#Herbal #Chastetreeberry Reduces #Symptoms of #PremenstrualSyndrome #PMS, According to Studies

By Kyle J. Norton

Chaste tree berry, the queen of all herbs may have potency in reducing symptoms and treatment of premenstrual syndrome.

According to Dr. Döll M, the extract of chaste tree berry decreased levels of prolactin serum during the first 3 weeks of the cycle of the premenstrual period, inducing stress-involved expression of symptoms of PMS.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, considered a Queen herb in treating menstrual problems and discomforts and used in herbal medicine for thousands of years as an aphrodisiac agent.

Premenstrual syndrome is a faulty function of the ovaries related to the women's menstrual cycle, affecting women's physical and emotional state, and sometimes interfering with daily activities as a result of hormone fluctuation. The syndrome occurs one to two weeks before menstruation and then declines when the period starts.

In a prospective, double-blind, placebo-controlled, parallel-group, multi-center clinical trial in compared VAC BNO 1095 extract and placebo for up to three cycles, conducted by the Peking Union Medical College Hospital, group treated with extract of vitex agnus castus showed significantly reduced symptoms of PMS with mean total PMSD score decreased from 29.23 at baseline (0 cycles) to 6.41 at the termination (3rd cycle) with no serious of side effects.


Furthermore, the extract of vitex agnus castus (VAC, BNO 1095) orally administrated in 67 patients enrolled and randomly assigned to receive one tablet of VAC or placebo once a day, exhibited decreased premenstrual syndrome symptoms at the 3rd cycle, including symptoms of negative affect, water retention, food cravings, and pain, in the treatment group, compared to the placebo group, especially in symptoms of water retention.

The moderate-to-severe premenstrual syndrome in Chinese women studies also showed a significantly greater improvement of symptoms with intake of vitex agnus castus (VAC, BNO 1095)group than placebo, including the symptom of insomnia.

Taking together, Chaste tree berry may be a safe herbal medicine for the treatment of PMS, through decreased levels of prolactin, negative factors, and ameliorated symptoms of the syndrome in many aspects.

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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Sources
(1) [The premenstrual syndrome: effectiveness of Vitex agnus castus].[Article in German]by Döll M1.(PubMed)
(2) Treatment for the premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China by He Z1, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin S.(PubMed)
(3) Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus(BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Wang X.(PubMed)
(4) Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women by Ma L1, Lin S, Chen R, Zhang Y, Chen F, Wang X.(PubMed)

#Herbal #Ashwagandha Inhibits the Onset of #KidneyCancer, According to Researchers

By Kyle J. Norton

Cancer, a class of diseases refers to a group of cells that grow and multiply disorderly and uncontrollably in a specific tissue of an organ.

Over time, after successfully penetrating the deeper layers of the organs, most cancer can travel a distance away to damage other healthy tissues via lymph or blood, leading to secondary metastasis.

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine, and formed part of the detoxified organs to filter out blood by removing wastes and extra water to make urine.

Kidney cancer is a medical condition associated with cell growth irregularly that starts in the cells on the surface of the inner lining of the kidney tissue, before spreading to the deeper layers to form a tumor through unlimited cell cycle division.

According to the statistics provided by the American Cancer Society, kidney cancer is among the 10 most common cancers in both men and women in the US. In 2019, approximately, 73,820 new cases of kidney cancer will be diagnosed including 44,120 in men and 29,700 in women. The disease also causes the death of 14,770 Americans, including 9,820 men and 4,950 women in the same year.


The causes of kidney cancer are unknown. However, epidemiologically, the increase in age, gender, smoking, obesity, family diabetes, long-term exposure to chemical toxins, and use of diuretic and nondiuretic anti-hypertensive medication are some prevalent factors found in patients with kidney cancer.

Some researchers suggested the increased incidence of kidney cancer in the US may correlate to obesity caused by the promotion of a high-fat diet over the past decades.

Dr. Wilson KM, the lead scientist in the joint study led by the Chan School of Public Health wrote, "Obesity has been largely measured as body mass index (BMI). Studies which evaluated other measures of obesity including waist circumference (WC), waist-to-hip ratio (WHR), as well as an increase in weight, have reported similar positive associations with RCC".

And " Although the mechanisms by which obesity influences renal carcinogenesis have been under-explored, insulin resistance and certain growth factors including insulin-like growth factor (IGF-1), sex steroid hormones, and biochemical markers such as adiponectin may be involved".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes renal protective activity, researchers examined the effects of Withaferin A, a major chemical constituent of Withania somnifera, in the renal cancer cell line.

According to tested analysis, withaferin A application resulted in apoptotic cell death in several types of human renal cancer cells in a dose-dependent manner.

Furthermore, withaferin A inhibited the Caki cells by inducing signature endoplasmic reticulum (ER) stress markers, leading to the accumulation of unfolded proteins associated with cancer cell death.

Moreover, CAAT/enhancer-binding protein-homologous protein (CHOP) associated with pro-apoptotic function in the integrated stress response was elevated by the injection of withaferin A.

Interestingly, withaferin A-induced ER stress causes cytotoxicity against renal cancer cells by increasing levels of reactive oxygen species (ROS).

Based on the findings, researchers said, "the present study provides strong evidence supporting an important role of the ER stress response in mediating withaferin A-induced apoptosis".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of renal cancer, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells by Choi MJ1, Park EJ, Min KJ, Park JW, Kwon TK. (PubMed)
(2) Obesity and Kidney Cancer by Wilson KM1,2, Cho E. (PubMed)

#Antioxidant #Sulforaphane (SFN) Inhibits the Oxidative Damage Against the Onset of Diabetic Cardiomyopathy, Researchers Say

By Kyle J. Norton

Diabetes is a medical condition characterized by the failure of the body to utilize insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.
Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor sites clogged up by fat and cholesterol.

Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.

The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk of developing microvascular and macrovascular complications. includes cardiovascular disease.

Diabetic cardiomyopathy is a complication of the heart muscle in people with diabetes, leading to heart failure that causes the reduced function of the heart to circulate blood through the body.
The most common symptoms of diabetic cardiomyopathy are the accumulation of fluid in the lungs or legs.

Dr. Adeghate E, in the examination of the diabetic cardiomyopathy associated with the structural changes in the myocardium of diabetes, wrote, " If left unmanaged, DM can lead to numerous long-term complications including micro- and macro-angiopathy and heart failure (HF)".

And, "Most diabetics usually die as a result of HF resulting from diabetes-induced coronary artery disease and cardiomyopathy. Coronary artery disease and cardiomyopathy are normally preceded by hyperglycemia (HG)".


In other words, managing diabetes by preventing the onset of hyperglycemia is the most effective way to reduce the risk of diabetic cardiomyopathy in diabetes.


More precisely, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.


With an aim to find a natural food for the prevention and treatment of diabetic cardiomyopathy, researchers examined the effect of broccoli sprout extract in an animal model.

The study included male db/db and age-matched wild-type (WT) mice given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for 3 months, including vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg).

According to the results of echocardiography and histopathological analysis, both BSE and SFN showed significant prevention of diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis.

Furthermore, BSE, like SFN, significantly exhibited the Nrf2 transcriptional activity associated with the protective effect of oxidative damage triggered by injury and inflammation.

In other words, stimulating the Nrf2 function of the protein, BSE, and SFN significantly prevented cardiac oxidative damage and inflammation.


Moreover, BSE at high doses exerted a similar effect as those of SFN. particularly, in BSE at a high dose that works synergistically with SFN to prevent DCM.

Based on the findings, researchers said, "BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.



Intake of SFN in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. (PubMed)
(2) Structural changes in the myocardium during diabetes-induced cardiomyopathy by Adeghate E1, Singh J. (PubMed)

Phytochemical 3,3'-Diindolylmethane Gobbles Up of Ovarian Cancer Cells, According to Studies

By Kyle J. Norton

Ovarian cancer is the medical and chronic condition characterized by irregular cell growth in the tissues found either in at the tail ends of the fallopian tubes or the ovaries.

According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.

The lifetime risk of a woman getting ovarian cancer is 1/78 compared to the lifetime dying risk of 1/108.

The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, acquired genetic mutation such as TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.

Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, changes in bowel habits, such as constipation. and a frequent need to urinate.

In seeking a natural product that processes anti-ovarian cancer property, researchers examined the effects of 3,3'-diindolylmethane (DIM) on ovarian cancer cell viability, invasion, and sensitivity to chemotherapy.

According to the final results obtained by the ovarian cancer SKOV3 and A2780 cell lines treated by the 3,3'-diindolylmethane (DIM), DIM treatment not only potently suppressed the viabilities of ovarian cancer cells but also inhibited xenograft growth in nude mice.

Furthermore, according to the gene analysis, DIM inhibited phosphorylation of STAT3 and AKT proteins and proteins activated by STAT3 and AKT involved in cell growth and division and cell movement in the ovarian cancer SKOV3 and A2780 cell lines

Moreover, DIM inhibited the production of protein and genes associated with the production of a new blood vessel for the cancer cells to grow, promotion of cancer cell survival and anti-apoptosis.

Additionally, in order to obtain more information about DIM anti-ovarian cancer effects, researchers examined the phytochemical activity of Interleukin (IL6) which has been found to be a major contributor to the initiation and progression of ovarian cancer.

During the experiment, human ovarian carcinoma-derived cell lines SKOV3 and A2780 treated with IL6 and/or DIM and subjected to in vitro proliferation, DIM inhibited the increase of ovarian cancer cell adhesion, migration, and invasion caused by the administration of IL-6 through deactivated the expression of protein STAT3 similar to that of the aforementioned study.

Importantly, DIM induced ovarian cancer cells apoptosis associated with the inhibition of the expression matrix metalloproteinases MMP-2 and MMP-9 associated with the pathologic relationship to cancer.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo by Zou M1, Xu C2, Li H3, Zhang X4, Fan W. (PubMed)
(2) IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells by Zou M1, Zhang X2, Xu C. (PubMed)

Lycopene Reduces the Risk of Atherosclerosis, Researchers Find

By Kyle J. Norton

Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries. Over time, continued plaque accumulation can lead to cardiovascular disease.

In other words, narrowing the arteries due to plaque accumulation is a major cause of heart disease and stroke.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, and physical inactivity.

The most common symptoms found in patients with antiatherosclerosis are involved in the reduced blood flow to the body including, chest pain or angina, pain in the leg, and arm, shortness of breath and fatigue, and confusion.

Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.

Dr. Lovren F and colleagues wrote, "Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases".

And, " A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.".


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potent compound for the protection of arterial functions, researchers investigated the effects of lycopene on the diet-induced increase in serum lipid levels and the initiation of atherosclerosis in an animal model.

New Zealand White (NZW) rabbits. enrolled in the study were divided into four groups of 9 animals each, fed either a standard diet, a high-cholesterol diet containing 0.5% cholesterol, a high-cholesterol diet containing placebo beadlets, or a high-cholesterol diet plus 5 mg/kg body weight/day of lycopene (in the form of lycopene beadlets), for 4 weeks.

According to the chemical analysis of phytochemicals, the animal group treated with lycopene beadlets showed significantly elevated lycopene plasma levels compared to other groups.

The lycopene group demonstrated a significant reduction of 50% in total cholesterol and LDL cholesterol serum levels compared to the high-cholesterol and placebo groups.

Levels of cholesteryl ester accumulated in the aorta were significantly decreased in the lycopene-treated group without a significant decrease in the extent of aortic surface lipid accumulation.

In other words, lycopene inhibited some parameters associated with the increased risk of atherosclerosis, particularly in cholesterol levels.

Based on the findings, researchers concluded, "Lycopene supplementation for 4 weeks increased lycopene plasma levels in the animals. Although we found strongly reduced total and LDL cholesterol serum levels as well as significantly lower amounts of cholesteryl ester in the aortae in the lycopene-treated group".

Moreover, in the comparison of the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene in the animal model, lycopene exerted an anti-atherosclerotic property in high cholesterol diet-fed rats by decreasing TC, LDL-C, VLDL-C, and triglycerides and increased HDL-C level significantly compared to the control.

Lycopene used a combination with Astaxanthin also showed better hypolipidemic and anti-atherogenic potential compared to the individual application.

Taken altogether, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of atherosclerosis pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of Antioxidant, Hypolipidemic, and Antiatherogenic Property of Lycopene and Astaxanthin in Atherosclerosis-induced Rats by Kumar R1, Salwe KJ2, Kumarappan M. (PubMed)
(2) Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits by Lorenz M1, Fechner M, Kalkowski J, Fröhlich K, Trautmann A, Böhm V, Liebisch G, Lehneis S, Schmitz G, Ludwig A, Baumann G, Stangl K, Stangl V. (PubMed)

#Enzyme #Bromelain In the Inhibiting the Risks of Invasive #Glioma Cells, According to Scientists

By Kyle J. Norton

A glioma is a type of brain and spinal cord tumor characterized by the alternation of DNA of the glial cells.
Believe it or not, gliomas have been found to account for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.

Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.

* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.

* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.

The exact cause is unknown. Epidemiologically, age, exposure to radiation, and family history are common risk factors that cause the onset of the disease,

Out of many prevalent factors, exposure to ionizing radiation has been found in many patients with glioma.

Dr. Maricruz Rivera, the lead scientist wrote, "Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 12–15 months with treatment consisting of surgical resection followed by ionizing radiation (IR) and chemotherapy".

And, "While IR provides the benefit of improved survival, it paradoxically promotes a selection of more malignant cellular phenotypes of GBM".


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of invasive glioma cells, researchers investigated bromelain, an aqueous extract from pineapple stem against anti-invasive gliomas.

According to the tested assays, bromelain significantly and reversibly reduced glioma cell adhesion, migration, and invasion without affecting cell viability.

In other words, bromelain inhibited cancer cell proliferation and spreading without inducing cell apoptosis.

Levels of alpha 3 beta 1 integrin associated with glioma cell spreading and CD44 protein associated with cancer cell progression were also inhibited by the administration of bromelain without affecting the gene expression.

In other words, the metabolic pathways for de novo nucleotide synthesis in cancer growth were greatly attenuated by bromelain.

Moreover, according to the transactivating signaling assay, bromelain inhibited the invasive glioma cell and was also attributed to the suppression of CRE-mediated signaling processes in stimulating tumor expansion.

Taken altogether, bromelain may be considered a supplement for the prevention and treatment of invasive glioma cells. , pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain reversibly inhibits invasive properties of glioma cells by Tysnes BB1, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. (PubMed)
(2) Ionizing Radiation in Glioblastoma Initiating Cells by Maricruz Rivera,1,2 Kumar Sukhdeo,1,3 and Jennifer Yu. (PMC)

#Broccoli' #Sulforaphane in the Prevention of the Onset of Neutrophilic #AirwayInflammation, Researchers Suggest

By Kyle J. Norton

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.

Airway inflammation is a lung inflammatory caused by both allergens and immune mistakenly attacking the respiratory tissues.

Chronic airway disease predominantly asthma and chronic obstructive pulmonary disease (COPD) have increased at an alarming rate in the US over the past 20 years.

According to the statistics provided by the WHO, globally, approximately 65 million people suffer from chronic obstructive pulmonary disease (COPD), causing the death of 3 million each year. and 334 million people suffer from asthma, affecting 14% of all children globally.

In the US, the prevalence of chronic airway disease was found to cause a major financial burden to society, with both direct and indirect costs.

Neutrophilic airway inflammation is a severe condition that plays a role in the progression of persistent airflow limitation in asthma and raises the possibility that this progression and the development of COPD.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of respiratory diseases, researchers examined the effect of sulforaphane, an active compound of broccoli anti-airway inflammation

The study included 16 subjects that were randomized, and fifteen subjects completed all visits.

According to the tested analysis, 3 days of broccoli sprout homogenate (BSH) significantly increased levels of SFN (p = 0.001) and its major metabolites. However, the BSH supplementation group showed no significant difference in sputum neutrophilia compared to the placebo.

Despite significantly increased plasma levels of SFN in the BSH group, post-O3 gene expression of NRF2 and phase II antioxidant defense genes in NECs and peripheral blood were not significantly different from placebo.

In other words, SFN with broccoli sprout homogenate in healthy human subjects did not induce the expression of antioxidant genes, NRF2.

Furthermore, BSH-induced high levels of SFN do not protect against neutrophilic airway inflammation in an ozone-exposure model.

Based on the results, researchers wrote, " These contradictory results may be due to different systemic levels of SFN achieved with dietary supplementation with BSH, which is not standardized"

And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".

In other words, SFN protected the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.

Taken altogether, broccoli sprouts processed abundantly SFN may not be considered supplements for the prevention of neutrophilic airway inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation by Duran CG1, Burbank AJ1, Mills KH1, Duckworth HR1, Aleman MM1, Kesic MJ2, Peden DB1, Pan Y3, Zhou H3, Hernandez ML. (PubMed)