Saturday 30 September 2017

Food Therapy: Kidney beans May Induce Risk of Intestinal Atrophy

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The use of plants for healing purposes have been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Intake of kidney beans may result in increased risk of the developed intestinal atrophy, the renowned institute study suggested.

Kidney beans with kidney shape, strong flavor and color of reddish brown in nature are often the excellent dietary selection with no cholesterol, but a good source of protein and minerals.

Intestinal atrophy is the abnormality of small intestine mucous membrane, caused by bacterial infection.

According to the University of Utrecht, animal fed with kidney bean induced mucosal atrophy microscopically causing atrophy and dissection of the intestinal villus in association with lengthen crypts with cells in increased mitotic activity in compared to than normal tissues.

In compared to controls, kidney bean intake significantly decreased the goblet cells in secrete gel-forming mucins, the major components of mucus but increased in the crypt region, a gland found in the intestinal epithelium lining of the small intestine and large intestine.

Dr. Kik MJ, the lead author of the study said, " feeding Phaseolus vulgaris beans reduced the digestive and absorptive capacity of the mucosa, resulting in weight loss and diarrhea in affected pigs".

In randomized study with mice fed to chow, elemental diet, elemental diet plus concanavalin-A and elemental diet plus phytohaemagglutinin groups, group fed phytohaemagglutinin showed a strong effect of chemical compound lectin in inducing cell proliferation in the small intestine and crypt fission of the middle and distal small intestine in compared to other groups.

The study also showed that phytohaemagglutinin with high amount of lectin also induced intestinal atrophy by affecting the gastric function and mobility through increased secretion of hormone in regulated gastric acid (HCl). In fact, the effects of lectins cause significant gastric trophy on the small intestine and colon may vary between different sites in the gastrointestinal tract.

In support to the above analysis, the Christian-Albrechts-Universität study
with 30 day old male rats pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 micrograms of the cholecystokinin A (CCK-A) antagonist MK 329, also found that oral administration of phytohaemagglutinin (PHA) in rats dose dependently induces growth of the small intestine through significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group.

The result of phytohaemagglutinin (PHA) intake in exhibit the intestine atrophy may be attributed to the lectin levels in increased production of hormone cholecystokinin in stimulated additional release of bile into the intestine.

Taking together, intake of kidney bean should be taken with care with patients with digestive problems as level of lectin may induce intestinal atrophy.



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Pathologic changes of the small intestinal mucosa of pigs after feeding Phaseolusvulgaris beans by Kik MJ1, Huisman J, van der Poel AF, Mouwen JM(PubMed)
(2) Lectins can reverse the dsstal intestinal atrophy associated with elemental diets in mice M by SASAKI*, A. J. FITZGERALD*, G. GRANT , M. A. GHATEIà, N. A. WRIGHT* & R. A. GOODLAD§(Wiley online Library)
(3) Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth byK-H Herziga, S Bardoczc, G Grantc, R Nustedeb, U R Fölscha, A Pusztaic(BMJ Journals)

Food Therapy: Kidney Bean, the Natural Antioxidants Whole Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.
Kidney bean may process a health benefit effect as an antioxidant functional food in reduced consequences of free radicals and foreign microbial invasion, causes of diseases.

Kidney bean is popular because of its kidney shape, strong flavor and color of reddish brown in nature, It is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

According to the joint study lead by Nanchang University, kidney bean exhibited a strong antioxidant activities through the levels of total phenolics and flavonoids with respective values in compared to 0.25-3.79 mg gallic acid  and 0.19-7.05 mg rutin found in analyzed chemical compounds assay.

In ultra-performance liquid chromatography with diode array detector (UPLC-DAD), kidney bean processed the antioxidant activity (AA) ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg and radicals inhibited by 50% (EC50)concentration.

The extracts of kidney also found to have a capability in inhibiting the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line through its antioxidant effects.

Dr. Ombra MN, the lead author said, "Cultivars differed in composition and concentration of polyphenols including anthocyanins; cooking affected the antioxidant activity only marginally."

Further to the study to compare the antioxidant activity of two solvents, aqueous (70%) acetone and water, and the extracts in relation to their phenolic contents, researchers found that queous acetone (70%) extracted containing more than twice of phenolics from hulls exhibited significantly higher antioxidant and stronger inhibitory effect on both cyclooxygenases, COX-1 and COX-2, (in expression of inflammation and inflammation in gastrointestinal tract), than water in regulated inflammation.

Dr. Oomah BD the lead author in the compared study said, "antioxidant activity that were significantly affected by cultivar and extracting solvent".

Taking together, kidney beans exhibited  a strong antioxidant effect through its procession of various phytochemical compounds, such as total phenolics and flavonoids, in regulated inflammation caused by free radicals and microbial invasion.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Nutrients, phytochemicals and antioxidant activities of 26 kidney bean cultivars by Kan L1, Nie S2, Hu J1, Wang S3, Cui SW4, Li Y1, Xu S1, Wu Y1, Wang J1, Bai Z1, Xie M1.(PubMed)
(2) Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking. by Ombra MN1, d'Acierno A1, Nazzaro F1, Riccardi R2, Spigno P2, Zaccardelli M3, Pane C3, Maione M1, Fratianni F1.(PubMed)
(3) Antioxidant and anti-inflammatory activities of bean ( Phaseolus vulgaris L.) hulls by Oomah BD1, Corbé A, Balasubramanian P.(PubMed)

Food Therapy: Kidney bean, the Whole Food in Reduced Risk and Treatment of Leukemia

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international jourenal Pharma and Bio science, ISSN 0975-6299.

If you expect that food and herbal medicine will ease the symptoms of your illness immediately after few day of treatment, you will be disappointed. Symptoms of the diseases can only be eased gradually, depending to stages of the treatment which directly address to the cause of the disease.

Intake of cooked Dried red kidney beans regularly may reduce risk and delay progression risk of Leukemia, a renowned institute study proposed.

Kidney bean is popular food, with  kidney shape, strong flavor and color in reddish brown in nature, used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Leukemia is condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chemical compound purified from dried kidney beans, namely, 7.3-kDa antifungal peptide, used mainly for treatment of fungal overgrowth, showed to suppress the spread of leukemia L1210 cells with an half concentration of 5.2±0.4 µM and 7.6±0.6 µM, according to the China Agricultural University.

Dr. Ma DZ, the lead researcher said, "(the antifungal peptide isolated from dried Nepalese large red beans) exerted an antiproliferative action on L1210 leukemia cells with an an half concentration of high doses at 15 and 60 microM, respectively".

Other chemical compound, L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds also enhanced anti-proliferative effect on ALL cells according to the WST-8 cell viability assay kit.

Furthermore, treatment of L-asparaginaseenzyme also involved significant in induced early apoptosis in acute Lymphoblastic leukemia in test subjects jn vivo.

According to the joint study lead by the King Abdulaziz University, the efficacy of novel L-asparaginaseenzyme, isolated from Phaseolus vulgaris seeds (P-Asp) in mice study showed that  mice treated with P-Asp had less distinct allergenic responses by immune system in expression of higher risk of carcinogens and reduced treatment effects.

There is no doubt that kidney beans may be a potential health benefit in targeting the risk of  Leukemia in early stage and prevent the progression of the cancer through anti-proliferative and induced tumors cell death.


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) An antifungal peptide with antiproliferative activity toward tumor cells from red kidney beans by Li M1, Wang H, Ng TB.(PubMed)
(2) A peptide with potent antifungal and antiproliferative activities from Nepalese large red beans by Ma DZ1, Wang HX, Ng TB.(PubMed)
(3) Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean" by Sun J1, Wang H, Ng TB.(PubMed)
(4) Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells by Li M1,2, Liu Q3, Cui Y4, Li D5, Wang H6, Ng TB7.(PubMed)

Thursday 28 September 2017

Food Therapy: Black bean, the Functional Food In Reduced Risk and Treatment of Osteocarcinoma

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Intake of black bean regular may reduce risk and delay progression and treatment of osteocarcinoma, an invasive form of bone cancer.

Osteocarcinoma is a condition of bone cancer caused by irregular cell growth in bone, affecting mostly adolescents and young adults..

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the The Chinese University of Hong Kong, hemagglutinin isolated from an edible legume, namely black bean, showed an anti proliferative activity against tumor cell lines MG-63 and HepG2 but not the normal cell line.

Malignant osteocarcinoma cell treated with the phytochemical also exerted a significant effect in shrinking of tumor cells as well as inducing apoptosis.

The study also stated that hemagglutinin also induced cell death through interfering the first stage of tumor cell division in expression of protein, RNA, and DNA and inducing mitochondrial membrane depolarization in controlling plasma membrane of a muscle or nerve cell


Furthermore, the study also suggested that the efficacy of hemagglutinin in causing cell death may be attributed to the function of protein in increased regulation of pro inflammatory expressions.

Dr. Dan X, the lead author said, " a novel hemagglutinin from an edible legume (showed) a growth-inhibitory effect on osteocarcinoma and liver cancer cells" and " The hemagglutinating activity of this hemagglutinin was demonstrated to be ion dependent and stable over a wide range of temperature and pH values".

The findings suggested that black bean may be considered as functional food in improved bone health as well as reducing risk and treatment of  osteocarcinoma, but further studies are necessary to confirm it's potency.


Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans by Dan X1, Wong JH1, Fang EF2, Chan FC3, Ng TB1(PubMed).

Food Therapy: Black Bean the Best on Ameliorated Oxidative Stress in Chronic Diseases

By Kyle J. Norton


People who turn to alternative medicine for treatment of diseases in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean may be used as function food to counter the over expression of free radicals through improved antioxidant activity, a university study postulated.

Oxidative Stress is the imbalance between free radical and antioxidant expression.
Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Illinois at Urbana-Champaign, the use of common bean peptides may contribute to reduced risk of complications associated to chronic diseases, including oxidative stress.

Proteins and synthesized pure peptides from Mexican black and Brazilian Carioca bean, all showed a significantly rate in reduced oxidative stress through over expression of antioxidant activity.

In a randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions, then blood of participants is collection before (fasting) and five hours postprandially, Oxidized LDL (oxLDL) showed a trend of declining observed after the Back Bean and antioxidant capacity matched meals at five hours compared to the FM group.

Dr. Reverri EJ, the lead author said" black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity".

In the compared black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE), on streptozotocin-induced diabetic mice study conducted by the Xuzhou Medical College, after 4 weeks of injection, researchers found that PPE, BBPE or PPE + BBPE, DM mice showed in some different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity.

The result indicated that mice treated with black bean or combination of black bean showed a significant in reduced levels of oxidative stress through enhanced antioxidant activities.

Taking together,  black bean may have a potential used as therapeutic whole food therapy for treatment in reduced oxidative stress in chronic illness.



Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress by Mojica L1,2, Luna-Vital DA1,3, González de Mejía E1.(PubMed)
(2) Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome by Reverri EJ1, Randolph JM2, Steinberg FM3, Kappagoda CT4, Edirisinghe I5, Burton-Freeman BM6,(PubMed)
(3) Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice by Wang JY1, Zhu C1, Qian TW1, Guo H1, Wang DD1, Zhang F1, Yin X1.(PubMed)

Food Therapy: Black Bean, The Best Functional Food in Reduced Risk of CVD and Heart Complications in Diabetics

By Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black or common bean may be considered as function foods in attenuated risk of Cardivascular disease, a renowned institute postulated.

Cardiovascular disease is a condition of heart attack caused by block of blood in vessel as a result of narrowing and hardening of blood vessels.

Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the University of Colorado Colorado Springs, individuals who eat more bean in promoted less glycaemic stress (hyperglycaemia and hyperinsulinaemia) may have a reduced risk of CVD,

The study also addressed the importance of bean efficacy on glycaemic response and the impact of that relationship may have on the risk of developing diabetes and CVD.
In Sprague-Dawley rats model and C57Bl/6 mice induced obesity by a diet, both bean diet,groups showed a significant in reduced plasma total cholesterol and LDL-cholesterol without affecting HDL-cholesterol or total TAG in short-term. And bean-fed obese mice not only induced weight loss but also improved plasma lipid profile within a 12 d time frame in compared to other groups.

The weight loss and reduced levels of blood cholesterol in tested subjects provided a significant information of dried bean function in ameliorated risk of cardiovascular disease.

Other in the study of risk of development of cardiovascular complications in patients with diabetes, suggested that the imbalance between reactive oxygen species and antioxidant systems in patients with types 2 diabetes may be leading causes of heart complications involving high cardiac collagen content.

Therefor, increased intake of bean diet may play a prevalent role in reduced risk of CVD by increased total antioxidant activity and reduced the expression of hyperglycaemic state, catalase and superoxide dismutase activity and tissue damage caused by lipid peroxidation.

Dr. Oliveira RJ, the lead author said, "The phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications".

Collectively, adding a bean portion in your diet daily may have a substantially reduced risk of heart disease and  heart complications in diabetics, in comparison to people with typical American diet.


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects by Hutchins AM1, Winham DM, Thompson SV.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats by Oliveira RJ1, de Oliveira VN, Deconte SR, Calábria LK, da Silva Moraes A, Espindola FS.(PubMed)

Food Therapy: Coffee and Coffee Caffeine Elevated and Ameliorated Menopause Symptoms Differently

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Menopause is a natural and biological progression of women at certain age. The reduced hormone levels of inaction of ovaries induced menstruation stop and a set of symptoms

Coffee, second to green tea, is a popular and social beverage all over the world, particular in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

A study conducted by a renowned institute suggested that coffee nd coffee caffeine may have potential effect in reduced severity of some menopause symptoms and elevation of others.

In a cross-sectional survey conducted using the Menopause Health Questionnaire, completed by 2,507 consecutive women with menopausal concerns at the Women's Health Clinic at Mayo Clinic (Rochester, MN) between July 25, 2005 and July 25, 2011, caffeine intake in participants showed a greater positive effect in expression of vasomotor symptom of menopause women in compared to non drinkers group.

Other, in a cross-sectional study of a community-based sample of 243 women with vasomotor symptoms to evaluate the menopause symptoms of hot flashes (HF) and night sweats (NS) in symptomatic middle-aged women, intake of coffee showed to elevate symptom of hot flashes (HF) and night sweats (NS) in compared to non drinkers.

And caffeine intake also is found as one of predictor in  exhibited both hot flashes (HF) and night sweats (NS)  in the same study group.

But in animal model, according to the behavioral tests and oxidative stress parameters in ovariectomized mice, caffeine intake also showed a significant in reduced symptoms of anxiety induced by oxidative stress.

Administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulate the oxidative stress and anxiety in menopause, the "Iuliu Hatieganu" University of Medicine and Pharmacy postulated.

Taking altogether, coffee and coffee caffeine may have a strong effect in reduced and elevated menopause symptoms, in types depending manner.


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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Caffeine and menopausal symptoms: what is the association? by Faubion SS1, Sood R, Thielen JM, Shuster LT.(PubMed)
(2) Perceived control, lifestyle, health, socio-demographic factors and menopause: impact on hot flashes and night sweats by Pimenta F1, Leal I, Maroco J, Ramos C.(PubMed)
(3) Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats by Caravan I1,1, Sevastre Berghian A1,1, Moldovan R1,1, Decea N1,1, Orasan R1,1, Filip GA1,1.(PubMed)