Kyle J. Norton
Regular drinking of green tea may have a potential effect on maintaining normal blood pressure and reducing the risk of hypertension, a recent study suggested.
Hypertension is an abnormal high of blood pressure, one of the major risk factors in the contributed early onset of cardiovascular disease.
Green tea, considered a functional food, has a number of health benefits and has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding one slice of ginger will do the trick of neutralization.
Hypertension of male Wistar rats induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20 mg/kg per day, orally, for 2 weeks], fed with green tea extract exhibited a strong effect in reduced hypertension (119 ± 1 mmHg) and higher renal sympathetic nerve activity (161 ± 12 spikes/s) than the control group (97 ± 2 spikes/s).
Green tea oral administration also showed a significant decrease in hypertensive parameters by amelioration. arterial baroreceptor function and vascular and systemic oxidative stress.
Furthermore, a total of 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old with metabolic syndrome were randomized into a saline-treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10), group fed with decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 ± 7 vs. 121 ± 3 mmHg, p = 0.01) in compared control fed with saline.
The study also suggested that fed mice with green tea also showed an antihypertensive effect in reduced vascular reactive oxygen species (ROS) formation and NADPH in the generation of ROS, as well as improving endothelium (cell lines the interior surface of blood vessels and lymphatic vessels)and lymphatic vessels dependent relaxation.
Dr. Ihm SH, the lead author said," (green tea extract) improved endothelial dysfunction and IR, and eventually lowered BP".
Taken together, there is no doubt that green tea processes a significant effect in reduced risk and treatment of hypertension through reduced oxidative stress and improved vascular relaxation as well as decreased metabolic syndrome in exaggerated hypertension.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) The antioxidant effects of green tea reduce blood pressure and sympathoexcitation in an experimental model of hypertension by Garcia ML1, Pontes RB, Nishi EE, Ibuki FK, Oliveira V, Sawaya AC, Carvalho PO, Nogueira FN Franco MD, Campos RR, Oyama LM, Bergamaschi CT.(PubMed)
(2) Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome by Ihm SH1, Jang SW, Kim OR, Chang K, Oak MH, Lee JO, Lim DY, Kim JH.(PubMed)
Friday, 6 October 2023
#Ginger Exerts Anti-#Arteriosclerosis Activity By Inhibiting Pathways Associated with Cholesterol Synthesis and Lipid Accumulation
Kyle J. Norton
Scientists may have found a natural remedy that has the potential to treat chronic mild stress, according to studies.
Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.
Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.
Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.
Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.
There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.
The American Institute of Stress in examining the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away from the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".
According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale) anti-chronic stress activity.
6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.
CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.
Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.
CMS before application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.
Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed increased plaque formation, the elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.
However, the injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol, and other isoprenoids, particularly the lipid synthesis in the liver tissues.
These results suggested the role of ginger in alleviating atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.
Dr. Wang S, the lead scientist wrote, "The antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".
Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.
Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.
The finding clearly suggested that 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.
Taken altogether, ginger-processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS
Scientists may have found a natural remedy that has the potential to treat chronic mild stress, according to studies.
Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.
Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.
Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.
Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.
There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.
The American Institute of Stress in examining the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away from the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".
According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale) anti-chronic stress activity.
6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.
CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.
Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.
CMS before application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.
Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed increased plaque formation, the elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.
However, the injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol, and other isoprenoids, particularly the lipid synthesis in the liver tissues.
These results suggested the role of ginger in alleviating atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.
Dr. Wang S, the lead scientist wrote, "The antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".
Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.
Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.
The finding clearly suggested that 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.
Taken altogether, ginger-processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS
#ManukaHoney Eye Drops (Optimel, Melcare, Australia) in the Treatment of #OcularDemodex and #DryEye, Reserachers Say
Kyle J. Norton
Scientists may have found a natural alternative for the treatment of Ocular Demodex and Dry-Eye, according to studies.
Believe it or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to US Federal Science, over 70% of Americans suffer from the presence of Demodex without even noticing.
The increase in age, and patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.
Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.
The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.
Dry eye happens mostly in older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.
Dry eye, in most cases, is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporating too quickly from the eyes and poor quality of tears.
People with dry eyes may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.
Honey is a miraculous product made by bees using nectar from flowers.,
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.
The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.
Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.
The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.
In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).
The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completing the study.
One group received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order.
The Optimal treatment exerted an improvement in Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms.
Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.
However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye.
Researchers at the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".
Taken together, honey, particularly Tualang honey may be considered a functional remedy for the prevention and treatment of ocular Demodex and dry eye, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.carights
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocularDemodex viability by Frame K1, Cheung IMY2, Wang MTM2, Turnbull PR1, Watters GA2, Craig JP. (PubMed)
(2) Treatment of contact lens related dry eye with antibacterial honey by Wong D1, Albietz JM1, Tran H1, Du Toit C1, Li AH1, Yun T1, Han J1, Schmid KL. (PubMed)
Scientists may have found a natural alternative for the treatment of Ocular Demodex and Dry-Eye, according to studies.
Believe it or not, the Demodex in eyelashes that cause the severity of ocular discomfort is quite common in the US. According to US Federal Science, over 70% of Americans suffer from the presence of Demodex without even noticing.
The increase in age, and patients with conjunctival papillary hypertrophy, are some most common Demodex risk factors.
Furthermore, methicillin-resistant Staphylococcus aureus (MRSA) was detected more often on eyelids with Demodex.
The finding strongly suggested that Demodex plays a pathogenic role in the ocular discomfort linked with aging.
Dry eye happens mostly in older adults is a condition in which a person doesn't have enough quality tears to clean and nourish the eye, leading to a chronic vision problem.
Dry eye, in most cases, is caused by the inadequate amount of tears due to lower than normal amount of tear production or tears evaporating too quickly from the eyes and poor quality of tears.
People with dry eyes may experience symptoms of irritation, gritty, scratchy or burning eyes; a feeling of something in their eyes; excess watering; and blurred vision.
Honey is a miraculous product made by bees using nectar from flowers.,
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
Researchers with an aim to find a natural source for the treatment of vision problem compared the Manuka honey and tea tree oil against ocular Demodex.
The study included 53 viable Demodex mites acquired from the epilated eyelashes of 9 participants with blepharitis and symptomatic dry eye. Then, the viable mites were randomized to one of five treatment groups: cyclodextrin-complexed and uncomplexed Manuka Honey, 100% and 50% tea tree oil, and no treatment.
Compared to the results of four treatments, researchers found that the survival probabilities are lowest with 100% tea tree oil, and highest with cyclodextrin-complexed and uncomplexed Manuka Honey.
The finding clearly suggested that the efficacy of cyclodextrin-complexed Manuka honey was comparable with 50% tea tree oil, an established treatment for ocular Demodex.
In order to reveal more information about honey anti-dry eye effects, researchers evaluated
the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia).
The study included 24 participants aged 20 to 55 years with contact lens-related dry eye randomized to two treatment groups with 20 completing the study.
One group received Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks while the other group completed the treatments in the reverse order.
The Optimal treatment exerted an improvement in Dry eye symptoms significantly and patients with more severe symptoms at baseline showed a greater improvement in symptoms.
Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.
However, due to the short duration of treatment, there were no significant differences observed in the objective signs of a dry eye.
Researchers at the experiment wrote in the final report, "Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use".
Taken together, honey, particularly Tualang honey may be considered a functional remedy for the prevention and treatment of ocular Demodex and dry eye, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.carights
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Comparing the in vitro effects of MGO™ Manuka honey and tea tree oil on ocularDemodex viability by Frame K1, Cheung IMY2, Wang MTM2, Turnbull PR1, Watters GA2, Craig JP. (PubMed)
(2) Treatment of contact lens related dry eye with antibacterial honey by Wong D1, Albietz JM1, Tran H1, Du Toit C1, Li AH1, Yun T1, Han J1, Schmid KL. (PubMed)
#Ginger Exerts Strong Cytotoxicity and Antioxidant Activities, According to Studies
Kyle J. Norton
Scientists may have found a kitchen spice that processes the potential to induce cancer cell death by cytotoxicity, according to studies.
Cytotoxicity is a process that stimulates the ability of certain chemicals or mediator cells to destroy living cells.
In herbal medicine, injection of plant extracts in some cases also induce cytotoxic effects to kill cancer cells without causing harm to nearby healthy cells through the protection of increased production of antioxidant enzymes.
In other words, the use of herbal medicine for the treatment of cancer can induce no side effects.
In cancer, the cytotoxic activity is carried out by the overexpression reactive oxygen activity, leading to cancer cell apoptosis through a number of mechanisms, including cell death programming and cell cycle arrest proteins.
In healthy cells, the ROS cytotoxic activity can also cause significant damage to the proteins, lipids, and DNA, leading to the onset of chronic diseases, including cancer.
Some researchers suggested that activating the expression gene associated with tumor suppression to prevent the damage of healthy cells during the injection of chemo drugs may provide a necessary step for the prevention of chemo side effects in cancer patients.
Dr. Chit Fang Cheok, in the differentiation of protecting normal cells from the cytotoxicity of chemotherapy, wrote, "The occurrence of intolerable side effects in patients undergoing chemotherapy is still a major clinical hurdle. Finding tumor-specific therapy and exploiting the differences between normal cells and tumor cells has led to strategies targeting oncogenic mutations or the deficiency of tumor suppressor pathways in cancers".
And, "The concept requires the use of two drugs, the first to arrest the normal cells and the second, to kill only cycling (tumor) cells".
More interestingly, "several recent studies demonstrate that p53 activation protects normal cells from the toxicity of drugs acting in the S-phase or M-phase, including Ara-C,2 taxol,3 Aurora kinase inhibitors4, and Polo-like kinase inhibitors".
These results strongly suggested the model provided by herbal medicine may some days be used by conventional medicine for the treatment of cancer without causing severe side effects.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers to find a natural ingredient for the treatment of cancer examined ginger's cytotoxic activity on cancer cells.
In vivo, researchers compared the anticancer effect of ginger in a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days vs control groups consisting of 10 hamsters for each group fed with 5-fluorouracil (positive control) or distilled water (untreated control).
Injection of crude ethanolic extracts of ginger at a dose of 10.95, 53.15, and 27.86 μg/ml with Median IC50 (concentration that inhibits cell growth by 50%) values exerted strong cytotoxicity and antioxidant activities.
The crude ethanolic extracts of ginger demonstrated a 7-9 fold in the function of genes associated with the transportation of the chemo drugs observed by the DNA fragments on the cancer cell line.
The extract also induced acute and subacute toxicity at the maximum dose of 5,000 mg/kg body weight.
Furthermore, the injection displayed a strong effect on the survival time and survival rate of the CCA-bearing hamsters compared to the control group (median of 54 vs 17 weeks.
Dr. Plengsuriyakarn T, the lead scientist said, "Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity".
Moreover, in the examined ginger anti-cancer activity, researchers investigated the cytotoxic and antitumor activity of ginger essential oil (GEO).
GEO showed potent in vitro cytotoxic activity against DLA and EAC cell lines. The IC50 values for the DLA cell line and EAC cell line were 18 μg/ml. were found to be 11 μg/ml and 18 μg/ml, respectively.
However, on L929 cell lines and to Vero cells, The IC50 of GEO was found to be 41 μg/ml and ˃100 ug/ml, respectively, significantly higher compared to the DLA cell line and EAC cell line.
Additionally, treatment with GEO (500 mg/kg and 1000 mg/kg body weight) significantly reduced the volume of solid tumor development by 54.4% and 62.4% respectively and the lifespan was increased up to 50% in 1000 mg/kg b. wt GEO treated ascites tumor-induced animals.
The findings once again, reconfirm the cytotoxic and antitumor effects of ginger.
Taken together, ginger, the kitchen, and pungent spice may be considered a functional food for the prevention and combined with primary therapy for the treatment of cancer with no or little side effects, pending the validity of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma by Plengsuriyakarn T1, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul W, Itharat A, Na-Bangchang K. (PubMed)
(2) Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe) by Jeena Kottarapat, Vijayasteltar B Liju, R. Kuttan. (Research Gate)
(3) Protecting normal cells from the cytotoxicity of chemotherapy by Chit Fang Cheok. (PMC)
Scientists may have found a kitchen spice that processes the potential to induce cancer cell death by cytotoxicity, according to studies.
Cytotoxicity is a process that stimulates the ability of certain chemicals or mediator cells to destroy living cells.
In herbal medicine, injection of plant extracts in some cases also induce cytotoxic effects to kill cancer cells without causing harm to nearby healthy cells through the protection of increased production of antioxidant enzymes.
In other words, the use of herbal medicine for the treatment of cancer can induce no side effects.
In cancer, the cytotoxic activity is carried out by the overexpression reactive oxygen activity, leading to cancer cell apoptosis through a number of mechanisms, including cell death programming and cell cycle arrest proteins.
In healthy cells, the ROS cytotoxic activity can also cause significant damage to the proteins, lipids, and DNA, leading to the onset of chronic diseases, including cancer.
Some researchers suggested that activating the expression gene associated with tumor suppression to prevent the damage of healthy cells during the injection of chemo drugs may provide a necessary step for the prevention of chemo side effects in cancer patients.
Dr. Chit Fang Cheok, in the differentiation of protecting normal cells from the cytotoxicity of chemotherapy, wrote, "The occurrence of intolerable side effects in patients undergoing chemotherapy is still a major clinical hurdle. Finding tumor-specific therapy and exploiting the differences between normal cells and tumor cells has led to strategies targeting oncogenic mutations or the deficiency of tumor suppressor pathways in cancers".
And, "The concept requires the use of two drugs, the first to arrest the normal cells and the second, to kill only cycling (tumor) cells".
More interestingly, "several recent studies demonstrate that p53 activation protects normal cells from the toxicity of drugs acting in the S-phase or M-phase, including Ara-C,2 taxol,3 Aurora kinase inhibitors4, and Polo-like kinase inhibitors".
These results strongly suggested the model provided by herbal medicine may some days be used by conventional medicine for the treatment of cancer without causing severe side effects.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers to find a natural ingredient for the treatment of cancer examined ginger's cytotoxic activity on cancer cells.
In vivo, researchers compared the anticancer effect of ginger in a total of 80 OV and nitrosamine (OV/ DMN)-induced CCA hamsters fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days vs control groups consisting of 10 hamsters for each group fed with 5-fluorouracil (positive control) or distilled water (untreated control).
Injection of crude ethanolic extracts of ginger at a dose of 10.95, 53.15, and 27.86 μg/ml with Median IC50 (concentration that inhibits cell growth by 50%) values exerted strong cytotoxicity and antioxidant activities.
The crude ethanolic extracts of ginger demonstrated a 7-9 fold in the function of genes associated with the transportation of the chemo drugs observed by the DNA fragments on the cancer cell line.
The extract also induced acute and subacute toxicity at the maximum dose of 5,000 mg/kg body weight.
Furthermore, the injection displayed a strong effect on the survival time and survival rate of the CCA-bearing hamsters compared to the control group (median of 54 vs 17 weeks.
Dr. Plengsuriyakarn T, the lead scientist said, "Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity".
Moreover, in the examined ginger anti-cancer activity, researchers investigated the cytotoxic and antitumor activity of ginger essential oil (GEO).
GEO showed potent in vitro cytotoxic activity against DLA and EAC cell lines. The IC50 values for the DLA cell line and EAC cell line were 18 μg/ml. were found to be 11 μg/ml and 18 μg/ml, respectively.
However, on L929 cell lines and to Vero cells, The IC50 of GEO was found to be 41 μg/ml and ˃100 ug/ml, respectively, significantly higher compared to the DLA cell line and EAC cell line.
Additionally, treatment with GEO (500 mg/kg and 1000 mg/kg body weight) significantly reduced the volume of solid tumor development by 54.4% and 62.4% respectively and the lifespan was increased up to 50% in 1000 mg/kg b. wt GEO treated ascites tumor-induced animals.
The findings once again, reconfirm the cytotoxic and antitumor effects of ginger.
Taken together, ginger, the kitchen, and pungent spice may be considered a functional food for the prevention and combined with primary therapy for the treatment of cancer with no or little side effects, pending the validity of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Cytotoxicity, toxicity, and anticancer activity of Zingiber officinale Roscoe against cholangiocarcinoma by Plengsuriyakarn T1, Viyanant V, Eursitthichai V, Tesana S, Chaijaroenkul W, Itharat A, Na-Bangchang K. (PubMed)
(2) Antitumor and cytotoxic activity of ginger essential oil (Zingiber officinale roscoe) by Jeena Kottarapat, Vijayasteltar B Liju, R. Kuttan. (Research Gate)
(3) Protecting normal cells from the cytotoxicity of chemotherapy by Chit Fang Cheok. (PMC)
#GreenTea Shows a Signoificant and Positive Effect on #MetabolicSyndrome, Reserachers Suggest
Kyle J. Norton
A recent study conducted by renowned institutes suggested that regular drinking of green tea may reduce the risk of prevalence of metabolic syndrome.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Metabolic syndrome is a biochemical and physiological factor associated with the risk of cardiovascular disease and type 2 diabetes.
In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negative association with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).
The study also found that high tea consumers had lower BMI, and waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, compared to low drinkers,
Other, in the study of dietary polyphenols, a major compound found in green tea including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database. conducted in Kraków, Poland, dietary polyphenol intake in the highest quartile was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively).
g
Dietary polyphenols in high quality showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both genders.
Dr. Grosso G, the lead author said, "(Depending on types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavonols, and dihydrochalcones had the most relevant role."
In support of the role of used of polyphenols in the treatment of Metabolic syndrome, a total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, researchers showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.
The study also stated that the most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, and hydroxycinnamic acids as they showed independently associated with lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.
Taken together, green tea with major chemical compounds of polyphenol may be used as a functional food in the prevention and treatment of metabolic syndrome.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3. (PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3. (PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)
A recent study conducted by renowned institutes suggested that regular drinking of green tea may reduce the risk of prevalence of metabolic syndrome.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful cases of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Metabolic syndrome is a biochemical and physiological factor associated with the risk of cardiovascular disease and type 2 diabetes.
In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negative association with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).
The study also found that high tea consumers had lower BMI, and waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, compared to low drinkers,
Other, in the study of dietary polyphenols, a major compound found in green tea including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database. conducted in Kraków, Poland, dietary polyphenol intake in the highest quartile was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively).
g
Dietary polyphenols in high quality showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both genders.
Dr. Grosso G, the lead author said, "(Depending on types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavonols, and dihydrochalcones had the most relevant role."
In support of the role of used of polyphenols in the treatment of Metabolic syndrome, a total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, researchers showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.
The study also stated that the most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, and hydroxycinnamic acids as they showed independently associated with lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.
Taken together, green tea with major chemical compounds of polyphenol may be used as a functional food in the prevention and treatment of metabolic syndrome.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3. (PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3. (PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)
#Ginger Inhibits Muscle Pain Caused by Eccentric Exercise, Researchers Reveal
Kyle J. Norton
Scientists may have found a natural ingredient for the treatment of muscle pain with no side effects, according to a study.
Muscle pain is the condition of pain that originates from the muscle. Muscle pain may be caused by injury or overexertion, infections of soft tissues, or inflammatory conditions.
Systemic muscle pain is the pain throughout the body, often induced by an infection, an illness, or a side effect of long-term intake of certain medications, such as cholesterol medications.
There are many risk factors associated with muscle pain, including
1. Physical activity (PA) that requires the intensity, duration, and repetitiveness of muscular activity.
2. Occupations often involve static load, repetitive movements, and high peak forces, occurring for a prolonged duration are also some risk factors that causally relate to muscle pain development.
3. Overtraining in physical exercise.
Most muscle pains can be treated with over-the-counter painkillers. If you are currently taking them for the treatment of muscle pain, please make sure you know all the side effects for preventive measures.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of muscle pain quickly examined the effects of 11 days of raw (study 1) and heat-treated (study 2) ginger supplementation on muscle pain.
Study 1 and 2 were identical double-blind, placebo-controlled, randomized experiments with 34 and 40 volunteers, respectively
Also, participants consumed 2 grams of either raw (study 1) or heated (study 2) ginger or placebo for 11 consecutive days and participants performed 18 eccentric actions of the elbow flexors to induce pain and inflammation.
According to the assays, ginger showed a significant pain reduction in 24 hours after eccentric exercise compared to placebo.
There was no significant difference between both types of ginger and placebo on other measures.
Daily supplementation with ginger reduced muscle pain caused by eccentric exercise, and this effect was not enhanced by heat-treating ginger.
Dr. and colleagues wrote, "Daily consumption of raw and heat-treated ginger resulted in moderate-to-large reductions in muscle pain following exercise-induced muscle injury".
In order to reveal additional information about ginger in treating muscle pain, researchers evaluated the acute effects of ginger on muscle pain, inflammation, and dysfunction induced by eccentric exercise.
The double-blind, cross-over design, included 27 participants who performed 24 eccentric actions of the non-dominant elbow flexors and ingested a 2 g dose of ginger or placebo 24 h and 48 h after exercise.
Before ginger treatment, eccentric exercise caused moderate arm pain (39 ± 20 mm; mean ± SD) dysfunction (14% decrease in ROM), and an increase in volume (1.8%).
Ginger consumption demonstrated no effect on muscle pain, dysfunction, or metabolic rate compared with the placebo before 24 hours.
However, after 24 hours, arm pain was reduced (13%, -5.9 ± 8.8 mm) the following day, 48 h after exercise.
Based on the finding, researchers said, "a single 2 g dose of ginger does not attenuate eccentric exercise-induced muscle pain, inflammation or dysfunction 45 min after ingestion. However, ginger may attenuate the day-to-day progression of muscle pain".
Taken together, ginger may be considered a functional alternative for the treatment of muscle pain after 24 hours, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise by Black CD1, Herring MP, Hurley DJ, O'Connor PJ. (PubMed)
(2) Acute effects of dietary ginger on muscle pain induced by eccentric exercise by Black CD1, O'Connor PJ. (PubMed)
(3) Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms by Karen Søgaard and Gisela Sjøgaard. (PMC)
Scientists may have found a natural ingredient for the treatment of muscle pain with no side effects, according to a study.
Muscle pain is the condition of pain that originates from the muscle. Muscle pain may be caused by injury or overexertion, infections of soft tissues, or inflammatory conditions.
Systemic muscle pain is the pain throughout the body, often induced by an infection, an illness, or a side effect of long-term intake of certain medications, such as cholesterol medications.
There are many risk factors associated with muscle pain, including
1. Physical activity (PA) that requires the intensity, duration, and repetitiveness of muscular activity.
2. Occupations often involve static load, repetitive movements, and high peak forces, occurring for a prolonged duration are also some risk factors that causally relate to muscle pain development.
3. Overtraining in physical exercise.
Most muscle pains can be treated with over-the-counter painkillers. If you are currently taking them for the treatment of muscle pain, please make sure you know all the side effects for preventive measures.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of muscle pain quickly examined the effects of 11 days of raw (study 1) and heat-treated (study 2) ginger supplementation on muscle pain.
Study 1 and 2 were identical double-blind, placebo-controlled, randomized experiments with 34 and 40 volunteers, respectively
Also, participants consumed 2 grams of either raw (study 1) or heated (study 2) ginger or placebo for 11 consecutive days and participants performed 18 eccentric actions of the elbow flexors to induce pain and inflammation.
According to the assays, ginger showed a significant pain reduction in 24 hours after eccentric exercise compared to placebo.
There was no significant difference between both types of ginger and placebo on other measures.
Daily supplementation with ginger reduced muscle pain caused by eccentric exercise, and this effect was not enhanced by heat-treating ginger.
Dr. and colleagues wrote, "Daily consumption of raw and heat-treated ginger resulted in moderate-to-large reductions in muscle pain following exercise-induced muscle injury".
In order to reveal additional information about ginger in treating muscle pain, researchers evaluated the acute effects of ginger on muscle pain, inflammation, and dysfunction induced by eccentric exercise.
The double-blind, cross-over design, included 27 participants who performed 24 eccentric actions of the non-dominant elbow flexors and ingested a 2 g dose of ginger or placebo 24 h and 48 h after exercise.
Before ginger treatment, eccentric exercise caused moderate arm pain (39 ± 20 mm; mean ± SD) dysfunction (14% decrease in ROM), and an increase in volume (1.8%).
Ginger consumption demonstrated no effect on muscle pain, dysfunction, or metabolic rate compared with the placebo before 24 hours.
However, after 24 hours, arm pain was reduced (13%, -5.9 ± 8.8 mm) the following day, 48 h after exercise.
Based on the finding, researchers said, "a single 2 g dose of ginger does not attenuate eccentric exercise-induced muscle pain, inflammation or dysfunction 45 min after ingestion. However, ginger may attenuate the day-to-day progression of muscle pain".
Taken together, ginger may be considered a functional alternative for the treatment of muscle pain after 24 hours, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise by Black CD1, Herring MP, Hurley DJ, O'Connor PJ. (PubMed)
(2) Acute effects of dietary ginger on muscle pain induced by eccentric exercise by Black CD1, O'Connor PJ. (PubMed)
(3) Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms by Karen Søgaard and Gisela Sjøgaard. (PMC)
#Herbal Ashwagandha Inhibits Cardio-Toxicity Induced by Doxorubicin, Researchers Suggest
Kyle J. Norton
Cardiotoxicity is a condition caused by toxin accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduces the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and the intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine, and Vitamin B deficiency have also been found to induce cardiotoxicity.
Cardiomyopathy is a severe case of cardiotoxicity.
Cardiomyopathy in most occurs in patients under chemotherapy. However, a group of diseases or disorders can also lead to damaged heart muscle. Injury to the heart muscle may induce cardiomyopathy, including viruses - such as human immunodeficiency virus (HIV), infection, long-standing high blood pressure, chronic or long-term alcohol use, and diabetes.
Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include
* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.
*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.
* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers It is considered anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of cardiovascular diseases, researchers examined the protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.
According to the results of the experiment, doxorubicin (10 mg/kg) -)-induced cardiac toxicity in male Wistar rats showed an increase of necrosis and apoptosis in heart tissues.
Furthermore, the elevation of malondialdehyde and protein carbonyl levels and catalase activity associated with the expression of oxidative stress also were found in the doxorubicin (10 mg/kg) rats.
The doxorubicin (10 mg/kg) rats also exhibited depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues, accompanied by increases of myeloperoxidase activity, total calcium content, and the expression of Bcl-2 protein in heart tissues.
Most importantly, all parameters induced by the injection of doxorubicin alterations were effectively attenuated by the administration of the purified standardized extract (1.5% withanolides; manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg).
Based on the evidence, researchers said, "Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug".
Taken together, Ashwagandha may be considered a supplement for the prevention and treatment of cardiotoxicity induced by medications, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats by Hamza A1, Amin A, Daoud S. (PubMed)
Cardiotoxicity is a condition caused by toxin accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduces the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and the intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine, and Vitamin B deficiency have also been found to induce cardiotoxicity.
Cardiomyopathy is a severe case of cardiotoxicity.
Cardiomyopathy in most occurs in patients under chemotherapy. However, a group of diseases or disorders can also lead to damaged heart muscle. Injury to the heart muscle may induce cardiomyopathy, including viruses - such as human immunodeficiency virus (HIV), infection, long-standing high blood pressure, chronic or long-term alcohol use, and diabetes.
Conventionally, treatment of cardiotoxicity depending on the cause of the disease may include
* Beta-blockers, for the improvement of the blood flow and reduction of palpitations, arrhythmias, and high blood pressure.
*ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow.
* Diuretics, by getting rid of excess fluids that reduce heart function in blood pumping
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers It is considered anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of cardiovascular diseases, researchers examined the protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats.
According to the results of the experiment, doxorubicin (10 mg/kg) -)-induced cardiac toxicity in male Wistar rats showed an increase of necrosis and apoptosis in heart tissues.
Furthermore, the elevation of malondialdehyde and protein carbonyl levels and catalase activity associated with the expression of oxidative stress also were found in the doxorubicin (10 mg/kg) rats.
The doxorubicin (10 mg/kg) rats also exhibited depletion of total antioxidant capacity and of superoxide dismutase level in cardiac tissues, accompanied by increases of myeloperoxidase activity, total calcium content, and the expression of Bcl-2 protein in heart tissues.
Most importantly, all parameters induced by the injection of doxorubicin alterations were effectively attenuated by the administration of the purified standardized extract (1.5% withanolides; manufactured by Idea Sphere Inc., American Fork, UT, USA) of Withania somnifera (300 mg/kg).
Based on the evidence, researchers said, "Thus, Withania may play a role in the protection against cardiotoxicity and thus might be a useful adjuvant therapy where doxorubicin is the cancer-treating drug".
Taken together, Ashwagandha may be considered a supplement for the prevention and treatment of cardiotoxicity induced by medications, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats by Hamza A1, Amin A, Daoud S. (PubMed)
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