Kyle J. Norton
Osteoarthritis (OA), a form of arthritis, is a chronic condition found mostly in the elderly and caused by wear and tear on a joint.
The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The condition affects over 25 million people in the United States.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.
Most common causes of OA are
* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long-term wear and tear, heavy long-term use, or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.
* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA).
* Cartilage
Cartilage is a flexible connective tissue that cushions the ends of bones in the joints that allowing the joints to move smoothly. Rough or worn down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.
The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,
In other words, lifelong protection of cartilage and joint damage and injury has an inverse association with the risk of OA.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.
The study included 103 patients with osteoarthritis of the knee randomly receiving either the combination of bromelain, trypsin, and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.
According to the tested assay,
* The mean value of the Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.
* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).
Where LFI is a measurement of the severity of osteoarthritis.
* ERC also showed the superior improvement of secondary efficacy criteria, compared to diclofenac
* The global judgment of efficacy by physician resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.
Furthermore, the majority of patients rate the tolerability in both drug groups as very good or good.
Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".
Taken together, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of Musculoskeletal Disorders (MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
Monday, 23 October 2023
#Phytochemical #Alliin Isolated from Garlic Inhibits #BreastCancer by Reducing Cell Proliferation and Metastasis, Researchers Suggest
Kyle J. Norton
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer begin in the cells on the surface of inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the early stage, breast cancer is a painless lump in the breast or armpit. However, at the later stage, most women with breast cancer may experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple, persistent tenderness of the breast and
unusual breast pain or discomfort.
According to statistics, the 5 years survival rate of early diagnosed breast cancer is closed to 100%.
However, in the rare case of aggressive inflammatory breast cancer (IBC) that induces the growth in sheets instead of lumps and invades nearby skin, the whole breast may go suddenly red and feel hot, resembling an inflammation.
The disease only occurs in 1-6% of all breast cancer cases in the USA. Women with IBC are first treated with chemotherapy before surgery. On average, the 5-year survival rate of women diagnosed with inflammatory breast cancer is 34% compared to the early stage of breast cancer of 100%.
Out of many risk factors associated with the risk of breast cancer, the genetic proposition is one of the factors that may predict the onset of the disease.
Dr. Turnbull C, the lead scientist said, "BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional cloning. Mutational screening of genes functionally related to BRCA1 and/or BRCA2 has revealed four genes, CHEK2, ATM, BRIP1, and PALB2; mutations in these genes are rare and confer an intermediate risk of breast cancer".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, and a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural potential for the treatment of breast cancer, researchers examined the combination of garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) effect on breast adenocarcinoma MCF-7 cells.
According to Western blotting assay, alliin and PTX worked synergistically to promote and potentiate apoptosis in MCF-7 cells by inhibiting the altered expression of importin-9 (IPO9) involved in transcription, cell signaling, and cell cycle regulation.
Furthermore, the inhibition of the IPO9 expression was also found to correlate with a significant reduction in the apoptotic cell population as well as with a decrease in F-actin content in the cancer cells, leading to alteration of cell DNA and in the cortical and nuclear/perinuclear areas of the cells.
Simultaneously, the inhibition of IPO9 by alliin and PTX was also accompanied by the increased post-translational expression of CFL1 associated with the reduction of cell proliferation and metastasis.
In other words, garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) induced breast cancer MCF-7 cell death by inhibiting the protein associated with cell differentiation and division through the reduction of cell proliferation and metastasis.
The combined compound exhibited anti-MCF-7 cell activity by targeting modulating the cytoskeleton present in the cytoplasm of cancer cells through some aforementioned mechanisms.
Taken together, alliin used alone or combined with primary medicine may be used for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best Before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel by Izdebska M1, Grzanka D2, Gagat M1, Hałas-Wiśniewska M1, Grzanka A. (PubMed)
(2) Genetic predisposition to breast cancer: past, present, and future by Turnbull C1, Rahman N. (PubMed)
#ThymeHoney Inhibits #Cancer Cell Proliferation, Inducing Cancer Apoptosis and Cell Cycle Arrest, According to Studies
Kyle J. Norton
Honey may have a significant effect on reducing the risk and treatment of endometrial cancer, some scientists suggested.
Endometrial cancer is a chronic condition characterized by irregular cells in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells on the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissues and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity, and use of hormone therapy are some of the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women's body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "Several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These results clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the disease. However, the study of PCOs in the endometrial cancer risk should also take into account obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, that there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopausal women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body are the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined honey's influence the estrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine, and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes the highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cell's viability.
Moreover, the application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, through its agonist/antagonist properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, "Honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken together, Thyme honey processed with major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapies for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
Honey may have a significant effect on reducing the risk and treatment of endometrial cancer, some scientists suggested.
Endometrial cancer is a chronic condition characterized by irregular cells in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells on the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissues and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity, and use of hormone therapy are some of the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women's body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "Several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These results clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the disease. However, the study of PCOs in the endometrial cancer risk should also take into account obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, that there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopausal women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body are the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined honey's influence the estrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine, and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes the highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cell's viability.
Moreover, the application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, through its agonist/antagonist properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, "Honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken together, Thyme honey processed with major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapies for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
#Herbal #Bilberry's #Anthocyanoside Inhibits Symptoms and Onset of Memory Impairment, Researchers Reveal
Kyle J. Norton
Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss can be temporarily forgotten, such as forgetting to pay a monthly bill and permanent such as no longer knowing your name. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.
According to statistics, dementia affects 47.5 million people worldwide. Every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.
The aim of the treatment of irreversible memory impairment is to improve the quality of life by delaying the progression of underlying diseases such as AD and PD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a potential compound for the treatment of memory deficits, with no side effects compared to those of conventional medicine, researchers examined the effects of anthocyanin pigments, a group of flavonoids, and a widespread class of phenolic compounds found abundantly in bilberry.
The study included the examination of elevated plus-maze and radial maze tasks cognitive performance fed approximately 3.2 mg kg(-1)day (oral) the anthocyanins. The lyophilized berries were administered for 30 days before the first training.
According to the step-down inhibitory avoidance, open field analysis, lyophilized berries significantly enhanced short-term memory, but not long-term memory and induced an increase in the number of crossings in the first exposure to the open field.
Interestingly, prolonged treatment with lyophilized berries did not have any significant effects in the elevated plus-maze task but improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, but did not alter reference memory in this task.
Researchers after taking into account co and confounders wrote in the final report, "These results suggest that lyophilized berries may be beneficial in the prevention of memory deficits, one of the symptoms related to AD, and corroborate previous findings showing that flavonoids present effects in several learning paradigms".
In other words, the efficacy of bilberry protects the memory function against the onset of deficits was attributed to the bioactive compound anthocyanin.
Taken together, bilberry-processed abundantly bioactive compound Anthocyanoside may be considered a functioning remedy for the prevention and treatment of symptoms of memory deficits in patients with AD, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)
Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss can be temporarily forgotten, such as forgetting to pay a monthly bill and permanent such as no longer knowing your name. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.
According to statistics, dementia affects 47.5 million people worldwide. Every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.
The aim of the treatment of irreversible memory impairment is to improve the quality of life by delaying the progression of underlying diseases such as AD and PD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a potential compound for the treatment of memory deficits, with no side effects compared to those of conventional medicine, researchers examined the effects of anthocyanin pigments, a group of flavonoids, and a widespread class of phenolic compounds found abundantly in bilberry.
The study included the examination of elevated plus-maze and radial maze tasks cognitive performance fed approximately 3.2 mg kg(-1)day (oral) the anthocyanins. The lyophilized berries were administered for 30 days before the first training.
According to the step-down inhibitory avoidance, open field analysis, lyophilized berries significantly enhanced short-term memory, but not long-term memory and induced an increase in the number of crossings in the first exposure to the open field.
Interestingly, prolonged treatment with lyophilized berries did not have any significant effects in the elevated plus-maze task but improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, but did not alter reference memory in this task.
Researchers after taking into account co and confounders wrote in the final report, "These results suggest that lyophilized berries may be beneficial in the prevention of memory deficits, one of the symptoms related to AD, and corroborate previous findings showing that flavonoids present effects in several learning paradigms".
In other words, the efficacy of bilberry protects the memory function against the onset of deficits was attributed to the bioactive compound anthocyanin.
Taken together, bilberry-processed abundantly bioactive compound Anthocyanoside may be considered a functioning remedy for the prevention and treatment of symptoms of memory deficits in patients with AD, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)
#Bromelain Processes Immune-Modulatory Activity Against the Onset of Infectious Diseases, Researchers Say
Kyle J. Norton
The immune system is a network of cells, tissues, and organs that provide the body's defense against infectious organisms and pathogens.
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprises the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process of destroying pathogens or preventing their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly, and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, chronic inflammatory diseases are also caused by the immune system's failure to destroy all foreign invaders in the acute infection in a set period, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes and cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocytes.
In order to obtain more information on bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely, encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment was carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain, and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken together, bromelain may be considered a remedy for the modulation of immune function, pending the confirmation of a large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
The immune system is a network of cells, tissues, and organs that provide the body's defense against infectious organisms and pathogens.
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprises the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process of destroying pathogens or preventing their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly, and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, chronic inflammatory diseases are also caused by the immune system's failure to destroy all foreign invaders in the acute infection in a set period, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes and cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocytes.
In order to obtain more information on bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely, encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment was carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain, and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken together, bromelain may be considered a remedy for the modulation of immune function, pending the confirmation of a large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
Sunday, 22 October 2023
#Phytochemical #Betanin or #Betanidin Exert a Strong #Antioxidant Activity, Researchers Say
Kyle J. Norton
Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.
Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stable, free radicals must donate or intercept an electron from other atoms, causing the domino's reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.
In other words, if the antioxidant enzymes no longer can perform the function of balancing the free radicals in the body, oxidative stress occurs.
Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.
Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".
In other words, by maintaining a healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
Some researchers suggested, that maintaining a balanced ratio of free radicals and antioxidants is the best way for good health.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system
In the major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.
In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.
Betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.
In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.
The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.
Based on the findings, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipoperoxyl radical reduction".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)
Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.
Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stable, free radicals must donate or intercept an electron from other atoms, causing the domino's reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.
In other words, if the antioxidant enzymes no longer can perform the function of balancing the free radicals in the body, oxidative stress occurs.
Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.
Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".
In other words, by maintaining a healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
Some researchers suggested, that maintaining a balanced ratio of free radicals and antioxidants is the best way for good health.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system
In the major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.
In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.
Betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.
In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.
The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.
Based on the findings, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipoperoxyl radical reduction".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)
3,3'-#Diindolylmethane Induces Glioblastoma Cells and Resistant #Glioblastoma Cells Death, Scientists Say
Kyle J. Norton
Scientists may have found a bioactive ingredient for the treatment of glioblastoma (GBM) and resistant glioblastoma with no side effects, according to studies.
Glioblastoma is one of the most aggressive cancers that begins within the brain.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients have survived longer than five years.
If you are male you are at 1.5 higher risk of glioblastoma, compared to your female counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.
Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change in body function may be one of the major risk factors that cause the incidence.
Dr. Judith Schwartzbaum, an associate professor of epidemiology and a member of The Ohio State University’s Comprehensive Cancer Center, in the study focused on the relationship between chemical signals from the immune system and the development of brain cancer uncovered the relationship between allergies, the immune system, and brain cancer. It appears that allergies may protect against the development of brain cancer.
She wrote, "It's important to identify the early stages of tumor development if we hope to intervene more effectively. " and "If you understand those early steps, maybe you can design treatments to block further tumor growth".
The results strongly suggested that people with a weakened immune system such as the elderly may be at a higher risk of glioblastoma
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers the concerned about current therapy deficits for the treatment of glioblastoma due to the limitation of limits the transport of essential drugs to the tumor sites. examined the effects of 3,3'-diindolylmethane by encapsulation in poly (lactic-co-glycolic acid) nanoparticles.
Nanoformulation loading of 27-87nm and encapsulation efficiency of 7.2% and 70% respectively were shown to induce the glioma cell's apoptosis internally.
Furthermore, in vivo, a bio-distribution study revealed the selective accumulation of the nanoformulation into rat brain tumor sites by crossing the blood-brain barrier.
Moreover, the nanoformulation also exhibited the abrogation of epidermal growth factor receptor pathway which has been found to that promote the growth and spread of glioblastoma cells.
Dr. Bhowmik A, the lead scientist after taking into account co and confounders, wrote, "Our novel nano preparation, therefore, shows great promise to serve as a template for targeted delivery of other therapeutics in treating GBM".
In order to reveal more information about the prognosis for glioblastoma patients, researchers examined the 3,3'-diindolylmethane anti-glioblastoma activity.
Indole-3-carbinol and related fragments, including 3,3'-Diindolylmethane exerted a potent anti glioblastoma activity with low micromolar activity, particularly resistant glioblastoma cell culture.
The finding clearly suggested that 3,3'-diindolylmethane alone or encapsulated in poly (lactic-co-glycolic acid) nanoparticles induced the glioblastoma cells and resistant glioblastoma cells death through a number of mechanisms.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
(2) Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3'-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression by Bhowmik A1, Chakravarti S1, Ghosh A2, Shaw R1, Bhandary S2, Bhattacharyya S3, Sen PC2, Ghosh MK. (PubMed)
(3) Immune System Research May Help Brain Tumor Diagnosis by Health Line
Scientists may have found a bioactive ingredient for the treatment of glioblastoma (GBM) and resistant glioblastoma with no side effects, according to studies.
Glioblastoma is one of the most aggressive cancers that begins within the brain.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients have survived longer than five years.
If you are male you are at 1.5 higher risk of glioblastoma, compared to your female counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, and a weakened immune system may be some risk factors associated with the onset of the disease.
Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change in body function may be one of the major risk factors that cause the incidence.
Dr. Judith Schwartzbaum, an associate professor of epidemiology and a member of The Ohio State University’s Comprehensive Cancer Center, in the study focused on the relationship between chemical signals from the immune system and the development of brain cancer uncovered the relationship between allergies, the immune system, and brain cancer. It appears that allergies may protect against the development of brain cancer.
She wrote, "It's important to identify the early stages of tumor development if we hope to intervene more effectively. " and "If you understand those early steps, maybe you can design treatments to block further tumor growth".
The results strongly suggested that people with a weakened immune system such as the elderly may be at a higher risk of glioblastoma
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers the concerned about current therapy deficits for the treatment of glioblastoma due to the limitation of limits the transport of essential drugs to the tumor sites. examined the effects of 3,3'-diindolylmethane by encapsulation in poly (lactic-co-glycolic acid) nanoparticles.
Nanoformulation loading of 27-87nm and encapsulation efficiency of 7.2% and 70% respectively were shown to induce the glioma cell's apoptosis internally.
Furthermore, in vivo, a bio-distribution study revealed the selective accumulation of the nanoformulation into rat brain tumor sites by crossing the blood-brain barrier.
Moreover, the nanoformulation also exhibited the abrogation of epidermal growth factor receptor pathway which has been found to that promote the growth and spread of glioblastoma cells.
Dr. Bhowmik A, the lead scientist after taking into account co and confounders, wrote, "Our novel nano preparation, therefore, shows great promise to serve as a template for targeted delivery of other therapeutics in treating GBM".
In order to reveal more information about the prognosis for glioblastoma patients, researchers examined the 3,3'-diindolylmethane anti-glioblastoma activity.
Indole-3-carbinol and related fragments, including 3,3'-Diindolylmethane exerted a potent anti glioblastoma activity with low micromolar activity, particularly resistant glioblastoma cell culture.
The finding clearly suggested that 3,3'-diindolylmethane alone or encapsulated in poly (lactic-co-glycolic acid) nanoparticles induced the glioblastoma cells and resistant glioblastoma cells death through a number of mechanisms.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
(2) Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3'-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression by Bhowmik A1, Chakravarti S1, Ghosh A2, Shaw R1, Bhandary S2, Bhattacharyya S3, Sen PC2, Ghosh MK. (PubMed)
(3) Immune System Research May Help Brain Tumor Diagnosis by Health Line
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