Kyle J. Norton
Free radical scavengers are antioxidants that function to protect the body against oxidative stress by inhibiting free radical oxidation before they can facilitate a chain reaction or by stopping the chain reaction before they can cause damage to the body.
Free radicals are highly reactive molecules. Internally, they are produced by our body cell metabolism. Externally, free radicals can enter our bodies from environmental sources, such as the air we breathe, the food we eat, and the water we drink.
More precisely, any chemical compounds or molecules that process oxygen atoms can be free radicals after chemical interaction.
Believe it or not, free radicals in moderate amounts benefit the body's functioning, such as NO for vascular-relaxation.
However, without interfering with the antioxidant, overexpression of free radicals has been found epidemiologically to damage the lipid and protein and induce the alternation of healthy cell DNA, leading to chronic diseases, including arthritis, cardiovascular disease, and diabetes.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals and antioxidant enzymes in the body.
Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.
Dr. Kota V. Ramana, the lead scientist in the joint study led by the University of Texas Medical Branch, wrote, "Lipid peroxidation is a complex chain reaction process due to the oxygen-free radicals mediated attack of cell membrane lipids such as polyunsaturated fatty acids (PUFA) resulting in cell damage and dysfunction".
And, "Indeed, a number of preclinical and clinical studies suggest the involvement of lipid peroxidation products in numerous pathological conditions such as inflammation, atherosclerosis, diabetes, aging, neurodegenerative diseases, and cancer".
In other words, an antioxidant with free radical scavenging activity may protect the body against the damage of various cellular components, including proteins, lipids, and DNA in the initiation of diseases.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases involved in oxidative stress, researchers examined the free radical-scavenging activity of indicaxanthin.
According to the tested analysis on the reaction of the phytochemical indicaxanthin with lipoperoxyl radicals generated in methyl linoleate methanol solution by 2,2'-azobis(2,4-dimethylvaleronitrile), and in aqueous soybean phosphatidylcholine unilamellar liposomes by 2,2'-azobis(2-amidinopropane) hydrochloride,
* Indicaxanthin incorporated in liposomes prevented lipid oxidation.
* The free radical scavenging property was found to be concentration-dependent, but not linearly related to the phytochemical concentration.
* In liposome, indicaxanthin showed a significant delay against oxidation, particularly in that of the lower concentration.
* However, in the corporation with alpha-tocopherol, Indicaxanthin exhibited cooperative antioxidant effects and reciprocal protective interactions.
* The increase of the ratio (indicaxanthin)/(alpha-tocopherol) showed a significant decrease in the extent of synergistic effects.
Taken together, indicaxanthin processes strong free radical scavenging activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
(2) Lipid Peroxidation Products in Human Health and Disease 2014 by Kota V. Ramana, 1 ,* Sanjay Srivastava, 2 and Sharad S. Singhal. (PMC)
Monday, 9 October 2023
#Herbal #Turmeric's #Curcumins Show a Reduction of Radiation Dermatitis Severity, Pain, Symptoms, and Improve Quality of Life in Radiation Therapy (RT) in Cancer Patients, Researchers Say
Kyle J. Norton
Radiodermatitis is a skin condition caused by exposure to ionizing radiation, particularly in patients with radiotherapy during cancer treatment.
The most common symptoms of RD are red patches accompanied by blistering.
Radiodermatitis can be classified
* Acute radiodermatitis develops in a few hours or weeks after the first exposure to radiation. The condition is healed itself in a short period of time
* Chronic RD is a condition of radiodermatitis that develops months, years, or even decades after radiation.
The persistent reaction of RD can lead to complications of telangiectasia, a condition of widened venules (tiny blood vessels) that cause threadlike red lines or patterns on the skin, leading to
reduced quality of life and cosmetic outcomes.
Dr. Sophie Seité, the lead scientist in the differentiation of the prevention and treatment of acute and chronic radiodermatitis wrote, "Today, treatment of radiodermatitis reactions is in its infancy. Although there is insufficient evidence available to form recommendations that would prevent or reduce radiodermatitis, some advances have been made using low-level light therapy (LLLT) or vascular lasers to control the symptoms".
And, "Some recent preclinical and clinical research suggests that LLLT has bio-stimulating properties which allow the tissues to regenerate and heal faster, reduce inflammation, and prevent fibrosis. Also, in late-onset radiodermatitis pulsed dye laser treatment has been shown to be beneficial in clearing radiation-induced telangiectasia. In the absence of evidence-based recommendations, the objective of this paper is to review how to prevent or manage the symptoms of radiodermatitis reactions".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to discover a natural compound for the treatment of radiodermatitis, a condition found to occur in 95% of patients receiving radiation therapy (RT) for cancer, researchers examined the efficacy of oral curcumin, one of the biologically active components in turmeric, at reducing radiation dermatitis severity (RDS) at the end of RT, using the RDS scale, compared to placebo.
The multisite, randomized, double-blinded, placebo-controlled trial involved in 686 breast cancer patients who received either four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.
More than 3% of the curcumin-treated group showed a reduction of radiation dermatitis severity compared to placebo.
The treatment group also report a change in pain, symptoms, and quality of life however, they were not statistically significant between arms.
In other words, oral curcumin reduced radiation dermatitis severity compared to placebo but not significantly.
In order to clarify the effect of curcumin on reducing radiation dermatitis severity (RDS) researchers assessed the ability of curcumin in 30 breast cancer patients.
The study involved 30 adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT (receiving radiotherapy) without concurrent chemotherapy, received 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT.
According to the weekly assessments and the Standard pooled variances t-test, curcumin reduced RDS compared to placebo at end of treatment.
Furthermore, 28.6% of curcumin-treated patients had moist desquamation, compared to placebo of 87.5%, according to Fisher's exact test.
Demographics, compliance, radiation skin dose, redness, pain, or symptoms are not significant differences in both groups.
Based on the findings, researchers wrote in the final report, "oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of radiodermatitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(2) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients by Ryan JL1, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. (PubMed)
(3) Prevention and treatment of acute and chronic radiodermatitis by Sophie Seité,1 René-Jean Bensadoun,2 and Jean-Michel Mazer. (PMC)
Radiodermatitis is a skin condition caused by exposure to ionizing radiation, particularly in patients with radiotherapy during cancer treatment.
The most common symptoms of RD are red patches accompanied by blistering.
Radiodermatitis can be classified
* Acute radiodermatitis develops in a few hours or weeks after the first exposure to radiation. The condition is healed itself in a short period of time
* Chronic RD is a condition of radiodermatitis that develops months, years, or even decades after radiation.
The persistent reaction of RD can lead to complications of telangiectasia, a condition of widened venules (tiny blood vessels) that cause threadlike red lines or patterns on the skin, leading to
reduced quality of life and cosmetic outcomes.
Dr. Sophie Seité, the lead scientist in the differentiation of the prevention and treatment of acute and chronic radiodermatitis wrote, "Today, treatment of radiodermatitis reactions is in its infancy. Although there is insufficient evidence available to form recommendations that would prevent or reduce radiodermatitis, some advances have been made using low-level light therapy (LLLT) or vascular lasers to control the symptoms".
And, "Some recent preclinical and clinical research suggests that LLLT has bio-stimulating properties which allow the tissues to regenerate and heal faster, reduce inflammation, and prevent fibrosis. Also, in late-onset radiodermatitis pulsed dye laser treatment has been shown to be beneficial in clearing radiation-induced telangiectasia. In the absence of evidence-based recommendations, the objective of this paper is to review how to prevent or manage the symptoms of radiodermatitis reactions".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to discover a natural compound for the treatment of radiodermatitis, a condition found to occur in 95% of patients receiving radiation therapy (RT) for cancer, researchers examined the efficacy of oral curcumin, one of the biologically active components in turmeric, at reducing radiation dermatitis severity (RDS) at the end of RT, using the RDS scale, compared to placebo.
The multisite, randomized, double-blinded, placebo-controlled trial involved in 686 breast cancer patients who received either four 500-mg capsules of placebo or curcumin three times daily throughout their prescribed course of RT until 1-week post-RT.
More than 3% of the curcumin-treated group showed a reduction of radiation dermatitis severity compared to placebo.
The treatment group also report a change in pain, symptoms, and quality of life however, they were not statistically significant between arms.
In other words, oral curcumin reduced radiation dermatitis severity compared to placebo but not significantly.
In order to clarify the effect of curcumin on reducing radiation dermatitis severity (RDS) researchers assessed the ability of curcumin in 30 breast cancer patients.
The study involved 30 adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT (receiving radiotherapy) without concurrent chemotherapy, received 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT.
According to the weekly assessments and the Standard pooled variances t-test, curcumin reduced RDS compared to placebo at end of treatment.
Furthermore, 28.6% of curcumin-treated patients had moist desquamation, compared to placebo of 87.5%, according to Fisher's exact test.
Demographics, compliance, radiation skin dose, redness, pain, or symptoms are not significant differences in both groups.
Based on the findings, researchers wrote in the final report, "oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of radiodermatitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients by Ryan Wolf J1,2,3, Heckler CE4,5, Guido JJ4,5, Peoples AR4, Gewandter JS6, Ling M7, Vinciguerra VP8, Anderson T9, Evans L10, Wade J11, Pentland AP12, Morrow GR. (PubMed)
(2) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients by Ryan JL1, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. (PubMed)
(3) Prevention and treatment of acute and chronic radiodermatitis by Sophie Seité,1 René-Jean Bensadoun,2 and Jean-Michel Mazer. (PMC)
#Fennel Seed Extract and 5-Methoxypsoralen (5-MoP) Found in Fennel Inhibit Toxins Caused by Drug Interaction, Scientists Show
Kyle J. Norton
Fennel seeds may have the potential to act as liver antitoxin enzymes in removing xenobiotics from our body, some scientists suggested.
Liver cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme, mainly found in the liver with the function in stimulating the removal of toxins from our body through the oxidation of small foreign organic molecules (xenobiotics).
Acute drug toxicity is a condition characterized by having too much of a drug in the body at once caused by overdoses of a certain medicine.
Otherwise, drug toxicity is a condition of toxin accumulation caused by long-term intake of medicine which has a strong and negative impact on the liver or kidney enzymes that are responsible for toxin removals.
The signs and symptoms of toxicity differ depending on the medication. However, the most common symptoms may include diarrhea, dizziness, nausea, stomach pains, vomiting, and weakness.
Untreated drug toxicity may induce complications of ataxia, muscle twitches, slurred speech, nystagmus, seizures, coma,....... and, in rare cases, heart problems and death.
Dr. ALASDAIR BRECKENRIDGE, in the article " A clinical pharmacologist's view of drug toxicity," wrote, "Our ability to understand the basis of adverse drug reactions has improved progressively, and with it, the ability to prevent their occurrence; one aim of the clinical pharmacologist is to identify patients at special risk" and " With a fair degree of certainty one can also predict that advances in bioinformatics, genomics, and combinatorial chemistry will progressively contribute to clinical toxicology in the future"(6).
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean
The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the study to compare the effectiveness of herbal compounds isolated from fennel against toxins that are mediated by human liver cytochrome P450 3A4, researchers found that 13 compounds process a strong inhibitory activity(1).
Among these compounds, 5-methoxypsoralen (5-MoP) showed the strongest inhibition of toxins induced by drug interaction with an IC50 value of 18.3 μm and with a mixed type of inhibition(1).
According to the Brescia University Hospital, 5-methoxypsoralen (5-MOP) may be considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis, proven by the study in compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV(5).
The University of Toyama conducted an experiment to examine whether methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4), suggested, 5-methoxypsoralen (5-MOP) showed the strongest inhibition with an IC50 value of 18.3 microM and a mixed type of inhibition, similar to those of above study.
With the preincubation time of 20 min only, 5-MOP showed preincubation time dependency with the IC50 value decreased from 18.3 microM with a preincubation time of 0 min to 4.6 microM with a preincubation time of 20 min(2).
These results suggested that 5-MOP acts as a human Liver Cytochrome P450 3A4 in the inhibition of toxins caused by drug interaction in a time-dependent manner.
Additionally, in the examination of the antitoxic effect of 30 sample plants of Indonesia, caused by the injection of xenobiotics, researchers showed that methanol extracts isolated from fennel seed exerted time-dependent inhibition toxins oxidized similarly to those of cytochrome P450 3A4 (CYP3A4) and CYP2D6.
In comparing the experimental injection to another plant with the same volume, fennel seed extract should contain mechanism-based inhibitors on CYP3A4.
Mechanism-based inhibition or suicide inhibition, also known as suicide inactivation is an irreversible form of enzyme inhibition. If you need more information about the definition, please click the link provided by the Evidence-Based Medicine.
Taken together, fennel and fennel seeds extract may be considered as a functional supplement in protect liver detoxed enzymes against overexpression of toxins caused by small foreign organic molecules.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator by Subehan1, Zaidi SF, Kadota S, Tezuka Y(PubMed)
(3) Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants by Subehan1, Usia T, Iwata H, Kadota S, Tezuka Y.(PubMed)
(4) Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen1 , Huang Huang2 , Brian C. Foster1,3, Teresa W. Tam1 , Tim Xing2 , Myron L. Smith2 , John T. Arnason1 , Humayoun Akhtar(J Pharm Pharm Sci (www.cspsCanada.org) 17(2) 254 - 265, 2014)
(5) A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis by Calzavara-Pinton P1, Ortel B, Carlino A, Honigsmann H, De Panfilis G(PubMed)
(6) A clinical pharmacologist's view of drug toxicity by ALASDAIR BRECKENRIDGE(PMC)
Fennel seeds may have the potential to act as liver antitoxin enzymes in removing xenobiotics from our body, some scientists suggested.
Liver cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme, mainly found in the liver with the function in stimulating the removal of toxins from our body through the oxidation of small foreign organic molecules (xenobiotics).
Acute drug toxicity is a condition characterized by having too much of a drug in the body at once caused by overdoses of a certain medicine.
Otherwise, drug toxicity is a condition of toxin accumulation caused by long-term intake of medicine which has a strong and negative impact on the liver or kidney enzymes that are responsible for toxin removals.
The signs and symptoms of toxicity differ depending on the medication. However, the most common symptoms may include diarrhea, dizziness, nausea, stomach pains, vomiting, and weakness.
Untreated drug toxicity may induce complications of ataxia, muscle twitches, slurred speech, nystagmus, seizures, coma,....... and, in rare cases, heart problems and death.
Dr. ALASDAIR BRECKENRIDGE, in the article " A clinical pharmacologist's view of drug toxicity," wrote, "Our ability to understand the basis of adverse drug reactions has improved progressively, and with it, the ability to prevent their occurrence; one aim of the clinical pharmacologist is to identify patients at special risk" and " With a fair degree of certainty one can also predict that advances in bioinformatics, genomics, and combinatorial chemistry will progressively contribute to clinical toxicology in the future"(6).
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean
The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the study to compare the effectiveness of herbal compounds isolated from fennel against toxins that are mediated by human liver cytochrome P450 3A4, researchers found that 13 compounds process a strong inhibitory activity(1).
Among these compounds, 5-methoxypsoralen (5-MoP) showed the strongest inhibition of toxins induced by drug interaction with an IC50 value of 18.3 μm and with a mixed type of inhibition(1).
According to the Brescia University Hospital, 5-methoxypsoralen (5-MOP) may be considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis, proven by the study in compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV(5).
The University of Toyama conducted an experiment to examine whether methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4), suggested, 5-methoxypsoralen (5-MOP) showed the strongest inhibition with an IC50 value of 18.3 microM and a mixed type of inhibition, similar to those of above study.
With the preincubation time of 20 min only, 5-MOP showed preincubation time dependency with the IC50 value decreased from 18.3 microM with a preincubation time of 0 min to 4.6 microM with a preincubation time of 20 min(2).
These results suggested that 5-MOP acts as a human Liver Cytochrome P450 3A4 in the inhibition of toxins caused by drug interaction in a time-dependent manner.
Additionally, in the examination of the antitoxic effect of 30 sample plants of Indonesia, caused by the injection of xenobiotics, researchers showed that methanol extracts isolated from fennel seed exerted time-dependent inhibition toxins oxidized similarly to those of cytochrome P450 3A4 (CYP3A4) and CYP2D6.
In comparing the experimental injection to another plant with the same volume, fennel seed extract should contain mechanism-based inhibitors on CYP3A4.
Mechanism-based inhibition or suicide inhibition, also known as suicide inactivation is an irreversible form of enzyme inhibition. If you need more information about the definition, please click the link provided by the Evidence-Based Medicine.
Taken together, fennel and fennel seeds extract may be considered as a functional supplement in protect liver detoxed enzymes against overexpression of toxins caused by small foreign organic molecules.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator by Subehan1, Zaidi SF, Kadota S, Tezuka Y(PubMed)
(3) Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants by Subehan1, Usia T, Iwata H, Kadota S, Tezuka Y.(PubMed)
(4) Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen1 , Huang Huang2 , Brian C. Foster1,3, Teresa W. Tam1 , Tim Xing2 , Myron L. Smith2 , John T. Arnason1 , Humayoun Akhtar(J Pharm Pharm Sci (www.cspsCanada.org) 17(2) 254 - 265, 2014)
(5) A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis by Calzavara-Pinton P1, Ortel B, Carlino A, Honigsmann H, De Panfilis G(PubMed)
(6) A clinical pharmacologist's view of drug toxicity by ALASDAIR BRECKENRIDGE(PMC)
#CruciferousVegetables' SFN inhibits NSCLC Cells to form spherical colonies To Induce Proliferation, Researchers Say
Kyle J. Norton
Cancer is the class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
The lung is a vital organ of humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the US.
The most common types of lung cancers include
* Squamous-cell carcinoma is often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.
The most common risk factors of non-small cell lung cancer (NSCLC) are long-term smoking and people exposed to long-term second-hand smoke.
According to the statistics, in 2019, approximately 228,150 adults including 116,440 men and 111,710 women in the United States will be diagnosed with non-small cell lung cancer (NSCLC). Lung cancer makes up about 13% of all new cancer diagnoses. Black men are about 20% more likely to get lung cancer than white men.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential compound for the treatment of lung cancer, researchers examined the anti-metastatic activity of Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables on two non-small cell lung cancer (NSCLC) cell lines, A549, and CL1-5 cells.
SFN exhibited more potent cytotoxicity against suspending rather than adherent cancer cells.
The inhibition of SFN was attributed to the induction of anoikis. evidenced by a loss of normal cell-matrix interactions, markers of apoptosis, and activation of the mitochondrial apoptotic pathway.
Furthermore, SFN also inhibited NSCLC cells to form spherical colonies, to induce proliferation.
Moreover, SFN also suppressed the activation of signaling pathways to induce cancer cell adhesion.
Based on the findings, researchers said, "These results provide new insight into mechanisms underlying the chemopreventive ability of SFN and suggest a potential benefit of SFN to interfere with tumor metastasis".
Taken altogether, Cruciferous vegetables may be considered functional foods for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells by Tsai JY1, Tsai SH1, Wu CC. (PubMed)
Cancer is the class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.
The lung is a vital organ of humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the US.
The most common types of lung cancers include
* Squamous-cell carcinoma is often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.
The most common risk factors of non-small cell lung cancer (NSCLC) are long-term smoking and people exposed to long-term second-hand smoke.
According to the statistics, in 2019, approximately 228,150 adults including 116,440 men and 111,710 women in the United States will be diagnosed with non-small cell lung cancer (NSCLC). Lung cancer makes up about 13% of all new cancer diagnoses. Black men are about 20% more likely to get lung cancer than white men.
Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.
In finding a potential compound for the treatment of lung cancer, researchers examined the anti-metastatic activity of Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables on two non-small cell lung cancer (NSCLC) cell lines, A549, and CL1-5 cells.
SFN exhibited more potent cytotoxicity against suspending rather than adherent cancer cells.
The inhibition of SFN was attributed to the induction of anoikis. evidenced by a loss of normal cell-matrix interactions, markers of apoptosis, and activation of the mitochondrial apoptotic pathway.
Furthermore, SFN also inhibited NSCLC cells to form spherical colonies, to induce proliferation.
Moreover, SFN also suppressed the activation of signaling pathways to induce cancer cell adhesion.
Based on the findings, researchers said, "These results provide new insight into mechanisms underlying the chemopreventive ability of SFN and suggest a potential benefit of SFN to interfere with tumor metastasis".
Taken altogether, Cruciferous vegetables may be considered functional foods for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells by Tsai JY1, Tsai SH1, Wu CC. (PubMed)
#Phytochemical #Betacyanins and #Betaxanthin Protect the Heart by Decreasing Oxidative Stress, Inflammation, and Apoptosis in Cardiac Tissues, According to Studies
Kyle J. Norton
According to the free radical theory, a free radical with a single unpaired electron in an outermost shell and highly reactive with other cells, which in turn, causes oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA, and RNA,..,
The theory also suggested that human aging is a result of widespread skin damage caused by a set of chain reactions auto-catalytically of overexpression of free radicals after attacking the lipid bilayers of the cell walls.
Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radicals that cannot be stopped.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants produced by the host that exists over a long period of time.
Free radicals are unstable atoms with an unpaired electron in the outermost ring. Therefore, in order for them to become stable, free radicals must steal or donate an electron from or to other atoms.
Long-term expression oxidative stress has been found to cause damage to the protein, lipid, and cell DNA, leading to an increased risk of chronic disease, including heart disease, diabetes, and cancers.
Antioxidants are stable atoms that inhibit oxidation.
Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.
Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boost the immune system.
Normally, antioxidant enzymes by the body are more than enough to counter the expression of free radicals that occur in our body every day. However, in people with a weakened immune system intake of dietary antioxidants such as supplements or fruits may improve levels of antioxidants in the body.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant effects of beetroot (Beta vulgaris L.) juice (BRJ), a good source of betalain (betacyanins and betaxanthin) pigments.
The study included rats with isoproterenol (ISP85 mg/kg injected at 24 h intervals)-induced myocardial ischemia followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.
According to the tested results* Pretreatment with BRJ (150 and 300 mg/kg) restored the cardiac endogenous antioxidants and reduced levels of oxidative/nitrosative stress, in rats treated by ISP.
* Overexpression of cardiac inflammatory cytokines such as TNF-α, IL-6, and IL-10 caused by ISP was inhibited by the pretreatment of BRJ compared to the untreated group.
* Furthermore, hyperlipidemia level-induced ISP was significantly reduced by the BRJ pretreatment.
* Moreover, BRJ also protected against the extent of histological damage, myonecrosis, and edema, and maintained the architecture of cardiomyocytes by exhibiting the effects of anti-apoptotic proteins such as Bcl-2 and inhibiting the effects of apoptotic proteins.
These results strongly suggested that betacyanins and betaxanthin found in BRJ mitigate cardiac dysfunction and structural damage by decreasing oxidative stress, inflammation, and apoptosis in cardiac tissues.
Based on the findings, researchers said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".
Taken together, betacyanins found abundantly in beetroot may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
According to the free radical theory, a free radical with a single unpaired electron in an outermost shell and highly reactive with other cells, which in turn, causes oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA, and RNA,..,
The theory also suggested that human aging is a result of widespread skin damage caused by a set of chain reactions auto-catalytically of overexpression of free radicals after attacking the lipid bilayers of the cell walls.
Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radicals that cannot be stopped.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants produced by the host that exists over a long period of time.
Free radicals are unstable atoms with an unpaired electron in the outermost ring. Therefore, in order for them to become stable, free radicals must steal or donate an electron from or to other atoms.
Long-term expression oxidative stress has been found to cause damage to the protein, lipid, and cell DNA, leading to an increased risk of chronic disease, including heart disease, diabetes, and cancers.
Antioxidants are stable atoms that inhibit oxidation.
Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.
Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boost the immune system.
Normally, antioxidant enzymes by the body are more than enough to counter the expression of free radicals that occur in our body every day. However, in people with a weakened immune system intake of dietary antioxidants such as supplements or fruits may improve levels of antioxidants in the body.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant effects of beetroot (Beta vulgaris L.) juice (BRJ), a good source of betalain (betacyanins and betaxanthin) pigments.
The study included rats with isoproterenol (ISP85 mg/kg injected at 24 h intervals)-induced myocardial ischemia followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.
According to the tested results* Pretreatment with BRJ (150 and 300 mg/kg) restored the cardiac endogenous antioxidants and reduced levels of oxidative/nitrosative stress, in rats treated by ISP.
* Overexpression of cardiac inflammatory cytokines such as TNF-α, IL-6, and IL-10 caused by ISP was inhibited by the pretreatment of BRJ compared to the untreated group.
* Furthermore, hyperlipidemia level-induced ISP was significantly reduced by the BRJ pretreatment.
* Moreover, BRJ also protected against the extent of histological damage, myonecrosis, and edema, and maintained the architecture of cardiomyocytes by exhibiting the effects of anti-apoptotic proteins such as Bcl-2 and inhibiting the effects of apoptotic proteins.
These results strongly suggested that betacyanins and betaxanthin found in BRJ mitigate cardiac dysfunction and structural damage by decreasing oxidative stress, inflammation, and apoptosis in cardiac tissues.
Based on the findings, researchers said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".
Taken together, betacyanins found abundantly in beetroot may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
Sunday, 8 October 2023
#Herbal #Cinnamon Inhibits Syndromes and Complications in #Diabetes, Researchers Say
Kyle J. Norton
Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professionals because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.
The herb has been used in herbal and traditional medicine as an anti-fungal and bacteria levels to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a reduction significant of blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)
Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content, and improved insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed that "the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism"(4)
In support of the above, chromium(Cr) and polyphenols found in cinnamon (Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that a high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)
A randomized clinical trial in which 70 patients with type II diabetes were assigned randomly to two groups (35 in cinnamon and 35 in the placebo group the test the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken together, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in the mouth with a large amount. Traditional Chinese medicine also insists that an Overdose of cinnamon can be toxic and damage to the liver(1).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods, and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professionals because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.
The herb has been used in herbal and traditional medicine as an anti-fungal and bacteria levels to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a reduction significant of blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)
Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content, and improved insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed that "the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism"(4)
In support of the above, chromium(Cr) and polyphenols found in cinnamon (Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that a high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)
A randomized clinical trial in which 70 patients with type II diabetes were assigned randomly to two groups (35 in cinnamon and 35 in the placebo group the test the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken together, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in the mouth with a large amount. Traditional Chinese medicine also insists that an Overdose of cinnamon can be toxic and damage to the liver(1).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods, and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
#Herbal #Angelica Sinensis Inhibits Genes Associated with the Induction of #OvarianCancer Cell Death, Researchers Say
Kyle J. Norton
Cancer is a deadly class of chronic disease caused by irregular cell growth in the tissue or specific organs in the body due to the alternation of cell DNA.
The ovaries are oval-shaped ovum-producing reproductive organs that form part of women's reproductive system that connect to the fallopian tubes and attach to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovaries take a turn to release an egg every month.
Ovarian cancer is medical a condition characterized by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversized tumor can travel a distance away to infect the nearby organs and tissue via fluid and blood circulation.
According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.
The lifetime risk of getting ovarian cancer in a woman is about 1 in 78. comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.
The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.
The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as the BRCA1 and BRCA2 gene, and acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the risk of the development of the disease.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
On finding a natural ingredient for the prevention and treatment of cancers, Z-Ligustilide, the most potent bioactive component of Angelica Sinensis on ovarian cancer cells.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the tested analysis,
* Z-Ligustilide resulted in apoptotic cell death by inducing oxidative stress on mitochondria.
* Furthermore. Z-Ligustilide enhanced the mitochondrial superoxide formation.
* NRF2, the antioxidant enzymes enhancer, and downstream antioxidant defense genes were elevated by tZ-Ligustilide in OVCAR-3 cells at the epigenetic level.
* Most importantly, NRF2 knockdown by siRNA resulted in increased cell death by Z-Ligustilide in ovarian cancer cells.
Based on the findings, researchers said, " Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death".
Taken altogether, angelica sinensis may be considered an antioxidant remedy for the prevention and treatment of human ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2 by Lang F1, Qu J2, Yin H3, Li L4, Zhi Y5, Liu Y6, Fang Z7, Hao E. (PubMed)
Cancer is a deadly class of chronic disease caused by irregular cell growth in the tissue or specific organs in the body due to the alternation of cell DNA.
The ovaries are oval-shaped ovum-producing reproductive organs that form part of women's reproductive system that connect to the fallopian tubes and attach to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovaries take a turn to release an egg every month.
Ovarian cancer is medical a condition characterized by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversized tumor can travel a distance away to infect the nearby organs and tissue via fluid and blood circulation.
According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.
The lifetime risk of getting ovarian cancer in a woman is about 1 in 78. comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.
The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.
The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as the BRCA1 and BRCA2 gene, and acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the risk of the development of the disease.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
On finding a natural ingredient for the prevention and treatment of cancers, Z-Ligustilide, the most potent bioactive component of Angelica Sinensis on ovarian cancer cells.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the tested analysis,
* Z-Ligustilide resulted in apoptotic cell death by inducing oxidative stress on mitochondria.
* Furthermore. Z-Ligustilide enhanced the mitochondrial superoxide formation.
* NRF2, the antioxidant enzymes enhancer, and downstream antioxidant defense genes were elevated by tZ-Ligustilide in OVCAR-3 cells at the epigenetic level.
* Most importantly, NRF2 knockdown by siRNA resulted in increased cell death by Z-Ligustilide in ovarian cancer cells.
Based on the findings, researchers said, " Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death".
Taken altogether, angelica sinensis may be considered an antioxidant remedy for the prevention and treatment of human ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2 by Lang F1, Qu J2, Yin H3, Li L4, Zhi Y5, Liu Y6, Fang Z7, Hao E. (PubMed)
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