Healthy Legume Navy Bean Alters Blood Lipid Metabolism Against the Risk of Cardiovascular Disease

By Kyle J. Norton

Lipids are fats synthesized by the liver dietary intake. Overexpression of triglycerides (TGs) and cholesterol have been found to cause diseases, although all lipids are physiologically important.

Cholesterol in moderate amounts plays a critical role in building strong cell membranes, producing vitamin D and steroid hormones and improving digestive functioning.

However, overexpression of "bad" cholesterol (low-density lipoprotein, LDL) and reduced levels of "good" cholesterol (high-density lipoprotein, HLD)  can cause high levels of cholesterol in the blood, leading to the increased risk of cardiovascular disease.

Lipid metabolism is the process to break down triglycerides into smaller chain fatty acids and subsequently into monoglyceride molecules through many steps of mechanisms, including

pancreatic enzymes and hormone cholecystokinin (CCK).

Lipid dysmetabolism that affects the function to deliver fatty acids to the apical membrane of enterocytes (intestinal absorptive cells) for absorption is associated with a number of medical conditions which has been found to cause chronic diseases including cardiovascular disease in type 2 diabetes, Crohn’s disease, Systemic autoimmune diseases, and obesity

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find potential ingredients for the prevention of cardio complications, researchers examined the effects of navy beans and rice bran on plasma metabolome or plasma of metabolites in children.

The pilot, randomized-controlled, clinical trial included 38 children (10 ± 0.8 years old) with abnormal cholesterol consumed a snack for 4 weeks containing either with navy bean or rice bran (control) including 17.5 g/day cooked navy bean powder; 15 g/day heat-stabilized rice bran; or 9 g/day navy beans and 8 g/day rice bran.

According to the tested assays, navy bean and/or rice bran consumption influenced 71 plasma compounds compared to control (p ≤ 0.05), with lipids representing 46% of the total plasma of metabolites.

Furthermore, the navy bean group exerted significant changes of 18 plasma lipids compared to 10 plasma lipids in the rice bran group and compared to control.

Compared to the baseline, navy beans group showed a change of 48 lipids in the navy bean group and compared to 40 in the rice bran group, compared to the baseline.

These results strongly suggested that navy bean influences the change of blood lipid metabolism that has strong implications for reducing CVD risk in children.

Moreover, researchers found the efficacy of anti-cardiovascular disease of the navy beam may be attributed to its chemical compounds in decreasing free fatty acids associated with metabolic diseases (palmitate and arachidonate) and increased the relative abundance of endogenous anti-inflammatory lipids (endocannabinoids, N-linoleoylglycine, 12,13-diHOME).

Taken altogether, the fermented navy bean may be considered a remedy for the prevention and treatment of cardiovascular disease,  pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Navy Bean and Rice Bran Intake Alters the Plasma Metabolome of Children at Risk for Cardiovascular Disease by Li KJ1, Borresen EC1, Jenkins-Puccetti N2, Luckasen G2, Ryan EP. (PubMed)

Herbal Bilberry, the Potent Treatment for Retinitis Pigmentosa

By Kyle J. Norton


Retinitis pigmentosa is a genetic condition characterized by the breakdown and gradual loss of cells in the retina.

The retina is the light-sensitive tissue lined the back of the eye. The function of the retina is to convert the light received into neural signals before sending them to the brain for visual recognition.

Most cases of retinitis pigmentosa are diagnosed during the teenage years and at birth. Some patients who carry the genetic preposition may develop the disease in the later years.

The later diagnosed case is usually mild with slow progression compared to those presented in the teen years and at birth.

Most common symptoms of patients with retinitis pigmentosa are difficulty seeing at night and a loss of side (peripheral) vision. However, at the disease progress into the later stage, most patients also experience tunnel vision.

Conventionally, the treatment of retinitis pigmentosa is totally depending on the condition. The aim of treatment is to slow the vision loss and improve the patient quality of life.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of retinitis pigmentosa with not side effects examined the effects of Bilberry (Vaccinium myrtillus L.) and lingonberry (Vacciniumvitis-idaea) containing high amounts of polyphenols (anthocyanins, resveratrol, and proanthocyanidins) against blue light a high-energy or short-wavelength visible light-induced retinal diseases such as age-related macular degeneration and retinitis pigmentosa. 

According to the results from the cultured murine photoreceptor (661 W) cells exposed to blue LED light following treatment with B-ext, L-ext, or their constituents (cyanidin, delphinidin, malvidin, trans-resveratrol, and procyanidin B2), B-ext, L-ext, NAC, and their active components improved the viability of 661 W cells against the blue light damage.

The efficacy was found to be attributed to the injection of tested compounds in inhibiting the generation of intracellular ROS induced by the blue LED light irradiation.

Furthermore, B-ext and L-d with also protected the cells integrity against the activation of proteins by stimuli associated with the production of production of proinflammatory cytokines.

Moreover, B-ext, L-ext, and NAC inhibited proteins involved cells death and autophagy against cell damaged by the blue light.

Dr. Ogawa K the lead scientist said, "These findings suggest that B-ext and L-ext containing high amounts of polyphenols exert protective effects against blue LED light-induced retinal photoreceptor cell damage mainly through inhibition of ROS production and activation of pro-apoptotic proteins".

In a murine model of photo-stressed retina, researchers examined the bilberry extract through a stomach tube in Balb/c mice (750 mg/kg body weight) light-induced visual function impairment.

According to the tested assays, bilberry extract suppressed photo-induced apoptosis in the photoreceptor cell layer and shortening of the outer segments of rod and cone photoreceptors.

Bilberry extracts also reduced the levels of photo-induced reactive oxygen species (ROS), oxidative and endoplasmic reticulum (ER) stress markers observed by the analysis.

In other words, bilberry inhibited the ER stress in the retina, and at least in part, in Müller glial cells. 

Based on the findings, researchers suggested, "bilberry extract attenuates photo-induced apoptosis and visual dysfunction most likely, and at least in part, through ROS reduction, and subsequent ER stress attenuation in the retina".

Taken altogether, bilberry processed abundantly bioactive compounds may be considered a function remedy for the prevention and treatment of age-related macular degeneration and retinitis pigmentosa, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro by Ogawa K, Kuse Y, Tsuruma K, Kobayashi S, Shimazawa M, Hara H1. (PubMed)
(2) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina by Osada H1, Okamoto T1,2, Kawashima H1,2, Toda E1, Miyake S1,3, Nagai N1,2, Kobayashi S3, Tsubota K2, Ozawa Y. (PubMed)

Bromelain, the Anti Acute Inflammation Whole Food

By Kyle J. Norton

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to the cover the site of damage and pro-inflammatory to kill off pathogens which try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

Most common symptoms of acute inflammation occurred with a short period of time such as hours is a pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.


On finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.

According to the tested assays,

* In vitro, bromelain modulated the immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.

* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.

* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.

In other words, through its anti-inflammatory activity, bromelain inhibited primary long-term effect on abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in induction of inflammation.

Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).

Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).

Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)

Herbal Turmeric,The Traditional Treatment of the Oral Lichen Planus

By Kyle J. Norton

Oral lichen planus (OLP) is a condition characterized by chronic inflammation, affecting the mucous membrane of the oral cavity.

The disease is caused by the abnormal reaction of the immune system that attacks and triggers the death of the basal cells of the oral epithelium.

Oral lichen planus can have different shapes an colors, including white, lacy patches, red, swollen tissues, or open sores.

Most common areas of oral cavity affected by oral lichen planus (OLP)  are inside of the cheeks, the gums, tongue, palate and the inner tissues of the lips.

Besides the aforementioned symptoms, patients with OLP may also experience symptoms of pain, burning sensation or pain, bleeding, and irritation with tooth brushing, inflammation of the gums (gingivitis).

In serious cases, OLP  can also affect the patients speaking, chewing or swallowing.

Conventionally, most cases of OLP are managed by pinpoint the allergens that trigger the immune attack accompanied by topical ointments or gels. Corticosteroids are the first line treatment with an aim to reduce inflammation and pain in patients with oral lichen planus.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of oral lichen planus (OLP), researchers launched a review to identify studies from the database of medical literature up to December 18, 2018.

4 trials assessed the comparative efficacy of topical curcumin vs. topical corticosteroids and 3 trials assessed the efficacy of oral curcumin vs. placebo were selected.

According to the results, topical curcumin showed to reduce pain, burning, and clinical manifestations of OLP versus baseline, effects similar or inferior to those of topical corticosteroids.

Interestingly, oral curcumin trials exerted no significant benefits of curcumin therapy versus placebo but there were some potential benefits and reasonable safety in an observational extension study.

In order to reveal more information about the effect of curcumin on OLP, researchers at Zhejiang University once again reviewed the published literature by searching PubMed, EMBASE, EBSCO, and Cochrane Library.

The search identified 9 studies which met the inclusion criteria, including six randomized, double-blind clinical trials; two pilot clinical trials; and one case report.

Based on the results of a total of 259 OLP patients included in the systematic review, researchers found that

* 7 studies showed statistically significant differences in pain severity and clinical appearance of oral lesions after treatment with curcumin compared to baseline.

* 3 controlled clinical trials compared to corticosteroids; curcumin exerted a similar efficacy in pain severity and clinical appearance of oral lesions.

Dr. Lv KJ, the lead scientist wrote, "Curcumin is a safe treatment and can be used as an adjunct in combination with corticosteroids to reduce pain, burning sensations, and the clinical appearance of oral lesions in OLP patients".

Taken altogether,  turmeric process a main ingredient of curcumin may be considered a supplement for the treatment of oral lichen planus, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, a turmeric extract, for oral lichen planus: A systematic review by White CM1,2, Chamberlin K1,3, Eisenberg E. (PubMed)
(2) Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review by Lv KJ1, Chen TC2, Wang GH1, Yao YN1, Yao H. (PubMed)

Whole Food Onion Protects the Endometrial Cells Integrity Against the Risk of Endometriosis

By Kyle J. Norton


Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else in the body instead of the inside of the uterus.

More precisely, during the maturation, the layer of endometriosis lining on the inside of the uterus is normally expelled, some of the endometriosis tissues grow somewhere else in the body.

Most common endometriosis tissues are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall. However, endometriosis has also been found in the fallopian tubes, the cervix, the vagina, and even the vulva.

According to the statistics, 20% of reproductive age women with endometriosis present without symptoms, 55% of women who have developed the new onset of severe menstrual cramps.

Additonally, endometriosis also induce sub-fertility (less fertile than a normal couple) in 25% of women.

Conventionally, endometriosis is treated either by medications or surgery, including
* Medication for pain with an aim to ease painful menstrual cramps.

* Hormone therapy may be accompanied by the pain medication also with an aim to reduce menstrual pain such as hormonal contraceptives. Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Progestin therapy. and aromatase inhibitors.

In surgery perspective,
* In women who want to get pregnant, surgery removes the endometriosis implants while preserving the uterus and ovaries.

* Hysterectomy with removal of the ovaries may be performed if pregnancy is not a concern.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of endometriosis, researchers examined the effects of quercetin (3,3',4',5,7-pentahydroxyflavone), a major dietary flavonol found in the onion on the risk of endometriosis.

In human endometriosis cell lines (VK2/E6E7 and End1/E6E7 cells), 

* Quercetin inhibited the proliferation and induced the cell cycle arrest.

* Administration of quercetin not only induced cell apoptosis with DNA fragmentation, loss of mitochondrial membrane potential but also exhibited cytotoxicity of reactive oxygen species production in the tested cell lines.

* Quercetin also suppressed the expression of signaling pathways associated with endometrial cells survival and growth.

On endometriosis auto-implanted mouse models,

* Administration of quercetin also promoted the antiproliferative and anti-inflammatory effects.

* Quercetin injection also attenuated the proliferation with sub-G0/G1 cell cycle arrest and increased the apoptosis of VK2/E6E7 and End1/E6E7 cells by inhibiting the gene associated with the onset and progression of endometriosis. 

In other words, quercetin inhibited the risk and onset of endometriosis by the increased expression and decrease expression of Micro RNA (miRNA) involved in the initiation and progression of endometriosis in vitro and vivo.

Dr. Park S, the lead scientist said, "Hence, quercetin may potentially act as a natural therapy to reduce and treat human endometriosis".

Taken altogether, onion processed an abundantly high amount of quercetin may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo by Park S1, Lim W2, Bazer FW3, Whang KY4, Song G. (PubMed)

Phytochemical 3,3'-Diindolylmethane, the Anti Nasopharyngeal Cancer Functional Supplement

By Kyle J. Norton


The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx. The early stage of nasopharyngeal cancer is asymptomatic due to the very small size of the tumor.

However, at the advanced stage, the oversize may suppress the nearby nerves and blood vessels, leading to severe throat pain and symptoms of a lump in your neck blood in the saliva, bloody discharged from your nose, particularly, persistent nasal congestion or ringing in your ears, accompanied with the general symptoms shared with other cancers.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.
Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

The exact causes of nasopharyngeal cancer are unknown. Gender, family history, ethnicity, where you live, poor diet, infected by the Epstein-Barr virus are some of the prevalent factors of nasopharyngeal cancer.

On finding potential and plant-based compound for the treatment of nasopharyngeal cancer, researchers examined the antitumor effects of DIM in a long-term low-dose manner in nasopharyngeal carcinoma (NPC).

The study included NPC cells induced by 20 µmol/l DIM for over a month.

During the experiment, the injection showed significantly reduced the cell metastasis in vivo.

Furthermore, according to assays, DIM significantly reduced the proliferation and migration of without inducing apoptosis.

Long-term dose administration also exerted antitumor activity by altering the signaling pathways which are mutated in human cancer and protein associated with the anti-apoptosis, proliferation and cell survivals.

Moreover, in order to reveal more information about DIM antitumor efficacy, researchers launched an investigation of the pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane (DIM) in various tumor cell types.

DIM-induced apoptosis and inhibited proliferation in nasopharyngeal carcinoma cells by inhibiting the activity of telomerase which is crucial for the survival of cancer cells, in a dose‑dependent manner.

The mRNA and protein expression of hTERT which is a catalytic component of human telomerase and used as a biomarker of a tumor was inhibited following treatment with DIM without causing a change of telomerase RNA (hTR).

In other words, DIM-induced apoptosis and inhibited proliferation were attributed to its activity on telomerase by targeting the expression of hTERT.

The results indicated that DIM inhibited nasopharyngeal carcinoma cells by shortening the telomeres in a concentration‑dependent manner.

Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and treatment of nasopharyngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) ERK signaling mediates long-term low concentration 3,3'-diindolylmethaneinhibited nasopharyngeal carcinoma growth and metastasis: An in vitro and in vivo study by Li F1, Chen C1, Chen SM1, Xiao BK1, Tao ZZ. (PubMed)
(2) Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity by Li F1, Xu Y2, Chen C1, Chen SM2, Xiao BK1, Tao ZZ. (PubMed)

Cucumber, the Best Food to Promote Heart Health

By Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting to 1 in 4 deaths.

Most common symptoms of heart disease are poor appetite, weight loss, shortness of breath,  sudden collapse, blood clots and stunted growth found in children.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.

By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.

Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".

And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.

According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.

Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.

More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.

In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.

Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.

At the end of the experiment, cucurbitacin B demonstrated a strong anti- hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.

Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery was also moralized by the application of cucurbitacin B.

Furthermore, gene expressions induced hypertrophic and fibrotic markers, reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection cucurbitacin B.

Taken altogether, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, PhD, MSN, RN,a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, PhD, MPH, FAHA, FAAN. (PMC)