Kyle J. Norton
Leukemia is a medical condition caused by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myeloid or lymphoblastic leukemia.
Bone marrow is the soft tissue inside the hollow center of the major bone, including the spine, pelvis, underarm, and leg...
Chronic leukemia is a disease characterized by a slow but still excessive build-up of relatively immature abnormal white blood cells.
Chronic leukemia has a tendency to spread slowly to other parts of the body through the bloodstream and/or lymphatic system.
Chronic Myeloid Leukemia (CML) is a condition of slow growth and the spreading of abnormal granulocytes. In CML, granulocytes have become abnormal and grow uncontrollably in the bone marrow and/or lymphatic system and appear less immature in the bloodstream.
According to the statistics provided by the American Cancer Society, in the US approximately 8,990 new cases will be diagnosed with CML, including 5,250 in men and 3,740 in women and 1,140 people will die of CML, including 660 men and 480 women in 2019.
Besides the constitutional symptoms, such as
* Fatigue
Fatigue is a result of not enough red blood cells to transport oxygen to the body cells.
* Infections
White blood no longer functions normally in fighting against foreign invasions such as viruses and bacteria.
* Unintentional weight loss
Weight loss of over 10% has been found in patients with CML.
* Loss of appetite
It is one of the general symptoms accompanied by cancers.
* Bone and joint pain
It is a result of increased bone marrow pressure due to an excess build-up of white blood cells.
* Fever
It is a result of infection
* Abnormal blood bleeding and bruising
They are the results of abnormal blood platelets.
8. Excessive sweating, night sweats
Night sweats are an early symptom of some cancers, especially in CML.
CML also induces specific symptoms such as
* Enlarged lymph nodes, spleen
In CML lymph nodes can swell more than 1cm in children and 2 cm in adults.
* Becoming too full easily is one of the specific symptoms of ALL due to enlarged lymph nodes or spleen pressing onto the abdomen.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a potential compound for the treatment of leukemia, researchers examined the antiproliferative effects of betanin, a principle betacyanin pigment, isolated from the fruits of Opuntia ficus-indica on chronic myeloid leukemia.
In the human chronic myeloid leukemia cell line (K562), the application of betanin decreased the proliferation of K562 cells at a dose and time-dependent with an IC(50) of 40 microM.
According to the tested analysis, the antiproliferative activity of betanin was associated with chromatin condensation, cell shrinkage, and membrane blebbing.
In other words, cells treated with betanin showed a fragmentation pattern typical for apoptotic cells.
Particularly, at 40 microM betanin, the phytochemical compound induced 28.4% cell cycle arrest in the sub-G0/G1 phase.
Moreover, treatment with betanin not only activated the proteins such as PARP cleavage associated with pro-apoptosis but also inhibited the proteins such as Bcl-2 involved in anti-apoptosis.
Based on the findings, Dr. Sreekanth D, the lead scientist wrote, "Betanin induces apoptosis in K562 cells through the intrinsic pathway and is mediated by the release of cytochrome c from mitochondria into the cytosol, and PARP cleavage".
Taken together, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of chronic myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562 by Sreekanth D1, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. (PubMed)
(2) Myelogenous leukemia - Chronic myelogenous leukemia (CML) by Kyle J. Norton
Tuesday, 10 October 2023
#Onion's Ethyl Acetate #Extract Exerts a Strong #Antibiotic-Like Activity, Researchers Suggest
Kyle J. Norton
Infection is a medical condition that can acute or chronic. Acute infection is sudden inflammation that occurs in a short period of time accompanied by a relatively brief period of symptoms.
Most cases of acute infection can be solved within days as the infectious agents are destroyed by the host immune system.
Chronic infection is the condition that lasts for a long period of time with the difficulty of clearing. Most cases of chronic infection are latent or slow infections that last the life of the host.
Antibiotics are medicines that inhibit the growth of or destroys microorganisms, including the popular penicillin or its derivatives
The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, and overuse of antibiotics has made many of them resistant to antibiotics.
There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.
There are many risk factors associated with the onset of bacterial infections
However, researchers do not know why people with the same health condition in the same family, some are prone to infectious disease, while others do not.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, and pain at the site of infection.
In severe cases, the patient may also experience symptoms of swollen lymph glands.
Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of infectious disease researchers examined the antibacterial and possible antibiotic potentiating activity of garlic and onion.
The study compared the efficacy of decoction as traditionally used and methanol, ethanol, ethyl acetate, and acetone extracts of onion and garlic on 15 bacterial strains (6 ATCC strains and 9 clinical isolates).
According to the tested differentiation,
* Ethyl acetate extract of onion combined with Streptomycin produced an indifferent effect on all tested bacterial strains.
* Ethyl acetate extract of onion combined with Chloramphenicol showed a synergistic effect against ATCC S. aureus (FIC 0.27-0.30) and Micrococci species (FIC 0.27-0.32).
The antibacterial activity of onion extracts may be attributed to the presence of a high concentration of phenolic compounds in the onion.
In other words, the antibacterial property of onion is totally dependent on the antioxidant content which may be altered due to the different methods of growth, including conventional and organic cultivation.
Based on the findings, researchers said, "This study has provided an opportunity to establish valuable baseline information on the antibiotic potentiating activity of onion and... which can be further exploited for the treatment and/or management of infectious diseases".
Taken together, onion may be considered a remedy for the prevention and treatment of infectious disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Onion and Garlic Extracts Potentiate the Efficacy of Conventional Antibiotics against Standard and Clinical Bacterial Isolates by Mahomoodally F1, Ramcharun S1, Zengin G. (PubMed)
Infection is a medical condition that can acute or chronic. Acute infection is sudden inflammation that occurs in a short period of time accompanied by a relatively brief period of symptoms.
Most cases of acute infection can be solved within days as the infectious agents are destroyed by the host immune system.
Chronic infection is the condition that lasts for a long period of time with the difficulty of clearing. Most cases of chronic infection are latent or slow infections that last the life of the host.
Antibiotics are medicines that inhibit the growth of or destroys microorganisms, including the popular penicillin or its derivatives
The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, and overuse of antibiotics has made many of them resistant to antibiotics.
There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.
There are many risk factors associated with the onset of bacterial infections
However, researchers do not know why people with the same health condition in the same family, some are prone to infectious disease, while others do not.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, and pain at the site of infection.
In severe cases, the patient may also experience symptoms of swollen lymph glands.
Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potential compound for the treatment of infectious disease researchers examined the antibacterial and possible antibiotic potentiating activity of garlic and onion.
The study compared the efficacy of decoction as traditionally used and methanol, ethanol, ethyl acetate, and acetone extracts of onion and garlic on 15 bacterial strains (6 ATCC strains and 9 clinical isolates).
According to the tested differentiation,
* Ethyl acetate extract of onion combined with Streptomycin produced an indifferent effect on all tested bacterial strains.
* Ethyl acetate extract of onion combined with Chloramphenicol showed a synergistic effect against ATCC S. aureus (FIC 0.27-0.30) and Micrococci species (FIC 0.27-0.32).
The antibacterial activity of onion extracts may be attributed to the presence of a high concentration of phenolic compounds in the onion.
In other words, the antibacterial property of onion is totally dependent on the antioxidant content which may be altered due to the different methods of growth, including conventional and organic cultivation.
Based on the findings, researchers said, "This study has provided an opportunity to establish valuable baseline information on the antibiotic potentiating activity of onion and... which can be further exploited for the treatment and/or management of infectious diseases".
Taken together, onion may be considered a remedy for the prevention and treatment of infectious disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Onion and Garlic Extracts Potentiate the Efficacy of Conventional Antibiotics against Standard and Clinical Bacterial Isolates by Mahomoodally F1, Ramcharun S1, Zengin G. (PubMed)
#Turmeric's #Curcumin Activates Pathways and Inhibits Genes Associated with A reduced Risk ofHead and Neck Cancer, Researchers Find
Kyle J. Norton
Cancer is a group of medical diseases characterized by cell growth irregularly in the organ tissue caused by DNA alternation.
Head and neck cancer (HNC) is a group of cancers located in the mouth, nose, throat, larynx, sinuses, or salivary glands.
According to the statistics, head and neck cancer accounts for about 4% of all cancers in the US. In 2019, approximately 65,410 Americans including 48,000 men and 17,410 women will develop head and neck cancer.
The overall survival rate of 5 years after diagnosis is 62%.
The use of tobacco products and excessive alcohol consumption are considered the most prevalent factors associated with the increased risk of the disease.
Additionally, viral infections including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer) are also found in some patients with HNC.
Epidemiologically, the overall incidence of HNC is decreasing in the US, particularly in those of the younger age group. However, the incidence of HPV-related cancers of the oropharynx has increased at an alarming rate.
Dr. Moustafa Mourad,, the lead scientist wrote, "The overall incidence of HNC is decreasing in the United States. However, there is an increasing incidence of HPV-related cancers of the oropharynx. Meaningful differences in cancer incidence and rate of change exist between men and women".
In the explanation of such an increase, the study suggested, "The recent increase in HPV-related cancer could be due to increased rates of oral HPV exposure because markers of high-risk sexual behavior such as younger ages of sexual debut, premarital sex, the average number of lifetime partners, and the practice of oral sex have increased among recent birth cohorts in the United States".
In other words, the risk of HPV-related HNC is also depending on the sexual behavior of individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential compound for the treatment of head and neck cancers. researchers the anticancer activity of a novel oral agent, curcumin on FaDu and Cal27 cell lines.
According to the tested analysis, curcumin inhibited growth and induced apoptosis of the FaDu and Cal27 cell lines associated with the inhibition of the migration of head and neck cancers (HNSCC) and blocking the tumor angiogenetic activity.
Furthermore, curcumin also induced cancer cell death by activating the intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8).
More precisely, the anti-HNSCC efficacy of curcumin was attributed to the activation of the pathway and nuclear factors associated with DNA damage.
In vivo, the injection of curcumin increased gene expression of SIRT1 in the regulation of cellular biological function in a xenograft mouse model.
In other words, by targeting the gene SIRT1 that promotes the survival of aging cells and increases cancer risk, curcumin not only can increase the chemo drug efficacy but also reduce the risk of side effects.
Taken together, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of head and neck cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1 by Hu A1, Huang JJ2, Li RL3, Lu ZY3, Duan JL3, Xu WH1, Chen XP1, Fan JP. (PubMed)
(2) Synthetic curcumin analog UBS109 inhibits the growth of head and necksquamous cell carcinoma xenografts by Zhu S, Moore TW, Morii N, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M. (PubMed)
(3) Epidemiological Trends of Head and Neck Cancer in the United States: A SEER Population Study by Moustafa Mourad, MD,* Thomas Jetmore, MD,† Ameya A. Jategaonkar, MD,‡ Sami Moubayed, MD,§ Erin Moshier, PhD,║ and Mark L. Urken, MD. (PMC)
Cancer is a group of medical diseases characterized by cell growth irregularly in the organ tissue caused by DNA alternation.
Head and neck cancer (HNC) is a group of cancers located in the mouth, nose, throat, larynx, sinuses, or salivary glands.
According to the statistics, head and neck cancer accounts for about 4% of all cancers in the US. In 2019, approximately 65,410 Americans including 48,000 men and 17,410 women will develop head and neck cancer.
The overall survival rate of 5 years after diagnosis is 62%.
The use of tobacco products and excessive alcohol consumption are considered the most prevalent factors associated with the increased risk of the disease.
Additionally, viral infections including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer) are also found in some patients with HNC.
Epidemiologically, the overall incidence of HNC is decreasing in the US, particularly in those of the younger age group. However, the incidence of HPV-related cancers of the oropharynx has increased at an alarming rate.
Dr. Moustafa Mourad,, the lead scientist wrote, "The overall incidence of HNC is decreasing in the United States. However, there is an increasing incidence of HPV-related cancers of the oropharynx. Meaningful differences in cancer incidence and rate of change exist between men and women".
In the explanation of such an increase, the study suggested, "The recent increase in HPV-related cancer could be due to increased rates of oral HPV exposure because markers of high-risk sexual behavior such as younger ages of sexual debut, premarital sex, the average number of lifetime partners, and the practice of oral sex have increased among recent birth cohorts in the United States".
In other words, the risk of HPV-related HNC is also depending on the sexual behavior of individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential compound for the treatment of head and neck cancers. researchers the anticancer activity of a novel oral agent, curcumin on FaDu and Cal27 cell lines.
According to the tested analysis, curcumin inhibited growth and induced apoptosis of the FaDu and Cal27 cell lines associated with the inhibition of the migration of head and neck cancers (HNSCC) and blocking the tumor angiogenetic activity.
Furthermore, curcumin also induced cancer cell death by activating the intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8).
More precisely, the anti-HNSCC efficacy of curcumin was attributed to the activation of the pathway and nuclear factors associated with DNA damage.
In vivo, the injection of curcumin increased gene expression of SIRT1 in the regulation of cellular biological function in a xenograft mouse model.
In other words, by targeting the gene SIRT1 that promotes the survival of aging cells and increases cancer risk, curcumin not only can increase the chemo drug efficacy but also reduce the risk of side effects.
Taken together, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of head and neck cancers, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1 by Hu A1, Huang JJ2, Li RL3, Lu ZY3, Duan JL3, Xu WH1, Chen XP1, Fan JP. (PubMed)
(2) Synthetic curcumin analog UBS109 inhibits the growth of head and necksquamous cell carcinoma xenografts by Zhu S, Moore TW, Morii N, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M. (PubMed)
(3) Epidemiological Trends of Head and Neck Cancer in the United States: A SEER Population Study by Moustafa Mourad, MD,* Thomas Jetmore, MD,† Ameya A. Jategaonkar, MD,‡ Sami Moubayed, MD,§ Erin Moshier, PhD,║ and Mark L. Urken, MD. (PMC)
#Phytochemical Betanin/isobetanin Mix Extracts Inhibit Proteins and Genes Associated with #BreastCancer Progression, According to Studies
Kyle J. Norton
Breast cancer is a chronic medical condition characterized by cell growth irregularly in the breast tissues due to DNA alternation.
Most cases of breast cancer begin in the cells on the surface of the inner lining of the breast tissues before penetrating into the deeper layers.
According to the statistics, in the US the lifetime of breast cancer in women is 1/8. In other words, if you are a woman, your risk of breast cancer development during your lifetime is 12.5%.
According to the prediction using historical data, in 2019, approximately 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are not identified. However, according to epidemiological studies, certain conditions may increase the risk of the disease such as being overweight, diet, inactivity, excessive alcohol consumption, smoking, and exposure to xenoestrogen.
Some researchers suggested that the discovery of oral contraceptive pills over the past few decades may correlate to the rise of breast cancer.
In other words, if you currently use an oral contraceptive, you are at a higher risk of the disease onset.
Dr. Kathleen E. Malone in the examined breast cancer risk in women who use oral contraceptives wrote, "Breast cancer incidence in Western countries is relatively high and apparently is increasing. That breast cancer appears to be influenced by other hormonally mediated factors leads to the hypothesis that the high rate of exposure to oral contraceptives among American women may also be associated with this increase".
And, "an increasing number of studies have appeared that suggest an elevated risk in relation to some aspects of oral contractive use".
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient in plant phytochemicals for the treatment of breast cancer without inducing adverse effects compared to those of conventional medicine, researchers examined the extracts containing betanin and its stereoisomer Isobetanin, which belongs to the betalain group of highly bioavailable antioxidants.
The study involved the analysis of the cytotoxicity of applying betanin-enriched extract then characterized on cancer and normal cells.
Betanin/Isobetanin concentrate significantly decreased cancer cell proliferation and viability of MCF-7-treated cells, by inducing the production of proteins associated with proapoptosis and genes associated with tumor suppression.
Observation of the increased alternation of the mitochondrial membrane potential suggested that the extracts cause cancer cell death by both intrinsic and extrinsic apoptotic pathways.
The death of MCF-7-treated cells is also attributed to betanin/isobetanin-induced autophagy.
Interestingly, the injection of betanin-enriched extract showed no obvious effect on normal cell lines.
Dr. Nowacki L, the lead scientist said, "The betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".
In other words, betanin/isobetanin mix extracts processed anti-breast cancer cell proliferation by inducing cell death without affecting the integrity and viability of the normal breast cells.
In the analysis of the FDA-approved red food color E162, used in suppressing the development of multi-organ tumors in experimental animals, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the estrogen receptor-positive human breast cancer cells (MCF-7).
Beetroot extract exerted a significantly lower cancer cell inhibition compared to doxorubicin.
The findings suggested that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract, according to the study.
Taken together, betanin used alone or combined with other phytochemicals may be considered supplements for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M2. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(3) Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)
Breast cancer is a chronic medical condition characterized by cell growth irregularly in the breast tissues due to DNA alternation.
Most cases of breast cancer begin in the cells on the surface of the inner lining of the breast tissues before penetrating into the deeper layers.
According to the statistics, in the US the lifetime of breast cancer in women is 1/8. In other words, if you are a woman, your risk of breast cancer development during your lifetime is 12.5%.
According to the prediction using historical data, in 2019, approximately 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.
The exact causes of breast cancer are not identified. However, according to epidemiological studies, certain conditions may increase the risk of the disease such as being overweight, diet, inactivity, excessive alcohol consumption, smoking, and exposure to xenoestrogen.
Some researchers suggested that the discovery of oral contraceptive pills over the past few decades may correlate to the rise of breast cancer.
In other words, if you currently use an oral contraceptive, you are at a higher risk of the disease onset.
Dr. Kathleen E. Malone in the examined breast cancer risk in women who use oral contraceptives wrote, "Breast cancer incidence in Western countries is relatively high and apparently is increasing. That breast cancer appears to be influenced by other hormonally mediated factors leads to the hypothesis that the high rate of exposure to oral contraceptives among American women may also be associated with this increase".
And, "an increasing number of studies have appeared that suggest an elevated risk in relation to some aspects of oral contractive use".
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential ingredient in plant phytochemicals for the treatment of breast cancer without inducing adverse effects compared to those of conventional medicine, researchers examined the extracts containing betanin and its stereoisomer Isobetanin, which belongs to the betalain group of highly bioavailable antioxidants.
The study involved the analysis of the cytotoxicity of applying betanin-enriched extract then characterized on cancer and normal cells.
Betanin/Isobetanin concentrate significantly decreased cancer cell proliferation and viability of MCF-7-treated cells, by inducing the production of proteins associated with proapoptosis and genes associated with tumor suppression.
Observation of the increased alternation of the mitochondrial membrane potential suggested that the extracts cause cancer cell death by both intrinsic and extrinsic apoptotic pathways.
The death of MCF-7-treated cells is also attributed to betanin/isobetanin-induced autophagy.
Interestingly, the injection of betanin-enriched extract showed no obvious effect on normal cell lines.
Dr. Nowacki L, the lead scientist said, "The betanin/isobetanin mix as a therapeutic anticancer compound, alone or in combination with classical chemotherapeutic drugs, especially in functional p53 tumors".
In other words, betanin/isobetanin mix extracts processed anti-breast cancer cell proliferation by inducing cell death without affecting the integrity and viability of the normal breast cells.
In the analysis of the FDA-approved red food color E162, used in suppressing the development of multi-organ tumors in experimental animals, researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (Adriamycin) in the estrogen receptor-positive human breast cancer cells (MCF-7).
Beetroot extract exerted a significantly lower cancer cell inhibition compared to doxorubicin.
The findings suggested that betanin, the major betacyanin constituent, may play an important role in the cytotoxicity exhibited by the red beetroot extract, according to the study.
Taken together, betanin used alone or combined with other phytochemicals may be considered supplements for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells by Nowacki L1,2, Vigneron P2, Rotellini L2, Cazzola H1, Merlier F1, Prost E1, Ralanairina R3, Gadonna JP3, Rossi C1, Vayssade M2. (PubMed)
(2) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(3) Oral Contraceptives and Breast Cancer: A Review of the Epidemiological Evidence with an Emphasis on Younger Women by Kathleen E. Malone. (NCBI)
#Phytochemical #Sulforaphane (Isothiocyanates) Exerts a Strong Cardio-Protective Activity Against Acute I/R Injury, Researchers Say
Kyle J. Norton
Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.
According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.
Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.
Other risk factors associated with the onset of cardiovascular disease include unhealthy diet, lack of exercise, being overweight, and smoking.
Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).
How to prevent the onset of CVD
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/
For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".
With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.
Sprague-Dawley rats selected for the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.
Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.
Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in the effluent during reperfusion, similar to that of 5-hydroxydecanoic acid (5-HD).
Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.
Particularly, sulforaphane also protects the heart cell against damage and apoptosis by promoting heart cell cycle division.
The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.
In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.
The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
At the end of the study, by examining the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.
These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.
More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.
Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"
Taken together, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)
Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.
According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.
Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.
Other risk factors associated with the onset of cardiovascular disease include unhealthy diet, lack of exercise, being overweight, and smoking.
Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).
How to prevent the onset of CVD
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/
For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".
With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.
Sprague-Dawley rats selected for the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.
Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.
Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in the effluent during reperfusion, similar to that of 5-hydroxydecanoic acid (5-HD).
Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.
Particularly, sulforaphane also protects the heart cell against damage and apoptosis by promoting heart cell cycle division.
The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.
In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.
The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given a vehicle only for the same period of time.
At the end of the study, by examining the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.
These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.
More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.
Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"
Taken together, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)
#Phytochemical #Isobetanin and Betalains in the Promotion of #Myeloperoxidase Against Microbial Infection, Researchers Say
Kyle J. Norton
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) plays a critical role that protecting our body against the invasion of microorganisms.
At cellular levels, myeloperoxidase (MPO) is demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens that may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggeration of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic predisposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degrees of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examined the effects of phytochemical indicaxanthin on the enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to be associated with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending the confirmation of the larger sample size and multicenter human study.
Intake of Isobetanin and betalains in the form of supplements should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) plays a critical role that protecting our body against the invasion of microorganisms.
At cellular levels, myeloperoxidase (MPO) is demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens that may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggeration of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic predisposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degrees of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examined the effects of phytochemical indicaxanthin on the enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to be associated with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending the confirmation of the larger sample size and multicenter human study.
Intake of Isobetanin and betalains in the form of supplements should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
#Sulforaphane Found in #BroccoliSprouts Inhibits Proteins Associated with the Onset of Neuro-degenerative Disease, According to Studies
Kyle J. Norton
Age-related neurological disorders or neurodegenerative diseases are the conditions associated with the progressive death of neurons due to aging, leading to problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term for neurodegenerative disease that causes a decline in memory and thinking skills that are severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
The most common type of dementia is Alzheimer's disease, the condition that destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of the degeneration of the hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
Parkinson's disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary viral, and toxicological exposure may also correlate to the development of diseases in the elderly.
Dr. Hung CW in the examination of the neurodegenerative disease in the aging population wrote, "Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".
And, "Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economic burdens".
With an aim to find a natural food for the prevention and treatment of neurodegenerative disease, researchers examined the effect of sulforaphane, an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica oleracea var) sprouts inflammatory conditions in aged models involving microglial activation.
According to the results of pretreatment of pulsed electric fields that trigger the biological role of normal broccoli against lipopolysaccharide-activated microglia, sulforaphane-enriched broccoli sprouts showed an excellent potency against neuroinflammation conditions, particularly in both 6 and 24 h of microglial activation.
Sulforaphane in broccoli sprouts also inhibited an inflammatory cascade by decreasing the function of proteins associated with the production of pro-inflammatory cytokines.
Furthermore, proteins associated with the production of antioxidant enzymes and inhibition of oxidative stress (Nrf2 and HO-1) were also increased by SFN followed by the lowered neuronal apoptosis induced by activated microglia.
Based on the results, researchers wrote, " sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis, particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation by Subedi L1, Cho K1, Park YU2, Choi HJ2, Kim SY. (PubMed)
(2) Aging and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao CL. (PubMed)
Age-related neurological disorders or neurodegenerative diseases are the conditions associated with the progressive death of neurons due to aging, leading to problems with movement (called ataxias), or mental functioning including Alzheimer's disease (AD) and dementia.
Dementia is a general term for neurodegenerative disease that causes a decline in memory and thinking skills that are severe enough to reduce a person's ability to perform everyday activities and quality of life.
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.
The most common type of dementia is Alzheimer's disease, the condition that destroys brain cells, causing problems with memory, thinking, and behavior severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Over 1 million people in the US alone are currently afflicted by Alzheimer's disease because of the degeneration of the hippocampus and cerebral cortex(3) of the brain where memory, language, and cognition are located.
Parkinson's disease (PD) is a disabling, progressive condition that causes cognitive deficit due to the interruption of frontal-subcortical loops that facilitate cognition and parallel the motor loop, and the loss of substantia nigra pars compacta (SNc) dopamine (DA) neurons.
Besides aging, geographical, hereditary viral, and toxicological exposure may also correlate to the development of diseases in the elderly.
Dr. Hung CW in the examination of the neurodegenerative disease in the aging population wrote, "Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".
And, "Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economic burdens".
With an aim to find a natural food for the prevention and treatment of neurodegenerative disease, researchers examined the effect of sulforaphane, an active compound produced after conversion of glucoraphanin by the myrosinase enzyme in broccoli (Brassica oleracea var) sprouts inflammatory conditions in aged models involving microglial activation.
According to the results of pretreatment of pulsed electric fields that trigger the biological role of normal broccoli against lipopolysaccharide-activated microglia, sulforaphane-enriched broccoli sprouts showed an excellent potency against neuroinflammation conditions, particularly in both 6 and 24 h of microglial activation.
Sulforaphane in broccoli sprouts also inhibited an inflammatory cascade by decreasing the function of proteins associated with the production of pro-inflammatory cytokines.
Furthermore, proteins associated with the production of antioxidant enzymes and inhibition of oxidative stress (Nrf2 and HO-1) were also increased by SFN followed by the lowered neuronal apoptosis induced by activated microglia.
Based on the results, researchers wrote, " sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis, particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders".
In other words, SFN protects the integrity of the neurons against neuron damage through its anti-neuroinflammatory and neuroprotective activities.
Taken altogether, broccoli sprouts processed abundantly SFN may be considered supplements for the prevention of neurodegenerative disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation by Subedi L1, Cho K1, Park YU2, Choi HJ2, Kim SY. (PubMed)
(2) Aging and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao CL. (PubMed)
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