Kyle J. Norton
Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.
Cognitive function is a mental process of the brain, with an aim to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.
On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.
In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and long-term use of medication, including Alzheimer's;s disease.
However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.
Some researchers suggested that for people who have metabolic syndrome (abnormally high blood pressure, high blood sugar, obesity, and abnormal cholesterol or triglyceride levels), mental illness, and previously disturbed state of mind due to fever, intoxication is also at a higher risk of the condition develops.
Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"
And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle on cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, may be highly informative for the development of interventions to reduce or delay age-related cognitive decline".
These explanations strongly agreed that following a healthy diet with plenty of fruits and vegetables and less saturated and trans fat, processed meat, refined products,...... salt, and sugar, and a lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, and antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.
In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematic inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production of inflammatory factors in the acute phase of infection.
The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.
From an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which causes cytotoxicity to neurons through its antioxidant and stimulated the production of the host antioxidant defense.
Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk in the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.
Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against progressive degeneration.
The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.
In acetylcholinesterase AChE-induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.
Dr. Preksha Dwivedi, the lead author, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract is used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".
Taken together, fennel, fennel extracts, or its bioactive anethole may be considered a functional food for enhancing memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cholinergic basis of the memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)
Sunday, 8 October 2023
Intake of Coffee Is Associated with a Reduced Risk of #PrimarySclerosingCholangitis #PSC, Researchers Suggest
Kyle J. Norton
A recent study suggested that coffee and caffeine consumption may be associated with a beansreduced risk of primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a medical condition of inflammation and obliterative fibrosis of the bile ducts.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the study of 606 patients with primary biliary cirrhosis (PBC), 480 with primary sclerosing cholangitis (PSC), and 564 healthy volunteers acted as controls, researchers filed the following results
1. 24% of patients with PSC had never drunk coffee in compared to 16% of controls.
2. Patients with PSC also consumed fewer lifetime cups per month and spent a smaller percentage of their lifetime drinking coffee compared to healthy adults.
Based on this information, Dr.Lammert C, the lead author opinionated, that coffee consumption is lower among patients with PSC, compared with controls.
Additionally, In patients with PSC, recruited from Oslo University Hospital Rikshospitalet in Norway through 2011, randomly chosen from the Norwegian Bone Marrow Donor Registry (control subjects) of 240 patients with PSC and 245 control subjects also indicated a similar conclusion as follow
1. In comparison to control, PSC patients showed a lower daily drinking coffee habit as the time of study and at the age of 18 years observed in men.
2. Ever daily coffee drinker at the age of 18 years was independently and negatively associated with PSC.
These results showed that coffee intake may have a profound effect on protection against the development of PSC.
The evidence demonstrated that coffee and caffeine consumption may have a significant effect on the attenuated risk of primary sclerosing cholangitis developing, but further large and multi-center studies are necessary to validate this claim.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis by Lammert C1, Juran BD1, Schlicht E1, Xie X2, Atkinson EJ2, de Andrade M2, Lazaridis KN3.(PubMed)
A recent study suggested that coffee and caffeine consumption may be associated with a beansreduced risk of primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a medical condition of inflammation and obliterative fibrosis of the bile ducts.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
In the study of 606 patients with primary biliary cirrhosis (PBC), 480 with primary sclerosing cholangitis (PSC), and 564 healthy volunteers acted as controls, researchers filed the following results
1. 24% of patients with PSC had never drunk coffee in compared to 16% of controls.
2. Patients with PSC also consumed fewer lifetime cups per month and spent a smaller percentage of their lifetime drinking coffee compared to healthy adults.
Based on this information, Dr.Lammert C, the lead author opinionated, that coffee consumption is lower among patients with PSC, compared with controls.
Additionally, In patients with PSC, recruited from Oslo University Hospital Rikshospitalet in Norway through 2011, randomly chosen from the Norwegian Bone Marrow Donor Registry (control subjects) of 240 patients with PSC and 245 control subjects also indicated a similar conclusion as follow
1. In comparison to control, PSC patients showed a lower daily drinking coffee habit as the time of study and at the age of 18 years observed in men.
2. Ever daily coffee drinker at the age of 18 years was independently and negatively associated with PSC.
These results showed that coffee intake may have a profound effect on protection against the development of PSC.
The evidence demonstrated that coffee and caffeine consumption may have a significant effect on the attenuated risk of primary sclerosing cholangitis developing, but further large and multi-center studies are necessary to validate this claim.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis by Lammert C1, Juran BD1, Schlicht E1, Xie X2, Atkinson EJ2, de Andrade M2, Lazaridis KN3.(PubMed)
#Herbal #Chastetreeberry Induces Cytotoxicity of Cancer, According to Studies
Kyle J. Norton
The study conducted by respectable institutions suggested that Chaste tree berries may have a potential effect in reducing the risk and treatment of gastric/stomach cancer.
Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric cancer.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
According to the Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) displayed a strong cytotoxic activity against human gastric cancer cells through induction of apoptosis.
The efficacy of anti-gastric cancer extract is a result of antioxidant activity in reduced progression of oxidative stress which can be detected through using 2',7'-dichlorofluorescin-diacetate.
Dr.Ohyama K, the lead author said, " Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell".
Furthermore, in support of the above differentiation, another study conducted by the same institution, suggested that Vitex extracted expressed a similar effect against human gastric signet ring carcinoma cell line, KATO-III, through separating or breaking of DNA in a time- and dose-dependent manner.
Additionally, the study also indicated, Vitex-induced apoptosis by elevated the intracellular oxidative stress and mitochondrial membrane damage of gastric cancer cell lines through the mediation of the presence of reduced type glutathione within the cell.
Other; investigations of the cytotoxicity of the extract against several human cancer cell lines, including gastric signet ring carcinoma (KATO-III), and colon carcinoma (COLO 201), showed that injection of the extract exhibited a significant effect in interference of the cell cycle division, reduced DNA abnormal expression through antioxidative reagent pyrrolidine dithiocarbamate or N-acetyl-L-cysteine (NAC).
Finally, according to Dr. Ohyama K, the lead author, the cytotoxic activity of Vitex extract may be attributed to the effect on cell growth in the expression of apoptotic cell death by increased intracellular oxidation.
Taken together, chaste tree berries exert an anti-cancer effect through various phytochemicals and may be used as a functional food for ameliorated risk and treatment of gastric cancer, but intake of a large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
The study conducted by respectable institutions suggested that Chaste tree berries may have a potential effect in reducing the risk and treatment of gastric/stomach cancer.
Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric cancer.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
According to the Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) displayed a strong cytotoxic activity against human gastric cancer cells through induction of apoptosis.
The efficacy of anti-gastric cancer extract is a result of antioxidant activity in reduced progression of oxidative stress which can be detected through using 2',7'-dichlorofluorescin-diacetate.
Dr.Ohyama K, the lead author said, " Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell".
Furthermore, in support of the above differentiation, another study conducted by the same institution, suggested that Vitex extracted expressed a similar effect against human gastric signet ring carcinoma cell line, KATO-III, through separating or breaking of DNA in a time- and dose-dependent manner.
Additionally, the study also indicated, Vitex-induced apoptosis by elevated the intracellular oxidative stress and mitochondrial membrane damage of gastric cancer cell lines through the mediation of the presence of reduced type glutathione within the cell.
Other; investigations of the cytotoxicity of the extract against several human cancer cell lines, including gastric signet ring carcinoma (KATO-III), and colon carcinoma (COLO 201), showed that injection of the extract exhibited a significant effect in interference of the cell cycle division, reduced DNA abnormal expression through antioxidative reagent pyrrolidine dithiocarbamate or N-acetyl-L-cysteine (NAC).
Finally, according to Dr. Ohyama K, the lead author, the cytotoxic activity of Vitex extract may be attributed to the effect on cell growth in the expression of apoptotic cell death by increased intracellular oxidation.
Taken together, chaste tree berries exert an anti-cancer effect through various phytochemicals and may be used as a functional food for ameliorated risk and treatment of gastric cancer, but intake of a large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
#Ginger's 6 #Shogaol Inhibits Aging Processes, According to Scientists
Kyle J. Norton
Aging is a natural process of becoming older. Antiaging is a term that relates to delayed aging. In other words, anti-aging is an action that makes your appearance look younger than your biological age.
The cause of aging has many theories, including the theory of the accumulation of damage due to oxidative stress in the initiation of DNA oxidation and the programmed aging concept due to DNA methylation.
However, regardless of the theories, the decrease in hormone production gradually found in the human body may be one of the major causes of aging progression.
In fact, reduced production of hormones affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.
Some researchers suggested that improved nutrient intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.
Dr. Simpson SJ, the lead scientist in the joint study led by the University of Sydney wrote, "Nearly a century of research has shown that nutritional interventions can delay aging and age-related diseases in many animal models and possibly humans".
And, "Nutritional geometry provides new perspectives on the relationship between nutrition and aging by focusing on calories, macronutrients and their interactions across a landscape of diets, and taking into account compensatory feeding in ad libitum-fed experiments".
The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, and macronutrients, you may delay the process of biological aging.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural ingredient that processes anti-aging properties examined the ameliorative effects of two antioxidant supplements, ginger and alpha lipoic acid (ALA), on hepatic ultrastructural alterations in old rats by evaluating the livers of young (4 months) and old (24 months) Wistar rats.
Before administration of ginger and ALA, the livers of old rats showed sinusoidal collapse and congestion, endothelial thickening and defenestration, inconsistent perisinusoidal extracellular matrix deposition, and aged hepatocytes associated with reduced liver function.
Injection of ginger and ALA supplementation completely normalized all the alternation due to aging in the tested old rats.
The findings strongly suggested the use of ginger and ALA as anti-aging products for improvement based on their amelioration of ultrastructural alterations in the livers of old rats.
Additionally, in order to get more information about ginger's antiaging effects, researchers examined the anti-aging natural products, the active constituent 6-shogaol isolated from ginger.
Application of the tested compound showed the lifespan-extending effect in a dose-dependent manner in Caenorhabditis elegans.
The anti-aging activity effects were attributed to 6 gingerols in increasing oxidative stress tolerances via antioxidant enzyme induction.
In the depth differentiation, researchers surprisingly found that 6-shogaol inhibits the aging process independent from other aging-related factors of C. elegans.
Taken together, ginger processed with high levels of 6 gingerols may be considered a functional anti-aging remedy, pending the confirmation of a larger sample-sized and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
10,000
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans by Lee EB1,2, Kim JH1, Kim YJ1, Noh YJ1, Kim SJ1, Hwang IH1, Kim DK3. (PubMed)
(2) Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver by Mahmoud YI1, Hegazy HG1. (PubMed)
(3) Dietary protein, aging and nutritional geometry by Simpson SJ1, Le Couteur DG2, Raubenheimer D3, Solon-Biet SM4, Cooney GJ4, Cogger VC2, Fontana L. (PubMed)
Aging is a natural process of becoming older. Antiaging is a term that relates to delayed aging. In other words, anti-aging is an action that makes your appearance look younger than your biological age.
The cause of aging has many theories, including the theory of the accumulation of damage due to oxidative stress in the initiation of DNA oxidation and the programmed aging concept due to DNA methylation.
However, regardless of the theories, the decrease in hormone production gradually found in the human body may be one of the major causes of aging progression.
In fact, reduced production of hormones affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.
Some researchers suggested that improved nutrient intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.
Dr. Simpson SJ, the lead scientist in the joint study led by the University of Sydney wrote, "Nearly a century of research has shown that nutritional interventions can delay aging and age-related diseases in many animal models and possibly humans".
And, "Nutritional geometry provides new perspectives on the relationship between nutrition and aging by focusing on calories, macronutrients and their interactions across a landscape of diets, and taking into account compensatory feeding in ad libitum-fed experiments".
The results strongly suggested that if you follow a healthy diet with nutrients diet by focusing on calories, and macronutrients, you may delay the process of biological aging.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural ingredient that processes anti-aging properties examined the ameliorative effects of two antioxidant supplements, ginger and alpha lipoic acid (ALA), on hepatic ultrastructural alterations in old rats by evaluating the livers of young (4 months) and old (24 months) Wistar rats.
Before administration of ginger and ALA, the livers of old rats showed sinusoidal collapse and congestion, endothelial thickening and defenestration, inconsistent perisinusoidal extracellular matrix deposition, and aged hepatocytes associated with reduced liver function.
Injection of ginger and ALA supplementation completely normalized all the alternation due to aging in the tested old rats.
The findings strongly suggested the use of ginger and ALA as anti-aging products for improvement based on their amelioration of ultrastructural alterations in the livers of old rats.
Additionally, in order to get more information about ginger's antiaging effects, researchers examined the anti-aging natural products, the active constituent 6-shogaol isolated from ginger.
Application of the tested compound showed the lifespan-extending effect in a dose-dependent manner in Caenorhabditis elegans.
The anti-aging activity effects were attributed to 6 gingerols in increasing oxidative stress tolerances via antioxidant enzyme induction.
In the depth differentiation, researchers surprisingly found that 6-shogaol inhibits the aging process independent from other aging-related factors of C. elegans.
Taken together, ginger processed with high levels of 6 gingerols may be considered a functional anti-aging remedy, pending the confirmation of a larger sample-sized and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
10,000
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans by Lee EB1,2, Kim JH1, Kim YJ1, Noh YJ1, Kim SJ1, Hwang IH1, Kim DK3. (PubMed)
(2) Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver by Mahmoud YI1, Hegazy HG1. (PubMed)
(3) Dietary protein, aging and nutritional geometry by Simpson SJ1, Le Couteur DG2, Raubenheimer D3, Solon-Biet SM4, Cooney GJ4, Cogger VC2, Fontana L. (PubMed)
#Phytochemical Sulforaphane (Dithiolthiones) Inhibits Parameters Associated with the Risk of #LiverDisease, According to Studies
Kyle J. Norton
Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.
Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overload.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.
If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.
According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.
These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but also cause a financial burden on the health care system.
Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.
Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".
And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".
With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.
Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.
CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.
The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.
SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.
The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowering the expression of free radicals as well as reducing the liver fat deposits.
Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity
Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.
Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.
The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
rights
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)
Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.
Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overload.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.
If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.
According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.
These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but also cause a financial burden on the health care system.
Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.
Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".
And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".
With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.
Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.
CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.
The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.
SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.
The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowering the expression of free radicals as well as reducing the liver fat deposits.
Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity
Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.
Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.
The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
rights
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)
#Inicaxanthin Regulates Enzymes and Proteins Associated with the Production of Pro-inflammatrry Cytokines, Researchers Suggest
Kyle J. Norton
Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.
Anti-inflammatory activity is the process of reducing inflammation or swelling without affecting the function of the immune system.
In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelets to cover the wound or cut and proinflammatory cytokines to destroy all invaders.
Most cases of acute infection are stopped at this phase and the wound is healed quickly.
However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recover stage may cause the formation of scars.
Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.
Additionally, if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.
Diseases associated with chronic inflammation induced by protein, lipid and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.
The results have been found to cause cell death and alternation of cell DNA.
In finding a potent compound that processes anti-inflammatory property, researchers investigated the activity of indicaxanthin, in an animal model of acute inflammation.
According to the tested differentiation of rats induced by injection of 0.2 mL of λ-carrageenin in the pleural cavity pretreated by indicaxanthin at 2 μmol/kg,
* Pretreatment of the phytochemical inhibited the release of pro-inflammatory PGE(2) (91.4%), NO (67.7%), IL-1β (53.6%), and TNF-α (71.1%) induced by carrageenan-induced rats.
* Furthermore, enzymes and proteins associated with the production of proinflammatory cytokines such as IL-1β (34.5%), TNF-α (81.6%), iNOS (75.2%), and COX2 (87.7%) mRNA were also inhibited by the pretreatment of indicaxanthin.
* iNOS (71.9%) and COX-2 (65.9%) enzyme expressions involved in the inflammatory processes that recruit the leukocytes are also inhibited by the bioactive compound.
* Moreover, enzymes associated with the induction of free radicals chain reaction were also curbed by the indicaxanthin at a time- and dose-dependently.
Pharmacokinetically, the most efficacy in inhibition of inflammation was found to have a maximum 0.22 ± 0.02 μmol/L (n = 15) plasma concentration of indicaxanthin, with a half-life of 1.15 ± 0.11 h.
Based on the findings, researchers said, "This dietary pigment has the potential to improve health and prevent inflammation-based disorders".
Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of inflammation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy by Allegra M1, Ianaro A, Tersigni M, Panza E, Tesoriere L, Livrea MA. (PubMed)
(2) Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells by Tesoriere L1, Attanzio A1, Allegra M1, Gentile C1, Livrea MA. (PubMed)
Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.
Anti-inflammatory activity is the process of reducing inflammation or swelling without affecting the function of the immune system.
In the acute phase of infection, the immune first line of defense, the white blood cells, macrophages stimulates the production of blood platelets to cover the wound or cut and proinflammatory cytokines to destroy all invaders.
Most cases of acute infection are stopped at this phase and the wound is healed quickly.
However, if the wound is too large, then the recovery may take a longer period and through 4 overlap recovery stages. Any interruption in the overlapped recover stage may cause the formation of scars.
Moreover, overproduction of proinflammatory cytokines that kills harmful pathogens may cause damage and death of nearby healthy cells, leading to the formation of scars, such as scar in the liver caused by hepatitis infection.
Additionally, if the immune system can not destroy the invasive pathogens in a set of times, it will compromise, leading to low-grade inflammation. Prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines can result in serious and chronic diseases.
Diseases associated with chronic inflammation induced by protein, lipid and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.
The results have been found to cause cell death and alternation of cell DNA.
In finding a potent compound that processes anti-inflammatory property, researchers investigated the activity of indicaxanthin, in an animal model of acute inflammation.
According to the tested differentiation of rats induced by injection of 0.2 mL of λ-carrageenin in the pleural cavity pretreated by indicaxanthin at 2 μmol/kg,
* Pretreatment of the phytochemical inhibited the release of pro-inflammatory PGE(2) (91.4%), NO (67.7%), IL-1β (53.6%), and TNF-α (71.1%) induced by carrageenan-induced rats.
* Furthermore, enzymes and proteins associated with the production of proinflammatory cytokines such as IL-1β (34.5%), TNF-α (81.6%), iNOS (75.2%), and COX2 (87.7%) mRNA were also inhibited by the pretreatment of indicaxanthin.
* iNOS (71.9%) and COX-2 (65.9%) enzyme expressions involved in the inflammatory processes that recruit the leukocytes are also inhibited by the bioactive compound.
* Moreover, enzymes associated with the induction of free radicals chain reaction were also curbed by the indicaxanthin at a time- and dose-dependently.
Pharmacokinetically, the most efficacy in inhibition of inflammation was found to have a maximum 0.22 ± 0.02 μmol/L (n = 15) plasma concentration of indicaxanthin, with a half-life of 1.15 ± 0.11 h.
Based on the findings, researchers said, "This dietary pigment has the potential to improve health and prevent inflammation-based disorders".
Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of inflammation, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy by Allegra M1, Ianaro A, Tersigni M, Panza E, Tesoriere L, Livrea MA. (PubMed)
(2) Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial permeability in IL-1β-exposed Caco-2 cells by Tesoriere L1, Attanzio A1, Allegra M1, Gentile C1, Livrea MA. (PubMed)
#CranberryExtract Improves Metabolic Profile induced by Lipid Dysfunction of #Obesity, According to Studies
Kyle J. Norton
A metabolic profile is a tool to diagnose metabolic disease.
A metabolic disease is a group of medical conditions that disrupt normal cell metabolism in converting food to energy.
The most common causes of metabolic disease are genetic prepositions. However, people with the mutated gene remain healthy for years.
Interestingly, cellular stress and family history have been found to be a major cause of the initiation of the symptoms of metabolic disease, epidemiologically.
As of today, there is no effective treatment for metabolic disease. Some children with metabolic disease diagnosed at an early age may respond very well. However, many do not respond well to therapy and cause severe problems, despite the early diagnosis.
Dr. Ingraham RH, the lead scientist at the Louisiana State University School of Veterinary Medicine wrote, "Except in cases of gross mismanagement, these profiles do not offer a "quick fix." In many of the reported cases in which diagnosis of herd problems was attributed to the metabolic profile, the clinician should have been able to identify the problem before the profile was conducted".
According to statistics, the metabolic disease is uncommon in the US. Metabolic disorders affect approximately 1 in 1,000 individuals.
People who are overweight and obesity and physical inactivity and have a condition of insulin resistance are most likely to have metabolic disease developing.
According to the statistics, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35%. From 1988–1994 to 2007–2012, the condition increased from 25.3% to 34.2%.
Out of many risk factors associated with the onset of metabolic syndrome, some researchers suggested the promotion of the Western diet over the past few decades may be the major culprit in inducing the rise of the metabolic syndrome, globally.
Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.
Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistics, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, inclduing over 650 million who were obese worldwide.
Dr. Shu-Zhong Jiang, the lead scientist wrote in the examination of the metabolic profile of the obese, "There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration".
And, "The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome".
The results strongly suggested that obese subjects are at an increased risk of metabolic disease.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of hypercholesterolemia, researchers examined the effect of cranberry extract (CE) on the improvement of lipid dysfunction in HFD-induced obesity in an animal model.
The study included postnatal day 120 (PN120), male Wistar rats assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44.5% (35.2% from lard) energy from fat.
According to the results from rats 12 animals from SD and HFD groups were killed at at At PN150 and others subdivided into four groups (n = 12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD) killed at PN180, HFD group showed higher body mass and visceral fat, cholesterol and triglyceride contents.
Furthermore, the HFD group demonstrated a significantly higher lipid peroxidation in plasma and tissues and higher protein carbonylation in the liver and adipose tissue compared to the SD group.
Application of CE not only inhibited the aforementioned parameters induced by a high-fat diet but also protected the liver tissues against by lowering lipid peroxidation and protein carbonylation and accumulation of liver fat without completely reversing the adiposity.
Based on the findings, researchers aid, "cranberry extract improved the metabolic profile and reduced oxidative damage and steatosis in HFD-fed rats, which suggests that it can help manage obesity-related disorders".
Taken together, cranberry may be considered a remedy for the improvement of the metabolic profile of obesity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet by Peixoto TC1, Moura EG1, de Oliveira E1, Soares PN1, Guarda DS1, Bernardino DN1, Ai XX1, Rodrigues VDST1, de Souza GR2, da Silva AJR2, Figueiredo MS1, Manhães AC3, Lisboa PC. (PubMed)
(2) Metabolic profile testing by Ingraham RH1, Kappel LC. (PubMed)
(3) Inflammatory mechanisms linking obesity and metabolic disease by Saltiel AR, Olefsky JM. (PubMed)
A metabolic profile is a tool to diagnose metabolic disease.
A metabolic disease is a group of medical conditions that disrupt normal cell metabolism in converting food to energy.
The most common causes of metabolic disease are genetic prepositions. However, people with the mutated gene remain healthy for years.
Interestingly, cellular stress and family history have been found to be a major cause of the initiation of the symptoms of metabolic disease, epidemiologically.
As of today, there is no effective treatment for metabolic disease. Some children with metabolic disease diagnosed at an early age may respond very well. However, many do not respond well to therapy and cause severe problems, despite the early diagnosis.
Dr. Ingraham RH, the lead scientist at the Louisiana State University School of Veterinary Medicine wrote, "Except in cases of gross mismanagement, these profiles do not offer a "quick fix." In many of the reported cases in which diagnosis of herd problems was attributed to the metabolic profile, the clinician should have been able to identify the problem before the profile was conducted".
According to statistics, the metabolic disease is uncommon in the US. Metabolic disorders affect approximately 1 in 1,000 individuals.
People who are overweight and obesity and physical inactivity and have a condition of insulin resistance are most likely to have metabolic disease developing.
According to the statistics, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35%. From 1988–1994 to 2007–2012, the condition increased from 25.3% to 34.2%.
Out of many risk factors associated with the onset of metabolic syndrome, some researchers suggested the promotion of the Western diet over the past few decades may be the major culprit in inducing the rise of the metabolic syndrome, globally.
Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.
Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistics, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, inclduing over 650 million who were obese worldwide.
Dr. Shu-Zhong Jiang, the lead scientist wrote in the examination of the metabolic profile of the obese, "There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration".
And, "The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome".
The results strongly suggested that obese subjects are at an increased risk of metabolic disease.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of hypercholesterolemia, researchers examined the effect of cranberry extract (CE) on the improvement of lipid dysfunction in HFD-induced obesity in an animal model.
The study included postnatal day 120 (PN120), male Wistar rats assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44.5% (35.2% from lard) energy from fat.
According to the results from rats 12 animals from SD and HFD groups were killed at at At PN150 and others subdivided into four groups (n = 12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD) killed at PN180, HFD group showed higher body mass and visceral fat, cholesterol and triglyceride contents.
Furthermore, the HFD group demonstrated a significantly higher lipid peroxidation in plasma and tissues and higher protein carbonylation in the liver and adipose tissue compared to the SD group.
Application of CE not only inhibited the aforementioned parameters induced by a high-fat diet but also protected the liver tissues against by lowering lipid peroxidation and protein carbonylation and accumulation of liver fat without completely reversing the adiposity.
Based on the findings, researchers aid, "cranberry extract improved the metabolic profile and reduced oxidative damage and steatosis in HFD-fed rats, which suggests that it can help manage obesity-related disorders".
Taken together, cranberry may be considered a remedy for the improvement of the metabolic profile of obesity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best BeforeKarate it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet by Peixoto TC1, Moura EG1, de Oliveira E1, Soares PN1, Guarda DS1, Bernardino DN1, Ai XX1, Rodrigues VDST1, de Souza GR2, da Silva AJR2, Figueiredo MS1, Manhães AC3, Lisboa PC. (PubMed)
(2) Metabolic profile testing by Ingraham RH1, Kappel LC. (PubMed)
(3) Inflammatory mechanisms linking obesity and metabolic disease by Saltiel AR, Olefsky JM. (PubMed)
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