Kyle J. Norton
Scientists may have found an herbal spice that processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.
Neuroprotection is an action that involves the use of a natural substance to protect the integrity and viability of neurons against damage or death.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neuro-degenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease.
The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.
A prolonged period of toxins and toxic chemicals accumulated that affect the brain function also have a strong impact on the onset of the disease.
Out of many factors, some researchers suggested that the prevalence of obesity may have some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.
Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".
And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".
The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound that processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.
The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.
Compared to ECAs at the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase in the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.
In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted better neuron-protective and antioxidant activity than of ECAs.
Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.
The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.
Based on the findings, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".
In order to reveal more information about turmeric's neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.
This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, and group 2 received 6 mg/kg nicotine. Groups 3, 4, 5, and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40, and 60 mg/kg i.p. respectively) for 21 days.
According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced the nicotine-induced motor activity disturbances.
Before the injection of curcumin nicotine treatment showed the increase of lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron apoptosis in the hippocampus.
Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.
Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress, and inflammation; and elevating the levels of P-CREB and BDNF associated with the improvement of cognitive function,
Taken together, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neurons' integrity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)
Friday, 27 October 2023
#Turmeric Reverses Stress-Induced Gastric Ulcercation, Researchers Find
Kyle J. Norton
Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss, loss of appetite, and gastrointestinal discomforts.
Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.
The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.
Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.
According to studies gastric ulcers can be preventable, you can protect yourself against the risk of gastric ulcers by
1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration.
2. Reducing intake of NSAID
NSAID has been proven to cause gastric Ulcer(9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.
3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, nitric oxide production, and neutrophil infiltration in the gastric mucosa(13).
4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p<0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p<0.001)(8).
5. Reducing stress
Stress has been found to increase the onset of gastric ulcers in people who suffered from the Great East Japan earthquake and tsunami. The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of gastric ulcers, researchers examined the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.
Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.
More precisely, MTrPP exerted an effective muco-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, and higher antioxidant/cytoprotective mechanisms associated with the gastric lesion.
By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.
In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.
In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.
According to the observation of 72 hours periodically and mortality recorded up to seven days, the application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.
Both the test drugs showed a significantly reversed stress-induced gastric ulceration compared to stress-control rats.
Taken together, curcumin used in the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcers, pending large sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton
Gastric or stomach ulcer is a condition of localized tissue erosion in the lining of the stomach.
The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss, loss of appetite, and gastrointestinal discomforts.
Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.
The imbalance between stomach acid and upper GI tract mucosa is the main cause of the condition onset associated with the use of certain medications, including aspirin, non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, and chronic gastritis.
Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.
According to studies gastric ulcers can be preventable, you can protect yourself against the risk of gastric ulcers by
1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration.
2. Reducing intake of NSAID
NSAID has been proven to cause gastric Ulcer(9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.
3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, nitric oxide production, and neutrophil infiltration in the gastric mucosa(13).
4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p<0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p<0.001)(8).
5. Reducing stress
Stress has been found to increase the onset of gastric ulcers in people who suffered from the Great East Japan earthquake and tsunami. The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural compound for the treatment of gastric ulcers, researchers examined the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.
Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.
More precisely, MTrPP exerted an effective muco-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, and higher antioxidant/cytoprotective mechanisms associated with the gastric lesion.
By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.
In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.
In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.
According to the observation of 72 hours periodically and mortality recorded up to seven days, the application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.
Both the test drugs showed a significantly reversed stress-induced gastric ulceration compared to stress-control rats.
Taken together, curcumin used in the intact (TrPP) and modified, and low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcers, pending large sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton
#ManukaHoney (MH) and #TualangHoney (TH) Process Anti Microbial Property, According to Studies
Kyle J. Norton
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria are killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, and skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiple disease in the specific tissues and organs, leading to colonization and facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by the persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These results firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony-forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity is processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumonia, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS), and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken together, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria are killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, and skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiple disease in the specific tissues and organs, leading to colonization and facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by the persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These results firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
In finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony-forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity is processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumonia, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS), and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken together, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Thursday, 26 October 2023
#Healthyfood #Tomato and Its #Lycopene Increase Insulin Sensitivity in Diabetics, Researchers Find
Kyle J. Norton
Glucose intolerance is a condition of cluster of metabolic conditions associated with higher-than-normal blood glucose levels.
Glucose tolerance is a test that examines how fast glucose is cleared from the blood.
Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the condition of elevated blood glucose that is below the diabetes
* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L
* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.
Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.
The most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,
Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.
Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".
"The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes induced by a high-saturated-fat (HSF) diet in vivo.
The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.
According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found in non-DTP treated groups.
In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance by increasing insulin sensitivity in the tested subject.
Also, in high-fat diet (HF)-induced obese mice treated by tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.
More precisely, TVB exerted anti-diabetic effect by TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, associated with enhanced glucose metabolism in obese mice.
The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.
Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for the improvement of glucose tolerance, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, PhD, RD. (PubMed)
Glucose intolerance is a condition of cluster of metabolic conditions associated with higher-than-normal blood glucose levels.
Glucose tolerance is a test that examines how fast glucose is cleared from the blood.
Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the condition of elevated blood glucose that is below the diabetes
* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L
* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.
Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.
The most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,
Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.
Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".
"The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes induced by a high-saturated-fat (HSF) diet in vivo.
The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.
According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found in non-DTP treated groups.
In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance by increasing insulin sensitivity in the tested subject.
Also, in high-fat diet (HF)-induced obese mice treated by tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.
More precisely, TVB exerted anti-diabetic effect by TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, associated with enhanced glucose metabolism in obese mice.
The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.
Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for the improvement of glucose tolerance, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, PhD, RD. (PubMed)
#Strawberry Inhibits Human Type 1 Allergy by Regulating Immune Cell Function, According to Studies
Kyle J. Norton
Scientists may have found a tasty whole food for the prevention and treatment of type 1 allergy with no side effects, according to studies.
The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.
According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.
Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.
Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.
The genetic proposition is also one of the prevalent risk factors for the allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".
The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with the allergic diathesis.,...
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
In finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.
Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against the exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.
On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).
The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.
Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen by LN and CA is mainly due to the inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.
Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".
Other bioactive compounds isolated from strawberries including the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.
The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.
The treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.
Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".
Taken together, strawberries, the tasty fruits processed with high amounts of bioactive compounds may be considered a functional fruit for the prevention and treatment of type 1 allergy with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
Scientists may have found a tasty whole food for the prevention and treatment of type 1 allergy with no side effects, according to studies.
The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.
According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.
Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.
Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.
The genetic proposition is also one of the prevalent risk factors for the allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".
The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with the allergic diathesis.,...
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
In finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.
Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against the exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.
On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).
The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.
Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen by LN and CA is mainly due to the inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.
Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".
Other bioactive compounds isolated from strawberries including the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.
The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.
The treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.
Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".
Taken together, strawberries, the tasty fruits processed with high amounts of bioactive compounds may be considered a functional fruit for the prevention and treatment of type 1 allergy with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
Quality Intake Per Week of #Onion Linearly Associated with A Reduced Risk of #@EndometrialCancer, Researchers Suggest
Kyle J. Norton
The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.
The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.
Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cell growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.
Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.
According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.
The most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for account for over 80% of cases of endometrial cancer that begins with irregular cell growth in the surface cells of the inner lining of the endometrium
Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.
* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, accounts for only 2 percent of all uterine cancers, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originating in the non-glandular connective tissue of the endometrium, with unknown origin.
* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer that originates from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and is not very responsive to chemotherapy or radiation.
* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.
According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake was 0.94 for <2 portions/week compared to garlic of 0.89.
The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.
In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.
Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.
Based on the findings, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".
Taken together, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.
The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.
Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cell growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.
Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.
According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.
The most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for account for over 80% of cases of endometrial cancer that begins with irregular cell growth in the surface cells of the inner lining of the endometrium
Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.
* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, accounts for only 2 percent of all uterine cancers, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originating in the non-glandular connective tissue of the endometrium, with unknown origin.
* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer that originates from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and is not very responsive to chemotherapy or radiation.
* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.
According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake was 0.94 for <2 portions/week compared to garlic of 0.89.
The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.
In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.
Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.
Based on the findings, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".
Taken together, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
#StrawberryExtract and Its Tannin-Rich Fraction Process Anti-Benign Prostatic Hyperplasia and Anti-Prostate Cancer Activity, Researchers Find
Kyle J. Norton
Scientists may have found a tasty whole fruit for the prevention and treatment of benign prostatic hyperplasia (enlarged prostate) and prostate cancer with no side effects, according to studies.
Benign prostatic hyperplasia happens mostly in the older age population group and is a condition of an enlarged prostate that can cause some serious urinary symptoms, such as blocking the flow of urine out of the bladder.
In many cases, an enlarged prostate can also induce bladder, urinary tract, or kidney problems and prostate cancer.
Prostate cancer is a slow growth and medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland
At the advanced stage, the cancerous cell can travel a distance away from the prostate to infect other healthy tissue, through blood and fluid circulation.
The causes of prostate cancer are unknown. Epidemiologically, researchers do know that the increase in age, ethnicity, family history, the genetic preposition of BRCA1 and/or BRCA2, and agent orange exposure is associated with an increased risk of the disease.
Some researchers suggested that poor eating habits and lifestyle are the most common risk factors associated with the onset of benign prostatic hyperplasia and prostate cancer. Therefore, by changing to a healthy diet, the risk of benign prostatic hyperplasia and prostate cancer may be preventable.
Dr. Devrim E, in the concern of the widespread prostate cancer and benign prostatic hyperplasia (BPH), over the last few decades said, "Garlic and its preparations have been used for the treatment of prostate cancer and relief of BPH symptoms for decades. It is thought that the mechanism(s) through which garlic may show anti-cancer and anti-inflammatory effects".
These results suggested adding garlic to your diet daily can decrease the incidence of both benign prostatic hyperplasia and prostate cancer with no side effects.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
Starting at age 40, the levels of the by-product prolactin of testosterone in men increase, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of an enlarged prostate is to naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of an enlarged prostate. Prostate Cancer is defined as a condition of the abnormal proliferation of cells in the prostate.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
With an aim to find the natural compound that processes the potency to inhibit benign prostatic hyperplasia (BPH), a common disease of the prostate that affects men as they age, and a risk factor for developing prostate cancer with no side effects, researchers at the Monash University looked into the anti-BPH activity of lycopene found abundantly in the strawberry by searching the database of medical literature.
Out of many medical studies that were examined, only 8 published randomized controlled trials (RCTs) comparing lycopene to placebo (or other interventions) for the treatment of BPH and prostate cancer met the inclusion criteria selected for this systematic review.
A meta-analysis of two studies indicated a decrease in PSA levels in men diagnosed with prostate cancer, who received lycopene compared to placebo.
In a human prostate epithelial cell line (P21) and two tumor cell lines (P21 tumor cell line 1 and 2) derived from the same patient, and a normal human breast epithelial cell line (B42) and a tumor line derived from it (B42 clone 16), researchers examined the cytotoxic effects of strawberry polyphenols.
By applying the polyphenol-rich extract derived from strawberry or anthocyanin or tannin-rich sub-fractions to the cell lines in doses varying from 50 to 1.5 microg/ml, researchers discovered the strawberry extract inhibited over 50% in cell survival of both the normal and the tumor lines with the doses of approximately 5 microg/ml.
The extracts were found to exert cytotoxicity to peripheral blood human lymphocytes with the doses higher levels of 20 microg/ml for a similar effect of a 50% reduction in cell survival.
Compound analysis assay suggested that the cytotoxicity retained in the tannin-rich fraction was considerably more toxic to all cells (normal or tumor cell lines or lymphocytes) than the anthocyanin-rich fraction tannin-rich fraction.
Furthermore, In LNCaP and PC-3) tumor cell lines, strawberry extract with concentrations of 50 microg/ml was required for a 50% reduction in cell survival.
The finding suggested that strawberries processed with high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of benign prostatic hyperplasia (BPH) and prostate cancer without inducing any side effects
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review by Ilic D, Misso M.(PubMed)
(2) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed)
(3) Lycopene for the prevention of prostate cancer by Ilic D, Forbes KM, Hassed C.(PubMed)
(4) Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? by Devrim E1, Durak I. (PubMed)
Scientists may have found a tasty whole fruit for the prevention and treatment of benign prostatic hyperplasia (enlarged prostate) and prostate cancer with no side effects, according to studies.
Benign prostatic hyperplasia happens mostly in the older age population group and is a condition of an enlarged prostate that can cause some serious urinary symptoms, such as blocking the flow of urine out of the bladder.
In many cases, an enlarged prostate can also induce bladder, urinary tract, or kidney problems and prostate cancer.
Prostate cancer is a slow growth and medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland
At the advanced stage, the cancerous cell can travel a distance away from the prostate to infect other healthy tissue, through blood and fluid circulation.
The causes of prostate cancer are unknown. Epidemiologically, researchers do know that the increase in age, ethnicity, family history, the genetic preposition of BRCA1 and/or BRCA2, and agent orange exposure is associated with an increased risk of the disease.
Some researchers suggested that poor eating habits and lifestyle are the most common risk factors associated with the onset of benign prostatic hyperplasia and prostate cancer. Therefore, by changing to a healthy diet, the risk of benign prostatic hyperplasia and prostate cancer may be preventable.
Dr. Devrim E, in the concern of the widespread prostate cancer and benign prostatic hyperplasia (BPH), over the last few decades said, "Garlic and its preparations have been used for the treatment of prostate cancer and relief of BPH symptoms for decades. It is thought that the mechanism(s) through which garlic may show anti-cancer and anti-inflammatory effects".
These results suggested adding garlic to your diet daily can decrease the incidence of both benign prostatic hyperplasia and prostate cancer with no side effects.
Strawberry is a genius of Fragaria × ananassa and belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
Starting at age 40, the levels of the by-product prolactin of testosterone in men increase, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of an enlarged prostate is to naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of an enlarged prostate. Prostate Cancer is defined as a condition of the abnormal proliferation of cells in the prostate.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
With an aim to find the natural compound that processes the potency to inhibit benign prostatic hyperplasia (BPH), a common disease of the prostate that affects men as they age, and a risk factor for developing prostate cancer with no side effects, researchers at the Monash University looked into the anti-BPH activity of lycopene found abundantly in the strawberry by searching the database of medical literature.
Out of many medical studies that were examined, only 8 published randomized controlled trials (RCTs) comparing lycopene to placebo (or other interventions) for the treatment of BPH and prostate cancer met the inclusion criteria selected for this systematic review.
A meta-analysis of two studies indicated a decrease in PSA levels in men diagnosed with prostate cancer, who received lycopene compared to placebo.
In a human prostate epithelial cell line (P21) and two tumor cell lines (P21 tumor cell line 1 and 2) derived from the same patient, and a normal human breast epithelial cell line (B42) and a tumor line derived from it (B42 clone 16), researchers examined the cytotoxic effects of strawberry polyphenols.
By applying the polyphenol-rich extract derived from strawberry or anthocyanin or tannin-rich sub-fractions to the cell lines in doses varying from 50 to 1.5 microg/ml, researchers discovered the strawberry extract inhibited over 50% in cell survival of both the normal and the tumor lines with the doses of approximately 5 microg/ml.
The extracts were found to exert cytotoxicity to peripheral blood human lymphocytes with the doses higher levels of 20 microg/ml for a similar effect of a 50% reduction in cell survival.
Compound analysis assay suggested that the cytotoxicity retained in the tannin-rich fraction was considerably more toxic to all cells (normal or tumor cell lines or lymphocytes) than the anthocyanin-rich fraction tannin-rich fraction.
Furthermore, In LNCaP and PC-3) tumor cell lines, strawberry extract with concentrations of 50 microg/ml was required for a 50% reduction in cell survival.
The finding suggested that strawberries processed with high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of benign prostatic hyperplasia (BPH) and prostate cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review by Ilic D, Misso M.(PubMed)
(2) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed)
(3) Lycopene for the prevention of prostate cancer by Ilic D, Forbes KM, Hassed C.(PubMed)
(4) Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? by Devrim E1, Durak I. (PubMed)
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