Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday 28 January 2015

(Preview) Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoarthritis

Weight Loss the Easy Ways
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Osteoarthritis

Osteoporosis is condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

I. Symptoms
1. Lower back pain, as a result of fractured or collapsed vertebra
People with Osteoporosis are susceptible to lower back pain than those without osteoporosis, according to a cross-sectional study, conducted from October 2002 to March 2003 to gather data from 24,435 adults aged 20 years and older selected randomly from Taiwan’s general population. The Osteoporosis rate of frequent low back pain in association with osteoporosis in men and women were 5.77 and 3.49 respectively(1).

2. Loss of height over time
Vertebral fracture cause of spinal core damage is associated to significant height loss in patients with osteoporosis, according to a study of 231 men and women over the age of 65 underwent DXA scan of their spine and hip (2).
Osteoporosis patients with chronic obstructive pulmonary disease (COPD) are found to associate to excessive height loss(3).

3. A stooped posture
Postural deformity of patients with osteoporosis is associated to contributed risk factor for postural instability and falls. Spinal curvature on postural instability in patients with osteoporosis may influence lumbar kyphosis(lower back curvature) in spinal inclination(4).

4. Easy bone fracture
Easy bone fracture may be results of a gradual loss of bone density.
Intravenous infusion of zoledronic acid (5 mg) at 12 months, found that Zoledronic acid treatment was associated with a significantly reduced risk of vertebral fracture(fractures in the spine, hip and wrist), among men with osteoporosis, according to a multicenter, double-blind, placebo-controlled trial of randomly assigned 1199 men with primary or hypogonadism-associated osteoporosis who were 50 to 85 years of age(5).

5. Neck and low back pain
Neck and low back pain, frequent in female are prevalent and highly associated in patients with headache and osteoporosis, according to 1-year prevalence of neck pain and low back pain in the Spanish population(6).

6. Depression
Spine BMD was negative correlations between anxiety, stress, but depression was found to have a unique significant contribution to the explained variance in right and left hip BMD(7).

7. Other symptoms
Women with osteoporosis re more likely to experience certain psychosomatic, gastrointestinal and swelling and vasomotor symptoms, especially depressive symptom if compared to women in generally good health(8).
8. Etc.

II. Causes and Risk Factors
A. Causes
1. Process of wear and repair
Osteoarthritis (OA) is a widespread degenerative disease of skeletal joints and often associated with senescence in vertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(6).
Improper repair process of injure of joints can also result of symptoms of Osteoarthritis (OA) in old age, according to TCM.

2. Nutrient deficiency
Poor nutritional conditions in early life are linked to greater prevalence of OA due the gradual deterioration of function(9).

3. Cartilage
Cartilage is a flexible connective tissue which cushions the ends of bones in your joints to allow the joints to move smoothly. If the cartilage becomes rough or wears down due to aging or damage, it can cause pain as a result of bone in the joint rubbing against another bone.

4. Etc.

B. Risk factors
1. Young Age at Diagnosis, Male Sex, and Decreased Lean Mass
According to Korea Cancer Center Hospital, Seoul,
a. Diagnosed before attainment of puberty, were showed to have a higher prevalence of osteoporosis
b. If you are males, you are at increased risk of osteopenia or osteoporosis than females
c. Regional lean mass was significantly associated to the reduce risk of affecting the limbs
(12).

2. Adult growth hormone replacement
Adult growth hormone replacement, were identified to associated to increased risk of osteoporosis and osteopenia, according to the study by Seoul National University College of Medicine(13).

3. Aging
Risk of osteoporosis increases with age.
Bone loss occurs during the normal aging process. In women, natural menopause also effect the additional bone losses, according to the study by Department of Medicine, College of Physicians and Surgeons, Columbia University(14).

4. Chlamydia pneumoniae
Individual presented of Chlamydia pneumoniae DNA are alsp associated to both in osteoporotic bone tissue(15).

5. Race
Lactose maldigestion showed a greater affect on low bone density. Extensive lactose maldigestion among Hispanic-American and Asian-American populations may elevate the risk for osteoporosis(16).

6. Family history
According to the reported physician-diagnosed osteoporosis and family history in a representative sample of U.S., family history is associated to a significant, independent risk factor for osteoporosis in U.S. women aged>or=35 years(17).

7. Body size
Large body size is associated to the risk of the development of osteoporosis and a salutary effect on BMD in both blacks and whites, in a study of three groups of postmenopausal women: 104 healthy black women, 45 healthy white women, and 52 osteoporotic white (18).

8. Diet and lifestyle
BMD was higher in habits of alcohol drinking, green tea drinking, and physical activity and lower in those with the habits of smoking and cheese consumption, in a study of total of 632 women age > or =60 years(19).

9. Heavy alcohol intake or alcoholism
Heavy alcohol intake or alcoholism, however, frequently disrupts calcium and bone homeostasis, leading to reduce bone mineral density and increase the incidence of fragility fracture, according to the study by Department of Endocrinology and Metabolism, Saitama Medical School(20).

10. Smoking and lower serum IGF-I levels
A lower BMI is found in patient who are current smoking history and lower serum IGF-I levels in middle-aged Korean men(21).

11. Other risk factors
The frequency of decreased bone mineral density, low vitamin and calcium diet content and insufficiency with vitamins are found among patients suffering from chronic diseases (of cardiovascular system, gastrointestinal tract, osteopenia and osteoporosis)(22).

III. Diagnosis According to the Clinical practice guidelines for the diagnosis and management of osteoporosis. Scientific Advisory Board, Osteoporosis Society of Canada, Screening and diagnostic methods: risk-factor assessment, clinical evaluation, measurement of bone mineral density, laboratory investigations.

If you are experience certain symptom of osteoporosis, the tests which your doctor order include
1. Blood and urinary tests
The aim of the tests is to check for the bone metabolism and the progression of bone (loss) diseases.

2. Dual energy X-ray absorptiometry (DXA)
Dual energy X-ray absorptiometry (DXA) is one most common test to measure the total bone density of including spine, hip, wrist etc. with accurate result.

3. Quantitative Ultrasound and computed tomography (QCT)
Quantitative ultrasound (QUS) is a portable and accurate technology used to evaluate bone density at the lumbar spine and hip without the use of ionizing radiation.
Computed Tomography (CT) scanner.a technology for measuring properties of bone at peripheral skeletal sites(23).
Dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT), which are now the standard methods for assessing osteoporosis severity and treatment efficacy(24), but in cross-sectional study of males with glucocorticoid-induced osteoporosis (GIO, quantitative computed tomography (QCT), High-resolution quantitative computed tomography (HRQCT)-based were more superior to DXA in discriminating between patients of differing prevalent vertebral fracture status(25).

4. Etc.

IV. Complication associated with Osteoporosis
Pain, Fractures, Vertebral, Wrist, Rib fractures are associated with Osteoporosis, according to the study of New advances in imaging osteoporosis and its complications(26)

V. The Diet
1. Green tea
Black tea polyphenol, theaflavin-3,3′-digallate (TFDG) and green tea, epigallocatechin-3-gallate (EGCG) are found to be a lead compounds for the treatment of bone resorption diseases, through inhibition of the formation and differentiation of osteoclasts, according to study.

2. Organic soy
Ingestion soy isoflavone extracts (not soy protein or foods containing isoflavones) supplements increased lumbar spine BMD in menopausal women, but not femoral neck, hip total, and trochanter BMD, according to study.

3. Milk thistle seeds
Silibin found abundantly in Milk thistle seeds has shown to promote bone-forming osteoblastogenesis and encumber osteoclastic bone resorption in vitro cell systems of murine osteoblastic MC3T3-E1 cells and RAW 264.7 murine macrophages.

4. Skin and seed of grape
Resveratrol, a phytohemical of skin and seed of grape promoted spontaneous osteogenesis(bone formation) but prevented adipogenesis(adipocytes in storage of fat) in human embryonic stem cell-derived mesenchymal progenitors, according to study.

VI. Antioxidants and Osteoporosis
Dietary and endogenous antioxidants were consistently lower in patients with osteoporosis, according to University of Perugia, leading to decrease antioxidant defenses and promoting pathogenesis of osteoporosis(32).

2. Selenium plus vitamins E and C
In rabbits study, combination of vitamins E and C given partially prevented this bone tissue destruction on the progress of osteoporosis. When combine with sodium selenite given together with vitamins E and C to the osteoporosis model rabbits, the long bone tissue of osteoporosis rabbits had almost the same structure as in normal rabbits(33).

3. Vitamin C
According to the study epidemiologic studies, correlate low vitamin C intake and genetic deletion of enzymes involved in de novo vitamin C synthesis are associated to bone loss and severe osteoporosis, respectively(34).

4. Calcium and vitamin D
Calcium supplements showed to reduce the rate of bone loss in osteoporotic patients. According to SENECA study, calcium treatment not only on bone mass but also on fracture incidence and vitamin D insufficiency is frequent in elderly populations in Europe. Supplementations with daily doses of 400-800 IU of vitamin D, given alone or in combination with calcium, are able to reverse vitamin D insufficiency, to prevent bone loss and to improve bone density in the elderly, according to University of Siena(35)
5. Etc.

VII. Treatments
A. In conventional medicine perspective
A.1. Bisphosphonates
1. Including Alendronate (Fosamax), Risedronate (Actonel, Atelvia), Ibandronate (Boniva), Zoledronic acid (Reclast, Zometa), etc.. Bisphosphonates are antiresorptive medications widely prescribed for treatment of osteoporosis. The drugs have shown to significantly reduce the risk of osteoporotic fractures(36). Higher risk patients should be treated by nonbisphosphonatefor 10 yr, have a holiday of no more than a year or two(37).

2. Side effects
a. Nausea
b. Abdominal pain
c. Difficulty swallowing
d. Rrisk of an inflamed esophagus or esophageal ulcers(38)
e. Risk of scleritis and a variety of ocular side effects(39)
f. Etc.

2. Hormone-related therapy
Hormone replacement therapy can help to maintain bone density for menopause women, but it increases
a, The risk of breast cancer and heart disease(40)
b. The risk for venous thromboembolism(41)
c. The risk of (Nonmelanoma Skin Cancers) NMSC.(42)
d. The risk of stroke(43)
e. etc.

B. In herbal medicine perspective
1. Red clover
Red clover extract (RCE) standardized to contain 40% isoflavones by weight (genistein, daidzein, biochanin A, and formononetin present as hydrolyzed aglycones) together with a modified alkaline supplementation have shown to improve OVX-induced osteoporosis while a mild metabolic alkalosis might further synergize some therapeutic aspects(44).

2. Organic soy
Soybean protein showed to promote higher rate of bone turnover in fed animals, together with enhancement of ertebral and femoral bone densities, according to nonbisphosphonate(45).

3. Soybeans, clover and alfalfa sprouts, and oilseeds (such as flaxseed)
In humans, animals, dietary phytoestrogens found in soybeans, clover and alfalfa sprouts, and oilseeds (such as flaxseed) play an important role in prevention of menopausal symptoms, osteoporosis, cancer, and heart disease(46).
4. Etc.

C. In traditional Chinese medicine perspective
Osteoporosis in elder is a condition of the drop of Kidney Jing. As we age, our kidney doesn’t have the energy to nourish the bones. The weak and brittle bone can, lead to the symptoms of earaches, ringing in the ears, hearing loss, hair loss, teeth problems, knee pain and lower back pain, loss of sex drive, including osteoporosis.

1. Du-Huo-Ji-Sheng-Tang and Du Zhong (Cortex Eucommiae)
Du-Huo-Ji-Sheng-Tang and Du Zhong (Cortex Eucommiae) was the most frequently prescribed herbal formula and single herb, respectively, for the treatment of osteoporosis, according to the study by the
Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital(47).

2. Zuogui Pill
Zuogui Pill showed effectively in preventions and treatments of glucocorticoid-induced osteoporosis in rats by up-regulating the expression of the key signal molecules inWnt signal transduction pathway(pass signals from outside of a cell through cell surface receptors to the inside of the cell)(48).

3. Embedding thread at Shenshu (BL 23)
Embedding thread at Shenshu (BL 23) was found to increase BMDs of hip and lumbar vertebrae in patinets with osteoporosis. The rate of bone fracture during 5 years after treatment was 2.1% significantly lower than 18.2% in the medication group(49).

4. Shaoyang Meridians
Foot-Shaoyang Meradians can modulate bony strength under physiological and pathological conditions, and treat osteoporosis which mainly manifests as ostealgia and easy fracture, according to Huangdi’s Internal Classic(50).

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Musculoskeletal disorders (MSDs) - Osteoarthritis by Kyle J. Norton

References
(a) http://www.ncbi.nlm.nih.gov/pubmed/7864688
(1) http://www.ncbi.nlm.nih.gov/pubmed/23052969
(2) http://www.ncbi.nlm.nih.gov/pubmed/20870048
(3) http://www.ncbi.nlm.nih.gov/pubmed/22896775
(4) http://www.ncbi.nlm.nih.gov/pubmed/19343468
(5) http://www.ncbi.nlm.nih.gov/pubmed/23113482
(6) http://www.ncbi.nlm.nih.gov/pubmed/21079541
(7) http://www.ncbi.nlm.nih.gov/pubmed/23095987
(8) http://www.ncbi.nlm.nih.gov/pubmed/23149863
(7) http://www.ncbi.nlm.nih.gov/pubmed/20618843
(12) http://www.ncbi.nlm.nih.gov/pubmed/23128330
(13) http://www.ncbi.nlm.nih.gov/pubmed/22057549
(14) http://www.ncbi.nlm.nih.gov/pubmed/12699295
(15) http://www.ncbi.nlm.nih.gov/pubmed/23160916
(16) http://www.ncbi.nlm.nih.gov/pubmed/11349943
(17) http://www.ncbi.nlm.nih.gov/pubmed/18541176
(18) http://www.ncbi.nlm.nih.gov/pubmed/8422511
(19) http://www.ncbi.nlm.nih.gov/pubmed/17657549
(20) http://www.ncbi.nlm.nih.gov/pubmed/15632479
(21) http://www.ncbi.nlm.nih.gov/pubmed/15221500
(22) http://www.ncbi.nlm.nih.gov/pubmed/19348280
(23) http://www.iscd.org/visitors/pdfs/10-QuantitativeUltrasoundintheMgmtofOsteo.pdf
(24) http://www.ncbi.nlm.nih.gov/pubmed/23154276
(25) http://www.ncbi.nlm.nih.gov/pubmed/23149277
(26) http://www.ncbi.nlm.nih.gov/pubmed/22618377
(32) http://www.ncbi.nlm.nih.gov/pubmed/12679433
(33) http://www.ncbi.nlm.nih.gov/pubmed/14677021
(34) http://www.ncbi.nlm.nih.gov/pubmed/23056580
(35) http://www.ncbi.nlm.nih.gov/pubmed/11683549
(37) http://www.ncbi.nlm.nih.gov/pubmed/20173017
(38) http://www.ncbi.nlm.nih.gov/pubmed/23137577
(39) http://www.ncbi.nlm.nih.gov/pubmed/14702129
(40) http://www.ncbi.nlm.nih.gov/pubmed/20424287
(41) http://www.ncbi.nlm.nih.gov/pubmed/19811247
(42) http://www.ncbi.nlm.nih.gov/pubmed/22215431
(43) http://www.ncbi.nlm.nih.gov/pubmed/21612355
(44) http://www.ncbi.nlm.nih.gov/pubmed/19503771
(45) http://www.ncbi.nlm.nih.gov/pubmed/8558297
(46) http://www.ncbi.nlm.nih.gov/pubmed/9240932
(47) http://www.ncbi.nlm.nih.gov/pubmed/23093986
(48) http://www.ncbi.nlm.nih.gov/pubmed/21977807
(49) http://www.ncbi.nlm.nih.gov/pubmed/20568431
(50) http://www.ncbi.nlm.nih.gov/pubmed/18630551

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine: Radix glycyrrhizae(Gan Cao)

Diseases of Central Nervous system

Dementia

Gan Cao, a sweet and neutral herb, also known as Licorice root, has been used in TCM as anti allergy(752), anti inflammation(751), anti ulcer(753), anti convulsion(754) and to treat stomach weakness(755), tired and lack of strength(756), enhance cardiac performance(757) and short of breath(758), cough with abundance of phlegm(751), etc., as it tonifies the Spleen, benefits the Qi, moistens the Lungs, calms cough, deaf or acute pain, by enhancing the function of all 12 channels.

Phytochemicals

1. Glycyrrhizic acid

2. 24-hydroxyglycyrrhetic acid

3. Licorice saponins A3

4. Licochalcone A

5. Licochalcone B

6. Licoflavone

7. Liquiritin

8. Liquiritigenin

9. Isoliquiritigenin

10. Ononins

11. 4′,7-dihydroxyflavone
12. Etc.

  Gan Cao used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(759). In senile dementia, Gan Cao exhibited its elicit memory-improving effects, through its antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(760).

1. In Alzheimer's disease (AD)
Vascular risk factors (VRF) has shown strong evidence in contribution to cognitive decline and the development of Alzheimer's disease (AD)(763) and dementia(761), Sini Decoction, a TCM formula containing Gan Cao enhanced cardiac function through significant suppression of lipid peroxidation(765) of myocardial homogenate(764), via scavenge oxygen free radicals activity(764). According to Korea Food Research Institute, Gan Cao attenuated the Amyloid beta protein (Abeta) involved in the progression of Alzheimer's disease (AD), through inhibition of Acetylcholinesterase activity(762), probably via mediation antioxidant actions against oxidative stress(762).

2. In Parkinson's diseases(PD)
Kampo kami-shoyo-san (TJ-24), a Korean traditional herbal medicine, containing Gan Cao, significantly reduce tremor, disturbances in muscular movement in antipsychotic-induced parkinsonism(766). The formula also showed effectively in relieved symptoms of panic attacks, anticipatory anxiety(767). Liquiritin, a flavonoids extracted from Glycyrrhizae radix, significantly promotes the neurite outgrowth in dose dependant manners, through overexpression of neural related genes, such as neurogenin 3, neurofibromatosis 1, associated to Alzheimer's disease or Parkinson's disease(768).

3. In learning and memory
Oral administration of Glycyrrhizae radix (GR) in rat study, showed to reduce anxiety and promote learning and memory in rats, by attenuating the behavioral and neurochemical impairments caused by repeated stress-induced alterations(770). Palmul-chongmyeong-tang, containing Gan Cao used in used as herbal medicine against ischemia, may be a potential agent for treatment of vascular dementia as it significantly improved learning and memory and attenuated cognitive impairment through reduction of the loss of cholinergic immunoreactivity in the hippocampus induced by cerebral ischemia in rat model(769).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton

@Healthy_Minds #BellLetsTalk

The best recipe for Diabetes: Leeks in White Wine and Butter

Tuesday 27 January 2015

#Breakingnews: Natural #remedy efficacy in attenuated #Aging & Photo #AgingSpots & #HyperPigmentation Within 3 Months

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, The Alan Hopkinson Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal pharma and Bio science, ISSN 0975-6299.
All right reserved. Reproduction and Translation to other languages of this publication are prohibited without consent of the writer.

Skin aging is one of the most visible aging processes occurred constantly in our skin. According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, and affect skin elasticity and tightness(1).
Dehydroascorbic Acid (DHA) is an oxidized form of vitamin C with Chemical Reaction and Structure as follows

According to Dr. Douglas Q. Kitt, Topical Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than vitamin C. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (2).

Liver spots or aging spots are condition of brown or black spots appearing on the surface of the skin due to aging and exposure to ultraviolet radiation from the sun. According to skin care guides, high concentration of Vitamin C may improve the skin and lighten the spots(3). Other articles insisted that liver spots may be the result of a deficiency of vitamin C(4). According to the Duke University Medical Center, the application of topical solutions containing vitamins C and E provided protection for human skin against damage caused by ultraviolet radiation(5)6)(7)(8).

According to Dr. Douglas Q. Kitt, Dehydroascorbic Acid (DHAA) permeates stratum corneum at a rate up to 12 times faster than vitamin C. This supports the concept that lower concentrations of DHAA in topical preparations can enhance skin vitamin C levels with less potential side effects (2).

Our previous study(8) indicated that Dehydroascorbic acid (DHA) 4% may effectively attenuate the roughness, scaliness and get rid off most aging spot and photo aging spots on facial skin in our 24 weeks study through it antioxidants, anti inflammation and free radicals scavenging activities.
Re examination facial skin of patients who continuously apply the formula, after 3 months showed a more profound effectiveness.

Dehydroascorbic acid (DHA) 4% showed effectively in re smoothing 100% and the getting rid of 100% aging and photo aging spots in patients with mild expression and to re smoothing 100% and getting rid of up to 90% aging and photo aging spots in patients with serve expression.

In skin pigmentation, resulted of damage most likely caused by UV sunlight, or unhealthy cells due to aging affecting the production of melanin, dehydroascorbic acid (DHA) 4% induced lightening affected areas up 90% through amelioration of the production of melanin, probably through antioxidants and anti inflammatory pathways as in vitamin C in inhibition of reactive nitrogen species (RNS) including nitric oxide (NO)(9).

Kyle J. Norton, the leading researcher said: " the formula is very easy to make, this discovery may benefits everyone who has tried many types of expensive cosmetic product without success". " The contribution of this discovery may some days induced non existence of aging and photo aging spots
in elders and decreased expression on facial hyperpigmentation".

Since the size of study is small, large example size and multi centers studies are necessary to improve this discovery validation and formula effectiveness, before producing the products in large scales to general public.

The equipment and Preparation 1. One bottle of synthetic vitamin C 100x 500mg tablets. You can purchase this in any pharmacy for about $5.00
2. A small bottle carries 100mL of warm tap water or still-water if desire.
3. A roll of bounty or a half hand size sponge.
4. A pair of plastic glove.

How to make Dehydroascorbic acid (DHA) 4% concentration
Day one
Put 8 tablets of synthetic vitamin C into the bottle which carries 100 mL of water[(8x500mg)/100mL=4000mg/100,000mg=4/100=4% concentration of Dehydroascorbic acid (DHA)] on the day before application to make sure all vitamin C tablets are dissolved.

How to remove Liver and Aging spots and re smooth the facial skin
Liver spot or aging spot is a condition of brown or black spots appeared on the surface of the skin due to aging as the skin is less able to regenerate from sun exposure.
The next day
Put on your glove. Shake the bottle well. Pour some Dehydroascorbic acid (DHA ) onto a piece of fold-twice bounty paper towels. Apply the solution 3 times a days by rubbing against the skin of the effects area with little pressure for about one minutes. Apply more solution if require. Dehydroascorbic acid (DHA) 4% concentration should be able to lighten most of Liver and Aging spots and re smooth some of the skin on the effect areas in a few days.

After applying, clean the sponge if used and glove, return and store the bottle of solution into first aid box in room temperature. Replace the solution every ten days to retain accurate concentration.

What to expect Dehydroascorbic acid (DHA) exhibited its detoxified, antioxidant, lightening and enhanced cell regeneration effects in getting rid of skin damage causes of aging liver and spots and lightening hyperpigmentation due to sun exposure.
1. In the first few days of application
a. Some of liver or aging spots and hyperpigmentation start to lighten
b. Some of the effected skin area start to smooth out
c. Reduction of visibility of the effect areas
2. Within 3 months
Dehydroascorbic acid (DHA) 4% showed effectively in re smoothing 100% in patients with mild and severe expression and getting rid of 90% and 100% aging and photo aging spots respectively in in patients with mild and severe expression and lightening 90% of hyperpigmentation.

Precautions 1. Always testing your topical skin solution, including Dehydroascorbic acid (DHA ) for allergic reaction, by applying a tiny portion onto your wrist for 5 minutes. Do not use the solution if there is allergic reaction.
2. Although there were no adverse effect in our study, please make sure you always wear gloves before applying, as higher concentration of the solution has shown to brownness on the finger nails.
3. The solution has shown to cause yellowness on the surface of some metal (very old) sinks, please make sure your test it to avoid the same messes.
4. Higher concentration of the solution has been used in skin tanning industry, please make the solution is completely absorbed(about 5- 10 minutes) into your skin before going to the extreme sun.
5. If the solution get into your eyes, use tap water to clear them.
6. Do not attempt to make higher solution and put them on your facial skin, as it has not been tested.

If you have any questions, please email me at kylenorton@live.ca

All articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying

References
(1) Skin ageing: natural weapons and strategies by Binic I¹, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(2) Topical Dehydroascorbic Acid (Oxidized Vitamin C) Permeates Stratum Corneum More Rapidly Than Ascorbic Acid by Douglas Q Kitt
(3) Liver Spot Removal: Vitamin C Products(Skin care guide)
(4) Lack of vitamin leads to brown spot on hand(livestrong)
(5) A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation by Murray JC¹, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR.(PubMed)
(6) UV photoprotection by combination topical antioxidants vitamin C and vitamin E by Lin JY¹, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, Pinnell SR.(PubMed)
(7) Protective effects of topical antioxidants in humans by Dreher F¹, Maibach H.(PubMed)
(8) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D¹, Dunston S, Faust H, Pinnell S.(PubMed)
(9) http://kylejnorton.blogspot.ca/2014/10/anti-skin-aging-in-dehydroascorbic-acid.html
(10) Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system. by Panich U¹, Tangsupa-a-nan V, Onkoksoong T, Kongtaphan K, Kasetsinsombat K, Akarasereenont P, Wongkajornsilp A.(PubMed)

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Radix polygalae(Yuan Zhi)

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia.

C.1.2. Radix polygalae(Yuan Zhi)
Yuan Zhi, sweet and slightly cool herb is also known as Thinleaf Milkwort Root, used in TCM as antibiotic property, anti-viral property(732), anti cancer(734) and anti depression(733) agent in treating hepatitis B, tumors in the digestive system, respiratory system and in the uterus, etc., as it calms the heart, transforms phlegm, resolves furuncle and oedema, expel toxin, etc. by enhancing the functions of spleen, lung and liver channels.

Phytochemicals
1. Protein-bound polysaccharide (PSK)
2. Polysaccharopeptides (PSP)
3. Tenuifolin
4. Onjisaponin B
5. Etc.

Yuan Zhi used in the treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in ameliorated amyloid pathology and related cognitive deficits(735). In aging related dementia, based on the history of use, and pharmacological investigation, Yuan Zhi showed a strong evidence in memory improving, including cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(736). Palmul-chongmyeong-tang, a traditional Chinese medicine formula containing Yuan zhi, exhibited improvement of learning and memory deficits, through reduction of loss of cholinergic immunoreactivity induced by cerebral ischemia(737).

  1. In Alzheimer's disease (AD)
In free radical involved neuro-degeneration in Alzheimer's disease (AD), pretreament with Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH) prescription significantly exhibited cytoprotective effects, through elevating cell survival, antioxidant enzyme activities and resulted decreased production  of malondialdehyde (MDA) which associated to Alzheimer's disease (AD)(738). Smart Soup (SS), composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), in oral administration of SS ameliorated the cognitive impairment of AD in animal model, effectively reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss(739).

2. In Parkinson's disease
Mutant Huntingtin gene caused by a poly-glutamine expansion in huntingtin( 740)and A53T α-synuclein, a protein found abundantly in the human brain, at the tips of nerve cells (neurons)(741) have shown to be associated with the development of Huntington disease and Parkinson disease. Yuan Zhi phytochemical, onjisaponin B and ethanol extracts showed to induce autophagy(743) through signalling pathway in participation of regulation of vascular function(742) in protection  of cells against pro-neuro apoptosis via the mitochondrial pathway(744). According to colege of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, in mouse models of Parkinson's disease, Yuan Zhi also exhibited it protective effects on dopaminergic neurons induced by toxicity(745).

3. In Huntington diseases
Mutant Hungtintin caused of degradation of long-lived cytoplasmic proteins, protein complexes (the gel-like substance enclosed within the cell membrane)(747), or damaged organelles(tiny structures that perform very specific functions within cells)(748) attentuated autophagy in asociateion of the development of Huntington diseases(746), onjisaponin B, found in Yuan Zhi, effectively induce  autophagy through its acceleration of both the removal of mutant huntingtin and and α-synuclein in PC-12 cells(749), which contain mixture of neuroblastic cells and eosinophilic cells(750).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton

Reference
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(732) http://www.ncbi.nlm.nih.gov/pubmed/22205352
(733) http://www.ncbi.nlm.nih.gov/pubmed/20541923
(734) http://www.ncbi.nlm.nih.gov/pubmed/?term=Yuan+zhi+tumors
(735) http://www.ncbi.nlm.nih.gov/pubmed/25386946
(736) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(737) http://www.ncbi.nlm.nih.gov/pubmed/17268076
(738) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(739) http://www.ncbi.nlm.nih.gov/pubmed/25386946
(740) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166352/
(741) http://en.wikipedia.org/wiki/Alpha-synuclein
(742) http://www.nature.com/hr/journal/v33/n5/full/hr201011a.html
(743) http://www.ncbi.nlm.nih.gov/pubmed/24248062
(744) http://www.ncbi.nlm.nih.gov/pubmed/17182613
(745) http://www.ncbi.nlm.nih.gov/pubmed/21195155
(746) http://www.ncbi.nlm.nih.gov/pubmed/18637946
(747) http://en.wikipedia.org/wiki/Cytoplasm
(748) http://www.wisegeek.com/what-are-organelles.htm
(749)http://www.ncbi.nlm.nih.gov/pubmed/?term=Radix+polygalae(+and+Huntinton+disease
(750) http://en.wikipedia.org/wiki/PC12_cell_line

The best recipe for Diabetes: Green Bean with Tomatoes

Monday 26 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Poria cocos(Fu Ling)

Diseases of Central Nervous system

Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.

V. Treatments
C. In traditional Chinese Medicine Perspective(*)
According to the Unilever R&D Shanghai, and Unilever R&D Vlaardingen, Dr. and the team of researchers, traditional Chinese medicine (TCM), in 3000 years' literary history, the top 5 TCM herb ingredients including Poria cocos(720), Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae have been used extensively for treatment of dementia.
C.1. 1. Poria cocos(Fu Ling)
Fu Ling, fu shen or fu ling pi also known as Poria, the bland, sweet and neutral herb has been used in TCM as diuretics(711) and to treat urinary difficulty(711), edema(711), diarrhea(715), emesis(717), vomiting(716), dizziness(716), heart diseases(717)(718), etc., as it eliminates water, strengthens the Spleen, calms the Mind, etc., by enhancing the functions of heart, spleen, lung and kidney channels. The herb has shown to exhibit various biological activities including anti-tumor(713), anti-inflammation(712), immunodepression(712) and antioxidant(711)(713)(714).

Phytochemicals
1. Pachymose
2. Albuninoid
3. Pachymaran
4. B-pachyman
5. B-pachymanase,
6. Pachymic acid,
7. Tumulosic acid,
8. Eburioic acid,
9. Pinicolic acid,
10. Etc.

Fu Ling(720) used for treatment and prevention of dementia(719) in traditional Chinese medicine, may be due to their effectiveness of phytochemicals in attenuation of oxidative stress in initiation of neurodegeneration and enhanced neuroprotection(719).

1. Learning and memory impairments
Kyung-Ok-Ko (KOK), the traditional Chine medicine formula, containing Poria cocos, showed effectively in exhibition of its anti-inflammatory effects in protection of brain neuron through attenuating memory(721)(722) and learning impairment(723). In senile dementia, herbal Poria cocos also elicited memory-improving effects in vivo and in vitro through its sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid antioxidants via cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities(722).Yokukansan (TJ-54), another Chinese medicine formula, containing Poria cocos, also inhibited neurological disorders, including dementia and Alzheimer's disease(723) symptoms of memory and behaviors disturbance(724), probably through its anti-cholinesterase activity(725).

2. Cognitive dysfunction
In patients of dementia with cognitive dysfunction, Liuwei Dihuang decoction, containing Poria cocos, showed significantly in attenuated the neural apoptosis, inflammation and Aβ deposition in the hippocampus and cerebral corte(726) causes of cognitive impairment(727) in streptozotocin-induced diabetic rat. In spatial cognition, herbal formula Toki-Shakuyaku-San and fractions of Angelica acutiloba, improved memory and working memory impaired by scopolamine in animal study(728).

3. Alzheimer disease
In mouse model of Alzheimer disease, herbal formula Jangwonhwan, not only showed effectively in ameliorated AD-like pathology, but also exhibited its neuroprotective effects against Abeta-induced cell death, and the Abeta accumulation and plaque deposition in the brain(730), probably through attenuation of reactive oxidative stress(729), by suppressed Aβ-induced apoptosis and ROS production(731).

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reprinted from Norton Journal, Volume I, Most Common Diseases of Ages of 50 Plus - Chapter of Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine by Kyle J. Norton

References
(*) http://www.hindawi.com/journals/ecam/2012/692621/
(711) http://www.ncbi.nlm.nih.gov/pubmed/23847967
(712) http://www.ncbi.nlm.nih.gov/pubmed/21347995
(713) http://www.ncbi.nlm.nih.gov/pubmed/24751506
(714) http://www.ncbi.nlm.nih.gov/pubmed/24875321
(715) http://www.ncbi.nlm.nih.gov/pubmed/?term=Poria+cocos+diarrhea
(716) http://www.ncbi.nlm.nih.gov/pubmed/19446542
(717) http://www.ncbi.nlm.nih.gov/pubmed/24933223
(718) http://www.ncbi.nlm.nih.gov/pubmed/15198902
(719) http://www.ncbi.nlm.nih.gov/pubmed/22303969
(720) http://www.ncbi.nlm.nih.gov/pubmed/23433049
(721) http://www.ncbi.nlm.nih.gov/pubmed/22303969
(722) http://www.ncbi.nlm.nih.gov/pubmed/21808655
(722) http://www.ncbi.nlm.nih.gov/pubmed/21305632
(723) http://www.ncbi.nlm.nih.gov/pubmed/20812276
(724) http://www.ncbi.nlm.nih.gov/pubmed/19801831
(725) http://www.ncbi.nlm.nih.gov/pubmed/15500267
(726) http://www.ncbi.nlm.nih.gov/pubmed/24041458
(727) http://www.ncbi.nlm.nih.gov/pubmed/22310556
(728) http://www.ncbi.nlm.nih.gov/pubmed/15351791
(729) http://www.ncbi.nlm.nih.gov/pubmed/20685330
(730) http://www.ncbi.nlm.nih.gov/pubmed/20669372
(731) http://www.ncbi.nlm.nih.gov/pubmed/21762767

Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Pages

Questions or Enquiries?

Wednesday 28 January 2015

(Preview) Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs) - Osteoarthritis

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine: Radix glycyrrhizae(Gan Cao)

Diseases of Central Nervous system

Dementia

The best recipe for Diabetes: Leeks in White Wine and Butter

Tuesday 27 January 2015

#Breakingnews: Natural #remedy efficacy in attenuated #Aging & Photo #AgingSpots & #HyperPigmentation Within 3 Months

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Radix polygalae(Yuan Zhi)

Diseases of Central Nervous system

Dementia

The best recipe for Diabetes: Green Bean with Tomatoes

Monday 26 January 2015

(Preview)Most common diseases of 50 plus - Diseases of Central Nervous system(CNS): Dementia - Treatments in Traditional Chinese Herbal Medicine Poria cocos(Fu Ling)

Diseases of Central Nervous system

Dementia