1, Endo EH, Ueda-Nakamura T, Nakamura CV, Garcia LB, Filho BP.(PubMed)
(283) Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agentsby Park KD1, Lee JH, Kim SH, Kang TH, Moon JS, Kim SU.(PubMed)
(284) Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicansby Dhamgaye S1, Devaux F2, Vandeputte P3, Khandelwal NK4, Sanglard D3, Mukhopadhyay G5, Prasad R4.(PubMed)
(285) Effect of two monoterpene phenols on antioxidant defense system in Candida albicansby Khan A1, Ahmad A2, Ahmad Khan L3, Padoa CJ4, van Vuuren S5, Manzoor N6.(PubMed)
(286) Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candidaby Ahmad A1, Khan A, Akhtar F, Yousuf S, Xess I, Khan LA, Manzoor N.(PubMed)
(287) Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damageby Ozbayer C1, Kurt H, Ozdemir Z, Tuncel T, Moheb Saadat S, Burukoglu D, Senturk H, Degirmenci I, Gunes HV.(PubMed)
(288) Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patientsby Askari F1, Rashidkhani B2, Hekmatdoost A3.(PubMed)
(289) Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in miceby Tankam JM1, Sawada Y, Ito M.(PubMed)
(290) An overview on chemical composition, bioactivity and processing of leaves of Cinnamomum tamalaby Sharma V1, Rao LJ.(PubMed)
(291) Antimicrobial activities of commercial essential oils and their components against food-borne pathogens and food spoilage bacteriaby Mith H1, Duré R2, Delcenserie V2, Zhiri A3, Daube G2, Clinquart A2.(PubMed)
(292) The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plantsby Miller AB1, Cates RG, Lawrence M, Soria JA, Espinoza LV, Martinez JV, Arbizú DA.(PubMed)
(293) Anticandidal efficacy of cinnamon oil against planktonic and biofilm cultures of Candida parapsilosis and Candida orthopsilosisby Pires RH1, Montanari LB, Martins CH, Zaia JE, Almeida AM, Matsumoto MT, Mendes-Giannini MJ.(PubMed)
(294) Properties and Uses for Herbs and Spices
(295) Fumigant activity of (E)-anethole identified in Illicium verum fruit against Blattella germanica by Chang KS1, Ahn YJ.(PubMed)
(296) Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogensby Botelho MA1, Nogueira NA, Bastos GM, Fonseca SG, Lemos TL, Matos FJ, Montenegro D, Heukelbach J, Rao VS, Brito GA.(PubMed)
(297) Hydrolates from lavender (Lavandula angustifolia) - their chemical composition as well as aromatic, antimicrobial and antioxidant propertiesby Prusinowska R1, Śmigielski K, Stobiecka A, Kunicka-Styczyńska A.(PubMed)
(298) Antioxidant capacity and total phenolic contents of oregano (Origanum vulgare), lavender (Lavandula angustifolia) and lemon balm (Melissa officinalis) from Romaniaby Spiridon I1, Colceru S, Anghel N, Teaca CA, Bodirlau R, Armatu A.(PubMed)
(299) Lavender essential oil inhalation suppresses allergic airway inflammation and mucous cell hyperplasia in a murine model of asthmaby Ueno-Iio T1, Shibakura M2, Yokota K1, Aoe M1, Hyoda T1, Shinohata R1, Kanehiro A3, Tanimoto M3, Kataoka M1.(PubMed)
(300) Lavandula luisieri essential oil as a source of antifungal drugsby Zuzarte M1, Gonçalves MJ, Cruz MT, Cavaleiro C, Canhoto J, Vaz S, Pinto E, Salgueiro L.(PubMed)(301) Antifungal activity of phenolic-rich Lavandula multifida L. essential oilby Zuzarte M1, Vale-Silva L, Gonçalves MJ, Cavaleiro C, Vaz S, Canhoto J, Pinto E, Salgueiro L.(PubMed)
(302) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed ratsby Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
(303) Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in ratsby Sebai H1, Jabri MA2, Souli A3, Rtibi K3, Selmi S3, Tebourbi O4, El-Benna J5, Sakly M4.
(PubMed)
(304) Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stressby Bhaskaran N1, Shukla S, Kanwal R, Srivastava JK, Gupta S.(PubMed)
(305) Study of antimicrobial activity of chamomile oilby Aggag ME, Yousef RT.(PubMed)
(306) Phenolic acids profile, antioxidant and antibacterial activity of chamomile, common yarrow and immortelle (Asteraceae)by Mekinić IG, Skroza D, Ljubenkov I, Krstulović L, Možina SS, Katalinić V.(PubMed)
(307) A novel colorimetric broth microdilution method to determine the minimum inhibitory concentration (MIC) of antibiotics and essential oilsagainst Helicobacter pyloriby Weseler A1, Geiss HK, Saller R, Reichling J.(PubMed)
(308) All-natural composite wound dressing films of essential oilsencapsulated in sodium alginate with antimicrobial propertiesby Liakos I1, Rizzello L2, Scurr DJ3, Pompa PP2, Bayer IS4, Athanassiou A5.(PubMed)

The Pro and Con of Vitamin B2 in Prostate Cancer, Scientists Reveal

By Kyle J. Norton

Vitamin B2 also known as Riboflavin, is a water-soluble, yellow-orange organic compound found abundantly in milk, meat, eggs, nuts, enriched flour, green vegetables, etc.

The vitamin is essential for normal cellular growth and function.

 The vitamin is also best known for converting energy from protein, fat, and carbohydrates during metabolism and its antioxidant effects in oxidation-reduction reactions.

Prostate cancer is a medical condition characterized by prostate cells growth uncontrollably and disorderly.

 At the late stage, prostate cancerous cell can travel a distance away from the prostate to infect other healthy organs and tissue.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

Epidemiological studies, linking vitamin B2 in reduced risk of prostate cancer have produced inconsistent results.

The Pro

 Luckily, in the study of Cancer Research and Product Development Laboratory, Immunal Ltd, active mixture AM: L-arginine, L-histidine, L-methionine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ascorbate, D-biotin, pyridoxine, riboflavin, adenine, L(-)malate), induced apoptosis through the mitochondrial pathway and G1 arrest in PC-3 cells and in PC-3 xenografts(3). 

Also, in the interaction of interaction between β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) and riboflavin(RF) indicated that both RF-βCD and RF-HPβCD complexes were cytotoxic to PC3 prostate cancer cells(4). 

Other researchers suggested that there is a weak associations between prostate cancer incidence and dietary intake of riboflavin and between riboflavin intake and prostate cancer mortality(5). 

But in the study of the role of diet in prostate cancer, researchers suggested that intake of linoleic acid and riboflavin (in subjects 50 years and over) could be protective when compared with control subjects(10).

In the study of the effects of irradiated riboflavin on androgen-independent human, by Universidade Estadual de Campinas, researchers showed that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner, through inhibited matrix-degrading proteases(invloved both the process of ECM remodeling and angiogenesis, and in a potential causal relationship between these processe) caused downregulation of VEGF(vascular endothelial growth factor ) and upregulation of TIMP1(inhibitor of metalloproteinases)(9).

The Con
Over expression of riboflavin carrier protein (RCP) in prostate cancer patient may be used as a marker in -targeted diagnosis and for the assessment of vascular metabolism in tumors(6). 

In localized both androgen-dependent and independent prostate cancer cell lines, antibodies to chicken RCP inhibited incorporation of tritiated thymidine into DNA and prevented riboflavin uptake in PC3 prostate cancer cells(7).

Other suggestion of elevated plasma concentrations of choline and vitamin B2 may be associated with an increased risk of prostate cancer(8).

In prostate cancer cell line cancer (LnCap), vitamin B2 intakes were not associated with prostate cancer survival(1)

And dietary supplements, including vitamn B2 effective treatments for PC patients is not supported by sound clinical evidence(2).

Taking altogether, vitamin B2 may be considered as a vital component of any treatment plan instead of sole mean for prevention and treatment in prostate cancer patients.

Over doses of vitamin B2 may cause symptoms of skin rashes, hypersensitivity, high blood pressure etc...


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) One-carbon metabolism-related nutrients and prostate cancer survival by Kasperzyk JL, Fall K, Mucci LA, Håkansson N, Wolk A, Johansson JE, Andersson SO, Andrén O(PubMed)
(2) Dietary supplements and prostate cancer: a systematic review of double-blind, placebo-controlled randomised clinical trials by Posadzki P, Lee MS, Onakpoya I, Lee HW, Ko BS, Ernst E.(PubMed)
(3) A mixture of amino acids and other small molecules present in the serum suppresses the growth of murine and human tumors in vivo by Kulcsár G, Gaál D, Kulcsár PI, Schulcz Á, Czömpöly T(PubMed)
(4) Non-inclusion complexes between riboflavin and cyclodextrins by de Jesus MB, Fraceto LF, Martini MF, Pickholz M, Ferreira CV, de Paula E(PubMed)
(5) Dietary intake of B vitamins and methionine and prostate cancerincidence and mortality by Bassett JK, Severi G, Hodge AM, Baglietto L, Hopper JL, English DR, Giles GG.(PubMed)
(6) Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors by Jayapaul J, Arns S, Lederle W, Lammers T, Comba P, Gätjens J, Kiessling F(PubMed)
(7) Biochemical characterization of riboflavin carrier protein (RCP) in prostate cancer by Johnson T, Ouhtit A, Gaur R, Fernando A, Schwarzenberger P, Su J, Ismail MF, El-Sayyad HI, Karande A, Elmageed ZA, Rao P, Raj M(PubMed)
(8) One-carbon metabolism and prostate cancer risk: prospective investigation of seven circulating B vitamins and metabolites by Johansson M, Van Guelpen B, Vollset SE, Hultdin J, Bergh A, Key T, Midttun O, Hallmans G, Ueland PM, Stattin P(PubMed)
(9) A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours by de Souza Queiroz KC, Zambuzzi WF, Santos de Souza AC, da Silva RA, Machado D, Justo GZ, Carvalho HF, Peppelenbosch MP, Ferreira C(PubMed)
(10) The role of diet in prostate cancer by Kaul L, Heshmat MY, Kovi J, Jackson MA, Jackson AG, Jones GW, Edson M, Enterline JP, Worrell RG, Perry SL(PubMed)