Endometriosis: The Good, Bad and Side effects of oral contraceptive pill(revised edition with references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

The oral contraceptive pill is defined as one type of birth control pill containing both estrogen and progesterone that helps to control unwanted pregnancy and reducing symptoms of abdominal pain before, during or after menstrual cycle such as endometriosis, premenstrual symptoms etc.

The pill is taken 21 days on, 7 day off.
1. The intention
a) It will help to reduce the bleeding by thinning the endometrial lining and reducing the flow of the period blood that help to decreases the risk of retrograde menstruation in endometriosis.
b) It also helps to inhibit hormone prostaglandins that causes muscle spasm in the ovary reducing the menstrual cramps(5)(7).
c) Since the pill reduces the heavy bleeding(6) of endometriosis, it is lesser the risk of bleeding into cysts and pelvic cavity.
d) Managing the endometriosis(8) by creating a continual pregnant-like state.
e) Reduced menstrual symptoms, such as headaches, genital irritation, tiredness, bloating(7).

2.   Risks and side effects
a) Risks
i) Since the oral contraceptive combination pill contains estrogen, it may cause blood clots(3), stroke(3),  heart disease(1) and induced breast cancer(2)
ii) Hypertension(1) and increase heart rate(1) caused by thickening of blood in arteries.
b) Side effects
i) Bleeding and spotting(4) as our body needs time to adjust to the substance in the pill, Normally, the bleeding and spotting will end in six months.
ii) Weigh gain(9)(10)(11)(inconclusive result) caused by synthetic progesterone in the pill in some women.

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References
(1) Prospective measurement of blood pressure and heart rate over 24 h in women using combined oral contraceptives with estradiol by Grandi G¹, Xholli A¹, Napolitano A¹, Piacenti I¹, Bellafronte M¹, Cagnacci A².(PubMed)
(2) Correlation of age at oral contraceptive pill start with age at breast cancer diagnosis by Imkampe AK¹, Bates T.(PubMed)
(3) Cerebral vein thrombosis in women using short course oral contraceptive consumption by Sasannejad P¹, Mellat Ardekani A², Velayati A¹, Shoeibi A¹, Saeidi M¹, Foroughipour M¹,Azarpazhooh MR¹.(PubMed)
(4) Phase 3 study of desogestrel and ethinyl estradiol combined oral contraceptive for pregnancy prevention by Kroll R¹, Howard B, Hsieh J, Ricciotti N.(PubMed)
(5) Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain symptoms caused by endometriosis in patients with migraine without aura by Morotti M¹, Remorgida V², Venturini PL², Ferrero S².(PubMed)
(6) Treatment of heavy menstrual bleeding with the estradiol valerate and dienogest oral contraceptive pill by Micks EA¹, Jensen JT.(PubMed)
(7) Continuous or extended cycle vs. cyclic use of combined oral contraceptives for contraception by Edelman AB¹, Gallo MF, Jensen JT, Nichols MD, Schulz KF, Grimes DA(PubMed)
(8) contraceptive health benefits: perception versus reality by Kaunitz AM.(PubMed)
(9)Oral contraceptives use and weight gain in women with a Central European life-style by Lech MM¹, Ostrowska L.(PubMed)
(10) Weight and body composition changes during oral contraceptive use in obese and normal weight women by Mayeda ER¹, Torgal AH, Westhoff CL.(PubMed)
(11) An exploratory analysis of associations between eating disordered symptoms, perceived weight changes, and oral contraceptive discontinuation among young minority women by Hall KS¹, White KO, Rickert VI, Reame NK, Westhoff CL.(PubMed)

Easy and Healthy Weight Loss recipe: Veggie Omelet

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe contributed by eat well and lose weight by better Holmesd and Gardens (more than 500 delicious satisfying recipes), published by Houghton Miffin Harcourt. You can view its website at www.hmhbooks.com
In a medium skillet heat 1 teaspoon olive oil over medium heat. Add 2 cups fresh spinach; 2green onions, sliced; and half of red sweet pepper, sliced. Cook for 1 minute or until spinach is wilted. spoon mixture into a bowl; set aside. Wipe skillet clean; coat skillet with non-sticking cooking spray and heat over medium high heat. Beat 2 eggs and edge toward center of the skillet.  when center is set but still gloss, add 1 ounce crumbled goat cheese and the vegetables. Fold in half and turn out onto the plate. Serve with whole grain dinner roll. Per serving; 403 cal., 25g fat (10 sat. fat) 445 mg chol., 476mg sodium, 24 carb., 7g sugar, 5g fiber, 24g pro.
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Endometriosis: The Types, Side Effect and Risks of Progesterone agonist(revised edition with references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

This type of pill contains no estrogen, also known as the progesterone-like pill or progestins, it helps to maintain milk production for breastfeeding mother and to thicken the cervical mucus, thereby preventing sperm from entering the uterus. This type of pill must be taken at a certain time every 24 hours for effectively.
I. Types of Progesterone medicines
a) Injecting medicine
Type of progesterone medication injected in the women body every three months, such as Depo Provera. It is good for women who want to have long term contraception, it may work well for some women but study shows that it causes bone loss and sometimes osteoporosis(2).
b) Implant medicine(4)
The other type of progesterone like medicine such as Implanon is implanted into the fat of a non dominant arm and last about 3 years. It may not cause bone loss as Depo Provera, but it causes male like pattern such as excessive hair growth and deepening the voice.
c) Oral Progesterone-like pills(1)(2)
i) Progesterone like pill in treating excessive menstruation
If a woman does not have progesterone irregularity, her doctor may prescribe this type of medicine for her. It helps to complete shredding of the endometrium and stops the abnormal bleeding. Besides all the good thing of this type of progesterone like pill, it also has it side effects, such as utilizing in nicotine addiction, traumatic brain injury (recently entered Phase III trial) and Alzheimer's disease, diabetic neuropathy and crush injuries(5).
ii) Other types
Other types of progesterone like medicines, such as Provera, Duphaston, they helps to relieve of menstrual cramp with no long term serious side effects by creating the pregnancy-like state but their short term side effects including spotting and bleeding, return of menses (2).

II. Side effects
Most side effects are caused by high levels of progesterone for women taking the progesterone only pill, such as
1) Anxiety and Mood swing(7)(8)
2) Weight gain(6)
3) Reduced libido(7)(8)
4) Fluid retention(9)
5) Acne(3)
6) Breast tenderness(16)
7) Oedema(3)
8) Hot flush(3)

III. Risks
1) Ectopic pregnancy
Women taking the progesterone only pill may increase the risk of pregnancy inside the fallopian tube
2) Progesterone only pill may increase the risk of pain in the lower abdomen(4), shortly after a missed or light period.
3) It also increases the risk of developing small, benign cysts in the ovary(13).
4) Breast(10), endometrial(11)(12) cancer(13)
5) Uterine fibroids(13)
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References
(1) New trends of progestins treatment of endometriosis.by Angioni S¹, Cofelice V, Pontis A, Tinelli R, Socolov R.(PubMed)
(2) The role of progestins in treating the pain of endometriosis.by Surrey ES.(PubMed)
(3) Progestagens and anti-progestagens for pain associated with endometriosis by Brown J¹, Kives S, Akhtar M.(PubMed)
(4)Endometriosis: pathogenesis and treatment by Vercellini P¹, Viganò P², Somigliana E¹, Fedele L¹.(PubMed)
(5) Novel actions of progesterone: what we know today and what will be the scenario in the future?by Kaore SN¹, Langade DK, Yadav VK, Sharma P, Thawani VR, Sharma R.(PubMed)
(6) Weight change at 12 months in users of three progestin-only contraceptive methods by Vickery Z¹, Madden T, Zhao Q, Secura GM, Allsworth JE, Peipert JF.(PubMed)
(7) Sexual function, mood and menopause symptoms in Lithuanian postmenopausal women by Jonusiene G¹, Zilaitiene B, Adomaitiene V, Aniuliene R, Bancroft J.(PubMed)
(8)Relation of androgen receptor sensitivity and mood to sexual desire in hormonal contraception users by Elaut E¹, Buysse A, De Sutter P, De Cuypere G, Gerris J, Deschepper E, T'Sjoen G.(PubMed)
(9) Calculated effect of fluid retention upon velocity of blood flow and turbulence: implications for atherosclerosis by Blankfield RP.(PubMed)
(10) Progestins and progesterone in hormone replacement therapy and the risk of breast cancer by Campagnoli C¹, Clavel-Chapelon F, Kaaks R, Peris C, Berrino F.(PubMed)
(11) Risk of endometrial cancer following estrogen replacement with and without progestins by Weiderpass E¹, Adami HO, Baron JA, Magnusson C, Bergström R, Lindgren A, Correia N, Persson I.(PubMed)
(12) Risks of Endometrial Cancer Associated With Different Hormone Replacement Therapies in the E3N Cohort, 1992-2008 by Fournier A, Dossus L, Mesrine S, Vilier A, Boutron-Ruault MC, Clavel-Chapelon F, Chabbert-Buffet N.(PubMed)
(13) Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer by Kim JJ¹, Kurita T, Bulun SE.(PubMed)
(14) [Ectopic pregnancy under Implanon contraception: a case of encysted haematocele].

[Article in French] by Mbarki C, Hsayaoui N, Ben Abdelaziz A, Khediri Z, Najjar M, Souai A, Somai M, Mezghenni S, Oueslati H.(PubMed)

(15) High progesterone levels and ciliary dysfunction--a possible cause of ectopic pregnancy by Paltieli Y¹, Eibschitz I, Ziskind G, Ohel G, Silbermann M, Weichselbaum A.(PubMed) 

(16) Types of progestogens in combined oral contraception: effectiveness and side-effects by Lawrie TA¹, Helmerhorst FM, Maitra NK, Kulier R, Bloemenkamp K, Gülmezoglu AM.(PubMed)

Weight Loss recipe for Tuna Lover: Tuna pispinach salad

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe contributed by eat well and lose weight by better Holmesd and Gardens (more than 500 delicious satisfying recipes), published by Houghton Miffin Harcourt. You can view its website at www.hmhbooks.com

In a small bowl stir together 1 green onion, sliced 1 teaspoon light mayo; 1 teaspoon lemon juice; 1/2 teaspoon snipped dill;  and 1 clove garlic minced. Add 3 ounces drain water packed tuna; toss. Arrange 1 cup spinach on  a plate. Arrange 1 Roma tomato sliced on spinach top with tuna mixture. Add 1/2 tablespoon sliced almonds. Serve with 1 ounce whole grain crackers and a pear.
Per serving; 357 cal., 12 fat (2 g sat. fat), 64 mg chol., 516 mg sodium, 35 g carb., 20 g sugar, 8g fiber, 24g pro.

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The easy, healthy and weight loss recipe: Rice pudding

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe contributed by eat well and lose weight by better Holmesd and Gardens (more than 500 delicious satisfying recipes), published by Houghton Miffin Harcourt. You can view its website at www.hmhbooks.com

In a small saucepan stir together 1/2 cup cooked brown rice, 1/2 cup fat free milk, 2 table and 2 teaspoons raisins, 2 teaspoons cinnamon sugar. Heat over medium heat stirring often. Sprinkle with a teaspoon sliced almonds, toasted. Serve with 6 ounces carton vanilla low fat yogurt.
Per serving; 408 cal., 8 fat (2g sat. fat), 10mg chol., 148 mg sodium, 72g carb., 44g sugar, 4g fiber, 16g pro.

Weight Loss the Easy Ways 
Andrea Albright Featured on Health and Fitness Jan. 2015
will Personally Coach You How to Get There The Easy Way

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Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

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Endometriosis: The Effects of Vitamin K(revised edition with references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Vitamin K was first discovered by Danish scientist Herrik Dam in 1929. It is a fat-soluble vitamin. It is best known for its ability of protein synthesis and blood coagulation. Dietary deficiency is extremely rare because it is produced by bacteria in the digestive system. Since it is fat soluble, it can be stored in our body and we do no need to take them regularly.

1. Nervous(1)(4) and circulation systems
Vitamin K activated protein Gas6 which has been shown to be actively involved in cell survival, chemotaxis, mitogenesis, and cell growth of neurons and glial cells(1). It also helps to convert glucose into glycogen(2) which is essential for improving the liver function in fighting against the forming of bad cholesterol accumulated(3) in the blood stream causing high blood pressure(3), making transportation of oxygen more difficult to the body's cell, increasing the risk of heart disease(4) and elevating tensions of nervous system. Glycogen can be stored in the liver, muscles, and can be used in case of deficiency.

2. Abnormal bleeding(5)(6) and menstrual Pain(7)
Vitamin K also helps in production of prothrombin which is an important substance for blood clotting. Women with endometriosis were found to have vitamin K deficiency leading to menstrual pain and  heavier than normal bleeding during menstruation.

3. Immune system
Since vitamin K helps to strengthen the liver's function(8)(9), indirectly it protects our body from environmental toxins and free radical invasion that may cause abnormal endometrial implants(9) and adhesion growing(9) somewhere else other than the endometrium as we mentioned in the other articles.

4. Cell Growth(10)(11)(12)
Vitamin K is also said to be an important vitamin that helps to regulate the cellular functions including cell adhesion, cell proliferation, and protection against the cell's cytoskeleton to break up the membrane and bulge outward causing the loss of membrane asymmetry and attachment. Deficiency of vitamin K may cause an increase in the risk of irregularity cellular growth, such as endometriosis.

5. Anemia(5)(6)(13)
Since vitamin K deficiency causes heavy bleeding for women with endometriosis adhered to the abdominal region leading to anemia as a result of depletion of red blood cells in the body or inability of the body to produce more red blood cell to cover the loss during menstruation


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References
(1) Vitamin K and the nervous system: an overview of its actions by Ferland G.(PubMed)
(2) Possible effects of one week vitamin K (menaquinone-4) tablets intake on glucose tolerance in healthy young male volunteers with different descarboxy prothrombin levels by Sakamoto N¹, Nishiike T, Iguchi H, Sakamoto K.(PubMed)
(3) Correlation of vitamin K-dependent clotting factors with cholesterol and triglycerides in healthy young adults by Hoffman CJ¹, Lawson WE, Miller RH, Hultin MB.(PubMed)
(4) [Frequency of use of oral vitamin K antagonists in patients with atrial fibrillation and cognitive function disturbances].[Article in Polish] by Gorzelak P, Zyzak S, Krewko Ł, Mozdzan M, Broncel M.(PubMed)
(5) Oral anticoagulation and vitamin K deficiency by Eichinger S.(PubMed)
)6) "Haemorrhagic disease of the newborn" 89 years later than expected: vitamin K deficiency bleeding by Seguna R¹, Maw KZ², Lyall HD², Bowles KM³.(PübMed)
(7)Vitamin K acupuncture pint injection for severe primary dysmenorrhea: an international pilot study by Wang L¹, Cardini F, Zhao W, Regalia AL, Wade C, Forcella E, Yu J.(PubMed)
(8)Procoagulant therapeutics in liver disease: a critique and clinical rationale by Shah NL, Intagliata NM, Northup PG, Argo CK, Caldwell SH.(PubMed)
(9) The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation by Vervoort LM¹, Ronden JE, Thijssen HH.(PubMed)
(10) Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo by Wei G¹, Wang M, Hyslop T, Wang Z, Carr BI.(PubMed)
(11) Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways by Wei G¹, Wang M, Carr BI.(PubMed)
(12) Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity by Acharya BR¹, Choudhury D, Das A, Chakrabarti G.(PubMed)
(13) Surgical evacuation of neonatal intracranial hemorrhage due to vitamin K deficiency bleeding.by Zidan AS¹, Abdel-Hady H.(PubMed)

WEight LOss Recipe Everyone Love: Sweet Fire Salmon

Posted By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Recipe contributed by eat well and lose weight by better Holmesd and Gardens (more than 500 delicious satisfying recipes), published by Houghton Miffin Harcourt. You can view its website at www.hmhbooks.com

Preheat oven to 450 degree F. Combine 1/2 teaspoon each chili powder and brown sugar, Sprinkle mixture over one 3 ounces salmon fillet; rub in. Roast salmon for 15 minutes or until it fakes with a fork. Meanwhile, in a small microwave-safe bowl combine 1/2 cup cooked brown rice; 1/4 frozen peas, thawed; and 1 green onion, sliced. Microwave for 1 minute. slice half of a cucumber; drizzle 2 teaspoon cider vinegar and 1/2 teaspoon olive oil. Serve salmon with rice mixture, cucumber mixture and lime wedges.
Per serving; 370 cal., 15g fat (3g sat. fat), 47mg chol., 72 mg sodium, 36g carb., 7g sugar, 5g fiber, 23g pro.


Weight Loss the Easy Ways 
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will Personally Coach You How to Get There The Easy Way

If You Are Looking For a SoulMate
Celebrity Patti Stanger Will Coach You To Get Him/Her
and Keep Him/Her for Good,The Simple Way
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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca