Kyle J. Norton
Cancer is a class of diseases characterized by abnormal cell growth that begins in the cells on the surface of the inner lining of the tissue of an organ caused by the alternation of cell DNA with unknown nature.
Under normal circumstances, cell growth is a natural process that happens daily to replace millions of dead cells. In some cases, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again regulated growth inhibitors.
In other words, healthy cell division is limited to several cycles. Comapred to normal cells, cells with an alternation of DNA or cancer cells can grow indefinitely.
Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.
At the early, most people with cancer are asymptomatic, however, later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite and localized symptoms such as severe pain and bleeding.
Cancer can be classified by the types of cells that have become malignant.
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.
* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells that originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.
* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of blood cells, including red blood cells, white blood cells, and platelets become cancerous.
* Germ cell tumor
Cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary but are more common in babies and young children.
* Blastoma
Blastoma is cancer derived from immature "precursor" or embryonic tissue, mostly in children.
The causes of cancer are not identified. However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the types of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of invasive tumors, researchers examined the potential effects of cranberry on cancer prevention and treatment.
According to the review of the medical literature by searching the database of PubMed, cranberry and/or its components may act as chemopreventive agents, that diminish the parameters associated with the onset of cancer, including the inhibition of cells oxidation and inflammatory-related processes, in vitro.
Cell proliferation angiogenesis and metastasis involved in cancer cell invasion were also attenuated by the administration of cranberry's apoptotic activity.
Dr. Mantzorou M, the lead scientist, after taking other factors into account wrote, " Cranberry could be considered as a conglomeration of potential effective anticancer drug-like compounds".
Additionally, in chemical constituents analysis, cranberry showed inhibitory action against cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma, and lymphoma.
The efficacy of anti-cancer activity was attributed to the chemical compounds that work synergistically to result in cellular death induction via apoptosis, necrosis, and autophagy, reduction of cellular proliferation, the elevation of reactive oxygen species, and modification of cytokine and signal transduction pathways, similar to those of aforementioned study.
Taken together, cranberry may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(2)Cranberry as a Promising Natural Source of Potential Nutraceuticals with Anticancer Activity by Mantzorou M1, Zarros A2, Theocharis S3, Pavlidou E1, Giaginis C. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen
Tuesday, 31 October 2023
#Phytochemical #Allicin Inhibits Liver Oxidativestress by Preventing Lipid Peroxidation of Liver Homogenate, Researchers Say
Kyle J. Norton
Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.
Scientists may have found a dietary and bioactive ingredient for the prevention and treatment of diseases associated with oxidative stress.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
Oxidative stress is a condition characterized by the overexpression of free radicals in the host body.
Most cases of oxidative stress are caused by the inability of the host liver to stimulate the production of antioxidant enzymes which play a critical role in inhibiting the free radical expression, causing oxidative stress.
In a healthy individual, the ratio of free radicals and antioxidant enzymes is always balanced.
However, an individual whose antioxidant enzymes were suppressed due to damage to the antioxidant enzymes' productive system or other sources may have a greater risk of the onset of oxidative stress.
Dietary antioxidant intake such as fruits and vegetables may be helpful to keep the free radicals in check.
Oxidative stress has been found to cause damage to cell lipids, proteins, and DNA, leading to many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
The oxidative stress that causes chronic ailment is a result of a chain reaction started by free radical donating or stealing an electron from another atom, leading to a domino effect that can not be stopped until all outer ring electron of free radicals is paired or inhibited by antioxidants.
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and is highly reactive to react with another cell.
Most free radicals and other ROS are derived internally either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
Antioxidants are biomolecules that inhibit oxidation.
On finding a natural ingredient and whole food for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effect of allicin (the active ingredient of garlic) contained in the commercial preparation Garlicin against hydroxyl radicals (.OH) using high-pressure liquid chromatographic (HPLC) method.
Allicin equivalent in Garlicin (1.8, 3.6, 7.2, 14.4, 21.6, 28.8, and 36 micrograms) produced concentration-dependent decreases in the formation of 2,3-DHBA and 2,5-DHBA, the OH adduct products.
The inhibition of the formation of 2,3-DHBA and 2,5-DHBA with 1.8 micrograms/ml was 32.36% and 43.2% respectively while with 36.0 micrograms/ml the inhibition was approximately 94.0% and 90.0% respectively.
These results suggested that allicin is highly active against the OH adduct products through its free radical scavenging activity.
Furthermore, Allicin also exerted a significant antioxidant activity by preventing the lipid peroxidation of liver homogenate in a concentration-dependent manner.
Additionally, by examining the antioxidant effects of four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers discovered
* Alliin scavenged superoxide, while allyl cysteine and allyl disulfide did not react with superoxide.
* Allicin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol exchange mechanism.
* Allicin did not exhibit hydroxyl radical scavenging activity in this study, probably due to some unknown mechanisms.
The finding suggested that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage.
Taken altogether, allicin-processed high levels of free radicals scavenging activity may be used for the prevention of the overexpression of ROS in the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.
Scientists may have found a dietary and bioactive ingredient for the prevention and treatment of diseases associated with oxidative stress.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
Oxidative stress is a condition characterized by the overexpression of free radicals in the host body.
Most cases of oxidative stress are caused by the inability of the host liver to stimulate the production of antioxidant enzymes which play a critical role in inhibiting the free radical expression, causing oxidative stress.
In a healthy individual, the ratio of free radicals and antioxidant enzymes is always balanced.
However, an individual whose antioxidant enzymes were suppressed due to damage to the antioxidant enzymes' productive system or other sources may have a greater risk of the onset of oxidative stress.
Dietary antioxidant intake such as fruits and vegetables may be helpful to keep the free radicals in check.
Oxidative stress has been found to cause damage to cell lipids, proteins, and DNA, leading to many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
The oxidative stress that causes chronic ailment is a result of a chain reaction started by free radical donating or stealing an electron from another atom, leading to a domino effect that can not be stopped until all outer ring electron of free radicals is paired or inhibited by antioxidants.
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and is highly reactive to react with another cell.
Most free radicals and other ROS are derived internally either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
Antioxidants are biomolecules that inhibit oxidation.
On finding a natural ingredient and whole food for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effect of allicin (the active ingredient of garlic) contained in the commercial preparation Garlicin against hydroxyl radicals (.OH) using high-pressure liquid chromatographic (HPLC) method.
Allicin equivalent in Garlicin (1.8, 3.6, 7.2, 14.4, 21.6, 28.8, and 36 micrograms) produced concentration-dependent decreases in the formation of 2,3-DHBA and 2,5-DHBA, the OH adduct products.
The inhibition of the formation of 2,3-DHBA and 2,5-DHBA with 1.8 micrograms/ml was 32.36% and 43.2% respectively while with 36.0 micrograms/ml the inhibition was approximately 94.0% and 90.0% respectively.
These results suggested that allicin is highly active against the OH adduct products through its free radical scavenging activity.
Furthermore, Allicin also exerted a significant antioxidant activity by preventing the lipid peroxidation of liver homogenate in a concentration-dependent manner.
Additionally, by examining the antioxidant effects of four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers discovered
* Alliin scavenged superoxide, while allyl cysteine and allyl disulfide did not react with superoxide.
* Allicin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol exchange mechanism.
* Allicin did not exhibit hydroxyl radical scavenging activity in this study, probably due to some unknown mechanisms.
The finding suggested that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage.
Taken altogether, allicin-processed high levels of free radicals scavenging activity may be used for the prevention of the overexpression of ROS in the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
#Antioxidant #Isothiocyanates Exert An Anti Proliferative Activity Against Cancers, Researchers Say
Kyle J. Norton
Dithiolthione, a phytochemical found abundantly in cruciferous vegetables may be the next target for the development of chemomedicine for the treatment of cancer without inducing any side effects, some studies suggested.
Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that starts on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissues and organs through blood and fluid circulation.
The causes of cancer are unknown. Epidemiological studies suggested that depending on the type of cancer, the most common risk factors are aging, tobacco, sun exposure, radiation exposure, chemical toxins, viruses and bacteria, change of hormones, family history, excessive alcohol drinking, poor diet, lack of physical activity and overweight or obesity.
However, most people with some of the above risk factors have never developed cancer.
A genetic preposition and acquired genetic mutation are the most risk factors that can precisely predict the percentage of prevalent risk of the onset of the disease.
Mutation of gene TP53 and PTEN. which produces a protein that suppresses the growth of tumors, genetic mutation of BRCA1 and BRCA2 genes is associated with the higher risk of cancer.
In acquiring genetic mutation, some researchers suggested that the result of errors in the cell cycle division caused by long-term exposure to carcinogenic substances such as tobacco smoke and occupations that require chemical exposure that also damages the cells' DNA are also some prevalent factors associated with the increased risk of cancers.
The US National Library of Medicine wrote "For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person's risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller".
Futhermore, on the other front of acquired genetic mutation, Dr. Michael R. Stratton, the lead author in the study "The cancer genome" said, "The cancer cell may have acquired, from exogenous sources, completely new DNA sequences, notably those of viruses such as human papillomavirus, Epstein Barr virus, hepatitis B virus, human T lymphotropic virus 1 and human herpesvirus 8, each of which is known to contribute to the genesis of one or more type of cancer".
Some researchers proposed that cancer may be the result of weakened immunity, Dr. Louise M.E. Janssen, the lead scientist in the study "The immune system in cancer metastasis: friend or foe?" said, " the primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease".
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
In the concerns of chemo drug side effects in the treatment of invasive cancers, researchers in the cancer team at the Shanghai Jiaotong University School of Medicine conducted an experiment to test the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.
The case-control study was conducted in urban Shanghai from December 2006 to December 2008) through a newly established "instant case reporting" system.
Intake of cruciferous vegetable intake and ITC consumption, urinary ITC levels (median (P25, P75)) were 95.0 (66.9, 135.8) g/d, 11.0 (7.1, 16.0) µmol/d, 0.95 (0.12, 2.92) µmol/g Cr respectively in treatment cases, all lower than those of controls, separately 107.4 (80.1, 154.1) g/d, 12.3 (8.0, 18.0) µmol/d, 1.78 (0.53, 5.28) µmol/g Cr with a statistically significant differences of 3.75.
The urinary levels of ITCs all cases were found to a correlation with cruciferous vegetable consumption and dietary ITC exposure.
Further analysis suggested that there is an inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes, and pancreatitis.
Dr. the lead author said, " High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all P trend <0.05)".
Moreover, in the study to test the combination of Thiazolo and isothiocyanates antiproliferative activity in a panel of 8 cancer cell lines, including lung (NCI-H322 and A549), epidermal (A431), glioblastoma (T98G), pancreatic (MIAPaCa-2), prostate (PC-3), human leukemia (HL-60) and breast (T47D) cells, researchers found that
* The application compound showed the induction of apoptosis in A549 cells at 10 μM, as indicated by the increase in the sub-G1 population.
* The compounds also induced apoptosis in HL-60 cells at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells. was also studied.ct
These results suggested that Thiazolo under the influence of isothiocyanates demonstrated potency in the inhibition of all cancer cell lines in a concentration and dose-dependent manner without inducing any side effects.
More importantly, Dr. Figueiredo SM, the lead scientist at the Campus Morro do Cruzeiro in the study "The anti-oxidant properties of isothiocyanates: a review" revealed that ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibit antitumor activity at post-initiation phase.
Additionally, the lead researcher also suggested that ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, and human ovarian cancer cells, and have anti-inflammatory properties in the treatment of human T-cell leukemia cells probably through improving antioxidant status.
Taken altogether, Phytochemical Isothiocyanates found abundantly in cruciferous vegetables may be considered a bioactive functional ingredient for the prevention and treatment of cancers, depending on the large sample size and multi-center in the human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA. (PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(4) The immune system in cancer metastasis: friend or foe? by Janssen LME1, Ramsay EE2, Logsdon CD2, Overwijk WW. (PubMed)
Dithiolthione, a phytochemical found abundantly in cruciferous vegetables may be the next target for the development of chemomedicine for the treatment of cancer without inducing any side effects, some studies suggested.
Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that starts on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissues and organs through blood and fluid circulation.
The causes of cancer are unknown. Epidemiological studies suggested that depending on the type of cancer, the most common risk factors are aging, tobacco, sun exposure, radiation exposure, chemical toxins, viruses and bacteria, change of hormones, family history, excessive alcohol drinking, poor diet, lack of physical activity and overweight or obesity.
However, most people with some of the above risk factors have never developed cancer.
A genetic preposition and acquired genetic mutation are the most risk factors that can precisely predict the percentage of prevalent risk of the onset of the disease.
Mutation of gene TP53 and PTEN. which produces a protein that suppresses the growth of tumors, genetic mutation of BRCA1 and BRCA2 genes is associated with the higher risk of cancer.
In acquiring genetic mutation, some researchers suggested that the result of errors in the cell cycle division caused by long-term exposure to carcinogenic substances such as tobacco smoke and occupations that require chemical exposure that also damages the cells' DNA are also some prevalent factors associated with the increased risk of cancers.
The US National Library of Medicine wrote "For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person's risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller".
Futhermore, on the other front of acquired genetic mutation, Dr. Michael R. Stratton, the lead author in the study "The cancer genome" said, "The cancer cell may have acquired, from exogenous sources, completely new DNA sequences, notably those of viruses such as human papillomavirus, Epstein Barr virus, hepatitis B virus, human T lymphotropic virus 1 and human herpesvirus 8, each of which is known to contribute to the genesis of one or more type of cancer".
Some researchers proposed that cancer may be the result of weakened immunity, Dr. Louise M.E. Janssen, the lead scientist in the study "The immune system in cancer metastasis: friend or foe?" said, " the primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease".
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
In the concerns of chemo drug side effects in the treatment of invasive cancers, researchers in the cancer team at the Shanghai Jiaotong University School of Medicine conducted an experiment to test the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.
The case-control study was conducted in urban Shanghai from December 2006 to December 2008) through a newly established "instant case reporting" system.
Intake of cruciferous vegetable intake and ITC consumption, urinary ITC levels (median (P25, P75)) were 95.0 (66.9, 135.8) g/d, 11.0 (7.1, 16.0) µmol/d, 0.95 (0.12, 2.92) µmol/g Cr respectively in treatment cases, all lower than those of controls, separately 107.4 (80.1, 154.1) g/d, 12.3 (8.0, 18.0) µmol/d, 1.78 (0.53, 5.28) µmol/g Cr with a statistically significant differences of 3.75.
The urinary levels of ITCs all cases were found to a correlation with cruciferous vegetable consumption and dietary ITC exposure.
Further analysis suggested that there is an inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes, and pancreatitis.
Dr. the lead author said, " High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all P trend <0.05)".
Moreover, in the study to test the combination of Thiazolo and isothiocyanates antiproliferative activity in a panel of 8 cancer cell lines, including lung (NCI-H322 and A549), epidermal (A431), glioblastoma (T98G), pancreatic (MIAPaCa-2), prostate (PC-3), human leukemia (HL-60) and breast (T47D) cells, researchers found that
* The application compound showed the induction of apoptosis in A549 cells at 10 μM, as indicated by the increase in the sub-G1 population.
* The compounds also induced apoptosis in HL-60 cells at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells. was also studied.ct
These results suggested that Thiazolo under the influence of isothiocyanates demonstrated potency in the inhibition of all cancer cell lines in a concentration and dose-dependent manner without inducing any side effects.
More importantly, Dr. Figueiredo SM, the lead scientist at the Campus Morro do Cruzeiro in the study "The anti-oxidant properties of isothiocyanates: a review" revealed that ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibit antitumor activity at post-initiation phase.
Additionally, the lead researcher also suggested that ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, and human ovarian cancer cells, and have anti-inflammatory properties in the treatment of human T-cell leukemia cells probably through improving antioxidant status.
Taken altogether, Phytochemical Isothiocyanates found abundantly in cruciferous vegetables may be considered a bioactive functional ingredient for the prevention and treatment of cancers, depending on the large sample size and multi-center in the human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA. (PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB. (PubMed)
(4) The immune system in cancer metastasis: friend or foe? by Janssen LME1, Ramsay EE2, Logsdon CD2, Overwijk WW. (PubMed)
#Healthyfood #CucumberExtract Inhibits Pain and Symptoms of Osteoarthritis Compared to Those of Glucosamine-Chondroitin (GC)
Kyle J. Norton
Osteoarthritis (OA) is a chronic condition affecting the joints in the hands, knees, hips, and spine mostly occurred in older adults.
More precisely, OA is a result in which the protective cartilage on the ends of your bones wears down over time due to repetitive movement of the same joints that cause the thinning cartilage, leading to bone rubbing on bone.
According to the statistics, in the US, over 25 million people are living with OA.
The precisive characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Believe it or not, other causes of OA also include
1. Process of wear and repair
Osteoarthritis (OA), widespread degenerative disease of skeletal joints(34) and is often associated with senescence invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries(35).
The improper repair process of injuring of joints can also result in symptoms of Osteoarthritis (OA)(36) in old age(37), according to TCM.
2. Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA)(35)(38), such as vitamin D.
On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA)(38).
3. Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in your joints and allowed the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone(39)(40).
In other words, osteoarthritis (OA) may also be the result of injuring (35), overuse(15)(16), Rheumatoid Arthritis(41), etc.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of osteoarthritis, researchers evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against glucosamine-chondroitin (GC) in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial that took place in three different centers. included 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA assigned to 2 groups (n= 61).
Among the groups, the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally10 mg twice daily of CSE.
According to the assays, on days 30, 60, 90, 120, 150, and 180 compared to the baseline (Day 0), the WOMAC score in the CSE group was decreased by 22.44% and 70.29% on days 30 and 180, respectively, compared to a 14.80% and 32.81% respectively decrease in the GC group.
The pain scores also showed similar trends in flavor to the CSE group. There was no adverse effect on the course of the experiment.
In other words, CSE is more effective for the treatment of OA compared to that of GC.
Dr. the lead scientists wrote, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
Taken together, cucumber extract may be used for the treatment of OA, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
Osteoarthritis (OA) is a chronic condition affecting the joints in the hands, knees, hips, and spine mostly occurred in older adults.
More precisely, OA is a result in which the protective cartilage on the ends of your bones wears down over time due to repetitive movement of the same joints that cause the thinning cartilage, leading to bone rubbing on bone.
According to the statistics, in the US, over 25 million people are living with OA.
The precisive characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Believe it or not, other causes of OA also include
1. Process of wear and repair
Osteoarthritis (OA), widespread degenerative disease of skeletal joints(34) and is often associated with senescence invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries(35).
The improper repair process of injuring of joints can also result in symptoms of Osteoarthritis (OA)(36) in old age(37), according to TCM.
2. Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA)(35)(38), such as vitamin D.
On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA)(38).
3. Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in your joints and allowed the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone(39)(40).
In other words, osteoarthritis (OA) may also be the result of injuring (35), overuse(15)(16), Rheumatoid Arthritis(41), etc.
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of osteoarthritis, researchers evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against glucosamine-chondroitin (GC) in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial that took place in three different centers. included 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA assigned to 2 groups (n= 61).
Among the groups, the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally10 mg twice daily of CSE.
According to the assays, on days 30, 60, 90, 120, 150, and 180 compared to the baseline (Day 0), the WOMAC score in the CSE group was decreased by 22.44% and 70.29% on days 30 and 180, respectively, compared to a 14.80% and 32.81% respectively decrease in the GC group.
The pain scores also showed similar trends in flavor to the CSE group. There was no adverse effect on the course of the experiment.
In other words, CSE is more effective for the treatment of OA compared to that of GC.
Dr. the lead scientists wrote, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
Taken together, cucumber extract may be used for the treatment of OA, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
#Phytochemical 3,3'-#Diindolylmethane Processes Anti-Malignant Mesothelioma Activity, Scientists Show
Kyle J. Norton
The bioactive compound 3,3'-Diindolylmethane or DIM may process strong and positive effects against the risk and progression of mesothelioma, according to studies.
Mesothelioma is a medical condition characterized by irregular cell growth in the thin layer of tissue that covers the internal organs, due to cell DNA alternation.
However, according to epidemiological studies, the most common area affected is the lining of the lungs and chest wall.
Most cases of mesothelioma start in the cell on the surface of the layered tissue. At the later stage, the cells of the larger size of the tumor can cause secondary tumors to develop in nearby organs and distant locations through the circulation of blood and fluids, leading to secondary metastasis.
The most common symptoms of mesothelioma are persistent dry cough or wheezing, shortness of breath, pain in the chest or abdomen, fatigue, and weakness.
In severe cases, patients may also experience symptoms of respiratory complications such as pleural effusion (fluid around the lungs).
If you experience some of the above symptoms, please check with your doctor to rule out the possibility.
Most common causes of mesothelioma are due to long-term exposure to asbestos as the disease is found in 80% of the patients. However, suggested that genetic preposition may also be the prevalent risk factor of the disease.
Dr. Ombretta Melaiu, the lead scientist in the investigation of the genetic susceptibility in the development of malignant pleural mesothelioma (MPM), wrote, "Among asbestos-exposed workers, several studies reported familial cases of MPM, suggesting that heredity could be important in the tumor development,.... the risk of developing MPM is increased of a limited extent among people exposed to asbestos with a positive history of familial cancers".
And, "In families and in animal models, mutations within BAP1 are strongly predisposing to develop MPM".
The results clearly suggested that if you carry the mutation gene BAP1, you are at a higher risk of MPM and other types of cancer.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Scientists concerned of malignant mesothelioma (MM), a very aggressive, lethal cancer, and its incidence is increasing worldwide examined the dietary phytochemicals that may process the potential for the treatment of MM with no side effects.
The study included several bioactive ingredients such as curcumin, epigallocatechin gallate, quercetin, genistein, pterostilbene, resveratrol, capsaicin, ellagic acid, benzyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, indole-3-carbinol, 3,3'-diindolylmethane (DIM), diallyl disulfide, betulinic acid, and oleanolic acid.
DIM was found to process the anti-MM activity by boosting the function of microRNA in the regulation of the activities of the genes.
MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression against the incidence of cancer. Increased expression of microRNAs is associated with numerous types of cancer.
Overexpression of miR-132 in vivo was associated with the severity of cancer patients.
Injection of DIM exerted anti mesothelioma potentials, through the expression of microRNA regulatory activities.was attributed to the suppression of macrophage infiltration and pro-inflammatory cytokines.
In other words, DIM modulated the immune response against the onset and progression of mesothelioma caused by the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.
Dr. Sayeed MA the lead scientist wrote in the final report, "In addition to microRNA regulatory activities, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, phenethyl isothiocyanate, and sulforaphane have anti-mesothelioma potentials, and pterostilbene, capsaicin, ellagic acid, benzyl isothiocyanate, indole-3-carbinol, 3,3'-diindolylmethane, diallyl disulfide, betulinic acid, and oleanolic acid have potentials to inhibit cancer by regulating the expression of various genes which are also known to be aberrant in MM".
Taken together, DIM may be considered a supplement for the prevention and combined with primary therapy for the treatment of MM, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma by Sayeed MA1, Bracci M2, Lucarini G2, Lazzarini R2, Di Primio R2, Santarelli L. (PubMed)
(2) The genetic susceptibility in the development of malignant pleural mesothelioma by Ombretta Melaiu, Federica Gemignani, and Stefano Landi. (PMC)
The bioactive compound 3,3'-Diindolylmethane or DIM may process strong and positive effects against the risk and progression of mesothelioma, according to studies.
Mesothelioma is a medical condition characterized by irregular cell growth in the thin layer of tissue that covers the internal organs, due to cell DNA alternation.
However, according to epidemiological studies, the most common area affected is the lining of the lungs and chest wall.
Most cases of mesothelioma start in the cell on the surface of the layered tissue. At the later stage, the cells of the larger size of the tumor can cause secondary tumors to develop in nearby organs and distant locations through the circulation of blood and fluids, leading to secondary metastasis.
The most common symptoms of mesothelioma are persistent dry cough or wheezing, shortness of breath, pain in the chest or abdomen, fatigue, and weakness.
In severe cases, patients may also experience symptoms of respiratory complications such as pleural effusion (fluid around the lungs).
If you experience some of the above symptoms, please check with your doctor to rule out the possibility.
Most common causes of mesothelioma are due to long-term exposure to asbestos as the disease is found in 80% of the patients. However, suggested that genetic preposition may also be the prevalent risk factor of the disease.
Dr. Ombretta Melaiu, the lead scientist in the investigation of the genetic susceptibility in the development of malignant pleural mesothelioma (MPM), wrote, "Among asbestos-exposed workers, several studies reported familial cases of MPM, suggesting that heredity could be important in the tumor development,.... the risk of developing MPM is increased of a limited extent among people exposed to asbestos with a positive history of familial cancers".
And, "In families and in animal models, mutations within BAP1 are strongly predisposing to develop MPM".
The results clearly suggested that if you carry the mutation gene BAP1, you are at a higher risk of MPM and other types of cancer.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Scientists concerned of malignant mesothelioma (MM), a very aggressive, lethal cancer, and its incidence is increasing worldwide examined the dietary phytochemicals that may process the potential for the treatment of MM with no side effects.
The study included several bioactive ingredients such as curcumin, epigallocatechin gallate, quercetin, genistein, pterostilbene, resveratrol, capsaicin, ellagic acid, benzyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, indole-3-carbinol, 3,3'-diindolylmethane (DIM), diallyl disulfide, betulinic acid, and oleanolic acid.
DIM was found to process the anti-MM activity by boosting the function of microRNA in the regulation of the activities of the genes.
MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression against the incidence of cancer. Increased expression of microRNAs is associated with numerous types of cancer.
Overexpression of miR-132 in vivo was associated with the severity of cancer patients.
Injection of DIM exerted anti mesothelioma potentials, through the expression of microRNA regulatory activities.was attributed to the suppression of macrophage infiltration and pro-inflammatory cytokines.
In other words, DIM modulated the immune response against the onset and progression of mesothelioma caused by the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.
Dr. Sayeed MA the lead scientist wrote in the final report, "In addition to microRNA regulatory activities, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, phenethyl isothiocyanate, and sulforaphane have anti-mesothelioma potentials, and pterostilbene, capsaicin, ellagic acid, benzyl isothiocyanate, indole-3-carbinol, 3,3'-diindolylmethane, diallyl disulfide, betulinic acid, and oleanolic acid have potentials to inhibit cancer by regulating the expression of various genes which are also known to be aberrant in MM".
Taken together, DIM may be considered a supplement for the prevention and combined with primary therapy for the treatment of MM, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma by Sayeed MA1, Bracci M2, Lucarini G2, Lazzarini R2, Di Primio R2, Santarelli L. (PubMed)
(2) The genetic susceptibility in the development of malignant pleural mesothelioma by Ombretta Melaiu, Federica Gemignani, and Stefano Landi. (PMC)
#Broccoli Improves Post-Ischemic Ventricular Function and Reduces Myocardial Infarction and Cardiomyocyte Apoptosis, Researchers Say
Kyle J. Norton
Acute brain infarction is a severe medical emergency characterized by the obstruction of the blood supply to the brain, causing the local death of the neurons in the brain. Prompt treatment can minimize brain damage and potential complications.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The exact causes of a blood clot that induces acute brain infarction are unknown. However, the trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache, and trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm, or leg, and trouble with seeing in one or both eyes.
Although, there are many factors associated with the risk of acute infarction. some researchers suggested an unhealthy diet may have a strong and negative implication on the onset of the condition.
Dr. Guo J, the lead scientist at the Peking Union Medical College & Chinese Academy of Medical Sciences wrote, "Some dietary patterns are risk factors for acute myocardial infarction (AMI)".
And, "Several dietary frequencies (serves per week) including vegetables, fruits, and tofu were closely associated with a decrease of AMI risk. The carbohydrate pattern showed a weak relationship with AMI. We observed a U-shaped association between frequencies of fat and protein pattern and AMI risk. Excessive fat intake increased the AMI risk.".
With an aim to find a natural food for the prevention and treatment of heart disease, researchers examined the effect of sulforaphane found in broccoli against myocardium from ischaemic reperfusion injury by comparing fresh broccoli and cooked broccoli cardioprotection.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
The study compared the two groups of rats that were fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
Based on the differentiation of isolated working hearts that were subjected to 30 min ischemia followed by 2 h of reperfusion. 30 min ischemia followed by 2 h of reperfusion, both cooked and steamed broccolis displayed significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control.
Additionally, both cooked and steamed broccolis demonstrated significantly enhanced induction of the survival signaling proteins and inhibition of death signaling proteins associated with heart tissue damage.
Furthermore, both cooked and steamed broccoli also protect the heart cells against the overexpression of free radicals by enhancing the levels of antioxidants.
However, steamed broccoli was found to have more cardioprotective abilities compared to those of cooked broccoli.
Moreover, levels of Trx2 and Trx reductase associated with redox activity were only enhanced in the steamed broccoli group.
Based on the findings, researchers said, " The results of the present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx".
Taken together, broccoli processed abundantly SFN may be considered supplements as a cardioprotective remedy, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(2) Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study by Guo J1, Li W, Wang Y, Chen T, Teo K, Liu LS, Yusuf S; INTERHEART China study investigators. (PubMed)
Acute brain infarction is a severe medical emergency characterized by the obstruction of the blood supply to the brain, causing the local death of the neurons in the brain. Prompt treatment can minimize brain damage and potential complications.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The exact causes of a blood clot that induces acute brain infarction are unknown. However, the trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache, and trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm, or leg, and trouble with seeing in one or both eyes.
Although, there are many factors associated with the risk of acute infarction. some researchers suggested an unhealthy diet may have a strong and negative implication on the onset of the condition.
Dr. Guo J, the lead scientist at the Peking Union Medical College & Chinese Academy of Medical Sciences wrote, "Some dietary patterns are risk factors for acute myocardial infarction (AMI)".
And, "Several dietary frequencies (serves per week) including vegetables, fruits, and tofu were closely associated with a decrease of AMI risk. The carbohydrate pattern showed a weak relationship with AMI. We observed a U-shaped association between frequencies of fat and protein pattern and AMI risk. Excessive fat intake increased the AMI risk.".
With an aim to find a natural food for the prevention and treatment of heart disease, researchers examined the effect of sulforaphane found in broccoli against myocardium from ischaemic reperfusion injury by comparing fresh broccoli and cooked broccoli cardioprotection.
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
The study compared the two groups of rats that were fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
Based on the differentiation of isolated working hearts that were subjected to 30 min ischemia followed by 2 h of reperfusion. 30 min ischemia followed by 2 h of reperfusion, both cooked and steamed broccolis displayed significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control.
Additionally, both cooked and steamed broccolis demonstrated significantly enhanced induction of the survival signaling proteins and inhibition of death signaling proteins associated with heart tissue damage.
Furthermore, both cooked and steamed broccoli also protect the heart cells against the overexpression of free radicals by enhancing the levels of antioxidants.
However, steamed broccoli was found to have more cardioprotective abilities compared to those of cooked broccoli.
Moreover, levels of Trx2 and Trx reductase associated with redox activity were only enhanced in the steamed broccoli group.
Based on the findings, researchers said, " The results of the present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx".
Taken together, broccoli processed abundantly SFN may be considered supplements as a cardioprotective remedy, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(2) Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study by Guo J1, Li W, Wang Y, Chen T, Teo K, Liu LS, Yusuf S; INTERHEART China study investigators. (PubMed)
#Herbal #Turmeric Improves Parameters Associated with the Risk of Metabolic Syndrome, Researchers Show
Kyle J. Norton
Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.
People who have 3 or more aforementioned conditions are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed cardiovascular disease (CVD) or diabetes.
Most common symptoms of metabolic symptoms are depending totally on the clustered conditions, including thirst and urination, fatigue, and blurred vision due to high blood glucose. However, in patients with no condition of hyperglycemia, metabolic syndrome is asymptomatic.
Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.
Conventionally, the treatment of metabolic syndrome is totally depending on the cluster of condition. People with fat around the waist or obese are recommended to lose weight in a weight management program accompanied by diet change.
Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.
Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".
And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".
The results clearly suggested if you are following a traditional diet with high fruits and vegetables and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, your risk metabolic syndrome can be decreased substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential compound that processes an anti-metabolic syndrome activity, researchers examined the Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).
The double-blind-randomized-controlled trial included a total of 250 healthy males with MetS randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900mg Black seeds and 1.5g Turmeric/day) or placebo for 8 weeks.
Based on the analysis, compared to the baseline, at 4 weeks, Black seed and Turmeric alone showed improvement in the parameters associated with the risk of MetS including the body-mass-index (BMI), waist circumference (WC), and body-fat-percent (BF%).
Furthermore, also at week 4, the combination improved all parameters involved in the risk of MetS, except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.
Moreover, at 8 weeks, Black seeds reduced lipids and FBG, whereas turmeric reduced LDL-cholesterol and CRP, compared to placebo.
More importantly, the combination group with a 60% dose of the individual herbs showed an improvement in all parameters from baseline, compared to placebo.
In other words, the combination showed complete inhibition of all parameters associated with the onset of metabolic syndrome compared to the selected inhibition of individual herbal medicine. Black seeds + Turmeric showed much better efficacy than the use of Black seed and Turmeric alone.
Based on the results, researchers said, " The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be used alone or combination with Black seed for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)
Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.
People who have 3 or more aforementioned conditions are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed cardiovascular disease (CVD) or diabetes.
Most common symptoms of metabolic symptoms are depending totally on the clustered conditions, including thirst and urination, fatigue, and blurred vision due to high blood glucose. However, in patients with no condition of hyperglycemia, metabolic syndrome is asymptomatic.
Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.
Conventionally, the treatment of metabolic syndrome is totally depending on the cluster of condition. People with fat around the waist or obese are recommended to lose weight in a weight management program accompanied by diet change.
Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.
Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".
And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".
The results clearly suggested if you are following a traditional diet with high fruits and vegetables and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, your risk metabolic syndrome can be decreased substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential compound that processes an anti-metabolic syndrome activity, researchers examined the Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).
The double-blind-randomized-controlled trial included a total of 250 healthy males with MetS randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900mg Black seeds and 1.5g Turmeric/day) or placebo for 8 weeks.
Based on the analysis, compared to the baseline, at 4 weeks, Black seed and Turmeric alone showed improvement in the parameters associated with the risk of MetS including the body-mass-index (BMI), waist circumference (WC), and body-fat-percent (BF%).
Furthermore, also at week 4, the combination improved all parameters involved in the risk of MetS, except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.
Moreover, at 8 weeks, Black seeds reduced lipids and FBG, whereas turmeric reduced LDL-cholesterol and CRP, compared to placebo.
More importantly, the combination group with a 60% dose of the individual herbs showed an improvement in all parameters from baseline, compared to placebo.
In other words, the combination showed complete inhibition of all parameters associated with the onset of metabolic syndrome compared to the selected inhibition of individual herbal medicine. Black seeds + Turmeric showed much better efficacy than the use of Black seed and Turmeric alone.
Based on the results, researchers said, " The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be used alone or combination with Black seed for the prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)
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