#Fennel Seed Extract and 5-Methoxypsoralen (5-MoP) Found in Fennel Inhibit Toxins Caused by Drug Interaction, Scientists Show

Kyle J. Norton


Fennel seeds may have the potential to act as liver antitoxin enzymes in removing xenobiotics from our body, some scientists suggested.

Liver cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme, mainly found in the liver with the function in stimulating the removal of toxins from our body through the oxidation of small foreign organic molecules (xenobiotics).

Acute drug toxicity is a condition characterized by having too much of a drug in the body at once caused by overdoses of a certain medicine.

Otherwise, drug toxicity is a condition of toxin accumulation caused by long-term intake of medicine which has a strong and negative impact on the liver or kidney enzymes that are responsible for toxin removals.

The signs and symptoms of toxicity differ depending on the medication. However, the most common symptoms may include diarrhea, dizziness, nausea, stomach pains, vomiting, and weakness.

Untreated drug toxicity may induce complications of ataxia, muscle twitches, slurred speech, nystagmus, seizures, coma,....... and, in rare cases, heart problems and death.

Dr. ALASDAIR BRECKENRIDGE, in the article " A clinical pharmacologist's view of drug toxicity," wrote, "Our ability to understand the basis of adverse drug reactions has improved progressively, and with it, the ability to prevent their occurrence; one aim of the clinical pharmacologist is to identify patients at special risk" and " With a fair degree of certainty one can also predict that advances in bioinformatics, genomics, and combinatorial chemistry will progressively contribute to clinical toxicology in the future"(6).

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean

The herb or food has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...

In the study to compare the effectiveness of herbal compounds isolated from fennel against toxins that are mediated by human liver cytochrome P450 3A4, researchers found that 13 compounds process a strong inhibitory activity(1).

Among these compounds, 5-methoxypsoralen (5-MoP) showed the strongest inhibition of toxins induced by drug interaction with an IC50 value of 18.3 μm and with a mixed type of inhibition(1).

According to the Brescia University Hospital, 5-methoxypsoralen (5-MOP) may be considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis, proven by the study in compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV(5).

The University of Toyama conducted an experiment to examine whether methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4), suggested, 5-methoxypsoralen (5-MOP) showed the strongest inhibition with an IC50 value of 18.3 microM and a mixed type of inhibition, similar to those of above study.

With the preincubation time of 20 min only, 5-MOP showed preincubation time dependency with the IC50 value decreased from 18.3 microM with a preincubation time of 0 min to 4.6 microM with a preincubation time of 20 min(2).

These results suggested that 5-MOP acts as a human Liver Cytochrome P450 3A4 in the inhibition of toxins caused by drug interaction in a time-dependent manner.

Additionally, in the examination of the antitoxic effect of 30 sample plants of Indonesia, caused by the injection of xenobiotics, researchers showed that methanol extracts isolated from fennel seed exerted time-dependent inhibition toxins oxidized similarly to those of cytochrome P450 3A4 (CYP3A4) and CYP2D6.

In comparing the experimental injection to another plant with the same volume, fennel seed extract should contain mechanism-based inhibitors on CYP3A4.

Mechanism-based inhibition or suicide inhibition, also known as suicide inactivation is an irreversible form of enzyme inhibition. If you need more information about the definition, please click the link provided by the Evidence-Based Medicine.


Taken together, fennel and fennel seeds extract may be considered as a functional supplement in protect liver detoxed enzymes against overexpression of toxins caused by small foreign organic molecules.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator by Subehan1, Zaidi SF, Kadota S, Tezuka Y(PubMed)
(3) Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants by Subehan1, Usia T, Iwata H, Kadota S, Tezuka Y.(PubMed)
(4) Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen1 , Huang Huang2 , Brian C. Foster1,3, Teresa W. Tam1 , Tim Xing2 , Myron L. Smith2 , John T. Arnason1 , Humayoun Akhtar(J Pharm Pharm Sci (www.cspsCanada.org) 17(2) 254 - 265, 2014)
(5) A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis by Calzavara-Pinton P1, Ortel B, Carlino A, Honigsmann H, De Panfilis G(PubMed)
(6) A clinical pharmacologist's view of drug toxicity by ALASDAIR BRECKENRIDGE(PMC)

#CruciferousVegetables' SFN inhibits NSCLC Cells to form spherical colonies To Induce Proliferation, Researchers Say

Kyle J. Norton


Cancer is the class of diseases associated with the growth of cells disorderly and uncontrollably due to the alternation of DNA.

The lung is a vital organ of humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air and then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In the US.

The most common types of lung cancers include
* Squamous-cell carcinoma is often found in an outer area of the lung,

* Large-cell carcinoma found in the center of the lung by an air tube

* Adenocarcinoma is found in any part of the lung.

Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.

The most common risk factors of non-small cell lung cancer (NSCLC) are long-term smoking and people exposed to long-term second-hand smoke.

According to the statistics, in 2019, approximately 228,150 adults including 116,440 men and 111,710 women in the United States will be diagnosed with non-small cell lung cancer (NSCLC). Lung cancer makes up about 13% of all new cancer diagnoses. Black men are about 20% more likely to get lung cancer than white men.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

In finding a potential compound for the treatment of lung cancer, researchers examined the anti-metastatic activity of Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables on two non-small cell lung cancer (NSCLC) cell lines, A549, and CL1-5 cells.

SFN exhibited more potent cytotoxicity against suspending rather than adherent cancer cells.

The inhibition of SFN was attributed to the induction of anoikis. evidenced by a loss of normal cell-matrix interactions, markers of apoptosis, and activation of the mitochondrial apoptotic pathway.


Furthermore, SFN also inhibited NSCLC cells to form spherical colonies, to induce proliferation.

Moreover, SFN also suppressed the activation of signaling pathways to induce cancer cell adhesion.

Based on the findings, researchers said, "These results provide new insight into mechanisms underlying the chemopreventive ability of SFN and suggest a potential benefit of SFN to interfere with tumor metastasis".

Taken altogether, Cruciferous vegetables may be considered functional foods for the prevention and treatment of non-small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells by Tsai JY1, Tsai SH1, Wu CC. (PubMed)

#Phytochemical #Betacyanins and #Betaxanthin Protect the Heart by Decreasing Oxidative Stress, Inflammation, and Apoptosis in Cardiac Tissues, According to Studies

Kyle J. Norton

According to the free radical theory, a free radical with a single unpaired electron in an outermost shell and highly reactive with other cells, which in turn, causes oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA, and RNA,..,

The theory also suggested that human aging is a result of widespread skin damage caused by a set of chain reactions auto-catalytically of overexpression of free radicals after attacking the lipid bilayers of the cell walls.

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radicals that cannot be stopped.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants produced by the host that exists over a long period of time.

Free radicals are unstable atoms with an unpaired electron in the outermost ring. Therefore, in order for them to become stable, free radicals must steal or donate an electron from or to other atoms.

Long-term expression oxidative stress has been found to cause damage to the protein, lipid, and cell DNA, leading to an increased risk of chronic disease, including heart disease, diabetes, and cancers.

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boost the immune system.

Normally, antioxidant enzymes by the body are more than enough to counter the expression of free radicals that occur in our body every day. However, in people with a weakened immune system intake of dietary antioxidants such as supplements or fruits may improve levels of antioxidants in the body.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant effects of beetroot (Beta vulgaris L.) juice (BRJ), a good source of betalain (betacyanins and betaxanthin) pigments.

The study included rats with isoproterenol (ISP85 mg/kg injected at 24 h intervals)-induced myocardial ischemia followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.


According to the tested results* Pretreatment with BRJ (150 and 300 mg/kg) restored the cardiac endogenous antioxidants and reduced levels of oxidative/nitrosative stress, in rats treated by ISP.
* Overexpression of cardiac inflammatory cytokines such as TNF-α, IL-6, and IL-10 caused by ISP was inhibited by the pretreatment of BRJ compared to the untreated group.


* Furthermore, hyperlipidemia level-induced ISP was significantly reduced by the BRJ pretreatment.


* Moreover, BRJ also protected against the extent of histological damage, myonecrosis, and edema, and maintained the architecture of cardiomyocytes by exhibiting the effects of anti-apoptotic proteins such as Bcl-2 and inhibiting the effects of apoptotic proteins.

These results strongly suggested that betacyanins and betaxanthin found in BRJ mitigate cardiac dysfunction and structural damage by decreasing oxidative stress, inflammation, and apoptosis in cardiac tissues.

Based on the findings, researchers said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".


Taken together, betacyanins found abundantly in beetroot may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)

#Herbal #Cinnamon Inhibits Syndromes and Complications in #Diabetes, Researchers Say

Kyle J. Norton

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professionals because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce blood sugar significantly with little or no adverse side effects.

The herb has been used in herbal and traditional medicine as an anti-fungal and bacteria levels to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a reduction significant of blood triglyceride levels even in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract improved fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content, and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed that "the effect of cinnamon significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR-medicated glucose and lipid metabolism"(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon (Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol, and HbA1c in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that a high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

A randomized clinical trial in which 70 patients with type II diabetes were assigned randomly to two groups (35 in cinnamon and 35 in the placebo group the test the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

Taken together, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. according to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and a burning sensation in the mouth with a large amount. Traditional Chinese medicine also insists that an Overdose of cinnamon can be toxic and damage to the liver(1).



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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Researched articles - Points of view of Vitamins, Foods, and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html

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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)

#Herbal #Angelica Sinensis Inhibits Genes Associated with the Induction of #OvarianCancer Cell Death, Researchers Say

Kyle J. Norton

Cancer is a deadly class of chronic disease caused by irregular cell growth in the tissue or specific organs in the body due to the alternation of cell DNA.
The ovaries are oval-shaped ovum-producing reproductive organs that form part of women's reproductive system that connect to the fallopian tubes and attach to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovaries take a turn to release an egg every month.

Ovarian cancer is medical a condition characterized by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversized tumor can travel a distance away to infect the nearby organs and tissue via fluid and blood circulation.

According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.


The lifetime risk of getting ovarian cancer in a woman is about 1 in 78. comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.


The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as the BRCA1 and BRCA2 gene, and acquired genetic mutation such as the TP53 tumor suppressor gene are susceptible to the risk of the development of the disease.


The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".

And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".


In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.

On finding a natural ingredient for the prevention and treatment of cancers, Z-Ligustilide, the most potent bioactive component of Angelica Sinensis on ovarian cancer cells.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the tested analysis,
* Z-Ligustilide resulted in apoptotic cell death by inducing oxidative stress on mitochondria.

* Furthermore. Z-Ligustilide enhanced the mitochondrial superoxide formation.


* NRF2, the antioxidant enzymes enhancer, and downstream antioxidant defense genes were elevated by tZ-Ligustilide in OVCAR-3 cells at the epigenetic level.


* Most importantly, NRF2 knockdown by siRNA resulted in increased cell death by Z-Ligustilide in ovarian cancer cells.

Based on the findings, researchers said, " Our result demonstrated the pro-survival role of NRF2 in Z-Ligustilide induced ovarian cancer cell death".

Taken altogether, angelica sinensis may be considered an antioxidant remedy for the prevention and treatment of human ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2 by Lang F1, Qu J2, Yin H3, Li L4, Zhi Y5, Liu Y6, Fang Z7, Hao E. (PubMed)

#Herbal #Ashwagandha Processes immune-Modulatory Activity by Regulating 15 Immune System Pathways, According to Studies

Kyle J. Norton

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.
Immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with an underactive immune system are susceptible to infection, recurrent infections.

* The overactive immune system is also known as autoimmune disease. In this case, patients suffer diseases associated with the immune system that attack the body tissues.

The immunomodulatory effect is a process in which the immune function is modulated to the needs of the body.

In the acute phase of infection, the immune macrophages, the first line of defense stimulate the production of blood palette to cover the wound or injury and pro-inflammatory cytokines to the site of infection to kill off pathogens before they can enter the body to multiply.

Most cases of infection are stopped at the acute phase, depending on the size and penetration of the wound.

The most common symptoms of acute inflammation occurred within a short period of time such as hours pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

However, if the immune system for whatever reason such as in people with a weakened immune system can not destroy the foreign invaders in a set period of time (3-8 weeks), it will adapt to the new change, leading to chronic low-grade inflammation.

Low-grade inflammation over time has been found to destroy cells and tissues in the affected area or organ, inducing chronic inflammatory diseases, including diabetes, arthritis, and cardiovascular disease.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound that modulatory the immune response, researchers examined the ashwagandha WS immunomodulatory effect.

According to the searching of the related studies and trials on Databases- DPED, UNPD, PubChem, Binding DB, ChEMBL, KEGG, and STRING, WS immune showed an immunomodulatory capability of regulating 15 immune system pathways.

Additionally, WS also exerted the immunomodulatory effect by targeting 16 proteins and protein-protein interactions.

Chemical analysis also suggested that the efficacy of WS in immunomodulation was also attributed to
the potential of withanolide-phytosterol combination and seven novel bioactive-immune target combinations.

Based on the findings, researchers said, "The study elucidated an in silico molecular mechanism of immunomodulation of WS. It unveils the potential of the withanolide-phytosterol combination to achieve better immunomodulation. Experimental validation of the network findings would aid in understanding the rationale behind WS immunomodulation as well as aid in bioactive formulation-based drug discovery.".

Taken together, Ashwagandha may be considered a functional herb for immune modulation, pending  the result of a larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORSrights TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Network ethnopharmacological evaluation of the immunomodulatory activity of Withania somnifera by Chandran U1, Patwardhan B. (PubMed)

#Broccoli+Cauliflower Inhibit the Onset of Acnes through their Anti Inflammatory Activity, Researchers Say

Kyle J. Norton

Acne is a skin condition characterized by dirt in oily skin pores.
Believe it or not, acne can also be caused by the hormone testosterone. Other forms of acne can also be found in women's pregnancy or the menstrual cycle due to hormone changes.


Holistically, acne is also induced by the system of toxins in the body, if the liver and kidney can not cleanse all toxins in the body, toxins will have to be eliminated through the skin, leading to skin diseases such as acne.

In general, acne is naturally preventable, some researchers suggested if you are following the below strategies
* Acne care treatment: cream and lotion
Be sure before applying skin cream or lotion in acne affected area, to wash it with mild soap and tepid water because water too hot or too cold might cause the breaking of capillaries (small veins).

The best choice of acne cream and lotion is the one made by using ingredients of natural remedies that exist in the kitchen of your home for cost-effectiveness with little or no side effects.


Although there are plenty of acne creams and lotions in pharmacy drug stores, you might only choose those that do not contain chemicals that may cause side effects to your sensitive skin.

Asking the pharmacist in the drugstore is the best approach. Please note that chemical preserves the product might cause side effects to your sensitive skin.

* Reducing intake of saturated fat
Saturated fat intake causes the build-up of cholesterol in capillaries, the small veins in your skin. Without giving enough oxygen to the skin cells, your skin becomes oily and easily attracts dirt, causing acne. To avoid this, you should substitute your red meat intake by 4- 8 servings every week with fish.

* Lower your body toxins
If the liver and kidney are not able to get rid of toxins completely, the skin becomes an extra burden to remove them, causing acne. To avoid this, adding some delicious antioxidants super-foods in your diet will help to solve this problem quickly such as garlic, ginger, etc.

4. Eat foods that purify your blood
Foods that purify your bloodstream will increase the circulation of blood to the skin, leading to more healthy skin that is immune from any skin problems.


Cauliflower and broccoli are members of the species Brassica oleracea belonging to the family Brassicaceae, native to Italy.

In finding a potent compound for the treatment of Acne vulgaris, researchers examined the efficacy of two different plant extracts against HaCaT cells, AE1-2.

Where AE1 consisted of Juglans regia (walnut husk), Myrtus communis (myrtle leaves), Matricaria chamomilla (chamomilla flowers), Urtica dioica (stinging nettle leaves), and Rosa damascena (rose flowers) and AE2 contained Brassica oleracea var. botrytis (broccoli) and B. oleracea var. Italica (cauliflower).

According to the results of the tested analysis, * The MIC values of the extracts were below 1/2048 µg/mL
* In gene differentiation, AE1 decreased the expression level of TNFα involved in systemic inflammation and suppressed the expression level of IL-1α involved in the activation of proinflammatory cytokine.

Furthermore, the gene hormone expression of SRD5A1 that converts testosterone dihydrotestosterone (DHT) induced elevated androgen levels seldom found in blood and urine from patients with acne were significantly reduced by the application of AE1.


* AE2 suppressed gene expression level of all aforementioned parameters, similar to those of AE1, including IL-1α, SRD5A1, TNFα.


Based on the findings, researchers wrote, "Both herbal extracts demonstrated strong antibacterial and anti-inflammatory activity in this preliminary trial. In conclusion, the topical application of these botanical extracts can be good candidates for local acne treatment".

Taken together, broccoli combined with cauliflower may be considered functional foods for the prevention and treatment of acne, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy of two plant extracts against acne vulgaris: Initial results of microbiological tests and cell culture studies by Kılıç S1, Okullu SÖ2, Kurt Ö2, Sevinç H1, Dündar C1, Altınordu F1, Türkoğlu M. (PubMed)