Sunday 17 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout - Diseases associated to- Hyperuricemia

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                        Diseases associated with  Gout


According to the UK Gout Society,  diseases associated to gout may include
5. Hyperuricemia
Hyperuricemia, a condition with over expression of uric acid in the blood through liver most often found in patients with gout. According to Dr. Li YM. said, "It has been widely accepted that the increase in the level of uric acid significantly raises the risks of gout, cardiovascular disease, and type 2 diabetes."
It is acceptance epidemiological studies that high fruit and soybean products dietary intervention could be an effective alternative to a standard diet for achieving clinically important reductions in SUA for asymptomatic hyperuricemia patients(61). And major dietary patterns such as animal products and fried food are associated to risk of hyperuricemia(62).
According to the Chiang Mai University, green tea extract (GTE) also promoted hypouricemic and anti gout effects through modestly lowering serum uric acid (SUA) level and decreasing uric acid clearance(63). 
Reduced intake of food with rich purine, alcohol intake as well as controlling obesity and blood pressure, improving the status of lipid metabolic disorder together with programs as hypertension control etc.(64).




References
(61) Comparison of the effect of high fruit and soybean products diet and standard diet interventions on serum uric acid in asymptomatic hyperuricemia adults: an open randomized controlled trial BY Zhang M1, Gao Y2, Wang X1, Liu W3, Zhang Y3, Huang G1.(PubMed)
(62) Major dietary patterns and risk of asymptomatic hyperuricemia in Chinese adults by Zhang M1, Chang H, Gao Y, Wang X, Xu W, Liu D, Li G, Huang G.(PubMed)
(63) Effects of green tea extract on serum uric acid and urate clearance in healthy individuals by Jatuworapruk K1, Srichairatanakool S, Ounjaijean S, Kasitanon N, Wangkaew S, Louthrenoo W.(PubMed)
(64) [Epidemiological study on hyperuricemia and gout in Foshan areas, Guangdong province.][Article in Chinese] by Yu JW1, Yang TG, Diao WX, Cai XQ, Li T, Zhong H, Hu DL, Chen CQ, Chen ZX.(PubMed)


Saturday 16 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Diseases associated with Gout - Hypertriglyceridemia

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                        Diseases associated with  Gout


According to the UK Gout Society,  diseases associated to gout may include
3. Hypertriglyceridemia
Unhealthy diet such as typical American diet with high in saturated and trans fat and lower intake of vegetables and fruits has been found to associated to hypertriglyceridemia in epiodemilogical literature in data bases of PubMed(41)(42)(43), particular to hypertriglyceridemia in men(46).
In the searching of the association of hypertriglyceridemia in patients with gout, according to the Osaka University Medical School, there is a close correlation between the degree of uric acid production and triglyceride (TG) metabolism in 148 male subjects with primary gout(45).
Dr. Naito HK and Dr. Mackenzie AH. insisted, " diet and, possibly, defective clearance of triglycerides may be etiologic factors associated with the abnormal serum triacylglycerol (triglyceride) and lipoprotein concentrations in these individuals"(44).
According to the Korean National Health and Nutrition Examination Surveys (KNHANES) 2007-2009, supported the potential beneficial role of vegetables and fruits consumption to reduce blood triglyceride levels in Asian populations(47).
Furthermore, High-fat ketogenic diets, the only treatment available for Glut1 deficiency (Glut1D) as od today, according to joint study led by the Children's Hospital Aschaffenburg Alzenau after 3 years intake, showed a gradual increase of blood lipids, followed by rapid, severe asymptomatic hypertriglyceridemia (1,910 mg/dL)(48).

(41) Dietary Glycemic Index and Glycemic Load Are Positively Associated with Risk of Developing Metabolic Syndrome in Middle-Aged and Elderly Adults by Juanola-Falgarona M1,2, Salas-Salvadó J1,2, Buil-Cosiales P2,3, Corella D2,4, Estruch R2,5, Ros E2,6, Fitó M2,7, Recondo J2,8, Gómez-Gracia E2,9, Fiol M2,10,Lapetra J2,11, Lamuela-Raventós RM2,12, Serra-Majem L2,13, Pintó X2,14, Muñoz MA2,15, Ruiz-Gutiérrez V2,16, Alfredo Martínez J2,17, Castro-Quezada I2,13,Bulló M1,2; PREvencion con DIeta MEDiterranea Study Investigators.(PubMed)
(42) Lipemia retinalis: a combination of genetics and the American diet and lifestyle by Nogales SL1, Grimes AL, Song HF.(PubMed)
(43) Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients withhypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial by Hlais S1, Reslan DR, Sarieddine HK, Nasreddine L, Taan G, Azar S, Obeid OA.(PubMed)
(44) Secondary hypertriglyceridemia and hyperlipoproteinemia in patients with primary asymptomatic gout by Naito HK, Mackenzie AH.(PubMed)
(45) Relationship between hypertriglyceridemia and uric acid production in primary gout by Matsubara K1, Matsuzawa Y, Jiao S, Takama T, Kubo M, Tarui S.(PubMed)
(46) Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study by Chen JH1, Pan WH, Hsu CC, Yeh WT, Chuang SY, Chen PY, Chen HC, Chang CT, Huang WL.(PubMed)
(47) Fruit and vegetable consumption and hypertriglyceridemia: Korean National Health and Nutrition Examination Surveys (KNHANES) 2007-2009 by Yuan C1,2, Lee HJ3, Shin HJ1,4, Stampfer MJ1,2,5, Cho E5,6,7.(PubMed)
(48) Severe Hypertriglyceridemia in Glut1D on Ketogenic Diet by Klepper J1, Leiendecker B2, Heussinger N1, Lausch E3, Bosch F4.(PubMed)

Friday 15 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Diseases associated with Gout - Renal insufficiency

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                        Diseases associated with  Gout


According to the UK Gout Society,  diseases associated to gout may include

2. Renal insufficiency
Patients with gout are associated to chronic kidney disease has been well documented in epidemiological literature(26). The joint study led by the Keele University suggested, "Chronic kidney disease and nephrolithiasis are commonly found amongst patients with gout. Gout is independently associated with both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its consequences"(33).
Dr. Krishnan E said, "Chronic kidney disease manifesting as reduced glomerular function or as presence of blood or protein in the urine increases the risk of incident gout"(34).
Chronic Kidney disease is defined as a condition of the progression loss of kidney function over period of many years. Stage of chronic kidney disease according to the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQ). 

In the review of literature from data base of PubMed, Brazil Nut(35)(36), Flax Seed(37) and Honey(38)(39) found effectively in treatment of renal insufficiency back by recent studies from some well known institutions  may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Chronic Kidney disease in patient with gout. For more information, please visit The Impossible Smoothie of Brazil Nut, Flax Seed and Honey For Prevention and Treatment of Chronic Kidney disease(40).

(33) Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies by Roughley MJ1, Belcher J2, Mallen CD3, Roddy E4.(PubMed)
(34) Chronic kidney disease and the risk of incident gout among middle-aged men: a seven-year prospective observational study by Krishnan E1.(PubMed)
(35) A follow-up study of the chronic kidney disease patients treated with Brazil nut: focus on inflammation and oxidative stress by Stockler-Pinto MB1, Malm O, Moraes C, Farage NE, Silva WS, Cozzolino SM, Mafra D.(PubMed)
(36) Brazil nut (Bertholletia excelsa, H.B.K.) improves oxidative stress and inflammation biomarkers in hemodialysis patients. by Stockler-Pinto MB1, Mafra D, Moraes C, Lobo J, Boaventura GT, Farage NE, Silva WS, Cozzolino SF, Malm O.(PubMed)
(37) Patient with hypertriglyceridemia, type 2 diabetes, and chronic kidney disease treated with atorvastatin andomega-3 Fatty Acid ethyl esters by Athyros VG1, Mikhailidis DP.(PubMed)
(38) Honey: a novel antioxidant by Erejuwa OO1, Sulaiman SA, Ab Wahab MS.(PubMed)
(39) Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients by Johnson DW1, van Eps C, Mudge DW, Wiggins KJ, Armstrong K, Hawley CM, Campbell SB, Isbel NM, Nimmo GR, Gibbs H.(PubMed)
(40) The Impossible Smoothie of Brazil Nut, Flax Seed and Honey For Prevention and Treatment of Chronic Kidney disease by Kyle J. Norton.


Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Diseases associated with Gout - Hypertension

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                   Diseases associated with  Gout

According to the UK Gout Society,  diseases associated to gout may include

1. Hypertension
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.

Dr, Gibson TJ said, "gout are associated with hypertension and chronic kidney disease is well established" and "(many medication such as Losartan may possess mild uricosuric properties and therefore has a role in treating hypertensive patients with gout"(26).
Western medication such as hydrochlorothiazide (HCTZ) and chlorthalidone (CTD), according to the University of Missouri, are effective used for treatment of hypertension in gout patients(27) with certain unwanted side effects.
Diet rich in fruits and vegetable and reduced intake of red meat, saturated fat and trans fat has shown to attenuated risk of hypertension(28). Recent study showed that celery(29) intake used conjunction with berries(30) and green tea(31) may be the potential drink for prevention and treatment of hypertension in patients with gout.
For more information visit: The Smoothies of celery, apple and green tea for prevention and treatment of Hypertension(32).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(26) Hypertension, its treatment, hyperuricaemia and gout by Gibson TJ1.(PubMed)
(27) Comparison of new-onset gout in adults prescribed chlorthalidone vs. hydrochlorothiazide for hypertension by Wilson L1, Nair KV, Saseen JJ.(PubMed)
(28) Fruit and Vegetable Consumption and the Incidence of Hypertension in Three Prospective Cohort Studies by Borgi L1, Muraki I2, Satija A2, Willett WC2, Rimm EB2, Forman JP2.(PubMed)
(29) The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose by Dianat M1, Veisi A1, Ahangarpour A1, Fathi Moghaddam H1.(PubMed)
(30) Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors by Toh JY1, Tan VM, Lim PC, Lim ST, Chong MF.(PubMed)
(31) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
(32) The Smoothies of celery, apple and green tea for prevention and treatment of Hypertension by Kyle J. Norton


Wednesday 13 April 2016

Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout: The Risk Factors

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                   Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.


                      Causes and risk factors
B. Risk factors
1. Improper diet
If you body can not get rid uric acid quickly, intake foods with high levels of purine such as Alcohol, Beverages, Beer, Anchovies, Smelt, Fish, Eggs, Herring, Mackerel, Sardine, Sweetbread, Liver, Kidney, etc., is at increased risk of gout(7)(8)(10). Several dietary factors increased the risk of incident gout, including meat intake, seafood intake, sugar sweetened soft drinks, and consumption of foods high in fructose(10).

2. Alcohol consumption
Dr. Singh JA and scientists at the Birmingham VA Medical Centre, indicated, of the 751 titles and abstracts, 53 studies met the criteria and were included in the review. Several risk factors were studied. Alcohol consumption increased the risk of incident gout, especially beer and hard liquor(10)(7).
 Others suggested that combined with their activities as urinate transporters and their strong associations with serum uric acid concentrations,

3. Medical conditions
Hypertension, renal insufficiency, hypertriglyceridemia, hypercholesterolemia, hyperuricemia, diabetes are associated to increased risk of gout(10). Patient with Chronic kidney disease are at higher risk of gout as a result of Serum uric acid control in gout was poor among patients without CKD and even worse among those with CKD(11). Distinct group differences by content of uric acid seem to arise from early onset of chronic renal failure in women.

4. Medication
Gout is also drug-related(21). Thiazide and loop diuretics users are at increased risk of gout(12)(10), according to Johns Hopkins University Bloomberg School of Public Health.

5. Race
Some ethnic groups are particularly susceptible to gout, probaby due to genetic predisposition(13)(14).
6. Age and sex  are associated to risk of the develop of gout(14)(15).

7. Genetics
GLUT9 and ABCG2 appeared to be important modulators of uric acid levels and likely of the risk of gout. Together with a growing list of environmental risk factors, these genetic data add considerably to our understanding of the pathogenesis of hyperuricemia and gout(16)(17)(19).

8. Family history 
Accoridng to the total of 543 cases of juvenile gout from the Ho-Ping Gout Database, and 5269 gouty cases with onset age of 40 to 50 years, family history is associated to increased risk of gout(18)(19)
9. Obesity, over weight, weight change
 Obesity and overweight are associated with a higher risk of incident gout and/or gout flare(10)(19).
Higher adiposity and weight gain are strong risk factors for gout in men, while weight loss is protective(5).

10. Menopause
Early menopause is associated with a higher risk of incident gout and/or gout flare(10). According to the16 years of follow-up (1 240 231 person-years), 1703 incident gout cases, conducted by the Taipei Municipal Hospital Gout Research Group, compared with premenopausal women, postmenopausal women had a higher risk of incident gout. Risk of gout is decreased among postmenopausal hormone users(22).

11. Recent surgery or trauma
According to Cleveland Clinic, risk of early postoperative gout is higher after bariatric surgery in comparison of patients undergoing other procedures(23)(24). There is a report of monoarticular gout following trauma in Medical College of Wisconsin literature(25).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(*) Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. by van Schaardenburg D1, Van den Brande KJ, Ligthart GJ, Breedveld FC, Hazes JM.(PubMed)
(4) Tophi as first clinical sign of gout by Thissen CA1, Frank J, Lucker GP.(PubMed)
(7) [Hyperuricemia and gout; the role of diet].[Article in Spanish]by Álvarez-Lario B1, Alonso-Valdivielso JL2.(PubMed)
(8) A perspective on diet and gout by Kedar E1, Simkin PA.(PubMed)
(10) Risk factors for gout and prevention: a systematic review of the literature by Singh JA1, Reddy SG, Kundukulam J.(PubMed)
(11) Chronic kidney disease in gout in a managed care setting by Fuldeore MJ1, Riedel AA, Zarotsky V, Pandya BJ, Dabbous O, Krishnan E.(PubMed)
(12) Diuretic Use, Increased Serum Urate and the Risk of Incident Gout in a Population-based Study of Hypertensive Adults: the Atherosclerosis Risk in the Communities Cohort by Mara A. McAdams DeMarco, MS, PhD,1 Janet W. Maynard, MD, MHS,2 Alan N. Baer, MD,2 Allan C. Gelber, MD, MPH, PhD,1,2 J. Hunter Young, MD, MHS,1,3 Alvaro Alonso, MD, MPH, PhD,4 and Josef Coresh, MD, PhD1,3(PMC)
(13) Global epidemiology of gout: prevalence, incidence and risk factors by Kuo CF1, Grainge MJ2, Zhang W3, Doherty M3.(PubMed)
(14) Gout: a review of nonmodifiable and modifiable risk factors by MacFarlane LA1, Kim SC2.(PubMed)
(15) The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets by Rasheed H1,2, McKinney C1, Stamp LK3, Dalbeth N4, Topless RK1, Day R5,6, Kannangara D5,6, Williams K5,6, Smith M7, Janssen M8, Jansen TL9, Joosten LA10, Radstake TR11, Riches PL12, Tausche AK13, Lioté F14,15, Lu L16, Stahl EA17, Choi HK16, So A18, Merriman TR1.(PubMed)
(16) Genetics of gout by Choi HK1, Zhu Y, Mount DB.(PubMed)
(17) ABCG2/BCRP dysfunction as a major cause of gout by Matsuo H1, Takada T, Ichida K, Nakamura T, Nakayama A, Suzuki H, Hosoya T, Shinomiya N(PubMed)
(18) Juvenile gout in Taiwan associated with family history and overweight by Chen SY1, Shen ML.(PubMed)
(19) Clinical features of familial gout and effects of probable genetic association between gout and its related disorders by Chen SY1, Chen CL, Shen ML, Kamatani N.(PubMed)
(20) Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study by Choi HK1, Atkinson K, Karlson EW, Curhan G.(PubMed)
(21) Hyperuricaemia and gout by Shipley M1.(PubMed)
(22) Menopause, postmenopausal hormone use and risk of incident gout by Hak AE1, Curhan GC, Grodstein F, Choi HK.(PubMed)
(23) The effect of bariatric surgery on gout: a comparative study by Romero-Talamás H1, Daigle CR1, Aminian A1, Corcelles R1, Brethauer SA1, Schauer PR2.(PubMed)
(24) Development of acute gouty attack in the morbidly obese population after bariatric surgery by Antozzi P1, Soto F, Arias F, Carrodeguas L, Ropos T, Zundel N, Szomstein S, Rosenthal R.(PubMed)
(25) Monoarticular gout following trauma: MR appearance by Ruiz ME1, Erickson SJ, Carrera GF, Hanel DP, Smith MD.(PubMed)


Most Common Disease of 50+: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout: The Causes

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                         Causes and risk factors

A. Causes
The causes of gout is as the result of high levels of uric acid in the body that can lead to forming of crystals causes of inflammation due to your body can not get rid of uric acid or have made too much uric acid(4). Reduced intake of meats and seafood and foods containing higher levels of uric acid, such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose) may be necessary(7)(8).
According to the New York University School of Medicine/Langone Medical Center, the prevalence of gout and hyperuricemia has increased dramatically during the last several decades, to the point that gout is the most common inflammatory arthritis in the United States, affecting approximately 8 million Americans(9) and contributing to great numbers of hypertension, chronic kidney disease, and cardiovascular disease(9).


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(*) Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. by van Schaardenburg D1, Van den Brande KJ, Ligthart GJ, Breedveld FC, Hazes JM.(PubMed)
(7) [Hyperuricemia and gout; the role of diet].[Article in Spanish]by Álvarez-Lario B1, Alonso-Valdivielso JL2.(PubMed)
(8) A perspective on diet and gout by Kedar E1, Simkin PA.(PubMed)
(9) Hyperuricemia, gout, and related comorbidities: cause and effect on a two-way street by Karis E1, Crittenden DB1, Pillinger MH1.(PubMed)


Tuesday 12 April 2016

Most Common Disease of 50 Plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Gout: The Symptoms

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
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Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                                  Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

                                                  The Symptoms

In the study carry out a cross-sectional survey on prevalence of musculoskeletal symptoms, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout, Dr. Dai SM, and the research team at the Second Military Medical University, in the interviewe a total of 6584 adults (3394 women, 3190 men) with the response rate of 86.6%. showed that symptoms occurred more frequently in the following sites: knee 7.0% (95% CI 6.4-7.6%), lower back 5.6% (95% CI 5.0-6.2%), shoulder 4.7% (95% CI 4.2-5.2%), and neck 2.4% (95% CI 2.0-2.8%). Women complained of rheumatic symptoms more frequently than men. The standardized rates of RA, AS, gout, symptomaticknee osteoarthritis, and soft tissue rheumatism were 0.28% (95% CI 0.15-0.41%), 0.11% (95% CI 0.03-0.19%), 0.22% (95% CI 0.11-0.33%), 4.1% (95% CI 3.6-4.6%), and 3.4% (95% CI 3.0-3.8%), respectively(1a).
Most frequent symptoms of gout as a result of tophus(4), according to studies including
1. Warmth(1), pain(1), particular endpoint pain(2), swelling(1), erythema(1), and extreme tenderness(2)(called podagra. when it effects the big toe), according to the Cadence Physician Group/Orthopaedics(1)
2. Very red or purplish skin on the affect joint(5)
3. Reduced movement of affect joint and big toe, according ot the study by the Auckland University of Technology, walking shoes with good footwear characteristics can influence plantar pressure values and encourage a more efficient heel to toe gait pattern in people with gout(3).
4. Induced skin itching and peeling when the affect joint begins to heal(5)
5. Intractable back pain and fever if it a  spinal gout(6).

In fact, symptoms are quite noticeable, you may feel well when you go to bed but wake up during the night with intense pain in one or few joints and sometime with fever. The symptoms may go away in a few days, but can return from time to time. Chronic gout can cause lumps(4) below the skin around the affect areas.

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References
(*) Musculoskeletal disorders and disability in persons aged 85 and over: a community survey. by van Schaardenburg D1, Van den Brande KJ, Ligthart GJ, Breedveld FC, Hazes JM.(PubMed)
(1) Diagnosis and management of gout in total knee arthroplasty by Buck M1, Delaney M.(PubMed)
(2) Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator by Terkeltaub RA, Schumacher HR, Carter JD, Baraf HS, Evans RR, Wang J, King-Davis S, Weinstein SP.(PubMed)
(3) The effect of good and poor walking shoe characteristics on plantar pressure and gait in people with gout by Stewart S1, Dalbeth N2, McNair P3, Parmar P4, Gow P5, Rome K3.(PubMed)
(4) Tophi as first clinical sign of gout by Thissen CA1, Frank J, Lucker GP.(PubMed)
(5) Symptoms of gout(NHS choice)
(6) [Fever and back pain--a case report of spinal gout].[Article in German] by Schorn C1, Behr C, Schwarting A.(PubMed)