Better Than Chemo DuP-697 in Inhibited Immune Suppressor Prostaglandin (PG)E(2) for Treatment of Non Small Cell Lung Cancer

Arnica may have a therapeutic and potential effect in reduced risk and treatment of non small cell lung cancer, some scientists suggested.

The result of the efficacy was reported by numbers of investigation conduced by several respectable institutes, such as University of Groningen and Center for Cancer Research, Bethesda and published on online medical literature.

Lung cancer is a chronic and medical condition characterized by the irregular and controllable cell growth in the lung tissue.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

According to the University of Groningen in the investigated cytotoxicity of 21 flavonoids and 5 sesquiterpene lactones presented in Arnica species on GLC4, a human small cell lung carcinoma cell line, using the microculture tetrazolium (MTT) assays.

* Application of compound cisplatin (IC50 = 1.1 microM and 2.9 microM showed a greatest inhibition of human small cell lung carcinoma cell line, through cytotoxitic activity in compared to most flavonoids isolated.

* The most toxic compound was the flavone jaceosidin on GLC4

* Helenalin, possessing both the reactive alpha-methylene-gamma-lactone moiety and a reactive alpha,beta-unsubstituted cyclopentenone ring, displayed the strongest cytotoxicity on GLC4.

Flavonoids processed significantly antioxidant and anti-inflammatory activities, according to online literature were found abundantly in tea, citrus fruit, citrus fruit juices, berries, red wine,....

And phytochemicals sesquiterpene lactones found in some herbs, such as Artichoke, Boneset Eupatorium perfoliatum, Burdock, Calea ternifolia, Chamomile,.... are also used for treatment of diseases associated to inflammatory, protozoal, bacterial and microbial infection.

Additionally, in the evaluated the effects of anethole dithiolethione modified valproate, diclofenac and sulindac isolated from Arnica on non-small cell lung cancer (NSCLC) cells, researchers found that injection of the bioactive chemicals exerted a potential anti lung cancer effect through inhibited the levels of prostaglandin (PG)E(2) in NSCLC cell lines A549 and NCI-H1299 in compared to the conventional medicine COX-2 inhibitor DuP-697.

Prostaglandin (PG)E(2) is linked to progression of several types of cancer through its tumor-associated inflammation in created an immunosuppressive microenvironment, allowing tumor cells to escape immunosurveillance.

Moreover, in compared to all anethole modificatiions in vivo, S-valproate and S-diclofenac, exerted a strong anti growth of A549 cells. but not S-sulindac.

S-valproate and S-diclofenac significantly inhibited A549 or NCI-H1299 xenograft proliferation in nude mice, but had no effect on the nude mouse body weight.

Dr. Moody TW, the lead author, after taking into comparable tests of all ingredients through Western blot, said, "S-valproate and S-diclofenac inhibit the growth of NSCLC cells and reduce PGE(2) levels, they may prove beneficial in the chemoprevention and/or therapy of NSCLC". 

 The information findings suggested that Arnica and its bioctive ingredients may be considered as a functional herb in prevention and combined with conventional standard therapy in stop progression and treatment of non small cell lung cancer.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ1, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(2) Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells by Moody TW1, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.(PubMed)
(3) A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia by Lam S1, MacAulay C, Le Riche JC, Dyachkova Y, Coldman A, Guillaud M, Hawk E, Christen MO, Gazdar AF.(PubMed)

Enjoy Alfalfa 8 Health Benefits But Beware of 2 Hidden Side Effects, According to Medical Literature

A. Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.

B. Nutrients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
13. Etc.

C. Health benefits of Alfalfa
1. Antioxidant
In a study of measurements of pH, water holding capacity, color, oxymyoglobin content, TBARS and oxidation-reduction potential in evaluating the effects of a dietary protein-xanthophylls (PX) concentrate of alfalfa to turkey diets conducted by University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland.(1), researchers found that TBARS and oxidation-reduction potential values suggested that the inclusion of the concentrate to turkey diets acts as an antioxidant in the raw meat.

2. Cholesterol
In a study to test the effect of Alfalfa used in traditional medicine to treat high blood cholesterol conducted by Malinow MR, McLaughlin P, Stafford C.(2), in 3 human volunteers during ingestion of diets containing alfalfaseeds (AS) for 3 weeks, researchers found that Plasma cholesterol concentrations were reduced and No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.

3. Hyperlipoproteinemia
In a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA (n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfaseeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(3), found that patients with type II HLP alfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low density lipoprotein (LDL) cholesterol from 7.69 to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of 17% and 18%, respectively. Maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia the LDL cholesterol decreased less than 5%. Apolipoprotein B decreased in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P less than 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.

4. Disease of autoimmune
In a study of five groups of 12-week-old female mice were per oral treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA (ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen (TAM, 0.375 mg/kg BW) as the positive control, conducted by Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan (4), researchers found that alhalfa decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.

5. Anti-inflammatory activity
In a study of anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA) in ,ice coducted by College of Life Science, National Taiwan University, Taipei, Taiwan, Republic of China.(5), researchers found that significantly higher survival rates than the control group and suggests that ASEA supplementation can suppress the production of pro-inflammatory cytokines and alleviate acute inflammatory hazards.

6. Systemic lupus erythematosus
In experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented,conducted by Oregon Health Sciences University, Portland (6), researchers indicate that a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.

7. Menopause symptoms
In a study of Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity, conducted by University of Illinois at Chicago (7), researchers found thatestrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

8. Neuroprotective activity
In a study of the neuroprotective effect of methanol extract of Medicago sativa (MS, Alfalfa) on ischemia and reperfusion-induced cerebral injury in mice, conducted by Institute of Pharmacy, Solan 173 223, India. (8)found that suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.

9. Etc

D. Side effects
1. High amount of vitamin K may reduce the effectiveness of anticoagulant medicine(9)
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill(10).

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Holistic System In Existence That Will Show You How To
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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) "Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing" by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER., posted in PubMed
(2) "Alfalfa seeds: effects on cholesterol metabolism." Posted in PubMed
(3) "Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia", posted in PubMed
(4) " The ethyl acetate extract of alfalfa sprout ameliorates disease severity ofautoimmune-prone MRL-lpr/lpr mice" by Hong YH, Huang CJ, Wang SC, Lin BF., posted in PubMed
(5) "Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo" by Hong YH, Chao WW, Chen ML, Lin BF., posted in PubMed
(6) "Dietary amino acid-induced systemic lupus erythematosus" by Montanaro A, Bardana EJ Jr., posted in PubMed
(7) "Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms" byLiu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL., posted inPubMed
(8) "Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult" by Bora KS, Sharma A., posted in PubMed

(9) Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True? A Systematic Review by Francesco Violi, MD, Gregory YH Lip, MD, Pasquale Pignatelli, MD, and Daniele Pastori, MD, Monitoring Editor: Xiwen Cheng(PMC)

(10) Alfalfa(Rexall Pharma Plus)

Aloe Vera 11 Impressive Health Benefits and 4 Ugly Adverse Effects, You Probably Want to Know, According to PubMed

Kyle J. Norton

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herbal medicine has become very popular for commercial cultivation due to its health benefits.

 Aloe vera has been used in herbal medicine in treatment of many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

A. Health benefits of Aloe Vera Based on Medical Literature
1. Cancer
Eventhough Aloe Vera is not one of the herb used in herbal medicine in treating cancer, but according to some studies, Aloe Vera has a property of inhibiting the growth of cancer and apoptosis, according to the study of "Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach" by de Melo JG, Santos AG, de Amorim EL, do Nascimento SC, de Albuquerque UP., posted in PubMed (1), researchers found that our analysis included papers published between 1980 and 2008. A total of 84 medicinal plant species were reported to be used for cancer and tumor prevention or treatment; 69.05% of these were cited as being used for the treatment of tumors and cancer in general and 30.95% for specific tumors or cancers. The plants that were cited at a higher frequency were Aloe vera, Euphorbia tirucalli, and Tabebuia impetiginosa.

2. Antiaging (Wrinkle Prevention)
There are many products of Aloe Vera sold commercially as an natural anti wrinkle magic in health perspective, is Aloe Vera really has that property? according to the study of "Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo" by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH., posted in PubMed(2), researchers filed the conclusion that Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.

3. Laxation
Aloe Vera beside enhances motility of the intestines, but also increases fecal volume and normalizes body weight, that can reduce the risk of constipation, according to the study of "The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats" by Wintola OA, Sunmonu TO, Afolayan AJ., posted in PubMed(3)

4. Skin
Aloe Vesa has been used as skin care as a cosmetic and pharmaceutical ingredients, according to the study of " Innovations in natural ingredients and their use in skin care' by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R., posted in PubMed(4), researchers wrote that Certain ingredients, such as colloidal oatmeal and aloe vera, have been identified as beneficial in the treatment of psoriasis and atopic dermatitis, respectively, due to their anti-inflammatory properties.

5. Wound
Aloe Vera has been used in herbal medicine beside improves wound healing as a result of the presence of mannose-6-phosphate, according to the study of "Anti-inflammatory and wound healing activity of a growth substance in Aloe vera" by Davis RH, Donato JJ, Hartman GM, Haas RC., posted in PubMed(5), but also enhances burn healing, according to the study of "Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats" by Hosseinimehr SJ, Khorasani G, Azadbakht M, Zamani P, Ghasemi M, Ahmadi A., posted in PubMed(6), researchers concluded that this study showed aloe cream to significantly increase reepithelialization in burn wounds as compared with silver sulfadiazine.

6. Diabetes
Aloe Vesa helps to treat diabetes by controlling the blood glucose, reducing hepatic transaminases plasma and tissue (liver and kidney) cholesterol, triglycerides, free fatty acids and phospholipids and improvement in plasma insulin levels, according to the study of "Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes" by Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S., posted in PubMed(7)

7. Immune system
Aloe Vera enhances the immune system by enhancing the immunological parameters in cellular immune response and phagocytosis, according to the study of "Modulation of Immune Response of BALB/Mice Bearing Lymphoma L5178Y Treated with Bitter Yellow Juice of Aloe vera (L) in vivo" by Oronzo-Barocio A, Zaitseva G, Chavez-Anaya A, Arceta-Gonzalez VI, Puebla-Perez AM, Alfaro-Bustamante F, Zimina IV, Arion VY., posted in PubMed(8)

8. Human papillomavirus (HPV)
The herb beside contains a antibactera and fungal properties, it also enhance the immune system infifgting against Human papillomavirus, according tothe study of "A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens"Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, Kulkarni SV, Doncel GF, Buck CB, Schiller JT, Muralidhar S, Bala M, Agrawal SS, Bansal K, Verma JK., posted in PubMed(9)

9. Antioxidants
Aloe Vera also is popular used in treating infection and inflamation as a result of its antioxidant property. according to the study of " In Vitro Antimicrobial and Antioxidant Activities of Anthrone and Chromone from the Latex of Aloe harlana Reynolds" by Asamenew G, Bisrat D, Mazumder A, Asres K., posted in PuibMed(10)

10. Weight loss
Since aloe Vera contains high amounts of collagen fiber, it can use as a weight loss program as more energy are needed for the digestive process, according to the article of "Collegen" posted in Wikipedia in the "use" section(11)

11. Low levels of cholesterol
Aloe Vera can help to reduce the levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides in blood serum, thus reducing the risk of cardivascular disease, according to the study of "Lipid lowering activity of hydrosoluble chitosan and association with Aloe vera L. and Brassica olearaceae" L' by Geremias R, Pedrosa RC, Locatelli C, de Fávere VT, Coury-Pedrosa R, Laranjeira MC., posted in PubMed(12)


B. Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed(13)
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. Oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause rheumatoid arthritis symptoms as a result of collagen in the plant, according to the study of "Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study" by Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I., posted in PubMed(14)


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) http://www.ncbi.nlm.nih.gov/pubmed/21528006
(2) http://www.ncbi.nlm.nih.gov/pubmed/20548848
(3) http://www.ncbi.nlm.nih.gov/pubmed/20723249
(4) http://www.ncbi.nlm.nih.gov/pubmed/20626172
(5) http://www.ncbi.nlm.nih.gov/pubmed/8169808
(6) http://www.ncbi.nlm.nih.gov/pubmed/20361881
(7) http://www.ncbi.nlm.nih.gov/pubmed/16487267
(8) http://www.ncbi.nlm.nih.gov/pubmed/12687115
(9) http://www.ncbi.nlm.nih.gov/pubmed/18571386
(10) http://www.ncbi.nlm.nih.gov/pubmed/21452374
(11) http://en.wikipedia.org/wiki/Collagen
(12) http://www.ncbi.nlm.nih.gov/pubmed/16557611
(13) http://www.ncbi.nlm.nih.gov/pubmed/17726067
(14) http://www.ncbi.nlm.nih.gov/pubmed?term=Oral%20type%20II%20collagen%20in%20the%20treatment%20of%20rheumatoid%20arthritis.%20A%20six-month%20double%20blind%20placebo-controlled%20study.%20

Eating Healthy, Replace Sugar with This Ingredient to Enjoy 22 Medical Benefits, According to PubMed

Kyle J. Norton.

Consumption of added sugars has a strong implication in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers(3).

To replace 1 cup of white sugar you can substitute it for 3/4 cup honey.

According to the the Universtà Politecnica delle Marche,

* Honey positively affects risk factors for cardiovascular diseases by inhibiting inflammation[1], improving endothelial function[2], as well as the plasma lipid profile[3], and increasing low-density lipoprotein resistance to oxidation[4](4). 

* Honey also displays an important antitumoral capacity[5], where polyphenols again are considered responsible for its complementary and overlapping mechanisms of chemopreventive activity in multistage carcinogenesis, by inhibiting mutagenesis or inducing apoptosis(4). 

*Moreover, honey positively modulates the glycemic response by reducing blood glucose[6], serum fructosamine[7] or glycosylated hemoglobin[8] concentrations and exerts antibacterial properties caused by its consistent amount of hydrogen peroxide[9] and non-peroxide[10] factors as flavonoids, methylglyoxal and defensin-1 peptide"(4).

Here are health benefits of honey

The rich golden liquid is the miraculous product made by bees using nectar from flowers. It is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Nutrients
1. Carbohydrates
2. Sugars
3. Protein
4. Water
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (Vitamin B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc

A. health benefits according to studies
1. Acute cough in children[11]
In the investigation of the effectiveness of honey for acute cough in children in ambulatory settings found that Dextromethorphan and honeydid not differ significantly on cough frequency (MD -0.49; 95% CI -1.15 to 0.17); cough severity (MD -0.50; 95% CI -1.28 to 0.29), bothersome cough(MD -0.29; 95% CI -1.14 to 0.56) and sleep quality of the children (MD -0.70; 95% CI -1.57 to 0.17) or their parents (MD -0.34; 95% CI -1.24 to 0.55) and concluded that we found insufficient evidence to advise for or against the use of honey for acute cough in children, according to "Honeyfor acute cough in children" by Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.(a)

2. Wound healing[12]
In the assessment of Potential role of honeyon wound healing found that honey may improve healing times in mild to moderate superficial and partial thickness burns compared with some conventional dressings. Honey dressings as an adjuvant to compression do not significantly increase leg ulcer healing at 12 weeks.

There is insufficient evidence to guide clinical practice in other areas. according to "Honey as a topical treatment for wounds" by Jull AB, Rodgers A, Walker N.(b)

3. Antiproliferative effect[13]
In the identification of honey and its effect on keloid fibroblasts found that the methanolic honey extraction has an antiproliferative effect on keloid fibroblasts and a range of volatile compounds has been identified from Tualang honey.

The antiproliferative effect of keloid fibroblasts towards Tualang honey may involve cell signaling pathway.

Identifying other volatile compounds from different organic solvents should be carried out in future, according to "Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts" by Nurul Syazana MS, Halim AS, Gan SH, Shamsuddin S.(c)

4. Antibacterial properties[14]
In the classification of Honey possesses therapeutic potential on antibiotic resistance of bacteria
found that Tualang honey exhibited variable activities against different microorganisms, but they were within the same range as those for manuka honey. This result suggests that tualang honey could potentially be used as an alternative therapeutic agent against certain microorganisms, particularly A. baumannii and S. maltophilia, according to "The antibacterial properties of Malaysian tualang honey against woundand enteric microorganisms in comparison to manuka honey" by Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(d)

5. Anti-inflammatory and antioxidant effects[15]
In assessment of Tualang honey and its anti-inflammatory and antioxidant effects found that Tualang honey has almost the equal effects when compared with the conventional treatment in treating alkali injury on rabbit's eye. Future research with more number of rabbits and control group is warranted to explore the anti-inflammatory and antioxidant effects of Tualang honey, according to "Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study" by Bashkaran K, Zunaina E, Bakiah S, Sulaiman SA, Sirajudeen K, Naik V.(e)


B. Health benefits according to concentration
Honey contains high amount of glucose and fructose that are simple sugar (monosaccharide) played an important role to enhance energy production in carbohydrate metabolism, as they
are absorbed by the body quickly through insulin and potassium[16].

C. Other health benefits
1. Antiseptic[17] and antibacterial properties[18]
Recently research study that honey have the antiseptic and antibacterial properties as it increases the immune system in fighting the forming of free radicals causes of inflammation and infection causes of infection due to enzyme glucose oxidase, according to the study of `Antibacterialproperties of tualang honey and its effect in burn wound management: a comparative study`by Nasir NA, Halim AS, Singh KK, Dorai AA, Haneef MN., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20576085), researchers found that Tualang honey has a bactericidal as well as bacteriostatic effect. It is useful as a dressing, as it is easier to apply and is less sticky compared to Manuka honey. However, for Gram positive bacteria, tualang honey is not as effective as usual care products such as silver-based dressing or medical grade honey dressing.

2. Diabetes chronic wound[19]
External used is proven to be effective for treating diabetes chronic wound that antibiotic can not be used, according to the study of `Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study`by Abdelatif M, Yakoot M, Etmaan M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/18376651, researchers indicated that Ninety-six per cent of the patients in groups 1 and 2 responded well, with a complete cure, defined as'complete closure of the ulcer without signs of underlying bone infection' by the end of week 9 and for the duration of the six-month follow-up period. All of the ulcers in group 1 healed, as did 92% of those in group 2. All patients in group 3 healed following surgical excision, debridement of necrotic tissue and conservative treatment with PEDYPHAR ointment.

3. Phosphorus[20]
Beside providing strength to bones and teeth by working together with calcium according to the study of `[The effect of one year therapy with recombinant human growth hormone (rhGH) on growth velocity, calcium-phosphorus metabolism, bone mineral density and changes in body composition in children with growth hormone deficiency (GHD)].[Article in Polish]`by Zak T, Basiak A, Zubkiewicz-Kucharska A, Noczyńska A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20529605), it also works with riboflavin and niacin to improve the digestive system in absorbing vital nutrients.

4. Iron[21] and iron deficiency anemia[22]
Iron is essential for the production of red blood cells and carrying life-giving oxygen to human cells. Deficiency of iron causes anemia, anemia of chronic disease, cough, anemia in pregnancy, etc., leading to reducing blood flow to the reproductive organ according to the study of `The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia` by Horiguchi H, Oguma E, Kayama F., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15784734)


Side effects

1. Because of the presence of botulinum endospores, children under one year of age should not be given honey
2. Honey may be poison if produced from the flowers of oleanders, rhododendrons, mountain laurels, sheep laurel, and azaleas etc.
3. It may contain traces of heavy metals, pesticides, etc.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Sources

(1) HOW TO SUBSTITUTE SUGAR IN YOUR BAKING & FREE SUBSTITUTES CHART! By Gemma Stafford .

(2) Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup by Nagai N1, Ito Y, Taga A.(PubMed)
(3) Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding by James M. Rippe1,2,* and Theodore J. Angelopoulos3(PubMed)
(4) Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases by Alvarez-Suarez JM1, Giampieri F, Battino M.(PubMed)
(a) http://www.ncbi.nlm.nih.gov/pubmed/20091616
(b) http://www.ncbi.nlm.nih.gov/pubmed/22050652
(c) http://www.ncbi.nlm.nih.gov/pubmed/21943200
(d) http://www.ncbi.nlm.nih.gov/pubmed/19754926
(e) http://www.ncbi.nlm.nih.gov/pubmed/21982267

No Scam! 13 Weeks to Grade A in Math from Scratch for High School Students

Kyle J. Norton

I was not good in literature, after a period of intensive study and writing, I ended up with a BA in Literature with Major in Criticism.

I was not good in Math, after a period of intensive study and practice, I ended up with double degrees of BSc in Applied and Pure Math with GPA of 3.59 while working part time, 16 h/w.

My conclusion, there is no such thing of idiot in math or literature, if you want, you can be good of them both.

Something really are wrong with our education system today. 

By teaching students at right directions, everyone of them can be a genius in any field.

I can do it so are you.

Our brain has adapted well for the constant and instant information inputs over thousand of years, by developing an amazing analysis skill which can not be compared by any mammal.

Proof: In some cultures, learning is the process of memorization without given any explanation by the teacher, but such cultures had produced many of the greatest master pieces in the world of literature.

Mathematics is the study with the use of abstraction and logical reasoning, evolved from counting, calculation, measurement, etc. to establish the truth from appropriately chosen axioms and definitions. Without definition and axiom, mathematics can not be exist.

With the acceptance of the definition arises many theorems which are the short cuts for exercises doing without going back to definition. In short, you can use the definition to prove theorems as well as exercises.

All mathematical questions are based on given hypothesis arises from the definition, then to prove certain results.

If you completely understand the definition as it is, then there will be no reason that you are not good in Math.

One of my good friend who is a math professor in the university told me once '
"Mathematics is a most lazy subject of human world if you can utilize your logical and analytic skill".

One more thing which you should know is our brain differentiats better in pictures than words.

 If you can't get the question, try to put it in pictures, you will find how easily the question is exposed and solved.

Let me get into the answer, How to do math well in high school. The article will be written under formation of a math question.

Hypothesis
Given There is a student not good in math but wants to do well.

Given a parent or parents will provide all supportive during the 13 weeks of hard work.

Assuming that the hypothesis is true, prove that the student will have an average of at least 80%
in math this school year and onward.

The requirement for the success is 2 hours a day, working on math problems in a duration of 13 weeks.

1. Once again, if you still want to be good in math, if your answer is yes, keep reading, if not, you can stop now. I don't want to waste your time.

2. How to start
Can you solve the math problem,
a. If you can, the keep doing for exercises. 

My recommendation is to solve all the problems first(not the applications), after you have masterminded them, then try the applications.

Applications are harder, because they require an experienced analytic skill, you should try to put them into a picture, list everything is given, if you can, try the next. If not, read it again. if you still can not solve it after few attempts, Stop and think............

If you can not get it, ask your teacher to solve it and remember what you didn't get. 

Believe me, you will learn your way to mathematics keywords. Do the same problem yourself and next and next.....

b. If you can not, there are few ways you can do it
b.1. If your parents can, ask them to solve a few questions in the subject
b.2. If you parents can not, ask your good friend and schoolmate at school
b.3. If no one help, ask your math teacher to solve a few questions
Can you solve other similar problems now, if you are, the follow the step (a).
If you still can not, then try to solve the same problems just solved by others (b). 

Can you do it now. If yes, do it a few more times with the same problems until you understand why they are done the way they are, then proceed with (a)

If not, restart with (b), this time ask questions in any step which you have hard time to understand, then redoing the same problems just solved again with reasoning. 

I believe, with all the hard works, now you have no problem to follow the step (a)
This step is one of most difficult task in 13 weeks duration. Some of my students require 3 -4 weeks to achieve.

For parents, your child needs your support and encourages in this stage, please provide them with a quiet environment and ready to help manner. 

It is easier said than done, many students feel tons of pressure and are ready to quit. 

It is up to the parents to encourage them to stay on course. 

Remember, after 13 weeks, you are A student in math.

3. Now you have entered the easier stage. Most students after 3-4 weeks intensively working, now start to do the problem solving themselves and occasional helps with application. 

Keep working on it. 

At this stage, you get at least 70% in any math test.

4. This is the 8th weeks of the 13, most students now have masterminded the problem solvings and applications. At this stage, you get at least 80+% in math test.

The progress is so fast, in eight weeks, you have improved your marks by over 100%, that your math teacher will put a careful eye on you to make sure that you are not cheating in the test.

5. At this stage, your parents may surprise that math is the subject that you try to do first in home study. 

It is human nature that we all want to do the easiest thing first.

6. You are approaching the 13th weeks now. 

You are recommended to read the definitions which you have skipped. If you don't understand it, read it again and again....

Well, in fact you can understand them without problem.

7. 13 weeks of intensive studying are almost over, you now can do math just like other courses.

Math now is considerable a very easy subject as you have build up yourself an analytic and logical skill without even noticing.

For high school students and non math major college students, it is more than enough to make a grade A in Math, but for math major college students, success is based on how you can utilize the definitions and Axioms to prove the theorems and applications.

Summary
Good luck to your journey

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Food Therapy: Green Tea, A Potent Ingredient in Inhibited Athlete's Foot (Tinea Pedis)

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and and treatment of athlete's foot( tinea pedis,), some scientists suggested.

The results of investigation were reported by several institutes, including the Tokyo Medical and Dental University and published online at medical literature.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

Athlete's foot( tinea pedis) is a common skin disease characterized by fungal infection.

Uncontrolled proliferation of yeast-fungi not only produces pungent odor but also facilitates the risks of small vesicles, fissures, scaling, and maceration.

Green tea is not one of the favorite natural ingredient used for treatment of athlete's foot (tinea pedis) in compared to the formula of aromatic oil powder-compound consisting of arrowroot, baking soda, basil oil, tea tree oil, sage oil, and clove oil which has been proven effective in 48 hours injection with enclosed feet in shoes and socks.

In the reaffirmed green tea polyphenols (GTP) in inhibited Trichophyton in vitro, researchers at the Tokyo Medical and Dental University launched an evaluation of the effects of GTP on interdigital tinea pedis in a total of 94  infected patients.

The enrolled patients were assigned either to a lukewarm water foot bath containing GTP(0.1% green tea polyphenol solution: 89.5% catechins) or placebo.

The foot baths were given once daily with feet cleaned with mild soap and rinsed with warm water before submersing into the warm GTP foot bath for 15 minutes up to the ankles.

Patients were also given instruction not to dry off the liquids after 15 minutes to ensure further skin penetration of green tea concentration.

At the end of 12 experiment, researchers found that either GTP or placebo exerted a significant reduction in the size of the affected area,  the recurrence rate and the microscopy findings.

In overall assessment, after taking into account of other co and con founders, green tea treatment group demonstrated significant improvements in compared to placebo group.

These results suggested that green tea (GTP) may process a strong anti fungal activity in reduced the symptoms expression of athlete's foot (tinea pedis), including redness, skin peeling, softening of the tissue.

Therefore, people with long term of athlete's foot (tinea pedis) may be beneficiary by applying the extract in practical use without inducing any adverse effects.

Taken together, green tea polyphenols may be considered as natural treatment of athlete's foot  (tinea pedis), however, due to the small sample size, researchers suggested that large sample size and multi centers investigation are necessary to re affirm this viability.

Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of a foot bath containing green tea polyphenols on interdigital tinea pedis by Ikeda S1, Kanoya Y, Nagata S.(PubMed)
(2) Athlete’s Foot (tinea pedis) by Centers for Disease Control and Prevention

The Secrets of ANTI Major Aging Signs Vitamin(5) in Inhibited Wrinkles, Roughness, Fine Lines, Enhanced Elasticity, De Hyperpigmentation Mark and Telomere Length, Scientists Revealed

By Kyle J. Norton

According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(1).

Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(2).

Vitamin E may have a substantial and therapeutic effect in reduced major signs of anging, some scientist suggested.

The results were published by number of respectable institutes, including Universiti Kebangsaan Malaysia and University of Ljubljana,

Vitamin E, a fat soluble vitamin, consisting eight different variants (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) with varying levels of biological activity, found abundantly in corn oil, soybean oil, margarine, wheat germ oil, sunflower,safflower oils, etc. plays an important role in neurological functions and inhibition of platelet aggregation, regulation of enzymatic activity, free radical scavenger, etc..

According to the Universiti Kebangsaan Malaysia, in stress-induced premature senescence (SIPS) model of human diploid fibroblasts (HDFs), γ-tocotrienol (GTT), a vitamin E variant showed to delay cellular senescence of human diploid fibroblasts through the inhibition of intrinsic mitochondria-mediated pathway which involved the regulation of pro- and anti-apoptotic genes and proteins(3) and prevented cellular aging in human diploid fibroblasts(4), probably through modulating gene expression(5) and protected against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase(6). 

The molecular mechanism of tocotrienol-rich fraction (TRF) study insisted that the variants protect against H(2)O(2)-induced oxidative stress in human skin fibroblast culture by modulating the expression of Skin Aging in COL I and COL III genes(Collagen gene) with concomitant increase in the rate of total collagen synthesis(7). 

According to the National University of Malaysia, f alpha-tocopherol (ATF), another variant of vitamin E protected against H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors(8).

Topical administration of alpha-tocopherol (ATF), in medium doses, may provide some degree of photoprotection against UVA(9). 

Some researchers suggested the potent of vitamins in reduced aging progression is a result of the balance between various skin antioxidants of vitamin E and C, through new delivery systems in induction of delivering vitamins C and E into the skin simultaneously(10). 

Other antioxidants such as vitamin E, certain flavonoids, and the carotenoids, β-carotene, lycopene and lutein, found in healthy foods may also improved skin health through protection against inflammation, oxidative stress, breakdown of the extracellular matrix(11). 

In Indian women with facial signs of aging study, the composition of niacinamide, panthenol, and tocopheryl acetate significantly reduced appearance of hyperpigmentation, improved skintone evenness, appearance of lightening of skin, versus control in 6 weeks(12).

Taken altogether, composition of vitamin E and other antioxidants and its variants may be effective
in reduced early onset of skin aging and inhibited skin aging progression, but large sample size and multi centers studies to improve these validation are necessary.

Over doses of vitamin E supplement can cause symptoms of blurred vision, weakness, dizziness, nausea, diarrhea, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.


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References
(1) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(2) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)

(3) Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts by Makpol S1, Abdul Rahim N, Hui CK, Ngah WZ(PubMed)
(4) Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts by Makpol S1, Zainuddin A, Chua KH, Yusof YA, Ngah WZ.(PubMed)
(5) Gamma-tocotrienol modulated gene expression in senescent human diploid fibroblasts as revealed by microarray analysis by Makpol S1, Zainuddin A, Chua KH, Mohd Yusof YA, Ngah WZ.(PubMed)
(6) Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals by Makpol S1, Abidin AZ, Sairin K, Mazlan M, Top GM, Ngah WZ.(PubMed)
(7) Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction by Makpol S1, Azura Jam F, Anum Mohd Yusof Y, Zurinah Wan Ngah W.(PubMed)
(8) Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals by Makpol S1, Zainuddin A, Rahim NA, Yusof YA, Ngah WZ.(PubMed)
(9) A pilot study of the photoprotective effect of almond phytochemicals in a 3D human skin equivalent by Evans-Johnson JA1, Garlick JA, Johnson EJ, Wang XD, Oliver Chen CY.(PubMed)
(10) Main approaches for delivering antioxidant vitamins through the skinto prevent skin ageing by Gašperlin M1, Gosenca M(PubMed)
(11) The role of phytonutrients in skin health by Evans JA1, Johnson EJ.(PubMed)
(12) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ.(PubMed)