Kyle J. Norton
Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.
According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.
Believe it or not, in 2000, prostatitis cost over $84 million, including the charge of diagnosis and treatment.
The most common symptoms of prostatitis are painful, difficult, and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.
In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction, and blood in the urine.
The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.
Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha-blockers to relax the bladder neck, and the muscle fibers, and anti-inflammatory medicine to ease pain and discomforts.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.
Phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by the University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.
At the end of the experiment, the treatment group showed a significant improvement in National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.
Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.
The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and inflammatory cells.
Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".
Taken together, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Saturday, 28 October 2023
#Carrots Inhibit Parameters Associated with a Reduced Risk of #OralDiseases, According to Studies
Kyle J. Norton
Scientists may have found a phytochemical isolated from carrots which process a significant potential to act as a nonsurgical aid in the treatment of oral diseases, some studies suggested.
Oral diseases are groups of a medical condition, including dental cavities, periodontal (gum) disease, oral cancer, oral infectious diseases, trauma from injuries, and hereditary lesions.
Some researchers suggested that oral health is an important part of your overall health.
The Ireland Dental Health Association in the article Links between oral & general health wrote, "A healthy mouth enables not only nutrition of the physical body but also enhances social interaction and promotes self-esteem and feelings of well-being" and "Bacteria from the mouth can cause infection in other parts of the body when the immune system has been compromised by disease or medical treatment".
Therefore, maintaining healthy oral health may result in reducing the risk that links the oral disease to other health problems such as diabetes, heart disease, and stroke.
Truly, there are some tips that may help you to prevent oral health problems, including visiting your dentist one to two times a year for a cleaning and checkup. brush your teeth with fluoride toothpaste a minimum of two times per day, replace your toothbrush or toothbrush head every three to four months, and floss at least once per day, according to the article published on Health Line.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
In the aim to find a natural pigment with potential to improve the oral health, researchers at the Swami Devi Dyal Hospital and Dental College conducted an experiment on some of the various classes of pigments in nature, particularly, the pigment lycopene, a red plant pigment found in tomatoes, apricots, guavas, carrots, watermelons, papayas, and pink grapefruits, with tomatoes being the largest contributor to the dietary intake of humans.
Application of lycopene not only exhibits higher antioxidant activity through the ability as singlet oxygen quenching phytochemical, but also exerts a multifunctional role as a nonsurgical aid in the treatment of oral diseases like leukoplakia, oral submucous fibrosis, lichen planus, oral squamous cell carcinoma, and also prevents the destruction of periodontal tissues.
The findings suggested adding 1 or 2 portions of tomatoes into your daily diet can provide absolute protection for your oral health.
Furthermore, in the examine the link between chronic periodontitis (CP), a multifactorial infect-inflammatory disease caused by the interaction of microbial agents present in the biofilm and oxidative stress (OS), an imbalance of the ratio between free radicals and antioxidant enzymes produced by the host body, researchers at the Federal University Rio Grande do Sul conducted a randomized, controlled, double-blind or blind studies to evaluate the effect of selected antioxidant
in chronic periodontitis patients.
Antioxidant including in the study are lycopene, vitamin C, vitamin E, capsules with fruits/vegetables/berry.
At the final report of the experiment, researchers indicated that only lycopene and vitamin E demonstrated statistically significant improvement when compared to a control group in terms of periodontal parameters.
These results were observed through oxidative stress patterns throughout the study. As only lycopene and vitamin E showed a reduction in the levels of oxidative stress compared to others.
Moreover, in the evaluation of the effect of lycopene along with routine scaling and root planing in terms of changes in clinical parameters and levels of circulating tumor necrosis factor-alpha (TNF-α), salivary interleukin 1beta (IL-1ß), and uric acid in chronic periodontitis, researchers launched a randomized, placebo-controlled, parallel design, double-blinded trial in a total of 42 subjects/
Out of 42 subjects were assigned to the test group (n = 21) received 8 mg lycopene/day and placebo group (n = 21) along with adjunctive scaling and root planing. Patients were monitored at baseline and at 2 months after therapy.
At the end of the study, researchers found that test group (Lycopene) showed better results after therapy compared to the placebo group with all assays, including Periodontal parameters regarding plaque index (PI), modified gingival index (MGI), bleeding on probing (BOP).
Although the serum TNF-α value, the pro-inflammatory cytokine was not statistically significant, it, however, showed an improvement compared to the placebo group.
Taken together, tomato and carrot processed abundant phytochemical lycopene may be an adjunct therapy combined with conventional medicine for the prevention and treatment of oral diseases.
Therefore, adding 2 or 3 portions of tomatoes or carrots or intake of lycopene supplement, according to the guideline on a regular basis may give you a perfect breath and oral health.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Lycopene in Preventing Oral Diseases as a Nonsurgical Aid of Treatment by Gupta S1, Jawanda MK2, Arora V3, Mehta N4, Yadav V(PubMed)
(2) The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review by Muniz FW1, Nogueira SB2, Mendes FL3, Rösing CK4, Moreira MM5, de Andrade GM6, Carvalho Rde S(PubMed)
(3) The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation by Arora N1, Avula H, Avula JK(PubMed)
Scientists may have found a phytochemical isolated from carrots which process a significant potential to act as a nonsurgical aid in the treatment of oral diseases, some studies suggested.
Oral diseases are groups of a medical condition, including dental cavities, periodontal (gum) disease, oral cancer, oral infectious diseases, trauma from injuries, and hereditary lesions.
Some researchers suggested that oral health is an important part of your overall health.
The Ireland Dental Health Association in the article Links between oral & general health wrote, "A healthy mouth enables not only nutrition of the physical body but also enhances social interaction and promotes self-esteem and feelings of well-being" and "Bacteria from the mouth can cause infection in other parts of the body when the immune system has been compromised by disease or medical treatment".
Therefore, maintaining healthy oral health may result in reducing the risk that links the oral disease to other health problems such as diabetes, heart disease, and stroke.
Truly, there are some tips that may help you to prevent oral health problems, including visiting your dentist one to two times a year for a cleaning and checkup. brush your teeth with fluoride toothpaste a minimum of two times per day, replace your toothbrush or toothbrush head every three to four months, and floss at least once per day, according to the article published on Health Line.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
In the aim to find a natural pigment with potential to improve the oral health, researchers at the Swami Devi Dyal Hospital and Dental College conducted an experiment on some of the various classes of pigments in nature, particularly, the pigment lycopene, a red plant pigment found in tomatoes, apricots, guavas, carrots, watermelons, papayas, and pink grapefruits, with tomatoes being the largest contributor to the dietary intake of humans.
Application of lycopene not only exhibits higher antioxidant activity through the ability as singlet oxygen quenching phytochemical, but also exerts a multifunctional role as a nonsurgical aid in the treatment of oral diseases like leukoplakia, oral submucous fibrosis, lichen planus, oral squamous cell carcinoma, and also prevents the destruction of periodontal tissues.
The findings suggested adding 1 or 2 portions of tomatoes into your daily diet can provide absolute protection for your oral health.
Furthermore, in the examine the link between chronic periodontitis (CP), a multifactorial infect-inflammatory disease caused by the interaction of microbial agents present in the biofilm and oxidative stress (OS), an imbalance of the ratio between free radicals and antioxidant enzymes produced by the host body, researchers at the Federal University Rio Grande do Sul conducted a randomized, controlled, double-blind or blind studies to evaluate the effect of selected antioxidant
in chronic periodontitis patients.
Antioxidant including in the study are lycopene, vitamin C, vitamin E, capsules with fruits/vegetables/berry.
At the final report of the experiment, researchers indicated that only lycopene and vitamin E demonstrated statistically significant improvement when compared to a control group in terms of periodontal parameters.
These results were observed through oxidative stress patterns throughout the study. As only lycopene and vitamin E showed a reduction in the levels of oxidative stress compared to others.
Moreover, in the evaluation of the effect of lycopene along with routine scaling and root planing in terms of changes in clinical parameters and levels of circulating tumor necrosis factor-alpha (TNF-α), salivary interleukin 1beta (IL-1ß), and uric acid in chronic periodontitis, researchers launched a randomized, placebo-controlled, parallel design, double-blinded trial in a total of 42 subjects/
Out of 42 subjects were assigned to the test group (n = 21) received 8 mg lycopene/day and placebo group (n = 21) along with adjunctive scaling and root planing. Patients were monitored at baseline and at 2 months after therapy.
At the end of the study, researchers found that test group (Lycopene) showed better results after therapy compared to the placebo group with all assays, including Periodontal parameters regarding plaque index (PI), modified gingival index (MGI), bleeding on probing (BOP).
Although the serum TNF-α value, the pro-inflammatory cytokine was not statistically significant, it, however, showed an improvement compared to the placebo group.
Taken together, tomato and carrot processed abundant phytochemical lycopene may be an adjunct therapy combined with conventional medicine for the prevention and treatment of oral diseases.
Therefore, adding 2 or 3 portions of tomatoes or carrots or intake of lycopene supplement, according to the guideline on a regular basis may give you a perfect breath and oral health.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Lycopene in Preventing Oral Diseases as a Nonsurgical Aid of Treatment by Gupta S1, Jawanda MK2, Arora V3, Mehta N4, Yadav V(PubMed)
(2) The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review by Muniz FW1, Nogueira SB2, Mendes FL3, Rösing CK4, Moreira MM5, de Andrade GM6, Carvalho Rde S(PubMed)
(3) The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation by Arora N1, Avula H, Avula JK(PubMed)
#Honey Inhibits the Growth of #BladderCancer Cells, Scientists Find
Kyle J. Norton
Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of the primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.
At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.
At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. However certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.
The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.
In fact, most people with some of the above risk factors have never developed bladder cancer even they are associated with the increased risk all their life.
Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to the epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.
Sadly, People with gene mutation are at the 70 % higher risk of bladder cancer compared to those do not.
Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".
And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey, is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.
The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).
In vitro studies application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.
FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.
Flow cytometry (FCM). the measurement of cancer cells' physical and chemical characteristics showed a lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.
Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.
And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.
Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".
Taken together, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)
Scientists may have found a natural food source that processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of the primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.
At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distant metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.
At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. However certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition, and exposure to chemicals are at a higher risk of the onset of the disease.
The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.
In fact, most people with some of the above risk factors have never developed bladder cancer even they are associated with the increased risk all their life.
Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to the epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.
Sadly, People with gene mutation are at the 70 % higher risk of bladder cancer compared to those do not.
Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of the p53 gene".
And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey, is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.
The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).
In vitro studies application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.
FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.
Flow cytometry (FCM). the measurement of cancer cells' physical and chemical characteristics showed a lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.
Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.
And, Honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.
Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".
Taken together, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)
#Strawberries Process Anti Inflammatory and Promoted Antioxidant Enzyme Activity, Researchers Find
Kyle J. Norton
Strawberry is a genius of Fragaria × ananassa and belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
Strawberry phenolics have antioxidant and anti-inflammatory action, maybe the potential impact of direct and indirect antimicrobial, anti-allergy, and anti-hypertensive properties, as well as the capacity to inhibit the activities of some physiological enzymes and receptor properties. Other isolated compounds, linocinnamarin (LN) and cinnamic acid (CA) are found to be effective in exhibiting antigen (Ag)-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and may be potentially used for alleviating symptoms of type I allergy and The flavonoids found to suppress the degranulation from Ag-stimulated RBL-2H3 cells to different extents and suggested that strawberry would be of some ameliorative benefit for the allergic symptoms.
References
(1|) The potential impact of strawberries on human health. by Giampieri F, Alvarez-Suarez JM, Mazzoni L, Romandini S, Bompadre S, Diamanti J, Capocasa F, Mezzetti B, Quiles JL, Ferreiro MS, Tulipani S, Battino M.(PubMed)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
Strawberry is a genius of Fragaria × ananassa and belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
Strawberry phenolics have antioxidant and anti-inflammatory action, maybe the potential impact of direct and indirect antimicrobial, anti-allergy, and anti-hypertensive properties, as well as the capacity to inhibit the activities of some physiological enzymes and receptor properties. Other isolated compounds, linocinnamarin (LN) and cinnamic acid (CA) are found to be effective in exhibiting antigen (Ag)-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells and may be potentially used for alleviating symptoms of type I allergy and The flavonoids found to suppress the degranulation from Ag-stimulated RBL-2H3 cells to different extents and suggested that strawberry would be of some ameliorative benefit for the allergic symptoms.
References
(1|) The potential impact of strawberries on human health. by Giampieri F, Alvarez-Suarez JM, Mazzoni L, Romandini S, Bompadre S, Diamanti J, Capocasa F, Mezzetti B, Quiles JL, Ferreiro MS, Tulipani S, Battino M.(PubMed)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
#Turmeric Extract Protects Liver Against Toxicity Induced by Doxorubicin (DOX), Researchers Reveal
Kyle J. Norton
Liver toxicity or hepatotoxicity is a condition in the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function in filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digest food, build strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to the study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, and hepatotoxic and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect against DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
Liver toxicity or hepatotoxicity is a condition in the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function in filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digest food, build strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to the study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, and hepatotoxic and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect against DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
#Honey Inhibits 5-FU Chemotoxicity and Improves 5-FU Chemotherapy in Cancer Patients, Scientists Suggest
Kyle J. Norton
Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.
Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.
However, as cancer progresses, the continued growth of tumors may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.
At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.
According to the statistics from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicines used for the treatment of cancer by killing cancer cells that have been spread to other tissues or organs.
Chemotoxicity is the side effect of chemo drugs.
The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.
According to the information of the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.
The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and easily infected.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In finding a natural ingredient or whole food that processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.
A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.
AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney
After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.
Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.
These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.
Moreover, to find a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.
Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.
Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.
This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.
Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.
The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.
Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)
Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.
Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.
However, as cancer progresses, the continued growth of tumors may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.
At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.
According to the statistics from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.
In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicines used for the treatment of cancer by killing cancer cells that have been spread to other tissues or organs.
Chemotoxicity is the side effect of chemo drugs.
The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.
According to the information of the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.
The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and easily infected.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In finding a natural ingredient or whole food that processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.
A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.
AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney
After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.
Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.
These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.
Moreover, to find a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.
Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.
Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.
This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.
Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.
The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.
Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)
#Chamomile Promotes Wound Healing by Increasing Wound-Breaking Strength, and Protein Collage Content, Researchers Show
Kyle J. Norton
Herbal chamomile expressed significant wound healing effect against injury and bacterial invasion induced more damage to the wound.
According to the Shiraz University of Medical Sciences, C. nobile therapy at 5% C. nobile ointment was an effective antibacterial activity and accelerated the progression of wound healing, in vivo.
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Wound healing is a natural stage of recovery of body injury.
In a Wistar male rats (210.0±4.2 g) divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg) study, groups treated with chamomile extract optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in the regulated immune system.
In the review of skin wound healing of phytomedicine, Dr. Pazyar N, the lead author said, " The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling" and " Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing.....(including chamomile".
The Roskilde Universitet, in support of the wound-healing effect of chamomile, suggested the extract of M. chamomilla administered topically has wound-healing potential in the linear incisional wound, according to an animal study.
Other studies also showed that chamomile proved effective in the treatment of oral mucositis in a hamster model.
Taken together, chamomile no doubt has consisted of significant wound-healing effects by exhibiting increased wound-breaking strength, and protein collage content through topical administration.
However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile). by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats by Oliveira BV1, Barros Silva PG1, Nojosa Jde S2, Brizeno LA3, Ferreira JM4, Sousa FB1, Mota MR1, Alves AP1.(PubMed)
(3) Skin wound healing and phytomedicine: a review by Pazyar N1, Yaghoobi R, Rafiee E, Mehrabian A, Feily A.(PubMed)
(4) Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats by Jarrahi M1, Vafaei AA, Taherian AA, Miladi H, Rashidi Pour A.(PubMed)
(5) Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster by Pavesi VC1, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, Fernandes KP, Mesquita-Ferrari RA, Martins MD.(PubMed)
Herbal chamomile expressed significant wound healing effect against injury and bacterial invasion induced more damage to the wound.
According to the Shiraz University of Medical Sciences, C. nobile therapy at 5% C. nobile ointment was an effective antibacterial activity and accelerated the progression of wound healing, in vivo.
Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Wound healing is a natural stage of recovery of body injury.
In a Wistar male rats (210.0±4.2 g) divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg) study, groups treated with chamomile extract optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in the regulated immune system.
In the review of skin wound healing of phytomedicine, Dr. Pazyar N, the lead author said, " The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling" and " Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing.....(including chamomile".
The Roskilde Universitet, in support of the wound-healing effect of chamomile, suggested the extract of M. chamomilla administered topically has wound-healing potential in the linear incisional wound, according to an animal study.
Other studies also showed that chamomile proved effective in the treatment of oral mucositis in a hamster model.
Taken together, chamomile no doubt has consisted of significant wound-healing effects by exhibiting increased wound-breaking strength, and protein collage content through topical administration.
However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile). by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats by Oliveira BV1, Barros Silva PG1, Nojosa Jde S2, Brizeno LA3, Ferreira JM4, Sousa FB1, Mota MR1, Alves AP1.(PubMed)
(3) Skin wound healing and phytomedicine: a review by Pazyar N1, Yaghoobi R, Rafiee E, Mehrabian A, Feily A.(PubMed)
(4) Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats by Jarrahi M1, Vafaei AA, Taherian AA, Miladi H, Rashidi Pour A.(PubMed)
(5) Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster by Pavesi VC1, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, Fernandes KP, Mesquita-Ferrari RA, Martins MD.(PubMed)
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