#Alliin Improves #BoneDensity in Osteoporotic Patients by Inhibting the Receptor Activator of Nuclear Factor, According to Studies

Kyle J. Norton

Free radical scavengers are antioxidants that inhibit free radicals before they can cause damage to the tissues and organs.

Free radicals are unstable and high reactive atoms with a single electron in the outermost ring. Therefore, in order to maintain stable, free radicals are ready to steal or donate a single electron from other stable atoms in the body, leading to a cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.


In the body, free radical is produced by cell metabolism that provides energy for body needs. Outside of the body, free radicals can be anywhere including the air we breathe and the foods we eat.


In other words, any chemical compound containing oxygen atoms can be free radicals during the process of a chemical reaction.


The most common types of free radical scavengers include
* Bilirubin
Bilirubin is a prosthetic group that breaks down molecules into smaller units to release energy, and excrete them through bile and urine.

* Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, and some bacteria.

* Flavonoids
Flavonoids neutralize many of reactive oxygen species (ROS), including singlet oxygen, hydroxyl, and superoxide radicals.

* Thiols (R-SH)
Chemically, thiol, an organosulfur compound has strong odors resembling that of garlic plays an important in the functioning of enzyme regulation, control of gene expression, protein trafficking, and receptor signaling.

* Coenzyme Q10
Coenzyme Q10 enhances energy production by promoting the process of the production of ATP then serving as fuel for the cells and acts as an antioxidant to prevent the generation of free radicals during this process.

* Vitamin A, C, E. D.
**Vitamin A
Vitamin A plays an important role that scavenging free radicals in the lining of the mouth and lungs. The vitamin also boosts the immune system in controlling free radicals, preventing oxidation of LDL and enhances the productions of insulin pancreas.

** Vitamin C
Vitamin C, an antioxidant and water-soluble vitamin, vitamin C can be easily carried in the blood, The vitamin not only restores the vitamin E but also fights against the forming of free radicals.

** Vitamin E
Vitamin E not only protects muscle weakness, repairs damaged tissues, lowers blood pressure and induce blood clotting in healing wound, but also moves into the fatty medium to prevent lipid peroxidation.

** Vitamin D
vitamin D, a group of fat-soluble secosteroids is also a membrane antioxidant with the ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In finding a natural compound for treating diseases associated with oxidative stress, researchers examined the alliin ability to inhibit osteoclast differentiation and fusion in osteoporosis.

According to the results of the experiment, alliin showed significant effects in the improvement of bone density in osteoporotic patients by inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast fusion and differentiation. in bone resorption by blocking the signaling pathway activation.

In additional differentiation of the alliin osteoporosis protective activity, researchers found that alliin decreased the generation of reactive oxygen species (ROS) by inhibiting the expression enzyme involved in the generation of free radicals.

In other words, alliin protects the bone density by decreasing the bone reabsorption and oxidative stress in the bone tissues.

Based on the findings, researchers wrote, "The overall results revealed that alliin could be a potential therapeutic agent in the treatment of osteoporosis".

Taken altogether, alliin may be considered a supplement as a free radical scavenger against the onset of oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(2) Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.) by Kim S1, Kim DB1, Jin W1, Park J1, Yoon W1, Lee Y1, Kim S1, Lee S1, Kim S1, Lee OH2, Shin D1, Yoo M. (PubMed)

#Turmeric Reduces Cholesterol Accumulation Associated with the Onset of #Atherosclerosis, Researchers Suggest

Kyle J. Norton

Cardiovascular diseases (CVD) are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.
According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, compared to women.
Believe it or not, more than 63),000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

Atherosclerosis is a condition caused by long-term plaques built up on the wall of the arteries. Over time, continued plaque accumulation can lead to cardiovascular disease.

In other words, narrowing the arteries due to plaque accumulation is a major cause of heart disease and stroke.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

The most common symptoms found in patients with antiatherosclerosis involve reduced blood flow to the body, including chest pain or angina, pain in the leg, and arm, shortness of breath fatigue, and confusion.

According to Dr. Roma Pahwa and colleagues, atherosclerosis causes approximately 50% of all deaths in Westernized society associated with the inflammation in the arteries involved in the accumulation of cholesterol in the bloodstream.

Epidemiologically, the most common risk factors of atherosclerosis are unhealthy blood cholesterol levels associated with high levels of bad and low levels of good cholesterol, high blood pressure, smoking, insulin resistance, diabetes, overweight or obesity, and physical inactivity.

Some researchers suggested that the promotion of a high-fat diet that induces widespread obesity in the Western world may be one of the major culprits that cause atherosclerosis.

Dr. Lovren F and colleagues wrote, "Obesity is a multifactorial chronic disease characterized by an accumulation of visceral and subcutaneous fat, which leads to a predisposition toward cardiometabolic diseases".

And, " A plethora of mechanisms, including abnormalities in lipid metabolism, insulin resistance, inflammation, endothelial dysfunction, adipokine imbalance, and inflammasome activation have been suggested to underlie the relationship between obesity and atherosclerosis.".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential compound for the treatment of multiple sclerosis (MS), researchers examined the efficacy of supplementation with curcumin in reducing intestinal cholesterol absorption in animal models.

The study included high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice that prevented atherosclerosis fed a high-fat diet supplemented with or without curcumin (0.1% w/w) for 16 weeks.

Based on the tested differentiation, the curcumin treatment group showed not only a reduced cholesterol accumulation in the aortas by 56% but also lowered plasma total cholesterol and low-density lipoprotein cholesterol levels compared to the non-curcumin group.

Furthermore, curcumin supplementation group also demonstrated a reduced risk of atherosclerotic lesions by 45%.

Moreover, the efficacy of the anti antiatherogenic effect of curcumin was associated with a significant decrease in intestinal cholesterol absorption by 51% by inhibiting the intestinal gene expression of Niemann-Pick C1-like 1 involved in cholesterol uptakes.

Collectively, researchers said, "These findings support the hypothesis that curcumin supplementation reduces intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed ApoE-/- mice".

And " Curcumin affords a potent antiatherogenic action by inhibiting intestinal cholesterol absorption in the mouse".

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of atherosclerosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy by Momtazi-Borojeni AA1,2, Abdollahi E3,4, Nikfar B5, Chaichian S6,7, Ekhlasi-Hundrieser M. (PubMed)
(2) Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice by Zou J1, Zhang S2, Li P2, Zheng X2, Feng D. (PubMed)
(3) Atherosclerosis by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(4) Obesity and atherosclerosis: mechanistic insights by Lovren F1, Teoh H2, Verma S. (PMC)

#Cranberry Inhibits Lung Cancer Cells Metabolism, Protein Modifications, and Cell Cycle Arrests, Researchers Show

Kyle J. Norton

The lung formed part of the respiratory system is a vital organ located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting it to the bloodstream and exhaling carbon dioxide from the bloodstream.
Lung diseases are a class of conditions associated with reduced function of the lung, including lung cancer.

Lung cancer is a medical condition associated with abnormal growth of the cells in the lung's tissue that begins in the cells on the surface of the inner lining tissues of the lung due to the alternation of cell DNA.

The most common form of primary lung cancer is derived from epithelial cells.

In the US, lung cancer is the leading cause of cancer deaths. According to the statistics from the American Cancer Society, in 2019, about 228,150 new cases of lung cancer, including 116,440 in men and 111,710 in women will be diagnosed in the US.

Sadly, lung cancer also caused the death of 142,670 Americans death, including 76,650 in men and 66,020 in women in the same year.

The lifetime risk of lung cancer in a man is 6.7% compared to 5.9% in a woman.

The exact causes of lung cancer are not known. However, epidemiologically, smoking tobacco, second-hand smoke, radon, asbestos, occupational exposure to certain chemicals, personal or family history of lung cancer and lung disease and exposure to radiation are some major factors found in patients with lung cancer.

Dr. Ozlü T, the lead scientist wrote, " Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking".

And, "The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers. Environmental cigarette smoke exposure and different types of smoking have been shown to cause pulmonary carcinoma. DNA adducts, the metabolites of smoke carcinogens bound covalently with DNA, are regarded as an indicator of cancer risk in smokers".


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.


On finding a potential compound for the protection of lung cell integrity, researchers examined the effect of the efficacy of proanthocyanidin-rich cranberry fraction (PAC) on lung cancer.


According to the tested analysis, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC or vehicle for 6 hours, PAC exerted a significant activity in the regulation of apoptosis, regulation of programmed cell death, positive regulation of cell death, positive regulation of apoptosis, and apoptotic mitochondrial changes.


Moreover, NCI-H460 human lung cancer cells treated with 50 µg/mL PAC showed a strong effect on cancer cell metabolism, protein modifications, and cell cycle by inhibiting the M phase of the mitotic cell cycle, mitosis, M phase, cell cycle checkpoint, and regulation of cell cycle process.

More precisely, PAC-induced lung cancer cell apoptosis and anti-proliferative activity through cell cycle arrest.

Furthermore, PAC treatment also enhanced the levels of glutathione S-transferases associated
with blocking cancer cell metastasis.


PAC treatment also down-regulated DNA metabolism, cell cycle, meiosis, mitosis and interestingly oncogenesis signaling.

PAC treatment also inhibited the alternation of ErbB receptors and signaling pathways and mTOR signaling pathways mutated in lung tumors, involved in cancer development and progression

Taken together, cranberry used in conjunction with other remedies may be considered a remedy for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry proanthocyanidins mediate growth arrest of lung cancer cells through modulation of gene expression and rapid induction of apoptosis by Kresty LA1, Howell AB, Baird M. (PubMed)
(2) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)

#Betanin Inhibits Oxidative DNA Damage Associated with the Risk of Inflammatory Bowel Disease, According to Studies

Kyle J. Norton

Colon cancer is a medical and chronic condition caused by the irregular growth of cells in the colon, due to the alternation of cell DNA.

Colon-formed part of the digestive tract, including the large intestine with the function to reabsorb fluid before passing them back to the blood and remove waste through the anus.

Colon cancer is one most slow cancers compared to other cancers. In some patients, colon cancer may exist in the colon more than 20 years before it is discovered.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 101,420 new cases of colon cancer will be diagnosed. Colon cancer also causes the death of 51,020 deaths. during 2019.

The lifetime risk associated with the onset of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Out of many risk factors involved in the onset of colorectal cancer, aging is one of the major culprits, according to epidemiological studies.

The median age diagnosed with colon cancer is 68 in men and 72 in women compared to the age of 63 of rectal cancer in both men and women.

However, over the past few decades, the incidence of colon cancer has been found to rise in the younger age groups, probably due to the promotion of a high-fat diet.

Dr. Robb Bird, the editor at worldwide health wrote, "Poor diet is associated with about 80 percent of colorectal cancer cases. Even 20 years ago studies were attributing colon cancers to high-fat diets. Colorectal cancer is the third most common cancer in the United States with more than 130,000 cases reported every year. These cancers are a result of a combination of several causes including genetic, epigenetic and environmental causes, such as diet. Hopefully, with more research, the exact pathways by which diet leads to cancer can be discovered. Once discovered, blocking these pathways can hopefully reduce the negative impact of a high-fat diet on colon cancer risk".


Betanin is Phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a potential compound for the treatment of continuing colonic inflammation, an important risk factor in the development of colorectal cancer, researchers examined phytochemical compound betanin isolated from beetroot (Beta vulgaris var. rubra) effects against colon cancer.

In patients with inflammatory bowel disease, such as ulcerative colitis (UC) and Crohn's disease (CD), administration of betanin exerted an inhibition against the oxidative DNA damage and induced apoptosis in neutrophils from the blood, compared to those obtained in colon carcinoma-derived Caco-2 cells.

In IBD patients' neutrophils, betanin treatment at the concentration of 100 μM for 24 h modulated the immune function by exerting anti-inflammatory activity, assessed by comet assay.


In Caco-2 cells, injection of H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

Betanin also exhibited the protein associated with pro-apoptotic function accompanied by the loss of mitochondrial transmembrane potential in the energy transformation.


In other words, betanin promotes the ROS cytotoxicity that leads to colon cancer cell death without harming the nearby cells through its antioxidant activity.

The findings strongly suggested betanin exerts anti-inflammatory and potentially cancer-preventive activity.

Taken together, betanin isolated from beetroot may be considered a supplement for the prevention and treatment of colon cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High-fat diet found to stimulate cell growth in the colon, increasing the risk of colon cancer by the World Health Net

#Healthyfood #CruciferousVegetables' #Sulforaphane Inhibits the Onset and Progression of Neurological Disorders, According to Studies

Kyle J. Norton


Neurological disorders are medical conditions characterized by any disorder of the nervous system caused by structural, biochemical, or electrical abnormalities.

There are many forms of neurological disorders. The most common types of the disease are neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease, epilepsy. multiple sclerosis and Migraines.

Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.

There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.

According to the Medical Press, globally, the burden of neurological disorders (Alzheimer's disease, Parkinson's disease, stroke, epilepsy, etc) has increased substantially over the past 25 years. These may be the results of over 25 years of economic expansion that have increased the living standard of millions of people in the Southeast Asian region.

The WHO in the evaluation of neurological disorder wrote, "Neurological disorders contribute to 92 million disability-adjusted life years (DALYs) in 2005 projected to increase to 103 million in 2030 (approximately a 12% increase). While Alzheimer's and other dementias are projected to show a 66% increase from 2005 to 2030".

Where one DALY represents the loss of the equivalent of one year of full health.

Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease Alzheimer's disease, and stroke.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

In finding a potential remedy for the protection of brain functioning, researchers examined the effects of cruciferous vegetables are a key part of the arsenal of nutrition-based approaches for reducing the risks of neurological disorders.

According to the search of related articles, in animal model systems, cruciferous vegetables exerted protective activity against neurodegenerative disorders like Alzheimer's and Parkinson's diseases.

In chemical analysis, the efficacy of crucifers in the inhibition of the onset and progression of neurological disorders was attributed to its most abundant bioactive compound the isothiocyanates, particularly sulforaphane.

Based on the findings, researchers said, "There is great promise for the regular use of cruciferous vegetables or supplements containing standardized levels of bioactive in the treatment and prevention of neurologic disorders".

And, " Many clinical and animal studies are underway, and the evidence is building to support this strategy".

Taken altogether, cruciferous vegetables may be considered functional remedies for the prevention of neurological disorders, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Crucifers and related vegetables and supplements for neurologic disorders: what is the evidence? by Panjwani AA1,2, Liu H1,3, Fahey JW. (PubMed)

#Bromelain Decreases Interleukins Involved in the Production of Pro-Inflammatory Cytokines Associated with the Onset of Allergic Airway Disease (AAD)

Kyle J. Norton

Chronic allergic airway disease (AAD) is a group of the diseases characterized by airway inflammation and airway hyperresponsiveness (AHR).

Airway inflammation is the hallmark of chronic obstructive pulmonary disease (COPD) associated with low-grade inflammation caused by the persistent production of proinflammatory cytokines by the immune system in the airway.


On the other hand, airway hyperresponsiveness (AHR) is a cardinal feature of asthma associated with the response of the immune system against pathogens.

The most common symptoms of coughing, wheezing, and shortness of breath in reactive airway disease (AAD) may not be due to asthma or other chronic airway conditions.

Conventionally, reactive airway inflammatory disease is treated with medication to control symptoms such as long-term use of an inhaler to relieve attacks and improve quality of life through avoidance of irritants.

If the cause of reactive airway disease is found, most cases of the condition may be cured by medication.


Dr. Jill R. Johnson, the lead scientist in the examination of Allergic Airway Disease: More than Meets the IgE? wrote, "After exposure, allergens crosslink with IgE on mast cells and induce histamine and leukotriene release (6), thereby initiating the allergic response and leading to the classic symptoms of allergy, i.e., sneezing and wheezing".

And, ". Omalizumab binds to the Ce3 domain of free IgE with high affinity (7), thereby inhibiting early- and late-phase asthmatic reactions (8) and decreasing the frequency of exacerbations in severe asthmatics (9). Omalizumab binding also prevents IgE from interacting with Fc«RI and Fc«RII1 on effector cells (mast cells, B cells, eosinophils, dendritic cells, and monocytes), thus impairing their activation and making them less sensitive to allergens, and disabling signaling cascades (10), with the end result of a reduction in symptoms".

In other words, allergic airway disease (AAD) is a result of an immune response upon exposure to the allergens, Therefore, by making the immune system less sensitive to allergens, symptoms of allergic airway disease (AAD) may be reduced.


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to discover a potential compound for the treatment of diseases associated with chronic inflammation, researchers examined the ability of bromelain to reduce the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

The study included female C57BL/6J mice with intraperitoneal OVA/alum and then challenged them with OVA aerosolization for 10 consecutive days.


On day 4, phosphate-buffered saline (PBS) was administrated to the control group (n = 10) and bromelain (6mg/kg) in PBS was administrated to the bromelain (intervention) group (n = 10).

According to the tested assays, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity indicated by reduced BAL total leukocytes, eosinophils, and cellular infiltrates via lung pathology compared to the control group.

Furthermore, bromelain also significantly reduced bronchoalveolar lavage (BAL) CD4+ associated and CD8+ T cells d with the T helper 2 (TH2) cells in the promotion of allergic inflammation process without affecting cell numbers in the spleen or hilar lymph node.

The efficacy of bromelain in the inhibition was attributed to the decreased interleukins involved in the production of pro-inflammatory cytokines.

In other words, bromelain protects asthma patients against allergic airway inflammation through its strong anti-inflammatory properties.

Based on the results, researchers said, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".

In order to find more information about bromelain anti-ADD activity, researchers investigated the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

Selected mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols to induce ADD followed by the treatment of either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.


According to the findings, bromelain showed a similar effect as the aforementioned results in reduced total BAL leukocytes, eosinophils, CD4+, and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13.

Taken altogether, bromelain may be considered a supplement for the prevention and treatment of allergic airway disease ADD, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)
(3) Allergic Airway Disease: More than Meets the IgE? by Jill R. Johnson, Ph.D. and James A. Harker, Ph.D

#Healthyfood #CruciferousVegetables Protect Cell Integrity Against DNA Damage Caused by Genotoxicity, Researchers Reveal

Kyle J. Norton

Genotoxicity is a process of destruction o a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. The most common genotoxins are radiation and toxic chemicals.

Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage of the germ cell.

Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.

The most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.

The antigenotoxic activity is a process to inhibit the property of chemical agents that induce damages to the genetic information, leading to mutation,anti-antimutagens

Cancer is a class of diseases associated with alternation of cell DNA or genetic change of cell.

Not all Genotoxicity is mutagenicity, but all mutagens are genotoxic.

Dr. Shareen H, the lead scientist in the study of "Chapter 18 - Genotoxicity and Cancer" wrote, "Genetic toxicology is the study of chemical and physical perturbations to DNA following exposure to endogenous or exogenous agents. Hazard assessment of engineered nanomaterials involves establishing the ability of these novel materials to induce DNA damage (genotoxicity) and to subsequently initiate tumor formation (carcinogenesis)".

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

Iand n finding a potential compound for the protection of cell DNA against damage, researchers examined the effects of cruciferous vegetables (CF) in protecting humans against cancer caused by chemically induced tumor formation.


According to the dietary information,* CF and their constituents showed the effect on enzymes involved in the metabolism of DNA-reactive carcinogens.

* In vitro models, sulforaphane, a bioactive compound found in CF exerted antigenotoxic effects on metabolically competent cell lines.

* Furthermore, Brassica juices induced the production of glutathione-S-transferases (GST) and cytochrome P-450 1A2 in human hepatoma cells (HepG2) against the genotoxic effects of B(a)P and other carcinogens.
* Moreover, brussels sprouts- and garden cress juices attenuated IQ-induced DNA damage and preneoplastic lesions in the colon and liver of rats.

* Most importantly, CF affects drug metabolism in humans and consumption of red cabbage led to changes in the pattern of meat-derived urinary mutagenicity.


Taken together, cruciferous vegetables may be considered functional foods for the protection of the cells against genotoxicity, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of cruciferous vegetables and their constituents on drug-metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens by Steinkellner H1, Rabot S, Freywald C, Nobis E, Scharf G, Chabicovsky M, Knasmüller S, Kassie F. (PubMed)
b(2) Chapter 18 - Genotoxicity and Cancer by Shareen H.Doak, Ying Liu, and ChunyingChen. (Science Direct)