Green Beans Inhibits Fat Cell Storing Activity in Obesity

By Kyle J. Norton

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity rates have increased for all age groups in the US over the last several decades, coincidently with the periods that promoted the Western diet.

Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".


And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".

The findings strongly suggested that widespread obesity has caused significant pressure on the public health care system and an impact in the financial and economic burden.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods.

The veggie can be classified into two major groups, bush beans, and pole beans.
On finding a potent veggie for the prevention of obesity, researchers investigated the antiobesity activity of methanolic and aqueous green bean extracts in an animal model.

Mature adipocytes 3T3-L1 and rat adipose tissue selected to the study treated by bean extracts at the doses pf 800 and 1000 µg/showed to increase glycerol release significantly related to the pathogenesis of obesity-related diseases compared to control.

Furthermore, extracts at concentrations between 500 and 1000 µg/mL reduced intracellular triglyceride accumulation associated with the risk of obesity by 34.4% and 47.1% compared to control.

More precisely, bioactive compounds of green beans exert a direct mechanism on fat cells storing through the breakdown of fats and other lipids to release fatty acids.

Based on the findings, researchers said, " Bean is a good candidate for the development of functional ingredients that can help reduce the high rates of death from cardiovascular diseases associated with obesity.".

Taken altogether, green beans may be used as an adjunct therapy for the prevention and treatment of obesity, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Phaseolus vulgaris Extract on Lipolytic Activity and Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes: A Strategy to Prevent Obesity by Castillo F1,2, González DR3,4, Moore-Carrasco R. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Tremmel M1, Gerdtham UG2,3,4, Nilsson PM5, Saha S. (PubMed)

Herbal Ashwagandha Reduces the Risk of Memory Loss

By Kyle J. Norton

Memory is one of the major function of the brain that collects and stores data or information which are retrieved when needed.

In other words, memory is the retention of information over time that have a strong influence on future action.

Memory impairment is a condition of partial or complete loss of memory, depending on the quality of the neuron that has been affected.

Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.

Memory impairment can be acute or chronic.

In acute impairment, memory is temporary loss in most cases associated with physical impact on the brain that causes injury of neurons.

Chronic memory impairment is the loss of memory that can get worse overtime found mostly in the elderly with neurodegenerative diseases, such as dementia.

In elderly or aging-induced memory loss are associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.

The most common risk factors associated with memory loss in the general population are long-term use of certain medications, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.

However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.

Dr. Scott E. Kanoski, the lead scientist in the review of the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".


And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".

The results clearly stated if you are a Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of brain health, researchers examined the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) on memory and cognitive functioning in adults with mild cognitive impairment (MCI).

The prospective, randomized, double-blind, placebo-controlled study included 50 adults assigned to the treatment of either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.

According to the analysis of Wechsler Memory Scale III subtest scores for logical memory,  at week 8, the ashwagandha treatment group exerted significant improvements in both immediate and general memory, compared with the placebo group.

Futhermore, verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), logical memory II (p = 0.006) scores were also significantly increase compared to placebo.

According to the scores of Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009), ashwagandha treatment group also displayed a significantly greater improvement in executive function, sustained attention, and information-processing speed also compared to placebo.

Based on the findings, researchers said, "Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.".

Taken altogether, Ashwagandha may be considered a functional herb for the improvement of the brain health, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions by Choudhary D1, Bhattacharyya S2, Bose S. (PubMed)
(2) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)

Turmeric, a Natural Prevention and Treatment of Neuro Inflammation

By Kyle J. Norton

The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.

Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.

Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Inflammation can be acute or chronic. In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of inflammatory cytokines to kill off micro-organisms that affect the function of the brain, leading to symptoms of fever, redness, and swelling.

Most cases of acute neuroinflammatory may be resolved within a few days without causing damage to the brain tissues.  However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic neuroinflammatory diseases.

Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.

Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"

And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of neurological disease, researchers examined the efficacy of a classical LPS model included aromatic-turmerone on neuroinflammation.

On LPS-induced neuroinflammation mice and BV2 cells, according to the tested analysis, oral administration of aromatic-turmerone not only reversed LPS-induced memory disturbance but also normalized glucose intake and metabolism in the brains.

The application of the aromatic-turmerone also protected the neuron viability by significantly limited brain damage by inhibiting the generation of inflammatory cytokines.associated with neuro-inflammation and activation of microglia involved in the immune system response to the LPS injection.

In vitro, aromatic-turmerone also targeted Toll-like receptor 4 which plays a key role in the innate immune system.in the mediation of downstream signaling associated with the activation of inflammatory mediators.

Based on the results, researchers said, "aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation and may be useful in the treatment of neuronal inflammatory diseases."

Taken altogether, turmeric may be considered supplements for the prevention and treatment of neuronal inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aromatic-Turmerone Attenuates LPS-Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4-Dependent Signaling Pathway by Chen M1, Chang YY1, Huang S1, Xiao LH1, Zhou W1, Zhang LY1, Li C1, Zhou RP2, Tang J3, Lin L4, Du ZY1, Zhang K. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)

Phytochemical Betaxanthins Processes Anti-Cancer Activity in Vitro

By Kyle J. Norton

Cancer is a group of cell mutated diseases caused by the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.

At the later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort and loss of appetite and localized symptoms such as severe pain and bleeding.

The exact causes of cancer are not identified. However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,.. The list goes on and on, depending on the types of cancer.

Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".

And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strong indicated the risk of cancer is increased substantially in obese.

Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

On finding a potent ingredient for the treatment of chronic disease, researchers investigated the effects of the green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. Rubra L.) against cancer.

According to the tested analysis, betaxanthins found in red beetroot accompanied by betacyanins comapred to apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside found in green beetroot showed considerable antiproliferative activities.

Furthermore, Vitexin-2-O-xyloside, in combination with betaxanthins and betacyanins, exerted antiproliferative activity in breast, liver, colon, and bladder cancer cell lines, through both intrinsic and extrinsic apoptotic pathways.

Genes associated with cancer survival were also inhibited by the aforementioned phytochemicals in both green and red beetroots.

Moreover, the combination of Vitexin-2-O-xyloside, betaxanthins and betacyanins and chemo drugs not only increased the drug anticancer activity but also reduce their toxicity and overcome the multidrug resistance of cancer cells.

Taken altogether, betaxanthins combined with other phytochemicals may be considered an anti-cancer remedy,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

Green Beans Gobbles Up Prostate Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of diseases associated with abnormal cell growth in a specific tissue of an organ, due to the alternation of DNA.

A primary tumor or original tumor is a tumor of the original site where it first arose and the tumor progression began and proceeded to yield a cancerous mass.

Cancer cells that grow to its tumor size, can invade and kill their neighbor cells by producing abnormal or excessive signaling chemicals (hormones or cytokines) which upset the normal chemical balance of the body and alter the metabolic pathways, leading to disordered and violent cellular behavior.

 At the early stage, due to the small size of the tumor, most patients are asymptomatic.

Prostate cancer is a medical and chronic condition in which the cells of the prostate have become cancerous due to the alternation of the cell's DNA.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spreads to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages of prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe it or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Anton Stangelberger,, the lead scientist at the joint study led by the University of Vienna, wrote, "

Due to increasing life expectancy and the introduction of prostate-specific antigen (PSA) screening, a rising number of elderly men are diagnosed with prostate cancer. Besides PSA serum levels and Gleason score, age is considered to be a key prognostic factor in terms of treatment decisions".


And, " Not every man who is diagnosed with prostate cancer will develop the clinically significant disease. This has led to the concept of expectant management for screen-detected, small-volume, low-grade disease, with the intention of providing therapy for those men with disease progression.".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent compound that processes chemopreventive activity, researchers examined BN999, a fermentation product of soybean, black bean, and green bean mixture in the inhibition of the growth of human prostate cancer.

The application of the mixed product showed a significant effect on inhibiting the growth of prostate adenocarcinoma PC-3 cells without causing obvious side effects.

Furthermore, BN999 induced apoptosis in colon cancer cells without affecting the healthy cells.

Based on the findings, researchers after taking into account co and confounder wrote, "these data suggest that BN999 has the potential to be used as cancer chemoprevention or therapeutic agent".

Taken altogether, green beans used combined with fermentation products of soybean, the black bean may be used as an adjunct therapy for the prevention of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB. (PubMed)
(2) Prostate Cancer in Elderly Men by Anton Stangelberger, MD,* Matthias Waldert, MD,* and Bob Djavan, MD, Ph.D. (PMC)

Antioxidant Lycopene in the Prevention and Treatment of Esophagitis

By Kyle J. Norton

Esophagitis or heartburn or gastroesophageal reflux disease (GERD). is a condition characterized by the going back up of acidic stomach contents to the esophagus.

Most cases of esophagitis are happened immediately after eating causing a burning sensation or pain in the lower chest area.

According to the statistics, in the US, approximately, 20% of people with acid reflux will develop esophagitis.

 More than 65% of people who suffer from acid reflux are 40 years old or older. And, 15 to 30 5 of the U.S. population has esophagitis

There is no single cause of esophagitis. Epidemiologically, eating large meals or lying down right after a meal, snacking close to bedtime, smoking, being overweight or obese, overeating certain foods such as citrus, tomato, chocolate, mint, garlic, onions, or spicy or fatty foods are some prevalent factors associated with the risk of esophagitis

First-time pregnancy women may also experience esophagitis caused by increasing levels of hormones combined with pressure from the growing fetus.

Furthermore, long-term intake of certain medications such as bronchodilators for asthma, progestin for birth control or to treat abnormal menstrual bleeding, sedatives for insomnia and anxiety, calcium channel blockers for high blood pressure.

Dr. Zeynel Mungan and colleagues in examing the medication risk of esophagitis wrote, "Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs".

And, "The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility".


Therefore, if you currently taking some of the aforementioned medication, please make sure that you know all the side effects for preventive measures.

Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of esophagitis, researchers examined the role of lycopene (L) on radiation-induced acute esophageal toxicity in an animal model.

60 Wistar albino rats.selected to the study were divided into five groups: control, L, radiotherapy (RT), L before RT (L + RT), and L before and after RT (L + RT + L). 6 mg/kg bw/day with L administered 7 days in the L group, 7 days before RT in the L + RT group, and 7 days before and after in the L + RT + L group.

According to the tested analysis, L levels were significantly higher in the L receiving groups, comapred to RT group.

Esophagitis was significantly worse in the RT group than in the none-RT groups. Injection of lycopene in the L + RT and the L + RT + L groups showed better results than the RT group.

Compared to RT group, grade 2-3 degenerative changes-necrosis and vacuole formation were significantly lesser in the L + RT and the L + RT + L groups.

Furthermore, subepithelial bulla formation and inflammation in the L + RT and the L + RT + L groups were also significantly decreased compared to the RT group.

Moreover, L + RT + L groups exerted the highest decrease to regeneration-mitosis compared to a moderate decrease in the L + RT group, comapred to RT groups.

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of esophagitis, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You.  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene in the Prevention of Radiation-Induced Esophagitis by Coskun H1, Andic F1, Daglıoglu YK2, Doran F3, Sahin K4, Tunalı C1, Kucuk O. (PubMed)
(2) Which drugs are risk factors for the development of gastroesophageal reflux disease? by Mungan Z, Pınarbaşı Şimşek B. (PubMed)

Turmeric, a Natural Prevention and Treatment of Chronic Lymphocytic Leukemia

By Kyle J. Norton

Cancer is a class of chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of the specific organ.

Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of organs before penetrating into deeper layers to form a tumor.

At the advanced stage, most cancers can travel through blood and fluid circulation to infect other healthy tissue and organ a distance away from the original site.

Leukemia is a medical condition caused by the abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. 

Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, and leg.

According to the statistics, approximately 176,200 people in the US will be diagnosed with leukemia, lymphoma or myeloma in 2019, accounting for 10% of all new cases of cancer diagnosed in the US.

Chronic lymphocytic leukemia (CLL), type of leukemia associated with a condition of slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies. 

In CLL, B-cell lymphocytes have become abnormal and grow out of control. They appear less immature in the bloodstream.

Besides the general symptoms shared by all types of leukemia, the most common specific symptoms of CLL are

*Abnormal bruising
It is normally occurred in the later stage of CLL due to immature white blood cells that affect the levels of platelets.

*Enlarged lymph nodes, spleen
In CLL, lymph nodes can swell more than 1cm in children and 2 cm in adult.

* Become too full easily
One of the specific symptoms of CLL due to enlarged lymph nodes or spleen pressing onto the abdomen.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of leukemia, researchers examined the effect of turmeric and the green tea extract epigallocatechin-3-gallate (EGCG) effects on the apoptotic machinery in chronic lymphocytic leukemia (CLL).

According to the tested assays, curcumin induced B-CLL cells apoptosis is associated with a dose-dependent.

Curcumin was more sensitive to its cytotoxic effects than B-CLL cells compared to normal B lymphocytes.

Furthermore, curcumin inhibited the protein (PARP) from doing its repair work in cancer cells and the cell dies in B-CLL cells by activating the programmed cell death gene.

Moreover, curcumin-induced B-CLL cells apoptosis also by the release of cytochrome c from the mitochondrial membrane.

Additionally, the inhibition of B-CLL cells of curcumin was also found in the inhibition of the activation of pro-survival pathways, including STAT3, Akt, and NF-κB.

Interestingly, Co-culture of B-CLL cells with stromal cells, curcumin-induced apoptosis at lower curcumin doses, but not at higher doses (20μM) (2). 

Based on these findings, researchers strongly believed that curcumin alone may be a less effective treatment for B-CLL due to incomplete apoptotic responses. 

In other words, curcumin enhanced the effectiveness of a variety of compounds for the treatment of B-CLL.

Taken altogether, turmeric processed abundantly bioactive compound curcumin combined with conventional medicine or other phytochemicals for the prevention and treatment of chronic lymphocytic leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evidence for and Against Green Tea and Turmeric in the Management of Chronic Lymphocytic Leukemia by Bange E1, Timlin C1, Kabel C2, Svoboda J1, Roeker L2, Mato AR. (PubMed)
(2) Turmeric and green tea: a recipe for B-Chronic Lymphocytic Leukemia by Laura S. Angelo and Razelle Kurzrock. (PMC)
(3) Lymphoblastic leukemia - Chronic lymphocytic leukemia (CLL) by Kyle J. Norton