Kyle J. Norton
Non-alcoholic Fatty Liver Disease is a liver disease characterized by fat accumulated in the liver, not caused by abusive alcohol consumption.
The disease is also manifested by steatosis, steatohepatitis, cirrhosis.
Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in US due to increase obesity in adult population.
Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).
In conventional medicine, treatments of NAFLD are mainly focus on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.
As of today, there are no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).
Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.
Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
Turmeric has long been used in herbal medicine in treating numbers of disease.
Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.
Curcumin, as an antihyperlipidemic agent, has been found to lower the “bad cholesterol” low density lipoprotein (LDL), and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.
In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.
2. Hawthorn
Hawthorn is a shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America.
The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.
Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).
3. Phytochemical Berberine and Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.
According to studies, these formulas not only improved biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.
In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.
5. Phytochemical Triterpenoid
Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.
In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.
Of these results, TF is effective in protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.
6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.
The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.
Peony, a very popular Chinese herb is emerging as in many study for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.
In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinaemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).
Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the over expression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).
These results suggested that paeony may consist a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in induction of fatty liver.
7. Bay berry
Bay berry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.
The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.
In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.
8. Green Tea
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.
These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.
Dr. Masterjohn C(7), the lead author said, “(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD”.
In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement of body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.
The phytocheimcal EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.
In fact EGCG not only promoted weigh loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.
Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.
9. Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries in treatment of strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.
In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).
At the end of the experiment, researchers found that both applications exert a significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injure or damage caused by the acute inflammation..
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower over expression of ROS in exhibited free radical chain reaction in induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substaintial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Taken together, remedies indicated may be considered as functional foods for treatment of non-alcoholic fatty liver disease (NAFLD).
However, additional data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies’ effects in complete the treatment possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal – The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author biography
Kyle J. Norton, Master of Nutritions
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
Sunday 17 June 2018
Friday 15 June 2018
The Natural Healing For Non Alcoholic Fatty Liver Disease, Cited By PubMed Literature
Non-alcoholic Fatty Liver Disease is a liver disease characterized by fat accumulated in the liver, not caused by abusive alcohol consumption.
The disease is also manifested by steatosis, steatohepatitis, cirrhosis.
Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in US due to increase obesity in adult population.
Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).
In conventional medicine, treatments of NAFLD are mainly focus on weight loss accompanied to pharmacologic therapy in control of insulin resistance and dyslipidemia.
As of today, there are no effective pharmacologic therapy approved specifically and directly for treatment of nonalcoholic fatty liver disease (NAFLD).
Finding the natural treatments for less or no side effects have become an urgency in many scientific communities, including researchers at the Universities.
Alternative medicines for the treatment of NAFLD have been expressed in numbers of successful histories.
1. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
Turmeric has long been used in herbal medicine in treating numbers of disease.
Today, its curcuminoid, curcumin has attracted interests from researchers in many parts of the world.
Curcumin, as an antihyperlipidemic agent, has been found to lower the "bad cholesterol" low density lipoprotein (LDL), and increase high density lipoprotein (HDL) of which reduce the risk of fat accumulated in the tissues in the liver.
In the support of the above, the water-soluble curcumin derivative was tested for its efficacy against steatohepatitis which is an inflammation of the liver with concurrent fat accumulation in liver, researchers found that the derivative not only significantly alleviates fibrosis but also decreases the grade of liver steatosis.
2. Hawthorn
Hawthorn is a shrubs and trees of the genus Crataegus, belongings to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America.
The herb has been used in traditional medicine to treat heart disease and symptoms of heart diseases such as irregular heartbeat, high blood pressure, chest pain, hardening of the arteries, etc., circulatory disorders and respiratory illnesses.
Out of 246 kinds of Chinese herb, hawthorn fruit is found in the list of many formulas for treatments of Nonalcoholic fatty liver disease (NAFLD).
3. Phytochemical Berberine and Resveratrol
Berberine and resveratrol, the phytochemical found abundantly in many vegetables and fruits as well as herbs and herbal formulas such as Polygonum hypoleucum Ohwi, and Artemisia sacrorum Ledeb., and formulae including Yinchenhao Decoction (, YCHD), Qushi Huayu Decoction (, QSHYD), and Danning Tablet.
According to studies, these formulas not only improved biochemical and histological change in nonalcoholic fatty liver disease, but also inhibited lipid accumulation by up regulating low-density lipoprotein receptor (LDLR) expression, alleviating lipid peroxidation, and reducing the production of inflammatory cytokines.
In such instance, Berberine and resveratrol, may be considered as a potential treatment for nonalcoholic fatty liver disease in the future.
5. Phytochemical Triterpenoid
Triterpenoid is a various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.
In the study to test the effect of Triterpenoid-rich fraction (TP) from Ilex hainanensis Merr. on NAFLD with Male Sprague-Dawley (SD) fed with a normal diet (control) or high fat diet (NAFLD model), after 4 weeks, then orally administrated TF (250 mg/kg) for another two weeks, researchers showed that TP not only improves the symptoms of the subjects, but also decreases the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, abnormality of lipid accumulation, levels of inflammation and infection and apoptosis response in the liver.
Of these results, TF is effective in protecting liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress.
6. Peony
Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony.
The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.
Peony, a very popular Chinese herb is emerging as in many study for its anti-inflammatory, anticoagulative, anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma.
In the study of the effects of peony in non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of peony group, scientists at end of experiment showed that oral administration of total glucosides not only inhibit hyperinsulinaemia but also decrease levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C).
Further analysis also found that peony also raises levels of high-density lipoprotein cholesterol (HDL-C)] and ameliorates the over expression of activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) and superoxide dismutase (SOD) as well as contents of malondialdehyde (MDA).
These results suggested that paeony may consist a potential effect in protecting liver function by modulating serum lipid and decreasing oxidative stress caused by lipid peroxidation in induction of fatty liver.
7. Bay berry
Bay berry is a species of Myrica gale, genus Myrica, belongings to the family Myricaceae.
The herbal medicine contains numbers of bioactive chemical constituents, including gallic acid, quercetin hexoside, quercetin deoxyhexoside, quercetin, anthocyanins, flavonols, and elllagitannins.
In a randomized, placebo-controlled, double-blind, crossover study of 44 participants (ages 18-25 y) given 250 mL of either bayberry juice or placebo twice daily for 4 wk, researchers found that intake of bay berry juice decreases inflammation and infection, liver cell apoptosis, and death of liver tissues as well as reducing risk of steatosis progression in precipitated NALFD.
8. Green Tea
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the University of Connecticut, Storrs, the efficacy of green tea for treatment of obese patients with nonalcoholic fatty liver disease is associated to its antioxidant compound polyphenolic catechins in induction of hypolipidemic, thermogenic, antioxidant, and anti-inflammatory activities.
These chemical compounds are also found to mitigate the occurrence and progression of NAFLD.
Dr. Masterjohn C(7), the lead author said, "(The phytochemical compounds are) demonstrating the hepatoprotective properties of green tea and its catechins and the proposed mechanisms by which these targeted dietary agents protect against NAFLD".
In mice fed on a high-fat diet for 24 weeks, then injected with EGCG (10, 20 and 40 mg·kg(-1)·d(-1), ip), for 4 weeks, researchers found that treated mice show a significant improvement of body weight, grade 2 or 3 liver fatty degeneration (steatosis, lobular inflammation and ballooning), severe hyperlipidemia, hyperglycemia, hyperinsulinemia and insulin resistance caused by high-fat diet.
The phytocheimcal EGCG, in dose-dependent also enhanced insulin clearance and upregulated IDE protein expression and enzyme activity in regulated levels of glucose in the liver of treated mice.
In fact EGCG not only promoted weigh loss but also attenuated symptoms of mice with nonalcoholic fatty liver disease.
Administration of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats, not only decreased weight gain and visceral fat but also reduced fasting serum insulin, glucose and lipids levels, through ameliorated expression of hepatic TG accumulation and cytoplasmic lipid droplet as well as diminished hepatic lipogenesis and triglycerides out flux from liver.
9. Anise
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries in treatment of strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.
In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an study of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO).
At the end of the experiment, researchers found that both applications exert a significantly reverse activities in increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decreased in high-density lipoprotein level caused by choline-deficient diet in dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injure or damage caused by the acute inflammation..
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significant lower over expression of ROS in exhibited free radical chain reaction in induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substaintial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Taken together, remedies indicated may be considered as functional foods for treatment of non-alcoholic fatty liver disease (NAFLD).
However, additional data collection on clinical studies performed with human consumption on large sample size and multi canters during the course of diseases will be necessary to complete the picture of above natural remedies' effects in complete the treatment possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author biography
Kyle J. Norton, Master of Nutritions
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)
(3) Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD) by Kim MS, Kung S, Grewal T, Roufogalis BD.(PubMed)
(4) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH.(PubMed)
(5) Non-alcoholic fatty liver disease and liver transplantation: Outcomes and advances by Said A.(PubMed)
(6) The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial by Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.(PubMed)
(7) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(8) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(9) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(10) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)
(11) Therapeutic potential of green tea in nonalcoholic fatty liver disease by Masterjohn C1, Bruno RS.(PubMed)
(12) Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice by Gan L1, Meng ZJ1, Xiong RB2, Guo JQ1, Lu XC1, Zheng ZW1, Deng YP1, Luo BD1, Zou F3, Li H1.(PubMed)
(13) Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats by Tan Y1, Kim J1, Cheng J1, Ong M1, Lao WG1, Jin XL1, Lin YG1, Xiao L1, Zhu XQ1, Qu XQ1.(PubMed)
(14) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
Thursday 14 June 2018
*9 Foods Stimulated Over Growth of Fungus Candida, You May Not Know
By Kyle J, Norton
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated over growth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except green apples, citrus, berries and avocado(186)
and artificial ingredients can depressed immune system(187).
2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).
3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida over growth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).
4. Alcohol(192)
Alcohol can depress the liver(193) and immune system(194)(195), causing over growth candida.
5. Caffeine, sugar and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida
6. Glutens
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).
7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promotes fungus overgrowth(202).
8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impact a particular flavor can depress the immune system(204), causing candida.
9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive track, including acetic acid ulcer(205).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC.(PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA.(PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid and ultraviolet radiation. Sarachek A, Bish JT.(PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP.(PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2.(PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)
Lifelong Use of 8 Types of Conventional Drugs May Cause Cognitive Dysfunction(Dementia and Dementia Like Symptoms) as We Age, Revealed by National Library of Medicine Studies
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every 5 years.
Dementia is the loss of mental and physical ability that are severe enough to interfere with people's daily life and Alzheimer's disease is the most common type of dementia in aging population.
Western diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable that can lead to dementia and other kind of diseases
Types of medication Can Cause Dementia or Dementia Like Symptoms
As aging, accumulation of toxins of certain medication used to treat certain diseases, such as antidepressants, sedatives, cardiovascular drugs and anti-anxiety medications may induce increased risk of cognitive dysfunction, leading to dementia and dementia-like symptoms(1).
1. Antidepressants, (selective serotonin reuptake inhibitors, antipsychotics and benzodiazepines)
An Antidepressant is a psychiatric medication used to treat mood disorders, such as major depression and dysthymia and anxiety disorders.
In a study conducted by Johns Hopkins Bayview Medical Center of total of 230 participants followed for a mean of 3.7 years with use of persistency index (PI) to calculate all antidepressants, selective serotonin reuptake inhibitors (SSRIs), antipsychotics (atypical and typical), and benzodiazepines as the proportion of observed time of medication exposure, researchers found that psychotropic medication used are associated with more rapid cognitive and functional decline in AD, expressed by symptoms scale.
Clinicians may tend to prescribe psychotropic medications to AD patients at risk of poorer outcomes, but one cannot rule out the possibility of poorer outcomes being caused by psychotropic medications(2)
2. Anti-inflammatory drugs (NSAIDs)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are pain reliever, used often to treat pain caused by over expression of inflammatory cytokines, such as arthritis.
There was a weak association between any NSAIDs and the risk of cognitively impaired, no dementia (CIND)(3)
3. Cannabis
Cannabis has been used for the treatment of a number of conditions, including neuropathic pain, spasticity associated with multiple sclerosis, and chemotherapy-induced nausea, etc,.
The study conducted by University of Western Australia showed that chronic use of cannabis may impair intellectual abilities but data on this topic remain sparse and difficult to interpret.
There are evidences that some drugs contribute to the causal pathway that leads to the development of cognitive impairment but currently available data do not support the introduction of a separate diagnostic category of drug-induced dementia (such as alcohol-related dementia)(4).
4. Hallucinogens
Hallucinogens, psychedelic drugs, used primary action to alter cognition and perception may cause distortion of sensory perception, and other psychic and somatic effects, including sweating, heart palpitations, blurring of vision, memory loss, trembling, and itching(5)
5. Corticosteroids
Corticosteroids are synthetic drugs closely resemble cortisol, a steroid hormones produced by the adrenal glands to assist the physiologic processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, behavior, etc.
An excess can cause agitation and even dementia like symptoms(6).
6. Fluoroquinolone antibiotics
Fluoroquinolone antibioticsare are medication taken to treat a variety of infections.
However, the drugs are associated to exhibit delirium in elderly patients(7).
7. H2-receptor antagonists
H2-receptor antagonists are medicines taken to reduce the amount of acid in the stomach by blocking one important producer of histamine2. These drugs are associated to induce delirium in elderly patients(8).
8. Anticonvulsants
Anticonvulsants are types of medication used to treat epileptic seizure act on brain through different mechanisms. Intake of anticonvulsants can precipitate drowsiness and difficulty thinking, some more commonly than others(9).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ehow.com/how-does_5510964_prescription-drugs-cause-dementia.html
(2) http://www.ncbi.nlm.nih.gov/pubmed/22374884
(3) http://www.ncbi.nlm.nih.gov/pubmed/22546354
(4) http://www.ncbi.nlm.nih.gov/pubmed/16240487
(5) http://serendip.brynmawr.edu/exchange/node/1880
(6) https://www.ncbi.nlm.nih.gov/pubmed/15728296
(7) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541197/
(8) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115775/
(9) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229254/
The Impact of Hormones On The Onset Of Dementia
Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
American typical diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable which can lead to dementia and other kind of diseases.
As we age, productions of hormone decrease gradually that can effect the cognitive function, leading to dementia.
According to Eric R. Braverman, MD in the article of Hormones Dementia, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient.
Growth hormone beginning from age 30 in both men and women, estrogen loss beginning at age 40 in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50.
The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age(1)
Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growthfactor-I (IGF-I) axis with ageing, and the possibility that the GH/IGF-I axis is involved in cognitive deficits has been recognized for several years.
The results of several studies addressing the deficiency of growth hormone (GH) in induction of dementia include
* Superimposable response of GH to GHRH than response of GH to GHRH in healthy individuals.
* Blunted GH to GHRH response in AD patients
* Higher GH concentrations in the morning; greater increase of GH to GHRH in AD patients than in controls(2).
Other reported that evidence favoring this idea stems from the ability of both hormones to stimulate beta amyloid release from neurons as well as by the stimulatory effect that IGF-I exerts on brain amyloid clearance.
In addition, insulin and IGF-I levels are altered in Alzheimer's patients and, probably in close association to these changes, cell sensitivity towards insulin--and possibly also IGF-I--is decreased in these patients.(3)
2. Estrogen
In the research of the association of decreased levels of estrogen and dementia, scientist at the Kings College London suggested that the positive effects of estrogen are most robust in young women and in older women who had initiated ET around the time of menopause(4).
Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women.
Prospective clinical trials are required to enable women and their physicians to weigh risks and benefits of estrogen-replacement therapy for the prevention of dementia(5)
3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, researchers found that serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40.
According to the Fremantle Hospital study, lower androgen levels are associated with increased plasma Abeta40 in older men with memory loss or dementia.
These results suggested that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).
4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), found that patients with AD and patients with CVD were found to have lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals.
Also, according to the final report, no significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with AD and those with CVD.
These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7).
Other study in the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA concentrations are significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed)
And DHEA levels are significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in AD, p<or=0.01)(8).
Spearman's rho correlation coefficient is a method used to measure the relationship between two variables using a monotonic function.
5. Sex-hormone binding globulin
There are evidence in the literature suggests that gonadotropins may be involved in processes in contribution to the etiology/pathogenesis of AD such as inflammation, cholesterol homeostasis, and insulin status.
Here we examine the potential mechanisms by which gonadotropins could influence neurodegenerative processes.(9)
6. Luteinizing hormone (LH)
Some researchers suspected that that another hormone of the hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), may be a major factor in AD pathogenesis.
In cell culture, LH increased amyloidogenic processing of amyloid-beta protein precursor, and in animal models of AD, pharmacologic suppression of LH and FSH reduced plaque formation.
Given the evidence supporting a pathogenic role for LH in AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients.(10)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
American typical diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable which can lead to dementia and other kind of diseases.
As we age, productions of hormone decrease gradually that can effect the cognitive function, leading to dementia.
According to Eric R. Braverman, MD in the article of Hormones Dementia, numerous studies have linked hormone supplementation as protective in the development of dementia regardless of whether or not these hormones are deficient but more so when they are deficient.
Growth hormone beginning from age 30 in both men and women, estrogen loss beginning at age 40 in women, testosterone loss beginning at age 40 in men and DHEA loss beginning in both men and women at age 50.
The loss of luteinizing and sex binding globulin hormones may also be associated with the development of dementia with age(1)
Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growthfactor-I (IGF-I) axis with ageing, and the possibility that the GH/IGF-I axis is involved in cognitive deficits has been recognized for several years.
The results of several studies addressing the deficiency of growth hormone (GH) in induction of dementia include
* Superimposable response of GH to GHRH than response of GH to GHRH in healthy individuals.
* Blunted GH to GHRH response in AD patients
* Higher GH concentrations in the morning; greater increase of GH to GHRH in AD patients than in controls(2).
Other reported that evidence favoring this idea stems from the ability of both hormones to stimulate beta amyloid release from neurons as well as by the stimulatory effect that IGF-I exerts on brain amyloid clearance.
In addition, insulin and IGF-I levels are altered in Alzheimer's patients and, probably in close association to these changes, cell sensitivity towards insulin--and possibly also IGF-I--is decreased in these patients.(3)
2. Estrogen
In the research of the association of decreased levels of estrogen and dementia, scientist at the Kings College London suggested that the positive effects of estrogen are most robust in young women and in older women who had initiated ET around the time of menopause(4).
Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease in postmenopausal women.
Prospective clinical trials are required to enable women and their physicians to weigh risks and benefits of estrogen-replacement therapy for the prevention of dementia(5)
3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, researchers found that serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40.
According to the Fremantle Hospital study, lower androgen levels are associated with increased plasma Abeta40 in older men with memory loss or dementia.
These results suggested that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).
4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), found that patients with AD and patients with CVD were found to have lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals.
Also, according to the final report, no significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with AD and those with CVD.
These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7).
Other study in the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA concentrations are significantly lower in AD patients compared to control (4.24+/-0.4 ng/ml for AD; 3.38+/-0.3 ng/ml for control, p=0.027, Mann-Whitney 1-tailed)
And DHEA levels are significantly correlated to DHEAS levels in both control and AD conditions (Spearman's rho correlation coefficient=0.635 in controls and 0.467 in AD, p<or=0.01)(8).
Spearman's rho correlation coefficient is a method used to measure the relationship between two variables using a monotonic function.
5. Sex-hormone binding globulin
There are evidence in the literature suggests that gonadotropins may be involved in processes in contribution to the etiology/pathogenesis of AD such as inflammation, cholesterol homeostasis, and insulin status.
Here we examine the potential mechanisms by which gonadotropins could influence neurodegenerative processes.(9)
6. Luteinizing hormone (LH)
Some researchers suspected that that another hormone of the hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), may be a major factor in AD pathogenesis.
In cell culture, LH increased amyloidogenic processing of amyloid-beta protein precursor, and in animal models of AD, pharmacologic suppression of LH and FSH reduced plaque formation.
Given the evidence supporting a pathogenic role for LH in AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients.(10)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601
Wednesday 13 June 2018
******The Effects of Beet Juice in Protected and Promoted Brain Health, Researchers Reveal
Scientists may have found a whole plant food juice, namely beet or beet root juice in exerted neuroprotective effect and promoted brain health, some scientists suggested.
Beet, best known as the beetroot or garden beet, belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
Brain health is a broader term of improved function of normal brain and protected the brain against damage and degeneration as we age.
Neuroprotection is an action used to ensure the brain to perform normal function against nerve cells damage, degeneration in inducing impairment.
The MVP Samaj's College of Pharmacy, in the study of the effect of beet juice and brain health suggested that methinic extract of beet used in experiment animal shows a significant effect in increased motor function at 200, and 300 mg/kg, in doseidepending manner.
Physically, oral administrated animal also showed a strong improvement of intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, locomotor activity and grip strength.
The efficacy of the extracted in contribution of brain health may due to phytochemicals of beet juice in restoring the defensive antioxidant enzymes in the brain against level of lipid peroxidation (LPO), a leading cause of neuro degeneration.
More interestingly, Betalains, major phytochemicals isolated from whole plant beetroot in the investigation of oxidative tress demonstrated a extraordinary neuro protective effect in inhibited over expression of free radicals in initiated oxidative processes that contributes to the early onset of several degenerative diseases.
Further examination of betanin bioavailability in four volunteers with consumption 300 mL of red beet juice, containing 120 mg of the antioxidant, researches found that the phytochemical shows a protection against certain oxidative stress-related disorders in humans after absorbed from the gut and identified in urine between 2-4 h.
Dr. Kanner J, the lead author said, "Antioxidant nutrients from fruits and vegetables are believed to be a class of compounds that exert their effects in humans by preventing oxidative processes which contribute to the onset of several degenerative diseases".
Collectively, Whole food beetroot or beet juice may be used as therapeutic agent for prevention of the early onset and treatment of neuro degenerative disease through protection of neuro cells against oxidation.
Natural Medicine for Fatty Liver And Obesity Reversal – The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Neuroprotective potential of Beta vulgaris L. in Parkinson's disease by Nade VS1, Kawale LA1, Zambre SS1, Kapure AB1.(PubMed)
(2) Betalains--a new class of dietary cationized antioxidants by Kanner J1, Harel S, Granit R.(PubMed)
(3) Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment by Emily E. Noble,1 Ted M. Hsu,1,2 and Scott E. Kanoski(PMC)
The MVP Samaj's College of Pharmacy, in the study of the effect of beet juice and brain health suggested that methinic extract of beet used in experiment animal shows a significant effect in increased motor function at 200, and 300 mg/kg, in doseidepending manner.
Physically, oral administrated animal also showed a strong improvement of intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, locomotor activity and grip strength.
The efficacy of the extracted in contribution of brain health may due to phytochemicals of beet juice in restoring the defensive antioxidant enzymes in the brain against level of lipid peroxidation (LPO), a leading cause of neuro degeneration.
More interestingly, Betalains, major phytochemicals isolated from whole plant beetroot in the investigation of oxidative tress demonstrated a extraordinary neuro protective effect in inhibited over expression of free radicals in initiated oxidative processes that contributes to the early onset of several degenerative diseases.
Further examination of betanin bioavailability in four volunteers with consumption 300 mL of red beet juice, containing 120 mg of the antioxidant, researches found that the phytochemical shows a protection against certain oxidative stress-related disorders in humans after absorbed from the gut and identified in urine between 2-4 h.
Dr. Kanner J, the lead author said, "Antioxidant nutrients from fruits and vegetables are believed to be a class of compounds that exert their effects in humans by preventing oxidative processes which contribute to the onset of several degenerative diseases".
Collectively, Whole food beetroot or beet juice may be used as therapeutic agent for prevention of the early onset and treatment of neuro degenerative disease through protection of neuro cells against oxidation.
Natural Medicine for Fatty Liver And Obesity Reversal – The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Neuroprotective potential of Beta vulgaris L. in Parkinson's disease by Nade VS1, Kawale LA1, Zambre SS1, Kapure AB1.(PubMed)
(2) Betalains--a new class of dietary cationized antioxidants by Kanner J1, Harel S, Granit R.(PubMed)
(3) Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment by Emily E. Noble,1 Ted M. Hsu,1,2 and Scott E. Kanoski(PMC)
Coffee's Chlorogenic Acid, Enhances Vascular Function in Prevention of Blood Vessels Related Diseases
By Kyle J. Norton
Chlorogenic acid, a major bioactive compound found in coffee may have a profound effect similar to those of nonsteroidal anti-inflammatory drugs (NSAIDs) in stimulated vascular function in moving blood, some studies suggested.
Vascular function is the action of arteries and veins, involving blood circulation in provided nutrients and fluids to the body cells and tissue, through adjusting the blood flow.
Abnormal vascular function found in image of PR interval in electrocardiography may associate to increase risk of cardiovascular diseases(3).
The normal of PR interval or period measured in milliseconds, is between 120 and 200ms in duration.
However, "PR-interval length, even in the conventionally normal range, is independently associated with endothelial dysfunction and increased arterial stiffness in healthy subjects free of atherosclerotic disease" said, Dr. Chan YH, the lead scientist.
According to medical literature, abnormal vascular function may increase risk of vascular disease, affecting the circulatory system in induction of peripheral artery, carotid artery and venus disease and blood clot.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the study lead by the University of Reading, chlorogenic acids isolated from coffee roasted bean, acutely improved vascular function, partly due to mediation of 5-CQA, a member in the group in regulated the normal function of arteries and veins.
Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid with function in modulated lignin biosynthesis in binding to cellulose fibers and hardens and strengthened the plant cell walls.
An acute randomized, controlled, cross-over human intervention trials is conducted by researchers at the University of Reading to examine the impact of coffee intake, matched for caffeine but differing in CQA content (89, and 310 mg) on flow-mediated dilatation (FMD) in 15 healthy male subjects, in compared a second intervention trial conducted with 24 healthy male subjects.
Observation of he impacts of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee(5-CQA; 450 mg and 900 mg) on FMD, found that
*. Low and high CGA(89 mg and 310 mg CGA) intake, show a significant effect on vascular function 1 hour after injecting coffee.
*. Coffee intake is closely associated to the paralleled to the appearance of CGA metabolites in regulated the normal function of arteries and veins at 5 hours
*. 5-CQA (450 mg) expressed an improvement by FMD assay after 1 hour of administration.
The information suggested that coffee has a strong effect in activated vascular function through expression of CGA and its metabolites in plasma and numbers of other phytochemicals including 3-, 4- and 5-feruloylquinic acid and ferulic-4'-O-sulfate at 1 h and isoferulic-3'-O-glucuronide and ferulic-4'-O-sulfate.
Interestingly, in the further illustration of coffee and its CGA effect on vascular abnormality, researchers at the joint study lead by the Bioactive Substance Research Group, University of Antioquia, Medellín, Colombia, launched an investigation of participant including 38 men and 37 women with a mean ± SD age of 38.5 and body mass index of 24.1 and randomly assigned to 3 groups* A control group that did not consume coffee or a placebo
*Group consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or
*Group consumed 400 mL coffee/d for 8 wk containing a medium high CGA content,
At the end of the experiment, researchers concluded
*. Coffee consumption over the period indicated and after 1 hours, show a significant presence of caffeic and ferulic acid concentrations in the coffee-drinking groups, with different values in 2 coffee injection group.
* At the same time, the levels of antioxidant expression increased substantially in 2 coffee intake group, but undetectable in control group or placebo.
* All amount of antioxidants and phytochemicals creased to exist after 8 weeks.
These results indicated the efficacy of tested acid not only has a strong implication in promoted vascular function in blood circulation but also exerted a similar function of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in decreased inflammation and prevented blood clots through its antioxidant properties.
The evidences in the study demonstrated the acute effect of coffee in promoting of vascular function in improved nutrients and fluids transportation by arteries and vessels.
Taking together, there is no doubt that coffee consumption have an enormous effect in improved vascular function in reduced risk of vascular diseases and diseases' complications.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials by Mills CE1, Flury A2, Marmet C3, Poquet L3, Rimoldi SF2, Sartori C4, Rexhaj E2, Brenner R2, Allemann Y2, Zimmermann D3, Gibson GR1, Mottram DS1, Oruna-Concha MJ1, Actis-Goretta L3, Spencer JP5.(PubMed)
(2) Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial by Agudelo-Ochoa GM1, Pulgarín-Zapata IC2, Velásquez-Rodriguez CM3, Duque-Ramírez M4, Naranjo-Cano M5, Quintero-Ortiz MM5, Lara-Guzmán OJ6, Muñoz-Durango K2.(PubMed)
(3) Abnormal vascular function in PR-interval prolongation by Chan YH1, Siu CW, Yiu KH, Li SW, Lau KK, Lam TH, Lau CP, Tse HF(PubMed)
According to the study lead by the University of Reading, chlorogenic acids isolated from coffee roasted bean, acutely improved vascular function, partly due to mediation of 5-CQA, a member in the group in regulated the normal function of arteries and veins.
Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid with function in modulated lignin biosynthesis in binding to cellulose fibers and hardens and strengthened the plant cell walls.
An acute randomized, controlled, cross-over human intervention trials is conducted by researchers at the University of Reading to examine the impact of coffee intake, matched for caffeine but differing in CQA content (89, and 310 mg) on flow-mediated dilatation (FMD) in 15 healthy male subjects, in compared a second intervention trial conducted with 24 healthy male subjects.
Observation of he impacts of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee(5-CQA; 450 mg and 900 mg) on FMD, found that
*. Low and high CGA(89 mg and 310 mg CGA) intake, show a significant effect on vascular function 1 hour after injecting coffee.
*. Coffee intake is closely associated to the paralleled to the appearance of CGA metabolites in regulated the normal function of arteries and veins at 5 hours
*. 5-CQA (450 mg) expressed an improvement by FMD assay after 1 hour of administration.
The information suggested that coffee has a strong effect in activated vascular function through expression of CGA and its metabolites in plasma and numbers of other phytochemicals including 3-, 4- and 5-feruloylquinic acid and ferulic-4'-O-sulfate at 1 h and isoferulic-3'-O-glucuronide and ferulic-4'-O-sulfate.
Interestingly, in the further illustration of coffee and its CGA effect on vascular abnormality, researchers at the joint study lead by the Bioactive Substance Research Group, University of Antioquia, Medellín, Colombia, launched an investigation of participant including 38 men and 37 women with a mean ± SD age of 38.5 and body mass index of 24.1 and randomly assigned to 3 groups* A control group that did not consume coffee or a placebo
*Group consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or
*Group consumed 400 mL coffee/d for 8 wk containing a medium high CGA content,
At the end of the experiment, researchers concluded
*. Coffee consumption over the period indicated and after 1 hours, show a significant presence of caffeic and ferulic acid concentrations in the coffee-drinking groups, with different values in 2 coffee injection group.
* At the same time, the levels of antioxidant expression increased substantially in 2 coffee intake group, but undetectable in control group or placebo.
* All amount of antioxidants and phytochemicals creased to exist after 8 weeks.
These results indicated the efficacy of tested acid not only has a strong implication in promoted vascular function in blood circulation but also exerted a similar function of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in decreased inflammation and prevented blood clots through its antioxidant properties.
The evidences in the study demonstrated the acute effect of coffee in promoting of vascular function in improved nutrients and fluids transportation by arteries and vessels.
Taking together, there is no doubt that coffee consumption have an enormous effect in improved vascular function in reduced risk of vascular diseases and diseases' complications.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials by Mills CE1, Flury A2, Marmet C3, Poquet L3, Rimoldi SF2, Sartori C4, Rexhaj E2, Brenner R2, Allemann Y2, Zimmermann D3, Gibson GR1, Mottram DS1, Oruna-Concha MJ1, Actis-Goretta L3, Spencer JP5.(PubMed)
(2) Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial by Agudelo-Ochoa GM1, Pulgarín-Zapata IC2, Velásquez-Rodriguez CM3, Duque-Ramírez M4, Naranjo-Cano M5, Quintero-Ortiz MM5, Lara-Guzmán OJ6, Muñoz-Durango K2.(PubMed)
(3) Abnormal vascular function in PR-interval prolongation by Chan YH1, Siu CW, Yiu KH, Li SW, Lau KK, Lam TH, Lau CP, Tse HF(PubMed)
Subscribe to:
Posts (Atom)