Kyle J. Norton
Scientists may have found a bioactive compound for the prevention and treatment of pancreatic cancer, according to studies.
Cancer of the pancreas or pancreatic cancer is a condition of a malignant neoplasm of the pancreas.
Most cases of primary pancreatic cancer start in the cells on the surface of the inner lining of the pancreas as a result of irregular cell growth caused by the alternation of DNA.
The pancreatic cancers start in the ducts (an exocrine component of the pancreas) carried pancreatic juices with cancer of an epithelium that originates in glandular tissue and accounts for over 75 - 90% of all cases of exocrine cancers.
According to the statistics, pancreatic cancer is the fourth leading cause of cancer death in both men and women in the US. Cancer has the poorest prognosis compared to other major types of cancer, with a 5-year survival rate of approximately 5%.
More precisely, in the US, the age-adjusted incidence of pancreatic cancer is higher in men compared to women regardless of ethnicity.
Epidemiologically, the increase in age, gender, ethnicity, smoking, being obese and obese, and certain medical conditions such as diabetes, and family history are associated with an increased risk of pancreatic cancer.
Some researchers suggested that genetic preposition also places the carrier at a greater risk for the onset of the disease.
Dr. Alison P. Klein, in the joint study led by the Johns Hopkins University School of Medicine, Baltimore, Maryland suggested people who carry the mutated gene BRCA2 or PALB2 and genetic variation at the ABO blood group locus are associated with a modest increased risk of pancreatic cancer.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
In finding the natural ingredient for the treatment of pancreatic cancer without inducing chemoresistance due to the overexpression of microRNA-21 (miR-21), researchers at the Seoul National University College of Medicine evaluated the efficacy of indole-3-carbinol (I3C) in suppressing miR-21 expression.
Where miR-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis, and tumor invasiveness by targeting the genes associated with cancer proliferation.
In human pancreatic cancer cells (Panc-1), injection of 13C inhibited the expression of miR-21 positively correlated in a time- and dose-dependent manner.
13C and gemcitabine combination therapy increased cytotoxicity in Panc-1 cells.
The efficacy of 13C was attributed to its activity in promoting cancer cell apoptosis by attenuating miR-21 transfection.
The finding suggested that I3C would be effective in enhancing the sensitivity of pancreatic cancer cells to gemcitabine via the inhibition of the overexpression of miR-21.
An additional experiment demonstrating the ability of a dietary agent, indole-3-carbinol (I3C), to lower the LD(50) of gemcitabine (Gemzar) in decreasing growth of both male (MiaPaca2) and female (SU86.86) pancreatic cancer cells, researchers found that* Without an injection of 13C, female pancreatic cancer cells were more resistant to gemcitabine.
* In male MiaPaca2 cells application of 1, 10, or 100 μM of I3C induced apoptosis by reactivating the tumor suppressor gene in pancreatic cancer cells.
* 13C also protects the healthy pancreas cells by enhancing the activity of the tumor suppressor gene.
Moreover, by examining the DNA methylation researchers suggested suppressor tumor gene (p16INK4a) inactivation in the promotion of hypermethylation is considered an early event in pancreatic carcinogenesis.
DNA methylation is a process by which methyl groups are added to the DNA molecule.
These results clearly indicated, that I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, is a powerful strategy for treating pancreatic cancer.
Taken altogether, the bioactive compound indole-3-carbinol (I3C) may be used for the prevention and treatment of pancreas cancer, pending the results of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol by Paik WH1, Kim HR, Park JK, Song BJ, Lee SH, Hwang JH.(PubMed)
(2) Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. by Lyn-Cook BD1, Mohammed SI, Davis C, Word B, Haefele A, Wang H, Hammons G.(PubMed)
(3) Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1 by Wang H1, Word BR, Lyn-Cook BD. (PubMed)
(4) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
Sunday, 8 October 2023
#Carotenoids Inhibits the Risk of #ColorectalCancer in Patients with DICER1 rs3742330 Genotypeancer, Researchers Say
Kyle J. Norton
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originates in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant type of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originates in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant type of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken together, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
#Cabbage Stimulates Protein Associated with Cell Survival and Against Apoptosis Caused Overexpression of Oxidative Stress
Kyle J. Norton
Mitochondria are the cell that converts food molecules into energy for the body tissues' needs. Mitochondria produce 90 percent of the energy for the body's function.
Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.
Genetically, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people.
Acquired mitochondrial dysfunction is caused by the long-term use of certain medications such as Metformin, medical conditions such as mitochondrial encephalomyopathy or infection, and environmental influences, such as xenochemicals, leading to less and less energy generated within the cells.
Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.
The most common symptoms of mitochondrial dysfunction include poor growth, muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.
Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver or kidney diseases, seizures, strokes, severe developmental delays, inability to walk, and dementia.
Conventionally, treatments for mitochondrial dysfunction are totally depending on the causes of the disease.
Dr. Sreenivas Avula, the lead scientist wrote, "Classification of therapies for mitochondrial disorders has evolved from the empirical therapies targeting residual respiratory chain to acting at the molecular level to alter the expression of mutated mtDNA genes within the cell nucleus".
And, " ...in the future, treatment strategies may employ a combination of pharmacological treatments that have undergone rigorous clinical trials targeting OXPHOS, as well as newer strategies at the molecular level".
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.
With an aim to find a natural food for the prevention of oxidative stress in the progression of cardiac diseases, researchers examined the effect of cabbage extract on mitochondrial dysfunction in H9c2 cardiomyoblasts.
According to the tested differentiation, the administration of cabbage extract protected the mitochondria against H2O2-induced cell death without eliciting cytotoxic effects.
Furthermore, cabbage extract enhanced the expression of antioxidant proteins (SOD-1, catalase, and GPx) against ROS production.
Moreover, the extracts also stimulate the protein associated with cell survival by inhibiting apoptotic responses in oxidative stress-exposed H9c2 cells.
More precisely, cabbage extract preserved mitochondrial functions upon oxidative stress.
Based on the results, researchers wrote, "These findings reveal that cabbage extract protects against oxidative stress and suggest that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".
Taken together, cabbage processed abundantly SFN may be considered a remedy for the prevention and treatment of mitochondrial dysfunction in the initiation of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2o2-induced oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
(2) Treatment of Mitochondrial Disorders by Sreenivas Avula,1 Sumit Parikh, MD,1 Scott Demarest, MD,2 Jonathan Kurz, MD,2 and Andrea Gropman, MD. (PMC)
Mitochondria are the cell that converts food molecules into energy for the body tissues' needs. Mitochondria produce 90 percent of the energy for the body's function.
Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.
Genetically, the genetic proposition has been found to alter the process of mitochondria in converting oxygen and food to energy in some people.
Acquired mitochondrial dysfunction is caused by the long-term use of certain medications such as Metformin, medical conditions such as mitochondrial encephalomyopathy or infection, and environmental influences, such as xenochemicals, leading to less and less energy generated within the cells.
Acquired mitochondrial dysfunction has been found in patients with Alzheimer’s disease, muscular dystrophy, Lou Gehrig’s disease, diabetes, and cancer.
The most common symptoms of mitochondrial dysfunction include poor growth, muscle weakness, muscle pain, low muscle tone, exercise intolerance, vision and/or hearing problems
learning disabilities, delays in development, and mental retardation depending on the location of the infected cells.
Diseases associated with mitochondrial dysfunction include Autism, autism-like features Heart, liver or kidney diseases, seizures, strokes, severe developmental delays, inability to walk, and dementia.
Conventionally, treatments for mitochondrial dysfunction are totally depending on the causes of the disease.
Dr. Sreenivas Avula, the lead scientist wrote, "Classification of therapies for mitochondrial disorders has evolved from the empirical therapies targeting residual respiratory chain to acting at the molecular level to alter the expression of mutated mtDNA genes within the cell nucleus".
And, " ...in the future, treatment strategies may employ a combination of pharmacological treatments that have undergone rigorous clinical trials targeting OXPHOS, as well as newer strategies at the molecular level".
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.
With an aim to find a natural food for the prevention of oxidative stress in the progression of cardiac diseases, researchers examined the effect of cabbage extract on mitochondrial dysfunction in H9c2 cardiomyoblasts.
According to the tested differentiation, the administration of cabbage extract protected the mitochondria against H2O2-induced cell death without eliciting cytotoxic effects.
Furthermore, cabbage extract enhanced the expression of antioxidant proteins (SOD-1, catalase, and GPx) against ROS production.
Moreover, the extracts also stimulate the protein associated with cell survival by inhibiting apoptotic responses in oxidative stress-exposed H9c2 cells.
More precisely, cabbage extract preserved mitochondrial functions upon oxidative stress.
Based on the results, researchers wrote, "These findings reveal that cabbage extract protects against oxidative stress and suggest that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".
Taken together, cabbage processed abundantly SFN may be considered a remedy for the prevention and treatment of mitochondrial dysfunction in the initiation of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cabbage (Brassica oleracea var. capitata) Protects against H2o2-induced oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
(2) Treatment of Mitochondrial Disorders by Sreenivas Avula,1 Sumit Parikh, MD,1 Scott Demarest, MD,2 Jonathan Kurz, MD,2 and Andrea Gropman, MD. (PMC)
#Phytochemical 3,3'-Diindolylmethane Inhibits Expressions Associated with Renal Fibrosis, According to Studies
Kyle J. Norton
Renal fibrosis is a progressive condition caused by excessive accumulation of extracellular matrix including collagen, enzymes, and glycoproteins which provided structural and biochemical support of surrounding the renal cells during aging and chronic kidney disease (CKD).
According to the statistics, CKD and renal fibrosis affect approximately half of the adults age 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
At the early stage of renal fibrosis, patients may experience symptoms of dull pain in the abdomen or back, pain on one side between your upper abdomen and back, leg pain. discoloration swelling in one or both legs.
If you have some of the aforementioned symptoms, you may have renal fibrosis, please make sure that you check with your doctor to rule out the possibility.
From the dialysis point of view of patients with renal fibrosis, Dr. Menn-Josephy H in examined the risk of dialysis in patients with renal fibrosis and wrote, "Surprisingly, 13.9% of patients with normal renal function had 25-49% fibrosis and 5% had more than 50% fibrosis on biopsy, and 5 years after undergoing biopsy 21% of patients with >50% fibrosis still remained dialysis-free. Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover the potential compound for the treatment of renal fibrosis, researchers examined the effects of 3,3'-Diindolylmethane (DIM) a natural acid condensation extracted from cruciferous plants, on renal fibrosis.
DIM has been found to process anti-hepatic and cardiac fibrosis models in a number of studies.
The study included the established unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models.
Injection of DIM reduced kidney injury and production of interstitial collagens fibrosis.
In the UUO model, DIM inhibited the expression of fibronectin, and collagen-1 associated with the formation of scars but retained E-cadherin involved in the formation of adherens junctions to bind cells with each other.
In other words, DIM protects the renal cells against the induction of renal fibrosis.
In vivo and in vitro, the administration of DIM is also found to suppress local fibroblast activation observed by the levels of myofibroblast markers α-SMA and vimentin.
Most importantly, DIM significantly inhibited the levels of pro-inflammatory cytokine-induced abnormal proliferation of NRK49F cells, in a time- and dose-dependent manner.
Furthermore, DIM also inhibited the expression of Smad2 phosphorylation in the formation of renal scar tissue.
Based on the results, researchers concluded that DIM protects renal cell integrity by inhibiting TGF-β/Smad2/3 signaling against the formation of renal fibrosis.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)
(2) Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient by CohortsMenn-Josephy H.a · Lee C.S.a · Nolin A.a · Christov M.c · Rybin D.V.d · Weinberg J.M.e · Henderson J.b · Bonegio R.a · Havasi A.(PubMed)
According to the statistics, CKD and renal fibrosis affect approximately half of the adults age 70 and over and 10% of the world's population.
In other words, renal fibrosis is a direct consequence caused by the inability of the kidney to regenerate after injury, leading to the formation of renal scars that results in a progressive loss of renal function.
Most cases of renal fibrosis ultimately lead to end-stage renal failure and a need for dialysis or kidney transplantation.
At the early stage of renal fibrosis, patients may experience symptoms of dull pain in the abdomen or back, pain on one side between your upper abdomen and back, leg pain. discoloration swelling in one or both legs.
If you have some of the aforementioned symptoms, you may have renal fibrosis, please make sure that you check with your doctor to rule out the possibility.
From the dialysis point of view of patients with renal fibrosis, Dr. Menn-Josephy H in examined the risk of dialysis in patients with renal fibrosis and wrote, "Surprisingly, 13.9% of patients with normal renal function had 25-49% fibrosis and 5% had more than 50% fibrosis on biopsy, and 5 years after undergoing biopsy 21% of patients with >50% fibrosis still remained dialysis-free. Conclusion: Renal fibrosis is an imperfect prognostic indicator for the development of ESRD and caution should be exercised in applying it too rigidly, especially in elderly or diabetic patients".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover the potential compound for the treatment of renal fibrosis, researchers examined the effects of 3,3'-Diindolylmethane (DIM) a natural acid condensation extracted from cruciferous plants, on renal fibrosis.
DIM has been found to process anti-hepatic and cardiac fibrosis models in a number of studies.
The study included the established unilateral ureteral obstruction (UUO) and transforming growth factor (TGF)-β1-stimulated normal rat kidney (NRK)-49F fibroblast cell mouse models.
Injection of DIM reduced kidney injury and production of interstitial collagens fibrosis.
In the UUO model, DIM inhibited the expression of fibronectin, and collagen-1 associated with the formation of scars but retained E-cadherin involved in the formation of adherens junctions to bind cells with each other.
In other words, DIM protects the renal cells against the induction of renal fibrosis.
In vivo and in vitro, the administration of DIM is also found to suppress local fibroblast activation observed by the levels of myofibroblast markers α-SMA and vimentin.
Most importantly, DIM significantly inhibited the levels of pro-inflammatory cytokine-induced abnormal proliferation of NRK49F cells, in a time- and dose-dependent manner.
Furthermore, DIM also inhibited the expression of Smad2 phosphorylation in the formation of renal scar tissue.
Based on the results, researchers concluded that DIM protects renal cell integrity by inhibiting TGF-β/Smad2/3 signaling against the formation of renal fibrosis.
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)
(2) Renal Interstitial Fibrosis: An Imperfect Predictor of Kidney Disease Progression in Some Patient by CohortsMenn-Josephy H.a · Lee C.S.a · Nolin A.a · Christov M.c · Rybin D.V.d · Weinberg J.M.e · Henderson J.b · Bonegio R.a · Havasi A.(PubMed)
#Phytochemicals #PhyticAcid Exerts a Strong Anticancer Activity by Inhibiting the Tumor Growth and Cell Proliferation, Researchers Find
Kyle J. Norton
Phytic acid (Inositol hexaphosphate) may have a potential effect in reducing the risk and treatment of cancers, some scientists suggested.
Cancer is a class of chronic diseases associated with the growth of irregular cells that start in the cells of the inner lining of a tissue or organ caused by DNA alternation.
At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth such as prostate and colon cancer.
Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the type of cancer.
According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
Cancers who are diagnosed in the early stage have a 5 years survival rate close to 100%. Therefore, the annual examination may be necessary for people who are classified as having a higher risk of cancer development.
The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, and family history in the same family, are susceptible to the onset of the disease while others do not.
Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factors are diagnosed with cancer.
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. However most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
With an aim to find a natural ingredient for the prevention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).
In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma, and glioblastoma.
The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhanced functions of the NK-cells, and exhibited cell cycle arrest and activated proteins associated with cell death programming.
Furthermore, in the findings, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),
At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.
In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.
Moreover, researchers found that the application of IP6 not only decreased cellular proliferation but also caused the differentiation of malignant cells often resulting in a reversion to a normal phenotype.
The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.
Taken together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)
Phytic acid (Inositol hexaphosphate) may have a potential effect in reducing the risk and treatment of cancers, some scientists suggested.
Cancer is a class of chronic diseases associated with the growth of irregular cells that start in the cells of the inner lining of a tissue or organ caused by DNA alternation.
At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth such as prostate and colon cancer.
Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the type of cancer.
According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
Cancers who are diagnosed in the early stage have a 5 years survival rate close to 100%. Therefore, the annual examination may be necessary for people who are classified as having a higher risk of cancer development.
The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, and family history in the same family, are susceptible to the onset of the disease while others do not.
Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factors are diagnosed with cancer.
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. However most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
With an aim to find a natural ingredient for the prevention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).
In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma, and glioblastoma.
The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhanced functions of the NK-cells, and exhibited cell cycle arrest and activated proteins associated with cell death programming.
Furthermore, in the findings, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),
At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.
In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.
Moreover, researchers found that the application of IP6 not only decreased cellular proliferation but also caused the differentiation of malignant cells often resulting in a reversion to a normal phenotype.
The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.
Taken together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)
#Turmeric Blocks the B-Amyloid (betaA) Insults in Reducing the Risk of #Alzheimer's disease, According to Studies
Kyle J. Norton
A neuron or nerve cell is a brain cell that carries electrical impulses. Neurons formed basic cords of the nervous system inclduing the brain, spinal cord, and peripheral nerves.
The function of neurons is to process and transmit information that controls the body function.
Amyloid beta is the main component of the amyloid plaques found in the brains of Alzheimer patients.
Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
In other words, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.
Compared to dementia, neurological disorders are a class of brain diseases associated with reduced function of the brain, depending on the region of the neurons that were affected.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages are living with Alzheimer's.
Believe it or not, 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggest that Alzheimer's disease is caused by a combination of genetic, lifestyle, and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic predisposition. Patients with such mutated genes on chromosomes 21, 14, and 1 are virtually guaranteed to develop the disease.
Dr. Lynn M. Bekris, the lead scientist said, "Alzheimer's disease (AD) is the most common cause of neurodegenerative disorder in elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances".
And, " Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele)".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the prevention of neuronal cell death in Alzheimer's disease, researchers compared the effects of curcuminoids, curcumin, demethoxycurcumin, and bisdemethoxycurcumin and alpha-Tocopherol on beta-Amyloid (betaA) induced oxidative stress in brain cells.
According to the results from the tested analysis, all phytochemicals isolated from turmeric blocked the insults from the beta (1-42) in PC12 rat pheochromocytoma and normal human umbilical vein endothelial (HUVEC) cells.
Furthermore, the ED(50) values of curcumin, demethoxycurcumin, and bisdemethoxycurcumin toward PC12 and HUVEC cells were 7.1+/-0.3, 4.7+/-0.1, 3.5+/-0.2 microg/ml and 6.8+/-0.4, 4.2+/-0.3, and 3.0+/-0.3 microg/ml, respectively.
Moreover, according to the DPPH radical trapping experiment assay, all 4 compounds exerted a strong antioxidant activity compared to that of alpha-tocopherol.
Additionally, the injection of alpha-tocopherol did not protect the cells from betaA(1-42) insult even at>50 microg/ml concentration.
Based on the results, researchers wrote, " The results suggest that these compounds may be protecting the cells from betaA(1-42) insult through antioxidant pathway".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Alzheimer's disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult by Kim DS1, Park SY, Kim JK. (PubMed)
(2) Genetics of Alzheimer's Disease by Lynn M. Bekris, Ph.D.,1 Chang-En Yu, Ph.D.,1 Thomas D. Bird, MD,2 and Debby W. Tsuang, MD, MSc. (PMC)
A neuron or nerve cell is a brain cell that carries electrical impulses. Neurons formed basic cords of the nervous system inclduing the brain, spinal cord, and peripheral nerves.
The function of neurons is to process and transmit information that controls the body function.
Amyloid beta is the main component of the amyloid plaques found in the brains of Alzheimer patients.
Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
In other words, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.
Compared to dementia, neurological disorders are a class of brain diseases associated with reduced function of the brain, depending on the region of the neurons that were affected.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.
According to the statistics, approximately 5.7 million Americans of all ages are living with Alzheimer's.
Believe it or not, 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Epidemiological studies suggest that Alzheimer's disease is caused by a combination of genetic, lifestyle, and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic predisposition. Patients with such mutated genes on chromosomes 21, 14, and 1 are virtually guaranteed to develop the disease.
Dr. Lynn M. Bekris, the lead scientist said, "Alzheimer's disease (AD) is the most common cause of neurodegenerative disorder in elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances".
And, " Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOEε4 allele)".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the prevention of neuronal cell death in Alzheimer's disease, researchers compared the effects of curcuminoids, curcumin, demethoxycurcumin, and bisdemethoxycurcumin and alpha-Tocopherol on beta-Amyloid (betaA) induced oxidative stress in brain cells.
According to the results from the tested analysis, all phytochemicals isolated from turmeric blocked the insults from the beta (1-42) in PC12 rat pheochromocytoma and normal human umbilical vein endothelial (HUVEC) cells.
Furthermore, the ED(50) values of curcumin, demethoxycurcumin, and bisdemethoxycurcumin toward PC12 and HUVEC cells were 7.1+/-0.3, 4.7+/-0.1, 3.5+/-0.2 microg/ml and 6.8+/-0.4, 4.2+/-0.3, and 3.0+/-0.3 microg/ml, respectively.
Moreover, according to the DPPH radical trapping experiment assay, all 4 compounds exerted a strong antioxidant activity compared to that of alpha-tocopherol.
Additionally, the injection of alpha-tocopherol did not protect the cells from betaA(1-42) insult even at>50 microg/ml concentration.
Based on the results, researchers wrote, " The results suggest that these compounds may be protecting the cells from betaA(1-42) insult through antioxidant pathway".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Alzheimer's disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult by Kim DS1, Park SY, Kim JK. (PubMed)
(2) Genetics of Alzheimer's Disease by Lynn M. Bekris, Ph.D.,1 Chang-En Yu, Ph.D.,1 Thomas D. Bird, MD,2 and Debby W. Tsuang, MD, MSc. (PMC)
#Phytochemical #Sulforaphane Activates Expression Associated with a Reduced Risk of #LungDiseases, Researchers Suggest
Kyle J. Norton
Scientists may have found a bioactive compound for the prevention and treatment of lung diseases with no side effects, according to studies.
Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.
People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.
According to the statistics from the World Health Organization, respiratory diseases are the leading causes of death and disability in the world. chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.
3 million people die from chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people suffer from asthma are children.
Long-term smoking is considered one of the leading risk factors of lung diseases. Other risk factors associated with the onset of lung diseases include radon, asbestos, second-hand smoke, and air pollution.
Depending on the area of the respiratory system effect. Lung diseases can be classified to
* Lung disease affecting the airway include asthma and COPD.
*Lung diseases affecting the air sac include pneumonia and tuberculosis.
* Lung diseases affecting the interstitium include interstitial lung disease.
* Lung diseases affecting the blood vessel include pulmonary embolism (PE).
* Lung diseases affecting the pleura include pleural effusion.
* Lung affecting the chest wall include obesity
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
With an aim to find a natural compound for the treatment of lung diseases researchers examined the effects of sulforaphane (SF) in the protein Nuclear factor-like 2 (Nrf2) in mice from arsenic-induced toxicity.
Where Nuclear factor-like 2 has been found to protect the body against a broad spectrum of diseases induced by environmental exposure to harmful substances through its detoxed activity.
Selected mice were exposed to 2 weeks of arsenic-containing dust. At the end of 2 weeks, tested mice showed pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung.
Pretreatment of sulforaphane activated the expression of Nrf2 only blocking the alternation caused by arsenic-containing dust but also restoring all the damages induced by the substances.
Furthermore, SF-mediated activation of Nrf2 also alleviated inflammatory responses by modulating cytokine production, thus reducing the oxidative stress in the tested mice.
These results clearly suggested that dietary intervention which targets the Nrf2 activation may have a significant effect on the reduction of adverse health effects associated with arsenic exposure.
In the mouse model, activation of NRF2 protein was also found to regulate the rhythmic expression of antioxidant genes involved in glutathione redox homeostasis in the mouse lung.
Moreover, in vivo bleomycin-induced lung fibrosis model, the pretreatment of SF restored the lung function by blocking the phenotype caused by bleomycin.
According to the observation of the lungs of the arrhythmic Clock(Δ19) mice, SF increased the levels of NRF2 and glutathione, the antioxidant enzymes produced by the host mice.
The results suggested that NRF2 activated by SF not only inhibited the oxidative damage but also protect the tested mice lungs against fibrositis.
Dr. Pekovic-Vaughan V, the lead scientist, after taking into account co and confounders, said, "Our findings reveal a pivotal role for the circadian control of the NRF2/glutathione pathway in combating oxidative/fibrotic lung damage, which might prompt new chronotherapeutic strategies for the treatment of human lung diseases, including idiopathic pulmonary fibrosis".
However, in wild-type neonatal mice exposed to hyperoxia. SF was also found to activate Nrf2 activation through the induced expression of anti-oxidant genes but did not attenuate alveolar growth arrest caused by exposure to hyperoxia.
This discovery strongly suggested that activation of activated Nrf2 may have a certain limit in protecting the lung and lung tissues against alveolar growth exposed to an excess supply of oxygen (O2) or higher than the normal partial pressure of oxygen.
Taken together, depending on the types of lung diseases, bioactive compound sulforaphane may be used for the prevention and combined with the primary therapy for the treatment of lung diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. by Zheng Y1, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. (PubMed)
(2) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status by McGrath-Morrow SA1, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S.(PubMed)
(3) The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis by Pekovic-Vaughan V1, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ.(PubMed)
Scientists may have found a bioactive compound for the prevention and treatment of lung diseases with no side effects, according to studies.
Lung diseases are medical conditions, affecting the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.
People with lung diseases have breathing problems, preventing them to get enough oxygen for the body's needs.
According to the statistics from the World Health Organization, respiratory diseases are the leading causes of death and disability in the world. chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease in the world, affecting 65 million and 334 million people, respectively.
3 million people die from chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people suffer from asthma are children.
Long-term smoking is considered one of the leading risk factors of lung diseases. Other risk factors associated with the onset of lung diseases include radon, asbestos, second-hand smoke, and air pollution.
Depending on the area of the respiratory system effect. Lung diseases can be classified to
* Lung disease affecting the airway include asthma and COPD.
*Lung diseases affecting the air sac include pneumonia and tuberculosis.
* Lung diseases affecting the interstitium include interstitial lung disease.
* Lung diseases affecting the blood vessel include pulmonary embolism (PE).
* Lung diseases affecting the pleura include pleural effusion.
* Lung affecting the chest wall include obesity
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
With an aim to find a natural compound for the treatment of lung diseases researchers examined the effects of sulforaphane (SF) in the protein Nuclear factor-like 2 (Nrf2) in mice from arsenic-induced toxicity.
Where Nuclear factor-like 2 has been found to protect the body against a broad spectrum of diseases induced by environmental exposure to harmful substances through its detoxed activity.
Selected mice were exposed to 2 weeks of arsenic-containing dust. At the end of 2 weeks, tested mice showed pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung.
Pretreatment of sulforaphane activated the expression of Nrf2 only blocking the alternation caused by arsenic-containing dust but also restoring all the damages induced by the substances.
Furthermore, SF-mediated activation of Nrf2 also alleviated inflammatory responses by modulating cytokine production, thus reducing the oxidative stress in the tested mice.
These results clearly suggested that dietary intervention which targets the Nrf2 activation may have a significant effect on the reduction of adverse health effects associated with arsenic exposure.
In the mouse model, activation of NRF2 protein was also found to regulate the rhythmic expression of antioxidant genes involved in glutathione redox homeostasis in the mouse lung.
Moreover, in vivo bleomycin-induced lung fibrosis model, the pretreatment of SF restored the lung function by blocking the phenotype caused by bleomycin.
According to the observation of the lungs of the arrhythmic Clock(Δ19) mice, SF increased the levels of NRF2 and glutathione, the antioxidant enzymes produced by the host mice.
The results suggested that NRF2 activated by SF not only inhibited the oxidative damage but also protect the tested mice lungs against fibrositis.
Dr. Pekovic-Vaughan V, the lead scientist, after taking into account co and confounders, said, "Our findings reveal a pivotal role for the circadian control of the NRF2/glutathione pathway in combating oxidative/fibrotic lung damage, which might prompt new chronotherapeutic strategies for the treatment of human lung diseases, including idiopathic pulmonary fibrosis".
However, in wild-type neonatal mice exposed to hyperoxia. SF was also found to activate Nrf2 activation through the induced expression of anti-oxidant genes but did not attenuate alveolar growth arrest caused by exposure to hyperoxia.
This discovery strongly suggested that activation of activated Nrf2 may have a certain limit in protecting the lung and lung tissues against alveolar growth exposed to an excess supply of oxygen (O2) or higher than the normal partial pressure of oxygen.
Taken together, depending on the types of lung diseases, bioactive compound sulforaphane may be used for the prevention and combined with the primary therapy for the treatment of lung diseases with no side effects.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. by Zheng Y1, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. (PubMed)
(2) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status by McGrath-Morrow SA1, Lauer T, Collaco JM, Lopez A, Malhotra D, Alekseyev YO, Neptune E, Wise R, Biswal S.(PubMed)
(3) The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis by Pekovic-Vaughan V1, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GT, Fukada Y, Meng QJ.(PubMed)
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