Kyle J. Norton
Antiplatelet activity is an action that prevents and treats blood clots.
Platelets are tiny blood cells that protect the other to prevent injury and infection by forming clots to stop bleeding.
Platelets are made in the bone marrow which also produces white and red blood cells.
Diseases associated with low and abnormal blood platelets include
* Thrombocytopenia is a condition characterized by low blood platelets due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, and nosebleed.
Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.
* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.
* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.
Most cases of secondary thrombocytosis are associated with other medical conditions such as anemia. The most common symptoms of secondary thrombocytosis are infection, inflammation, some types of cancer, and reactions to medicines.
* Platelet dysfunction is a rare condition that links to poor platelet function. In other words, it is a disease caused by abnormal function of blood platelets without affecting the number of platelets in the blood.
This means the number of platelets is normal, but the platelets don't work as they should. Medicines such as aspirin can cause this. It's important to know which medicines affect platelets. Know that while taking these medicines you have an increased risk of bleeding.
Antiplatelet agents used in conventional medicine process the main function to prevent platelets from clumping. However, they also exert a similar effect as anticoagulation in the prevention of blood clots from forming and growing.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of platelet aggression against the risk of cardiovascular disease, researchers examined the pharmacological aspect of onion antiplatelet activity in human subjects
The study included 12 human subjects who received yellow hybrid storage onions that were steamed for 0, 1, 3, 6, 10, and 15 min.
According to the tested assay, steamed onions not only destroyed the antiplatelet activity between 3 and 6 min of steaming but also stimulated platelet activity at 10 min of steaming without affecting the polyphenolic concentration and soluble solids.
Furthermore, cooked onion extracts also reverse the inhibitory effect on blood platelets by 25%, compared to steamed onion.
The findings were consistent across all donors.
The results strongly suggested that cooked onion preparations may result in the destruction or reversal of antiplatelet activity.
Moreover, in examining the anti-blood platelet activity of f2 different cooking systems of a convection oven and microwaves) in several time-temperature variables, researchers also found that
* Whole", "quarters", and "crushed" onions lost their antiplatelet activity after 30, 20, and 10 min of oven heating, respectively.
* Extensively cooked onions may stimulate platelet aggregation instead of antiplatelet aggregation.
Collectively, raw onion processed anti-antiplatelet activity compared to the cooked and extensive cooked onion in the promotion of platelet aggregation
Taken together, raw onion may be considered an antiplatelet remedy for the prevention and treatment of cardiovascular disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Steam-cooking rapidly destroys and reverses onion-induced antiplatelet activity by Hansen EA1, Folts JD, Goldman IL. (PubMed)
(2) Effect of processing and cooking conditions on onion (Allium cepa L.) induced antiplatelet activity and thiosulfinate content by Cavagnaro PF1, Galmarini CR. (PubMed)
Tuesday, 24 October 2023
#Phytochemical Allicin Processes Anti Hyper Cholesterol Activity, According to Studies
Kyle J. Norton
Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from dietary sources. High-density lipoprotein neutralizes the levels of LDL by returning them to the liver.
Some researchers suggested that diets high in trans fats, saturated fat, sugar, smoking, and medical conditions such as diabetes or high blood pressure are associated with an increased risk of high blood cholesterol.
Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole grains has a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.
Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".
The finding clearly suggested that if you follow a diet with high in saturated and trans fat, red meat, and processed food and low in fruits and vegetables and whole-grain, you are at an increased risk of high blood cholesterol.
High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.
In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not only in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also in decreasing appetite daily.
Other in the study of the same but with rats fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels, and systolic blood pressure in hypercholesterolemic rats. These results showed that allicin may be considered a potent agent in treating hypercholesterol in the future.
In finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.
Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.
After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.
The allicin alkaline-fed group also showed the most decrease in daily food consumption compared to control.
Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.
These results suggested that allicin has potential value as a cholesterol-lowering candidate, and may be used for protection against the onset of atherosclerosis.
Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed normal diet researchers found that* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.
* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.
* The blood pressure of the high-cholesterol diet animals was significantly higher compared to the animals receiving the control diet.
* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.
Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglyceride levels, and systolic blood pressure in hypercholesterolemic rats.
Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)
Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.
Allicin is a phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from dietary sources. High-density lipoprotein neutralizes the levels of LDL by returning them to the liver.
Some researchers suggested that diets high in trans fats, saturated fat, sugar, smoking, and medical conditions such as diabetes or high blood pressure are associated with an increased risk of high blood cholesterol.
Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole grains has a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.
Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".
The finding clearly suggested that if you follow a diet with high in saturated and trans fat, red meat, and processed food and low in fruits and vegetables and whole-grain, you are at an increased risk of high blood cholesterol.
High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.
In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not only in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also in decreasing appetite daily.
Other in the study of the same but with rats fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels, and systolic blood pressure in hypercholesterolemic rats. These results showed that allicin may be considered a potent agent in treating hypercholesterol in the future.
In finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.
Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.
After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.
The allicin alkaline-fed group also showed the most decrease in daily food consumption compared to control.
Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.
These results suggested that allicin has potential value as a cholesterol-lowering candidate, and may be used for protection against the onset of atherosclerosis.
Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed normal diet researchers found that* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.
* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.
* The blood pressure of the high-cholesterol diet animals was significantly higher compared to the animals receiving the control diet.
* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.
Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglyceride levels, and systolic blood pressure in hypercholesterolemic rats.
Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)
#Herbal #Bilberry's Purified Anthocyanin Inhibits and Slows Progression of #Parkinson's disease (PD), According to Studies
Kyle J. Norton
Parkinson's disease (PD) is a chronic and medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling movement.
Some patients in the very early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
Researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even if they have similar health conditions and are from the same family.
However, they do know, according to the epidemiological study, that age, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.
Please note that most people process some of the conditions that have never developed Parkinson's disease.
Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea, and cola are less likely to get Parkinson's disease compared to those who don't.
Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".
And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".
The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural ingredient that processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.
V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).
The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.
According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.
The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.
Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)
Parkinson's disease (PD) is a chronic and medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling movement.
Some patients in the very early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
Researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even if they have similar health conditions and are from the same family.
However, they do know, according to the epidemiological study, that age, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.
Please note that most people process some of the conditions that have never developed Parkinson's disease.
Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea, and cola are less likely to get Parkinson's disease compared to those who don't.
Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".
And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".
The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural ingredient that processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.
V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).
The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.
According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.
The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.
Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".
Taken together, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)
#Herbal #Ashwagandha Inhibits Symptoms and Enhances Treatment in Patients with HIV Infection Through Its #Immunomodulatory Effects, Researchers Find
Kyle J. Norton
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).
Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).
According to the statistic, AIDS is the fifth leading cause of death in the US.
People between ages 25 and 44 in the United States are at substantially higher risk compared to other age groups.
Approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mother to children.
Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.
According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mother to children.
If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, swollen lymph nodes,...
If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.
The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, received two capsules of the test drug twice daily for 18 months.
According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.
The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.
Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.
Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.
However, mild gastrointestinal adverse effects had been reported by some of the participants.
Based on the evidence, researchers said, "Herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".
Taken together, Ashwagandha may be considered supplements for the prevention and treatment of HIV infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).
Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).
According to the statistic, AIDS is the fifth leading cause of death in the US.
People between ages 25 and 44 in the United States are at substantially higher risk compared to other age groups.
Approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mother to children.
Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.
According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, infected mother to children.
If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, swollen lymph nodes,...
If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.
The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, received two capsules of the test drug twice daily for 18 months.
According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.
The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.
Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.
Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.
However, mild gastrointestinal adverse effects had been reported by some of the participants.
Based on the evidence, researchers said, "Herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".
Taken together, Ashwagandha may be considered supplements for the prevention and treatment of HIV infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)
#Phytochemical #Indicaxanthin Inhibits the Formation of Plagues that Cause #Atherosclerosis, Researchers Suggest
Kyle J. Norton
Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.
Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.
However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.
Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery
Most people with atherosclerosis are asymptomatic at the early stage.
Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplements is also found to elevated the condition risk, particularly in the elderly.
Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.
Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise.
Dr. Singh RB, the lead scientist wrote, "Adherence to diet and exercise was obtained through questionnaires and information obtained was quantified into a formula. After 24 weeks, the overall score of diet and exercises were significantly higher in group A(intervention diet( than in group B(control). There was a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of betalains, found abundantly in beets, chard, etc.
With an aim to find a natural compound for the treatment of atherosclerosis, researchers at the Università di Palermo investigated the effect of phytochemical indicaxanthin (Ild) a major compound found in beetroot on human atheromas.
7-Ketocholesterol (7-KC)-induced the development of human atheromas, according to the kinetic measurements within 24 h, before injection of indicaxanthin showed the early formation of intracellular reactive oxygen species over basal levels, preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺, involved in reactive oxygen species (ROS) production. and associated with the progressive depletion of antioxidant activity of total thiols.
Furthermore, 7-KC- also induced the expression of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) associated with the production of proinflammatory cytokines and innate and adaptive immune response.
Where 7-Ketocholesterol (7-KC) induced apoptosis of macrophages has been found to elevated the plaque progression and endoplasmic reticulum stress caused by the secretion of pro-inflammatory, procoagulant, and proteolytic molecules by macrophages.
Believe it or not, Co-incubation of 2·5 μm of indicaxanthin completely prevented 7-KC-induced pro-apoptotic events.
In other words, indicaxanthin protects the macrophage's integrity against apoptosis, thus reducing the risk of plaque accumulated on the wall of the arteries in facilitating the onset of atherosclerosis.
Based on the findings, researchers concluded, "The effects of Ind may be ascribed to inhibition of NOX-4 basal activity and over-expression, inhibition of NF-κB activation, maintaining cell redox balance and Ca homeostasis, with the prevention of mitochondrial damage and consequently apoptosis".
Taken together, phytochemical indicaxanthin (Ild) found in beetroot may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Intake of indicaxanthin (Ild) in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)
(3) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)
Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.
Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.
However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.
Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery
Most people with atherosclerosis are asymptomatic at the early stage.
Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplements is also found to elevated the condition risk, particularly in the elderly.
Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.
Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise.
Dr. Singh RB, the lead scientist wrote, "Adherence to diet and exercise was obtained through questionnaires and information obtained was quantified into a formula. After 24 weeks, the overall score of diet and exercises were significantly higher in group A(intervention diet( than in group B(control). There was a significant decrease in serum total cholesterol (13.3%), low-density lipoprotein cholesterol (16.9%), triglycerides (19.2%), fasting blood glucose (19.5%) and blood pressures (11.5/6.2 mm Hg) in the intervention group compared with initial levels and changes in group B".
Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of betalains, found abundantly in beets, chard, etc.
With an aim to find a natural compound for the treatment of atherosclerosis, researchers at the Università di Palermo investigated the effect of phytochemical indicaxanthin (Ild) a major compound found in beetroot on human atheromas.
7-Ketocholesterol (7-KC)-induced the development of human atheromas, according to the kinetic measurements within 24 h, before injection of indicaxanthin showed the early formation of intracellular reactive oxygen species over basal levels, preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺, involved in reactive oxygen species (ROS) production. and associated with the progressive depletion of antioxidant activity of total thiols.
Furthermore, 7-KC- also induced the expression of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) associated with the production of proinflammatory cytokines and innate and adaptive immune response.
Where 7-Ketocholesterol (7-KC) induced apoptosis of macrophages has been found to elevated the plaque progression and endoplasmic reticulum stress caused by the secretion of pro-inflammatory, procoagulant, and proteolytic molecules by macrophages.
Believe it or not, Co-incubation of 2·5 μm of indicaxanthin completely prevented 7-KC-induced pro-apoptotic events.
In other words, indicaxanthin protects the macrophage's integrity against apoptosis, thus reducing the risk of plaque accumulated on the wall of the arteries in facilitating the onset of atherosclerosis.
Based on the findings, researchers concluded, "The effects of Ind may be ascribed to inhibition of NOX-4 basal activity and over-expression, inhibition of NF-κB activation, maintaining cell redox balance and Ca homeostasis, with the prevention of mitochondrial damage and consequently apoptosis".
Taken together, phytochemical indicaxanthin (Ild) found in beetroot may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Intake of indicaxanthin (Ild) in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)
(3) Effects of diet and lifestyle changes on atherosclerotic risk factors after 24 weeks on the Indian Diet Heart Study by Singh RB1, Singh NK, Rastogi SS, Mani UV, Niaz MA. (PubMed)
#Daidzein and the Garlic Enzyme Alliinase Induce #OvarianCancer Cell Apoptosis through Its Cytotoxic Effects, According to Studies
Kyle J. Norton
Ovarian cancer is a chronic medical condition caused by cell growth irregularly in the tissue of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progresses, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvic area, and changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman's risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate is specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imaging in the luciferase expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to the placebo, only small individual foci of luminescence at the site of tumor cells inoculation were found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cell apoptosis through its cytotoxic effects without causing harm to nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken together, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
Ovarian cancer is a chronic medical condition caused by cell growth irregularly in the tissue of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progresses, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvic area, and changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman's risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to the epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate is specifically bound to ovarian cancer cells and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imaging in the luciferase expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to the placebo, only small individual foci of luminescence at the site of tumor cells inoculation were found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cell apoptosis through its cytotoxic effects without causing harm to nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken together, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
#ManukaHoney Inhibits Parameters Associated with the Risk of Acute and Chronic Inflammatory Diseases, Researchers Find
Kyle J. Norton
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulate the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms that may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead to the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "The beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the study, the Manuka honey-treated group displayed a significantly decreased ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken together, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulate the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms that may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead to the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "The beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the study, the Manuka honey-treated group displayed a significantly decreased ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken together, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
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