By Kyle J. Norton, Scholar, Master of Nutrition
Decreased hormonal secretions due to aging stimulates the production of the enzyme 5-alpha reductase to converse testosterone to gihydro-testosterones DHT, leading to hair growth back thinner or not growth back at all.
DHT shrinks the follicles, causing hair thins.
Commonly, hair receded at the forehead, crown and temple for men and thins over the entire scalp for women.
Herbal treatment for hair loss has existed throughout human history, but epidemiological studies, linking herbs effectiveness in treating hair loss have produced inconsistent results.
Androgenetic alopecia is a common hair loss in men and women.
In men, it causes baldness patterns, receding at the forehead.
In women, the hair becomes thinner all over the head, and the hairline does not recede.
1. Thujae occidentalis
Thujae occidentalis is an evergreen coniferous tree, belonging to the cypress family, native to the United States and the southeast of Canada. the herb has been used in folk medicine in treating warts, ringworm and thrush.
In HEK 293 cell line derived from human embryonic kidney cells grown in tissue culture, with expressing human 5alpha-reductase (type 2), researchers found that thujae occidentalis semen (TOS) extract in comparison with gamma-linolenic acid and finasteride (a synthetic drug used to be for the treatment of benign prostatic hyperplasia), topically applied to fuzzy rat and androchronogenetic alopecia (AGA) mouse, shows effectiveness in treating male pattern baldness by dictating androgen conversion with higher inhibition activity of 5alpha-reductase type 2 than that of gamma-linolenic acid, but lower than that of finasteride.
These result indicated that the extract may be a potent agent for treating male baldness(1).
2. Cuscuta reflexa Roxb(Dodder)
Cuscuta reflexa Roxb is a Perennial tree, belongings to the family Cuscutaceae, native to the Eastern Asia.
Petroleum ether extract of C. reflexa, in the experiment used as a topical application, showed the inhibition of 5alpha-reductase activity, hair growth-promoting activity, by blocking conversion of testosterone to dihydrotestosterone which causes hair receded(2).
3. Citrullus colocynthis Schrad
Citrullus colocynthis is a desert viny plant native to the Mediterranean Basin and Asia.
The herb has been used in folk medicine for treatments of cancer, carcinoma, endothelioma, leukemia, corns, tumors, etc.
In androgen-induced alopecia mice, application of the petroleum ether extract of C. colocynthis showed an effectiveness in enhancing follicular density, exhibited hair growth-promoting activity in anagenic phase in compared to standard finasteride(3).
4. Eclipta alba(false daisy)
Eclipta alba is a species of E. prostrata , belongings to the family Asteraceae, native to India, China, Thailand, and Brazil.
The herb has been used in folk medicine for treatments of combating swelling, inflammation, skin conditions, etc..
Petroleum ether and ethanol extract of E. alba Hassk in comparison with minoxidil 2% in rat study, exhibited hair growth pattern better than the positive control minoxidil 2% with significantly reduced time for complete hair growth.(4)
5. Garlic
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia.
The herb or food has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.,
Experiment of garlic gel in promoting hair growth suggested that garlic gel shows a positive response in enhancing the application of topical betamethasone valerate(5).
6. Onion
The onion is a plants in the genus Allium, belongings to the family Alliaceae, a close relation of garlic.
It is often called the “king of vegetables” because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world’s cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
Topical crude onion juice in the study against hair loss, exhibited re-growth of terminal coarse hairs after two weeks of application, in significantly higher among males compared to females, after 4 weeks(6).
7. Polygonum multiflorum
He Shou wu is also known as Chinese Knotweed, genus Fallopia, belongings to Polygonaceae, native to central and southern China.
The herbal medicne has been used in traditional Chinese medicine in treating hyperlipemia, neurasthenia, split personality, premature white hair, nerve injuries, skin wind rash, constipation, etc..
Ethanol extract from Polygonum multiflorumroots in the experiment using dermal papilla cells (DPCs), showed to increase the proliferation of DPCs which plays an impotant role in enhancing hair growth and hair-fiber length significantly(7).
In topically applied to the shaved dorsal skin of telogenic C57BL6/N mice, the extract stimulated hair growth by inducing anagen phase and the number and the size of hair follicles(8).
8. Platycladus
Thuja orientalis is a evergreen coniferous tree belongings to the family Cupressaceae, native to northwestern China.
The herbs has been used in traditional medicine in treating baldness and hair loss in East Asia.
T. orientalis extract, in the experiment of topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, induced an earlier anagen phase and prolonged the mature anagen phase, reduced earlier induction of β-catenin and Shh proteins in hair follicles.
These result indicated that Thuja orientalis may be beneficiary as a potential hair growth-promoting agent.(9).
9. Asiasari radix(Chinese wild ginger root)
Asiasari radix has been used in Asian traditionally medicine for treating hair loss in to stimulate hair growth.
In female C57BL/6 and C3H mice, topical application of Asiasari radix extract showed an effectiveness in promoting hair growth and increased protein synthesis in vibrissae follicle cultures and the proliferation of both HaCaT and human DP cells in vitro.(10)
10. Sophora flavescens
Sophora flavescens is a species of genus Sophora, belongings to family Fabaceae.
The herb has been used in traditional medicine for treatments of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage etc.
In the experiment of topical application of Sophora flavescens extract in C57BL/6 mice, researchers found that injection of the extract enhances on hair growth may be mediated through the regulation of growth factors in dermal papilla cells and inhibited the type II 5alpha-reductase activity(11).
11. Crinum asiaticum
Crinum asiaticum is a genus of Crimum, belongings to the family Amaryllidaceae, native to Jeju Island, Korea.
The herb has been used in herbal medicine for treatments of injury and inflamed joints, swellings, swollen joints, lumbago, pains and in cases of headache, fever, etc.
Topical application of the EtOH extract of C. asiaticum onto the back of C57BL/6, increased the proliferation of immortalized vibrissa dermal papilla cells, cell nuclear antigen (PCNA) in the bulb region and the hair-fiber lengths of vibrissa(12).
Norgalanthamine, a chemical constituent of Crinum asiaticum, also induced anagen progression of the hair shaft and increased the proliferation of immortalized vibrissa dermal papilla cells(16)
12. Ishige sinicola
Ishige sinicola is a genus of brown algae (class Phaeophyceae), belongings to the family Ishigeaceae native to native to Jeju Island, Korea.
Topical application of I. sinicola extract onto the back of C57BL/6 mice inhibited anagen progression of the hair shaft and activity of the activity of 5α-reductase and increased cell proliferation vibrissa dermal papilla cells (DPCs), downregulated p27kip1 in stopping or slowing down the cell division cycle(13).
13. Acenthopanax koreanum
Acanthopanax koreanum Nakai (Araliaceae), a well-known herbal medicine in Jeju Island, Korea, has been used as a tonic agent in treating stress-related states(14).
In the experiment of immortalized rat vibrissa dermal papilla cells treated with extract of A. koreanum leaves, showed an enhancement of the proliferation of dermal papilla cells, of the hair-fiber lengths of the vibrissa follicles by increasing the nuclear β-catenin level, and up-regulation of cyclin D1, cyclin E (regulating cell cycle progression) and CDK2(Cells decide at the end of mitosis to either start the next cell cycle and downregulation of the expression of p27(kip1)(Cyclin-dependent kinase inhibitor) in the dermal papilla cells(15).
14. Schisandra nigra
Schisandra nigra, a plant native to Jeju Island, South Korea has been used in traditional medicine for liver protection and treatments of nervous, respiratory system.
Topical application of the EtOH extract of S. nigra onto the back of C57BL/6 mice nigra, exhibited the increased hair-fiber lengths of the vibrissa follicles, induced anagen progression of the hair shaft and increased both the expression of proliferating cell nuclear antigen (PCNA) in the bulb matrix region and the proliferation of immortalized vibrissa dermal papilla cells(17).
The enhancement of herbal medicine for treatments of hair loss, linking to inhibit anagen progression of the hair shaft and activity of 5α-reductase, increase proliferation vibrissa dermal papilla cells with little or no side effects has produced some promising results.
Some days, they may be considered as approval prominent treatments, in improving appearance and quality of life by reducing the psychological stress with affordable cost.
Once again, please consult with you doctor or related field specialist before applying,
STOP HAIR LOSS - PERMANENTLY, Fill in Bald Spots, Stop Thinning Hair And , Restore Receding Hair Lines, Naturally
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References
(1) The extract of Thujae occidentalis semen inhibited 5alpha-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse by Park WS, Lee CH, Lee BG, Chang IS.(PubMed)
(2) Effect of Cuscuta reflexa Roxb on androgen-induced alopecia by Pandit S, Chauhan NS, Dixit VK.(PubMed)
(3) Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia by Dhanotia R, Chauhan NS, Saraf DK, Dixit VK.(PubMed)
(4) Hair growth promoting activity of Eclipta alba in male albino rats by Roy RK, Thakur M, Dixit VK.(PubMed)
(5) Combination of topical garlic gel and betamethasone valerate cream in the treatment of localized alopecia areata: a double-blind randomized controlled study by Hajheydari Z, Jamshidi M, Akbari J, Mohammadpour R.(PubMed)
(6) Onion juice (Allium cepa L.), a new topical treatment for alopeciaareata by Sharquie KE, Al-Obaidi HK.(PubMed)
(7) Promotion effect of constituents from the root of Polygonum multiflorumon hair growth by Sun YN, Cui L, Li W, Yan XT, Yang SY, Kang JI, Kang HK, Kim YH.(PubMed)
(8) Topical application of Polygonum multiflorum extract induces hairgrowth of resting hair follicles through upregulating Shh and β-catenin expression in C57BL/6 mice by Park HJ, Zhang N, Park DK.(PubMed)
(9) Hair growth-promoting activity of hot water extract of Thuja orientalis by Zhang NN, Park DK, Park HJ.(PubMed)
(10) The hair growth promoting effect of Asiasari radix extract and its molecular regulation. ho SS, Park SJ, Hwang SL, Lee MH, Kim CD, Lee IH, Chang SY, Rang MJ.(PubMed)
(11) The hair growth promoting effect of Sophora flavescens extract and its molecular regulation by Roh SS, Kim CD, Lee MH, Hwang SL, Rang MJ, Yoon YK.(PubMed)
(12) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed).
(13) The promoting effect of Ishige sinicola on hair growth by Kang JI, Kim EJ, Kim MK, Jeon YJ, Kang SM, Koh YS, Yoo ES, Kang HK.(PubMed)
(14) The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice by Jung JM, Park SJ, Lee YW, Lee HE, Hong SI, Lew JH, Hong E, Shim JS, Cheong JH, Ryu JH.(PubMed)
(15)Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth by Kim SC, Kang JI, Park DB, Lee YK, Hyun JW, Koh YS, Yoo ES, Kim JA, Kim YH, Kang HK.(PubMed)
(16) Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth by Kim SC, Kang JI, Kim MK, Hyun JH, Boo HJ, Park DB, Lee YJ, Yoo ES, Kim YH, Kim YH, Kang HK.(PubMed)
(17) Promotion effect of Schisandra nigra on the growth of hair by Kang JI, Kim SC, Hyun JH, Kang JH, Park DB, Lee YJ, Yoo ES, Kang HK.(PubMed)
Monday 25 June 2018
*The Fruits That Kill Breast Cancer Cells, Revealed By MEDLINE Studies
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but to discover an effective prevention and treatment with little or no side effects has proven difficultly.
According to statistic, the risk of getting invasive breast cancer during life time of a women is 1/8.
Healthy diet with plenty vegetables and fruits(1)(2)(3) with change of life style(4)(5)(6) may be the only choice for women in reducing risk of the diseases.
1. Blueberry
Blueberry is a flower plant, belongings to the family Eriaceae, native to Northern America.
Triple-negative breast cancer TNBC, a cancer does not express the genes for estrogen receptor (ER), progesterone receptor(PR), and HER2(gene) affecting approximately 15% of all caner cases.
Female MDA-MB-231 tumor-bearing mice fed with high fat diet with 5% whole blueberry powder (BB), inhibited TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways through immune response in reduced tumor growth and metastasis(40).
In 17β-estradiol-mediated mammary tumorigenesis, 5% blueberry diet, decreased tumor volume and multiplicity significantly, by down regulation of CYP 1A1(enzymes, able to activate compounds with carcinogenic properties) and ER-α (a receptor activated by the sex hormone estrogen)genes expression and also favorable modulation of microRNA (mir-18a and mir-34c) levels in gene regulation(41).
Other chemical constituents such as anthocyanin and anthocyanin-pyruvic acid adduct extract of blueberry restricted cancer cell proliferation by acting as cell anti invasive factors and chemoinhibitors(42).
2. Avocado
Avocados, the green-skinned, pear-shaped fruit that ripens after harvesting are a commercially valuable fruit cultivated in tropical climates throughout the world, native to the Caribbean, Mexico, South America and Central America, belongings to the flowering plant family Lauraceous.
Avocado-produced toxin persin may contain a positive anti breast cancer effect(43).
Persin exerted an significant anti breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Application of persin in animal model, selectively induced G2-M cell cycle arrest and cell death through caspase-dependent pathway(44).
3. Strawberry
Strawberries is a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Methanolic extract of strawberry (MESB) fruits induced cytotoxicity in cancer cells, irrespective of origin, in a concentration- and time-dependent manner, in the testing against leukaemia (CEM) and breast cancer (T47D) cell lines through induction of intrinsic pathway of apoptosis by activating p73 (a tumor suppressor) in breast cancer cells, when tumor suppressor gene p53 was mutated(46).
Polyphenols, a major chemical component found in strawberry, exhibited cytotoxic with doses of approximately 50 microg/ml, inducing 50% reduction in cell survival in both the normal and the tumor lines, including (MCF-7) breast cancer cell lines(47).
In other study, freeze-dried fruits of two strawberry cultivars ethanol extract, strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell lines(48).
4. Pomegranate
Pomegranate is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
Pomegranate extracts and genistein exerted anti cancer effect in inhibition of cell proliferation and induction of apoptosis in human breast cancer cells(MCF-7) in doses and time depending manner(49) by downregulated HR genes (a ubiquitous cellular pathway that mediates transfer of genetic information) and increased expression of microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (regulation of gene expression)(50).
Pomegranate fruit extracts (PFEs), in dose-dependent inhibited NF-kB-dependent reporter gene responses associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression as these genes are associated with tumor cell invasion and metastasis(51).
6. Grapes
Resveratrol, a polyphenolic compound known as a good chemopreventive agent for inhibiting carcinogenesis processes that target the regulators of cell function and DNA replication, found abundantly in grapes, berries and peanuts are associated to reduced risk of breast caner.
HS-1793, a synthetic version of the compound of resveratrol induced G2/M(DNA damage checkpoint) arrest in the cell cycle progression through induction of p53(tumor suppressor gene)-dependent apoptosis in MCF-7 cells(52).
Catechin (RQC), a polyphenol, was effective in ameliorated mammary tumor growth and metastasis, by reduced Akt (multiple cellular process activity, induced the activation of AMPK(cellular energy)), and inhibited mTOR(mediate cellular responses) signaling in breast cancer cells(53).
In Her-2 breast cancer, fox grape seed extract increased the expression of Bax(an apoptosis promoter) and AIF(Apoptosis inducing factor), and decreased total PARP(cellular processes) expression, leading to significant downregulation of Her-2 in MCF-7 cells(54).
7. Pineapple
Pineapple is a species of Ananas Comos, belongings to the family Bromeliaceae and native to southern Brazil and Paraguay, cultivated for commercial uses.
Pineapple rich of vitamins and mineral and digesting enzyme bromelin seems to help digestion after a high protein meal.
Persin exerted an significant anti breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Bromelain, a major chemical constituent exerted anti-metastasis against breast cancer by up regulating the function of c-Jun N-terminal kinase in cell proliferation, differentiation, survival and migration and p38 kinase to cause programmed cell death(56).
In GI-101A breast cancer cells, bromelain induced cell death via activation of the apoptosis mechanism, in increased dose-dependent by promoting apoptosis and cytokine processing of caspase-9 and caspase-3 coinciding with elevation of serum CK18 levels(56).
In the brMDA-MB-231 mammary carcinoma, oral administration of bromelain increased the reduced bMAK- and MAK-cell activity in cell cycle regulation from 7.8% to 54% (bMAK-cell activity) and from 16% to 47% (MAK-cell activity by stimulating the deficient monocytic cellular cytotoxicity of mammary tumor(57).
8. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, originated in Central Asia.
In estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cell lines, apple phytochemical extracts significantly inhibited cell proliferation in a dose-dependent manner and cell cycle modulation(58).
In breast carcinoma Mcf-7 and Mcf-7:Her18 cells, peels of apple were effective in antiproliferation accompanied by a G0-G1 phase arrest in cell cycle through activated tumor suppressor protein that suppressed the regulation of cell invasion, metastasis, and angiogenesis(59).
Study of apple extracts and quercetin 3-beta-d-glucoside combination, also showed to possess the synergistic effect in MCF-7 cell proliferation(60).
9. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to the Southeast Asia.
Polymethoxyflavones (PMFs), a chemical compound found in sweet orange (Citrus sinensis L.) peel, induced Ca(2+)-mediated apoptosis in human breast cancer cells through proapoptotic activity(61).
D-limonene, another compound in orange peel oil, in rodent studies, also exhibited chemotherapeutic activity against mammary cells, through the induction of tumor cell apoptosis, tumor redifferentiation, and/or suppression of key proteins of cell growth-regulating (62).
Taken Together, vegetables(7)(8) and fruits(9)(10) or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the breast cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.
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Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD.(PubMed)
(2) Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Life style and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(44) A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL.(PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.(PubMed)
(46) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubvMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD.(PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC.(PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND.(PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF.(PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- ol vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.(PubMed)
(58) Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL.(PubMed)
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD.(PubMed)
(2) Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Life style and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(44) A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL.(PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.(PubMed)
(46) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubvMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD.(PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC.(PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND.(PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF.(PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- ol vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.(PubMed)
(58) Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL.(PubMed)
Weight Loss And Weight Maintenance Problems? Try This Legume, Scientists Say
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of many diseases, but single ingredient isolated from such plants may induce opposite outcomes.
According to the University of Calgary study, dried peas fiber may have a profound and positive effect in induced and sustained weight loss in over weight and obese subjects.
Obesity is a medical condition characterized by excess body fat accumulated overtime.
The health line in its website indicates, there are as much as 20 reasons, "Why You're Not Losing Weight" in the article with the same tittle,
Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of many diseases, but single ingredient isolated from such plants may induce opposite outcomes.
According to the University of Calgary study, dried peas fiber may have a profound and positive effect in induced and sustained weight loss in over weight and obese subjects.
Obesity is a medical condition characterized by excess body fat accumulated overtime.
Overweight is a condition of excess body weight relatively to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity.
Statistic shows, 68% of American population are either overweight or obese.
The article written by LOUISE LUCAS AND ALAN RAPPEPORT and posted on Financial Times, suggested, " Diet aids are often more successful at shedding dollars than pounds – for manufacturers as well as consumers and "The weight-management industry, worth $11-billion in retail sales according to data company Euromonitor, should by rights be a major beneficiary of the times".
However, how many people have followed through all those programs? How may people have maintained the weight reduction? The answers are debatable, depending to who you talk to.
One thing for sure, most weight programs are not working to their promises, for whatever reasons, otherwise the statistic should show a rate reduction of obesity in US, over the years.
1. Maybe You Are Losing Without Realizing it
2. You're Not Keeping Track of What You're Eating
3. You're Not Eating Enough Protein
4. You're Eating Too Many Calories
5. You're Not Eating Whole Foods
6. You're Not Lifting Weights
7. You're Binge Eating (Even on Healthy Food)
8. You're Not Doing Cardio
9. You're Still Drinking Sugar
10. You're Not Sleeping Well
11. You're Not Cutting Back on Carbohydrates
12. You're Eating Too Often
13. You're Not Drinking Water
14. You're Drinking Too Much Alcohol
15. You're Not Eating Mindfully
16. You Have a Medical Condition That is Making Things Harder
17. You're Addicted to Junk Food
18. You've Been Starving Yourself For Too Long
19. Your Expectations Are Unrealistic
20. You're Too Focused on "Dieting"
5. You're Not Eating Whole Foods
6. You're Not Lifting Weights
7. You're Binge Eating (Even on Healthy Food)
8. You're Not Doing Cardio
9. You're Still Drinking Sugar
10. You're Not Sleeping Well
11. You're Not Cutting Back on Carbohydrates
12. You're Eating Too Often
13. You're Not Drinking Water
14. You're Drinking Too Much Alcohol
15. You're Not Eating Mindfully
16. You Have a Medical Condition That is Making Things Harder
17. You're Addicted to Junk Food
18. You've Been Starving Yourself For Too Long
19. Your Expectations Are Unrealistic
20. You're Too Focused on "Dieting"
If you want to know more of the above differentiation, I courage you to click the cited link at Why You're Not Losing Weight"
Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.
In a double blind, placebo controlled, parallel group study, with overweight and obese (BMI = 25-38) adults randomized to either a 15 g/d yellow pea fibre supplemented group or isocaloric placebo group for 12 weeks (n = 30/group), researchers found that peas fiber displays a significant effect in weight reduction through various mechanisms, including improvement of metabolic syndrome and gut microbiota expression.
Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.
In a double blind, placebo controlled, parallel group study, with overweight and obese (BMI = 25-38) adults randomized to either a 15 g/d yellow pea fibre supplemented group or isocaloric placebo group for 12 weeks (n = 30/group), researchers found that peas fiber displays a significant effect in weight reduction through various mechanisms, including improvement of metabolic syndrome and gut microbiota expression.
Metabolic syndrome is associated to weight gain due to its effects in increased odds of low HDL and high triglycerides relative in compared to participants with continuously stable weights(4).
According to the Université de la Méditerranée, gut microbiota expression is correlated to host weight. And microbial changes in the human gut were proposed to be one of the possible causes of obesity(5).
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a randomizedcontrolled trialby Jennifer E Lambert,1 Jill A Parnell,2 Jay Han,3 Troy Sturzenegger,3 Heather A Paul,4 Hans J Vogel,4,5 and Raylene A Reimer
1,4(PMC)
(2) Dietary adherence and satisfaction with a bean-based high-fiber weight loss diet: a pilot study by Turner TF1, Nance LM1, Strickland WD1, Malcolm RJ1, Pechon S1, O'Neil PM1.(PubMed)
(3) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(4) Metabolic Syndrome and Weight Gain in Adulthood by Dawn E. Alley1 and Virginia W. Chang(PMC)
(5) The relationship between gut microbiota and weight gain in humans by Angelakis E1, Armougom F, Million M, Raoult D.(PubMed)
Dr. Jennifer E Lambert, the lead author said, " feeding the prebiotic fibre oligofructose for 12 weeks reduced levels of the orexigenic hormone ghrelin and increased levels of the anorexigenic hormone PYY in overweight adults which corresponded with lower self-reported energy intake [13]. In the long-term, these changes in postprandial peptide secretion may promote weight loss through reductions in ad libitum food intake", and "Both bacterial abundance and composition can be altered with lifestyle changes. Indeed, part of the role of intestinal bacteria in weight control has been elucidated through study of patients receiving bariatric surgery".
Additionally, in the examined the nutritional effects and acceptability of two high-fiber hypocaloric diets differing in sources of fiber: (a) beans or (b) fruits, vegetables, and whole grains of 2 men, 18 women, mean age = 46.9, and mean BMI = 30.6.with participants completed 3-day food diaries in each of the two baseline weeks, researchers indicated that
*. There are no difference in outcome of fiber intake of all groups. Both diets increased fiber intake from 16.6 in compared to baseline.
*. Fiber intake showed a consistent effect in reduced weight status over treatment in both groups with mean weight loss was 1.4 kg.
*. Returned questionnaire also addressed the hunger decreased and fullness increased during the testing period in both groups.
*. Both diets were rated as potentially acceptable as long as six months.
The findings evidences suggested that bean and fruits, vegetables, and whole grains fiber demonstrated a similar efficacy in increased satiation, and reduced hunger in induced weight loss.
.
Interestingly, in a total of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomised to a high-fibre bean-rich diet with fibre intakes of 35.5 (18.6) g day(-1) for women and 42.5 (30.3) g day(-1) for men, or a low-carbohydrate diet, researchers found that in 123 (71.1%) completers at 16 weeks
*. The mean (SD) weight loss of both groups was 4.1 (4.0) kg.
*, Fiber dietary group expresses a higher weight loss of 5.2 in compared to 4.5 kg in low-carbohydrate group.
3. High-fibre diet shows a better decreased low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to low-carbohydrate diet.
Dr. Tonstad S, the led author said."After 52 weeks, the low-carbohydrate (n = 24) group tended to retain weight loss better than the high-fibre group (P = 0.06), although total cholesterol remained lower with the bean-rich diet (P = 0.049)."
Taking altogether, there is no doubt that fibers of bean or other sources as functional foods, may have strong implication in induced weight loos and weight management for over weight and obese subjects.
The amounts of fiber intake should be consulted with your doctors to prevent overdoses constipation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Additionally, in the examined the nutritional effects and acceptability of two high-fiber hypocaloric diets differing in sources of fiber: (a) beans or (b) fruits, vegetables, and whole grains of 2 men, 18 women, mean age = 46.9, and mean BMI = 30.6.with participants completed 3-day food diaries in each of the two baseline weeks, researchers indicated that
*. There are no difference in outcome of fiber intake of all groups. Both diets increased fiber intake from 16.6 in compared to baseline.
*. Fiber intake showed a consistent effect in reduced weight status over treatment in both groups with mean weight loss was 1.4 kg.
*. Returned questionnaire also addressed the hunger decreased and fullness increased during the testing period in both groups.
*. Both diets were rated as potentially acceptable as long as six months.
The findings evidences suggested that bean and fruits, vegetables, and whole grains fiber demonstrated a similar efficacy in increased satiation, and reduced hunger in induced weight loss.
.
Interestingly, in a total of 173 women and men, with a mean body mass index of approximately 36 kg m(-2) (one-fifth with diabetes type 2) randomised to a high-fibre bean-rich diet with fibre intakes of 35.5 (18.6) g day(-1) for women and 42.5 (30.3) g day(-1) for men, or a low-carbohydrate diet, researchers found that in 123 (71.1%) completers at 16 weeks
*. The mean (SD) weight loss of both groups was 4.1 (4.0) kg.
*, Fiber dietary group expresses a higher weight loss of 5.2 in compared to 4.5 kg in low-carbohydrate group.
3. High-fibre diet shows a better decreased low-density lipoprotein (LDL)-cholesterol and total cholesterol levels in compared to low-carbohydrate diet.
Dr. Tonstad S, the led author said."After 52 weeks, the low-carbohydrate (n = 24) group tended to retain weight loss better than the high-fibre group (P = 0.06), although total cholesterol remained lower with the bean-rich diet (P = 0.049)."
Taking altogether, there is no doubt that fibers of bean or other sources as functional foods, may have strong implication in induced weight loos and weight management for over weight and obese subjects.
The amounts of fiber intake should be consulted with your doctors to prevent overdoses constipation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Evaluation of yellow pea fibre supplementation on weight loss and the gut microbiota: a randomizedcontrolled trialby Jennifer E Lambert,1 Jill A Parnell,2 Jay Han,3 Troy Sturzenegger,3 Heather A Paul,4 Hans J Vogel,4,5 and Raylene A Reimer
1,4(PMC)(2) Dietary adherence and satisfaction with a bean-based high-fiber weight loss diet: a pilot study by Turner TF1, Nance LM1, Strickland WD1, Malcolm RJ1, Pechon S1, O'Neil PM1.(PubMed)
(3) A high-fibre bean-rich diet versus a low-carbohydrate diet for obesity by Tonstad S1, Malik N, Haddad E.(PubMed)
(4) Metabolic Syndrome and Weight Gain in Adulthood by Dawn E. Alley
1 and Virginia W. Chang(PMC)(5) The relationship between gut microbiota and weight gain in humans by Angelakis E1, Armougom F, Million M, Raoult D.(PubMed)
*Infectious Diseases: The Anti Over Growth of Candida Diet That Works, Cited by MEDLINE
By Kyle J. Norton, Scholar, Master of Nutrition
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Over growth of candida is associated to some life threatening and chronic implications, including toxic shock syndrome(TSS), scalded skin syndrome (SSS), irritable bowel syndrome ,..... and
Fibromyalgia(a)
The Anti Over Growth of Candida Diet
1. Apple Cider Vinegar
Apple Cider Vinegar is a type of vinegar made from cider or apple must and has a pale to medium amber color.
Beside it is known for treating obesity(208)(209), the liquid is rich in natural enzymes which aid in digestion,
Apple cider vinegar also balances your body's pH level,
Its high amount of antioxidants also restore the natural balance of healthy bacteria in the gut by creating a perfect environment for those healthy bacteria to grow, while keeping candida in check(207) by enhancing the immune function(210) in regulating the microorganism in the body.
2. Coconut oil
Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm tree, native to the tropical world.
Coconut oil, is one of most effective antibacterial(including Candida)(211)(213), antioxidant(214), antiviral(215) agents, used in traditional medicinal remedies for treatment of benign prostatic hyperplasia(216) and inflammation(217). Caprylic acid, a minor constituent of coconut oil has been demonstrated to inhibit fungal growth(212)(218), both topically and internally.
3. Garlic
Garlic is species of Allium sativum, belongings to the family Alliaceae, used as both food and medicine in many cultures for thousands of years.
Garlic cloves are used as a remedy for infections(219)(220), digestive disorders(221), and fungal infections, including candida(222), due to large number of anti-fungal properties of sulphur, allicin, alliin, alliinase and S-allylcysteine.
4. Ginger
Ginger is a species of Zingiber officinale, belongings to the family Zingiberaceae, used as a delicacy, medicine, or spice in many cultures.
The gingerrols in ginger increase the motility of the gastrointestinal tract(223) and as analgesic(224)(226), sedative(225), antipyretic(226), antibacterial(227) and anti- inflammatory(228) properties.
Researcher (Am. J. Applied Sci., 6 (6): 1067-1069, 2009) found that ginger extract with plentiful of gingerol inhibits the growth of many bacteria and fungi, including candida ablicans(229)
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Over growth of candida is associated to some life threatening and chronic implications, including toxic shock syndrome(TSS), scalded skin syndrome (SSS), irritable bowel syndrome ,..... and
Fibromyalgia(a)
The Anti Over Growth of Candida Diet
1. Apple Cider Vinegar
Apple Cider Vinegar is a type of vinegar made from cider or apple must and has a pale to medium amber color.
Beside it is known for treating obesity(208)(209), the liquid is rich in natural enzymes which aid in digestion,
Apple cider vinegar also balances your body's pH level,
Its high amount of antioxidants also restore the natural balance of healthy bacteria in the gut by creating a perfect environment for those healthy bacteria to grow, while keeping candida in check(207) by enhancing the immune function(210) in regulating the microorganism in the body.
2. Coconut oil
Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm tree, native to the tropical world.
Coconut oil, is one of most effective antibacterial(including Candida)(211)(213), antioxidant(214), antiviral(215) agents, used in traditional medicinal remedies for treatment of benign prostatic hyperplasia(216) and inflammation(217). Caprylic acid, a minor constituent of coconut oil has been demonstrated to inhibit fungal growth(212)(218), both topically and internally.
3. Garlic
Garlic is species of Allium sativum, belongings to the family Alliaceae, used as both food and medicine in many cultures for thousands of years.
Garlic cloves are used as a remedy for infections(219)(220), digestive disorders(221), and fungal infections, including candida(222), due to large number of anti-fungal properties of sulphur, allicin, alliin, alliinase and S-allylcysteine.
4. Ginger
Ginger is a species of Zingiber officinale, belongings to the family Zingiberaceae, used as a delicacy, medicine, or spice in many cultures.
The gingerrols in ginger increase the motility of the gastrointestinal tract(223) and as analgesic(224)(226), sedative(225), antipyretic(226), antibacterial(227) and anti- inflammatory(228) properties.
Researcher (Am. J. Applied Sci., 6 (6): 1067-1069, 2009) found that ginger extract with plentiful of gingerol inhibits the growth of many bacteria and fungi, including candida ablicans(229)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
(a) Infectious Disease: Beware Of Some Life Threatening And Chronic Complications Associated To Over Growth of Candida by Kyle J. Norton
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(Care 2)(209) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR.(PubMed)
(210) Apple Cider Vinegar Recipes(Immunology)
(211) Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile by Shilling M1, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, Woolverton CJ.(PubMed)
(212) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms by Huang CB1, Alimova Y, Myers TM, Ebersole JL.(PubMed)
(213) Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus by Tangwatcharin P1, Khopaibool P.(PubMed)
(214) Antioxidant capacity and phenolic acids of virgin coconut oil by Marina AM1, Man YB, Nazimah SA, Amin I.(PubMed)
(215) Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention by DebMandal M1, Mandal S.(PubMed)
(216) Effects of coconut oil on testosterone-induced prostatic hyperplasiain Sprague-Dawley rats by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(217) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(218) Caprylic Acid and glyceryl trinitrate combination for eradication of biofilm by Rosenblatt J1, Reitzel RA2, Raad I2.(PubMed)
(219) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infectionsby Bjarnsholt T1, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.(PubMed)
(220) An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infectionsby Tessema B1, Mulu A, Kassu A, Yismaw G.(PubMed)
(221) Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice by Gamboa-Leon R1, Vera-Ku M1, Peraza-Sanchez SR2, Ku-Chulim C1, Horta-Baas A1, Rosado-Vallado M1.(PubMed)
(222) The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trialby Watson CJ1, Grando D, Fairley CK, Chondros P, Garland SM, Myers SP, Pirotta M.(PubMed)
(223) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptorsby Pertz HH1, Lehmann J, Roth-Ehrang R, Elz S.(PubMed)
(224) Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in ratsby Darvishzadeh-Mahani F1, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L.(PubMed)
(225) Stimulative and sedative effects of essential oils upon inhalation in mice.by Lim WC1, Seo JM, Lee CI, Pyo HB, Lee BC.(PubMed)
(226) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a reviewby Pereira MM1, Haniadka R, Chacko PP, Palatty PL, Baliga MS.(PubMed)
(227) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteriaby Park M1, Bae J, Lee DS.(PubMed)
(228) Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in miceby Shieh YH1, Huang HM2, Wang CC3, Lee CC4, Fan CK5, Lee YL6.(PubMed)
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
(a) Infectious Disease: Beware Of Some Life Threatening And Chronic Complications Associated To Over Growth of Candida by Kyle J. Norton
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(Care 2)(209) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR.(PubMed)
(210) Apple Cider Vinegar Recipes(Immunology)
(211) Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile by Shilling M1, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, Woolverton CJ.(PubMed)
(212) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms by Huang CB1, Alimova Y, Myers TM, Ebersole JL.(PubMed)
(213) Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus by Tangwatcharin P1, Khopaibool P.(PubMed)
(214) Antioxidant capacity and phenolic acids of virgin coconut oil by Marina AM1, Man YB, Nazimah SA, Amin I.(PubMed)
(215) Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention by DebMandal M1, Mandal S.(PubMed)
(216) Effects of coconut oil on testosterone-induced prostatic hyperplasiain Sprague-Dawley rats by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(217) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(218) Caprylic Acid and glyceryl trinitrate combination for eradication of biofilm by Rosenblatt J1, Reitzel RA2, Raad I2.(PubMed)
(219) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infectionsby Bjarnsholt T1, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.(PubMed)
(220) An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infectionsby Tessema B1, Mulu A, Kassu A, Yismaw G.(PubMed)
(221) Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice by Gamboa-Leon R1, Vera-Ku M1, Peraza-Sanchez SR2, Ku-Chulim C1, Horta-Baas A1, Rosado-Vallado M1.(PubMed)
(222) The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trialby Watson CJ1, Grando D, Fairley CK, Chondros P, Garland SM, Myers SP, Pirotta M.(PubMed)
(223) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptorsby Pertz HH1, Lehmann J, Roth-Ehrang R, Elz S.(PubMed)
(224) Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in ratsby Darvishzadeh-Mahani F1, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L.(PubMed)
(225) Stimulative and sedative effects of essential oils upon inhalation in mice.by Lim WC1, Seo JM, Lee CI, Pyo HB, Lee BC.(PubMed)
(226) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a reviewby Pereira MM1, Haniadka R, Chacko PP, Palatty PL, Baliga MS.(PubMed)
(227) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteriaby Park M1, Bae J, Lee DS.(PubMed)
(228) Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in miceby Shieh YH1, Huang HM2, Wang CC3, Lee CC4, Fan CK5, Lee YL6.(PubMed)
Sunday 24 June 2018
*Detoxification - How to Detox and Nourish Your Lung for Optimal Health
By Kyle J. Norton, Scholar, Master of Nutrition
Liver, kidney and skin.are 3 major and vital organs with function in protected our body against toxins accumulation.
Everyday toxins are removed by these organs to maintain the organs and tissue integrity and viability. So the body can perform its function in an optimized form.
If one of these organs starts to malfunction, others must take the toxins and remove them.
In cases of our body cannot completely remove all the toxins, toxins will be accumulated in the organs and tissue, leading to weakening of organs and tissue function in induction of chronic ailments.
Herbal medicine have been used to tonify and eliminate toxins from our body over thousand of years, according to Dr. Edward Group, one of the best natural detox methods is a six or seven day cleanse using distilled water, organic, raw apple cider vinegar, aloe vera, Oxy-Powder, and a probiotic supplement.
(10) Polysaccharide from Ephedra sinica Stapf inhibits inflammation expression by regulating Factor-β1/Smad2 signaling by Liang S1, Meng X2, Wang Z3, Liu J4, Kuang H5, Wang Q(PubMed)In cases of our body cannot completely remove all the toxins, toxins will be accumulated in the organs and tissue, leading to weakening of organs and tissue function in induction of chronic ailments.
In fact, selection are so complex and professional, depending to the experience and preference of practitioners. Completely different methods used in compared to conventional medicine, treatment of one drug for all. In herbal medicine, same disease of 2 persons may be treated with different formula and different diseases may be treated with the same formula
Herbal medicine in detoxed your lung
1. Lotus Root Tea
Made from the root of the esteemed Asian water lily, lotus root dissolves and eliminates mucus and lung congestion over time.
Lotus root traditionally has been used to neutralize toxins accumulated in the lung as well as in treating other respiratory diseases such as asthma, tuberculosis, and coughing.
Lotus root with tons of bioactive compounds such as total phenols, gallic acid and polyphenols and high levels of antioxidant activity protects the lung against onset of diseases(1).
1. Lotus Root Tea
Made from the root of the esteemed Asian water lily, lotus root dissolves and eliminates mucus and lung congestion over time.
Lotus root traditionally has been used to neutralize toxins accumulated in the lung as well as in treating other respiratory diseases such as asthma, tuberculosis, and coughing.
Lotus root with tons of bioactive compounds such as total phenols, gallic acid and polyphenols and high levels of antioxidant activity protects the lung against onset of diseases(1).
According to the School of Health & Life Sciences, King's College, "the human lung, from infancy through to old age, can be subjected to deleterious oxidative events as a consequence of inhaling environmental pollutants or irritants, succumbing to several pulmonary diseases (including infant and adult respiratory distress syndromes, asthma, chronic obstructive pulmonary disease, cystic fibrosis and cancer) and receiving treatment for these diseases"(2).
2. Platycodon Root
Moreover, the phytochemical also show a marked protective effect against bronchial asthma induced by inhalation of histamine in conscious guinea pig(7).
“Ephedra, when taken as directed – no more than 90mg/day and not to be taken by those with pre-existing heart conditions – is safe and effective for those looking to lose weight,” said David Fabrican’t, the FDA’s appointed person on dietary supplement regulations,.after FDA lifting the 10-year ban on weight-loss blockbuster botanical ephedra.
Application of the herbal medicine were effective in protected bronchial epithelium(8), inhibited influenza viral pneumonia(9) and chronic obstructive pulmonary diseases (COPD)(10).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars by Park YS1, Towantakavanit K, Kowalska T, Jung ST, Ham KS, Heo BG, Cho JY, Yun JG, Kim HJ, Gorinstein S(PubMed)
(2) Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease by Kelly FJ(PubMed)
(3) Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells by Choi JH1, Jin SW, Kim HG, Choi CY, Lee HS, Ryu SY, Chung YC, Hwang YJ, Um YJ, Jeong TC, Jeong HG(PubMed)
(4) Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro by Tao W1, Su Q2, Wang H3, Guo S4, Chen Y4, Duan J5, Wang S(PubMed)
(5) ALL ABOUT WILD CHERRY BARK (PRINTABLE MONOGRAPH) by Herbal Academy
(6) Protective effects of Isofraxidin against lipopolysaccharide-induced acute lunginjury in mice by Niu X1, Wang Y2, Li W3, Mu Q2, Li H2, Yao H2, Zhang H(PubMed)
(7) [Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri (L.)Cuss].[Article in Chinese] by Chen Z1, Duan X.(PubMed)
(8) Effect of San-ao Decoction, a traditional Chinese prescription, on IL-4 treated normal human bronchial epithelium by Li Y1, Wang MY, Fan XS, Qi X, Chen Y, Zhang H, Zhao QC(PubMed)
(9) Protective effects of Yinhuapinggan granule on mice with influenza viral pneumonia by Peng XQ1, Zhou HF1, Lu YY2, Chen JK1, Wan HT3, Zhang YY(PubMed)
Platycodon has been used in Chinese medicine for over a century
in treating abscesses, respiratory disorders, and intestinal disorders.
Study shows that platycodon roots not only help to treat coughs due to purulent sputum and inflammation in the chest area but also demonstrate a lung protective activity(4).
According to Chungnam National University, in vitro, Platycodon grandiflorum root-derived saponins exerted inhibition of (Changkil saponins: CKS) ovalbumin-induced airway inflammation in mice(3).
Study shows that platycodon roots not only help to treat coughs due to purulent sputum and inflammation in the chest area but also demonstrate a lung protective activity(4).
According to Chungnam National University, in vitro, Platycodon grandiflorum root-derived saponins exerted inhibition of (Changkil saponins: CKS) ovalbumin-induced airway inflammation in mice(3).
3. Wild Cherry Bark
Wild cherry bark traditionally has been used to treat irritable and
persistent
cough of bronchitis, and pertussis due to increased
irritability of respiratory mucosa.
The herb also exerts lung protective effects due to due to its astringent, sedative, antispasmodic, and bronchodilator actions in inhibited dries mucus, expectoration, coughing, particularly, in open of the airways(5).
The herb also exerts lung protective effects due to due to its astringent, sedative, antispasmodic, and bronchodilator actions in inhibited dries mucus, expectoration, coughing, particularly, in open of the airways(5).
4. Mullein
Mullein contains coumarin and rotenone.
Mullein contains coumarin and rotenone.
It has a long history of
being used as a medicine for treatment for asthma
and respiratory disorders.
The herb also sooths the mucous membranes, reduces inflammation and encourages healthy fluid production in the lungs.
According to the Xi'an Jiaotong University, Isofraxidin (IF), a coumarin compound isolated from the natural medicinal plants, including mullein displayed a significant anti-bacterial, anti-oxidant, and anti-inflammatory activities in protected the against injure in animal model(6).
The herb also sooths the mucous membranes, reduces inflammation and encourages healthy fluid production in the lungs.
According to the Xi'an Jiaotong University, Isofraxidin (IF), a coumarin compound isolated from the natural medicinal plants, including mullein displayed a significant anti-bacterial, anti-oxidant, and anti-inflammatory activities in protected the against injure in animal model(6).
5. Ephedra
Epphedra has been used in Chinese medicine traditionally for 5,000
years in treating asthma, hay fever and the common cold.
It also helps to support healthy sinus nasal lung and respiratory function by removing toxins in the lung.
It also helps to support healthy sinus nasal lung and respiratory function by removing toxins in the lung.
Application of the herbal medicine were effective in protected bronchial epithelium(8), inhibited influenza viral pneumonia(9) and chronic obstructive pulmonary diseases (COPD)(10).
6. Elecampane
Elecampane is also called horse-heal with function for
treatment of shortness of breath and promotion of a strong
lung.
Elecampane is a wonderful lung tonic.medicine for treating asthma, and soothing the lining of the lungs.
Accoridng to the study by the Daegu Gyeongbuk Institute for Oriental Medicine Industry, intake of
Elecampane exerted strong anti-asthmatic(11) and anti lung cancer(12) and inhibition of mucus hypersecretion effects in vitro(11).
Elecampane is a wonderful lung tonic.medicine for treating asthma, and soothing the lining of the lungs.
Accoridng to the study by the Daegu Gyeongbuk Institute for Oriental Medicine Industry, intake of
Elecampane exerted strong anti-asthmatic(11) and anti lung cancer(12) and inhibition of mucus hypersecretion effects in vitro(11).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Bioactive compounds and antioxidant and antiproliferative activities of Korean white lotus cultivars by Park YS1, Towantakavanit K, Kowalska T, Jung ST, Ham KS, Heo BG, Cho JY, Yun JG, Kim HJ, Gorinstein S(PubMed)
(2) Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease by Kelly FJ(PubMed)
(3) Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells by Choi JH1, Jin SW, Kim HG, Choi CY, Lee HS, Ryu SY, Chung YC, Hwang YJ, Um YJ, Jeong TC, Jeong HG(PubMed)
(4) Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro by Tao W1, Su Q2, Wang H3, Guo S4, Chen Y4, Duan J5, Wang S(PubMed)
(5) ALL ABOUT WILD CHERRY BARK (PRINTABLE MONOGRAPH) by Herbal Academy
(6) Protective effects of Isofraxidin against lipopolysaccharide-induced acute lunginjury in mice by Niu X1, Wang Y2, Li W3, Mu Q2, Li H2, Yao H2, Zhang H(PubMed)
(7) [Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri (L.)Cuss].[Article in Chinese] by Chen Z1, Duan X.(PubMed)
(8) Effect of San-ao Decoction, a traditional Chinese prescription, on IL-4 treated normal human bronchial epithelium by Li Y1, Wang MY, Fan XS, Qi X, Chen Y, Zhang H, Zhao QC(PubMed)
(9) Protective effects of Yinhuapinggan granule on mice with influenza viral pneumonia by Peng XQ1, Zhou HF1, Lu YY2, Chen JK1, Wan HT3, Zhang YY(PubMed)
(11) Alleviaon of OVA-induced airway inflammation by flowers of Inula japonica in a murine model of asthma by Park YN1, Lee YJ, Choi JH, Jin M, Yang JH, Li Y, Lee J, Li X, Kim KJ, Son JK, Chang HW, Kim JY, Lee E(PubMed)
(12)1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling by Zhengfu H1, Hu Z1, Huiwen M1, Zhijun L1, Jiaojie Z2, Xiaoyi Y3, Xiujun C(PubMed)
*Degenerative Disease: Beware of Dementia Caused By Acquired Or Hereditary Mutation of Genes, MEDLINE Studies Show
By Kyle J. Norton, Scholar and Master of Nutrition
According to US statistic, the rate has been falling sharply by 24 % from 2000 t0 2012 in age group of 65 and older. And the average age of people diagnosed with dementia in 2000, are 80.7 in compared to 82,4% in 2012(1).
Sadly, Alzheimer's disease is the sixth-leading cause of death in the United States, and the fifth-leading cause of death among those age 65 and older(2).
The diseases also is a leading cause of in reduced quality of life due to disability and poor health.
Unfortunately, the prevalent risk of dementia have escalated substantially in the East due to economic prosperity over last 30 years in increased living standard of population over a billion.
As a large percentage of these population are followers of Western diet as they have made a lots of money in compared to others and the past.
Dementia is the loss of mental ability that is severe enough to interfere with people's every day quality of life.
And, Alzheimer's disease is the most common type of dementia in aging people.
Genetic mutation is a condition of changes of DNA structure and alteration in the inherited nucleic acid sequence of the genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their children.
According to medical literature, genes mutation, specific genes that cause autosomal dominant dementia in the family may increase substantial risk of early onset dementia.
According to US statistic, the rate has been falling sharply by 24 % from 2000 t0 2012 in age group of 65 and older. And the average age of people diagnosed with dementia in 2000, are 80.7 in compared to 82,4% in 2012(1).
One in 10 people will be diagnosed of dementia as some point in their lifetime. And 5.7 million Americans of all ages are living with Alzheimer's dementia in 2018.
Sadly, Alzheimer's disease is the sixth-leading cause of death in the United States, and the fifth-leading cause of death among those age 65 and older(2).
Unfortunately, the prevalent risk of dementia have escalated substantially in the East due to economic prosperity over last 30 years in increased living standard of population over a billion.
As a large percentage of these population are followers of Western diet as they have made a lots of money in compared to others and the past.
Dementia is the loss of mental ability that is severe enough to interfere with people's every day quality of life.
And, Alzheimer's disease is the most common type of dementia in aging people.
Genetic mutation is a condition of changes of DNA structure and alteration in the inherited nucleic acid sequence of the genotype(169). There are always a concern of some dementia patients with inherited trails for passing them to their children.
According to medical literature, genes mutation, specific genes that cause autosomal dominant dementia in the family may increase substantial risk of early onset dementia.
However, one must also include disease-causing genes mutation as it is the most common age-related dementia.
Certain genes, according to Medline studies are associated to early onset of dementia, including
1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26
Genetic mutation of chromosome 2q35-q36 Lewy bodies (DLB) are multiplex, due to its complex mechanism than generally monogenic disorders. Identifying the first familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)
2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high risk of cognitive decline due to the recurrent R155Hmutation, according to University of Genova(171).
3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid precursor protein (APP ) gene, presenillin gene (PSEN-1), and presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).
4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation was found to associate to significantly decreased cerebral blood flow (CBF) affecting brain capillaries(173) and contributing to the early on set of dementia.
5. Mutations in the NOTCH3
Mutations in the NOTCH3 gene are responsible for hereditary stroke disorder, contributed to an adult onset of hereditary ischemic stroke, vascular dementia and psychiatric disorders(174).
References
(1) U.S. Dementia Rates Are Dropping Even as Population Ages, by NewYork Time
(2) 2018 ALZHEIMER'S DISEASE FACTS AND FIGURES by Alzheimer's Association
(169) Smoking: effects on multiple sclerosis susceptibility and disease progression by Dean M. Wingerchuk(PMC)
(170) Comprehensive genetic and mutation analysis of familial dementia with Lewy bodies linked to 2q35-q36 by Meeus B1, Nuytemans K, Crosiers D, Engelborghs S, Peeters K, Mattheijssens M, Elinck E, Corsmit E, De Deyn PP, Van Broeckhoven C, Theuns J.(PubMed)
(171) Inclusion body myopathy, Paget's disease of the bone and frontotemporal dementia: recurrence of the VCP R155H mutation in an Italian family and implications for genetic counselling by Viassolo V1, Previtali SC, Schiatti E, Magnani G, Minetti C, Zara F, Grasso M, Dagna-Bricarelli F, Di Maria E.(PubMed)
(172) About Dementia Types of Dementia Genetic Mutations(Dementia guide)
(173) Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI. by Lunau L1, Mouridsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P; FReJA Consortium.(PubMed)
(174) Novel mutation of the notch3 gene in arabic family with CADASIL. by Bohlega S1.(PubMed)
Certain genes, according to Medline studies are associated to early onset of dementia, including
1. Linkage of Dementia with Lewy bodies (DLB) to 2q35-q26
Genetic mutation of chromosome 2q35-q36 Lewy bodies (DLB) are multiplex, due to its complex mechanism than generally monogenic disorders. Identifying the first familial DLB gene may contribute to an entry point of DLB pathology, according to Belgian family,researchers(170)
2. VCP gene R155H mutation
Some patients in the same family with frontotemporal dementia (FTD) have been diagnosed with high risk of cognitive decline due to the recurrent R155Hmutation, according to University of Genova(171).
3. Genetic mutation and Alzheimer's disease
4 genes have been identified to affect development of AD. with the amyloid precursor protein (APP ) gene, presenillin gene (PSEN-1), and presenillin gene (PSEN-1)) affect younger people, and apolipoprotein E (APOE ) iaffects older people(172).
4. Chromosome 3 (FTD-3) caused by a truncating mutation in CHMP2B
Presymptomatic CHMP2B mutation was found to associate to significantly decreased cerebral blood flow (CBF) affecting brain capillaries(173) and contributing to the early on set of dementia.
5. Mutations in the NOTCH3
Mutations in the NOTCH3 gene are responsible for hereditary stroke disorder, contributed to an adult onset of hereditary ischemic stroke, vascular dementia and psychiatric disorders(174).
(1) U.S. Dementia Rates Are Dropping Even as Population Ages, by NewYork Time
(2) 2018 ALZHEIMER'S DISEASE FACTS AND FIGURES by Alzheimer's Association
(169) Smoking: effects on multiple sclerosis susceptibility and disease progression by Dean M. Wingerchuk(PMC)
(170) Comprehensive genetic and mutation analysis of familial dementia with Lewy bodies linked to 2q35-q36 by Meeus B1, Nuytemans K, Crosiers D, Engelborghs S, Peeters K, Mattheijssens M, Elinck E, Corsmit E, De Deyn PP, Van Broeckhoven C, Theuns J.(PubMed)
(171) Inclusion body myopathy, Paget's disease of the bone and frontotemporal dementia: recurrence of the VCP R155H mutation in an Italian family and implications for genetic counselling by Viassolo V1, Previtali SC, Schiatti E, Magnani G, Minetti C, Zara F, Grasso M, Dagna-Bricarelli F, Di Maria E.(PubMed)
(172) About Dementia Types of Dementia Genetic Mutations(Dementia guide)
(173) Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI. by Lunau L1, Mouridsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P; FReJA Consortium.(PubMed)
(174) Novel mutation of the notch3 gene in arabic family with CADASIL. by Bohlega S1.(PubMed)
Saturday 23 June 2018
Anti Aging: The Natural Remedy Used Popularly In Skin Care Products Against All Aspects of Aging, Medline Studies Reveal
Kyle J. Norton
Skin aging is a natural process with skin expression of thinner, paler and pigmented spots, including age spots, liver spots.
Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)..., particularly, in aging cosmetic products.
Numbers of herbal whole foods and theirs phytochemicals have been found in many anti aging products and they are sold to general public with or without clinical and non clinical trials.
How many of these types of products are actually working, the numbers are vague, depending to who do you talk to.
According to the statistic, 10 of most common herbal plants may be consumed or only be used as topical application, include aloe vera, the first in the list, avocado, almond, henna, sandalwood, saffron, elder tree, neem, lavender and amla. The list may be altered, depending to specialist preferences.
Some researchers suggested that honey best known for its properties of dressing for wounds and burns, may be also used as cosmetic anti aging substance as it exerts emollient, humectant, soothing, and hair conditioning effects, keeps the skin juvenile and retards wrinkle formation, regulates pH and prevents pathogen infections, through its antioxidant activities(1).
Cosmetic products are very profitable business. Global anti-aging market is growing rapidly, the total sale may reach over $331.41 billion by 2021, according to Orbis Research
The causes of skin aging can be both intrinsic and extrinsic factors, Dr. Poljšak B and colleagues in the study of skin aging said, " It is well accepted that oxidative stress contributes significantly to extrinsic skin aging, although findings point towards reactive oxygen species (ROS) as one of the major causes of and single most important contributor; not only does ROS production increase with age, but human skin cells' ability to repair DNA damage steadily decreases over the years"(3).
Oxidative stress over expression in the outer skin layer due to environment stress and lifestyle and diet preferences may interfere the normal growth of healthy skin, leading to onset of skin aging.
These results are actually caused by incapability of the body enzymes with function in stimulated production of antioxidants to counter the levels of free radicals and their domino effects, causing alternation of the ratio of antioxidants and reactive oxygen species in the host body in induction of skin aging..
Truly, intrinsic and extrinsic aging causes significant alter the skin structure and components, that subsequently can impair molecular characteristics and biochemical processes, suggested by Dr. Fang JY, the lead author at joint study lead by the Chang Gung University(2).
The list of preventable risk factors and common causes of skin aging can be interestingly, including
* UV exposure
* Makeup wipes
* Dirty makeup brushes
*Poor diet
* Stress,
* Smoking
* Excessive alcohol intake
* Repetitive facial expressions
* Physical inactivity,......
Aloe Vera or Aloe Vera supplement may be used to delay skin aging degeneration, particularly, in expression of wrinkle.
Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.
It is very popular and cultivated commercially, due to its health benefits.
The herbal medicine has been used for treatment of many kinds of ailments, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
Wrinkle is a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particular in the face.
According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin, thus reducing risk of skin wrinkle.
In a 12-week, randomized, double-blind, placebo-controlled study of 48 apparently healthy men (age range: 30-59 years; average: 45 years), given oral Aloe sterol supplementation for 12 weeks, at the end of week 12 researchers found that the application shows a significant improvement of the skin elasticity index in comparison to the baseline value.
Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".
Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.
In fact, daily application of Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulating collagen and hyaluronic acid production by human dermal fibroblasts.
Injection of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3, according to the Food Ingredients and Technology Institute 12 weeks study suggested.
Taking altogether, there is no doubt that oral and topical administration of aloe vera or aloe vera supplements may improve skin condition caused by skin degeneration in all aspects, but quality of amount intake should only be prescribed by related field specialist.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Skin aging is a natural process with skin expression of thinner, paler and pigmented spots, including age spots, liver spots.
Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)..., particularly, in aging cosmetic products.
Numbers of herbal whole foods and theirs phytochemicals have been found in many anti aging products and they are sold to general public with or without clinical and non clinical trials.
How many of these types of products are actually working, the numbers are vague, depending to who do you talk to.
According to the statistic, 10 of most common herbal plants may be consumed or only be used as topical application, include aloe vera, the first in the list, avocado, almond, henna, sandalwood, saffron, elder tree, neem, lavender and amla. The list may be altered, depending to specialist preferences.
Some researchers suggested that honey best known for its properties of dressing for wounds and burns, may be also used as cosmetic anti aging substance as it exerts emollient, humectant, soothing, and hair conditioning effects, keeps the skin juvenile and retards wrinkle formation, regulates pH and prevents pathogen infections, through its antioxidant activities(1).
Cosmetic products are very profitable business. Global anti-aging market is growing rapidly, the total sale may reach over $331.41 billion by 2021, according to Orbis Research
The causes of skin aging can be both intrinsic and extrinsic factors, Dr. Poljšak B and colleagues in the study of skin aging said, " It is well accepted that oxidative stress contributes significantly to extrinsic skin aging, although findings point towards reactive oxygen species (ROS) as one of the major causes of and single most important contributor; not only does ROS production increase with age, but human skin cells' ability to repair DNA damage steadily decreases over the years"(3).
Oxidative stress over expression in the outer skin layer due to environment stress and lifestyle and diet preferences may interfere the normal growth of healthy skin, leading to onset of skin aging.
These results are actually caused by incapability of the body enzymes with function in stimulated production of antioxidants to counter the levels of free radicals and their domino effects, causing alternation of the ratio of antioxidants and reactive oxygen species in the host body in induction of skin aging..
Truly, intrinsic and extrinsic aging causes significant alter the skin structure and components, that subsequently can impair molecular characteristics and biochemical processes, suggested by Dr. Fang JY, the lead author at joint study lead by the Chang Gung University(2).
The list of preventable risk factors and common causes of skin aging can be interestingly, including
* UV exposure
* Makeup wipes
* Dirty makeup brushes
*Poor diet
* Stress,
* Smoking
* Excessive alcohol intake
* Repetitive facial expressions
* Physical inactivity,......
Aloe Vera or Aloe Vera supplement may be used to delay skin aging degeneration, particularly, in expression of wrinkle.
Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.
It is very popular and cultivated commercially, due to its health benefits.
The herbal medicine has been used for treatment of many kinds of ailments, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.
Wrinkle is a skin degenerative condition caused by the loss of dermis and subcutaneous fat layer underneath the skin, leading to a slight line or fold on the skin, particular in the face.
According to the Food Ingredients & Technology Institute, daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin, thus reducing risk of skin wrinkle.
In a 12-week, randomized, double-blind, placebo-controlled study of 48 apparently healthy men (age range: 30-59 years; average: 45 years), given oral Aloe sterol supplementation for 12 weeks, at the end of week 12 researchers found that the application shows a significant improvement of the skin elasticity index in comparison to the baseline value.
Dr. Tanaka M, the lead author said, "Aloe sterol ingestion increased skin elasticity in the photodamaged skin of men aged <46 years, and "No Aloe sterol intake-dependent harmful phenomenon was observed during the intake period".
Furthermore, in vitro, Aloe sterols increased production of collagen and hyaluronic acid, natural substance in skin response to connective, epithelial, and neural tissues. approximately two-fold and 1.5-fold, and promoted gene expression levels in human dermal fibroblasts.
In fact, daily application of Aloe sterol-containing Aloe vera gel powder (AVGP) significantly reduced facial wrinkles in women aged ≥40 years as well as stimulating collagen and hyaluronic acid production by human dermal fibroblasts.
Injection of Aloe Vera gel enhanced healthy skin through promoting elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores and skin fatigue area F3, according to the Food Ingredients and Technology Institute 12 weeks study suggested.
Taking altogether, there is no doubt that oral and topical administration of aloe vera or aloe vera supplements may improve skin condition caused by skin degeneration in all aspects, but quality of amount intake should only be prescribed by related field specialist.
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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Scholar and Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L(PubMed)
(2) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics by Fang JY1,2, Wang PW3, Huang CH4, Chen MH5,6, Wu YR7, Pan TL(PubMed)
(3) Intrinsic skin aging: the role of oxidative stress by Poljšak B1, Dahmane RG, Godić A(PubMed)
(4) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(5) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(6) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2.(PubMed)
Kyle J. Norton, Scholar and Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L(PubMed)
(2) Skin aging caused by intrinsic or extrinsic processes characterized with functional proteomics by Fang JY1,2, Wang PW3, Huang CH4, Chen MH5,6, Wu YR7, Pan TL(PubMed)
(3) Intrinsic skin aging: the role of oxidative stress by Poljšak B1, Dahmane RG, Godić A(PubMed)
(4) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women by Tanaka M1, Misawa E1, Yamauchi K1, Abe F1, Ishizaki C2.(PubMed)
(5) Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial by Tanaka M1, Yamamoto Y, Misawa E, Nabeshima K, Saito M, Yamauchi K, Abe F, Furukawa F.(PubMed)
(6) Aloe sterol supplementation improves skin elasticity in Japanese men with sunlight-exposed skin: a 12-week double-blind, randomized controlled trial by Tanaka M1, Yamamoto Y2, Misawa E1, Nabeshima K1, Saito M1, Yamauchi K1, Abe F1, Furukawa F2.(PubMed)
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